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P53866

- SQS1_YEAST

UniProt

P53866 - SQS1_YEAST

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Protein

Protein SQS1

Gene
SQS1, YNL224C, N1269
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants.1 Publication

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. maturation of SSU-rRNA Source: SGD
  2. mRNA splicing, via spliceosome Source: SGD
  3. positive regulation of ATPase activity Source: SGD
  4. positive regulation of helicase activity Source: SGD
  5. rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-33227-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SQS1
Alternative name(s):
Squelch of splicing suppression protein 1
Gene namesi
Name:SQS1
Ordered Locus Names:YNL224C
ORF Names:N1269
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL224c.
SGDiS000005168. SQS1.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. 90S preribosome Source: SGD
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
  4. preribosome, large subunit precursor Source: SGD
  5. preribosome, small subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Protein SQS1PRO_0000203388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Phosphoserine1 Publication
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei255 – 2551Phosphoserine1 Publication
Modified residuei334 – 3341Phosphoserine1 Publication
Modified residuei343 – 3431Phosphoserine2 Publications
Modified residuei345 – 3451Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53866.
PaxDbiP53866.

Expressioni

Gene expression databases

GenevestigatoriP53866.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRP43P531317EBI-29168,EBI-505

Protein-protein interaction databases

BioGridi35612. 65 interactions.
DIPiDIP-6728N.
IntActiP53866. 7 interactions.
MINTiMINT-618682.
STRINGi4932.YNL224C.

Structurei

3D structure databases

ProteinModelPortaliP53866.
SMRiP53866. Positions 596-656.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini594 – 65663R3HAdd
BLAST
Domaini720 – 76748G-patchAdd
BLAST

Sequence similaritiesi

Belongs to the SQS1 family.
Contains 1 G-patch domain.
Contains 1 R3H domain.

Phylogenomic databases

eggNOGiNOG114135.
HOGENOMiHOG000154406.
OMAiNIGRRML.
OrthoDBiEOG7ZGXCD.

Family and domain databases

Gene3Di3.30.1370.50. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR001374. R3H_ss-bd.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF82708. SSF82708. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53866-1 [UniParc]FASTAAdd to Basket

« Hide

MAKRHSHYQG SRRRHARGSN SKKAGRGNAK GIQGRKIKKK PTPTNSWHNS    50
SIPLGEGDLD DVGADFNPGR AFISPKTIED YYFGRDAKSR SMKMGGLRPG 100
NRYDSSTDLQ AGRAAFRKRP MQFVKAKEVY DPSHNMIQKL RAKNETKNSE 150
EIVEREADVF EEPGKMTSDV EYINNEDSEN EDDDSQNSPS TDHSLSSNES 200
KVEDGDLFFV DEEAQQSPDL TKIKRVCIEE IARPREVAIE FDPILTIGKV 250
ELSVSEGNES KEISVDVPNK GNKTYHPFAG YISNVLHGMH TSDSDNDELD 300
YEIETENNSE PLYESSASSE VDQGFNYVGQ RHNSRADNNL LPSPSPQLTE 350
DIKCLSINGT KTFEGNNDNL PSPASEELEF GFKEEDFVIN TNDIVVSNIR 400
MGGVDNSYYL RCYRLLGDYD FHWIDQDLLT DFVVDELGLP EDRLPAYLNF 450
IKNSLIPKIE PAEPTYSDIP ISDSSDEGDS YEGDSYEDDE DMASSVVHSD 500
IEEGLDDLIA YTLKHDTERF KTFETKSLET KGKGKKKKLL IDDALALDTE 550
TLETLQSKFS KRIETKAKKR KAKEDFIDQE NRNSNDMLKK YPYGLHIQNI 600
KDEFESFLSR NNDRLTFPPL DPHGNKTVMK IAKHYNMKSS KIGKANHTSV 650
VVEKIKKTKW SSPNYSLIDQ LMRQRPVFMR IDIRRPREEQ AAFERTKTIR 700
GKFHVKEGEI VGQNAPEIGN ENIGRRMLEK LGWKSGEGLG IQGNKGISEP 750
IFAKIKKNRS GLRHSES 767
Length:767
Mass (Da):86,950
Last modified:October 1, 1996 - v1
Checksum:iCE5650B8679BF8C0
GO

Sequence cautioni

The sequence AAA86499.1 differs from that shown. Reason: Frameshift at position 257.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69381 Genomic DNA. Translation: CAA93374.1.
Z71500 Genomic DNA. Translation: CAA96127.1.
U20390 Genomic DNA. Translation: AAA86499.1. Frameshift.
BK006947 Genomic DNA. Translation: DAA10332.1.
PIRiS63182.
RefSeqiNP_014175.1. NM_001183062.1.

Genome annotation databases

EnsemblFungiiYNL224C; YNL224C; YNL224C.
GeneIDi855497.
KEGGisce:YNL224C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69381 Genomic DNA. Translation: CAA93374.1 .
Z71500 Genomic DNA. Translation: CAA96127.1 .
U20390 Genomic DNA. Translation: AAA86499.1 . Frameshift.
BK006947 Genomic DNA. Translation: DAA10332.1 .
PIRi S63182.
RefSeqi NP_014175.1. NM_001183062.1.

3D structure databases

ProteinModelPortali P53866.
SMRi P53866. Positions 596-656.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35612. 65 interactions.
DIPi DIP-6728N.
IntActi P53866. 7 interactions.
MINTi MINT-618682.
STRINGi 4932.YNL224C.

Proteomic databases

MaxQBi P53866.
PaxDbi P53866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL224C ; YNL224C ; YNL224C .
GeneIDi 855497.
KEGGi sce:YNL224C.

Organism-specific databases

CYGDi YNL224c.
SGDi S000005168. SQS1.

Phylogenomic databases

eggNOGi NOG114135.
HOGENOMi HOG000154406.
OMAi NIGRRML.
OrthoDBi EOG7ZGXCD.

Enzyme and pathway databases

BioCyci YEAST:G3O-33227-MONOMER.

Miscellaneous databases

NextBioi 979487.

Gene expression databases

Genevestigatori P53866.

Family and domain databases

Gene3Di 3.30.1370.50. 1 hit.
InterProi IPR000467. G_patch_dom.
IPR001374. R3H_ss-bd.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
[Graphical view ]
SUPFAMi SSF82708. SSF82708. 1 hit.
PROSITEi PS50174. G_PATCH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of cosmid 14-5 from chromosome XIV reveals 21 open reading frames including a novel gene encoding a globin-like domain."
    Pandolfo D., de Antoni A., Lanfranchi G., Valle G.
    Yeast 12:1071-1076(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Sun Z., Hampsey M.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Inhibition of a spliceosome turnover pathway suppresses splicing defects."
    Pandit S., Lynn B., Rymond B.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:13700-13705(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217; SER-255 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; SER-334; SER-343 AND SER-345, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSQS1_YEAST
AccessioniPrimary (citable) accession number: P53866
Secondary accession number(s): D6W0W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1440 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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