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Protein

Protein SQS1

Gene

SQS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants.1 Publication

Miscellaneous

Present with 1440 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • maturation of SSU-rRNA Source: SGD
  • mRNA splicing, via spliceosome Source: SGD
  • positive regulation of ATPase activity Source: SGD
  • positive regulation of helicase activity Source: SGD
  • rRNA processing Source: SGD

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-33227-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SQS1
Alternative name(s):
Squelch of splicing suppression protein 1
Gene namesi
Name:SQS1
Ordered Locus Names:YNL224C
ORF Names:N1269
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL224C
SGDiS000005168 SQS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033881 – 767Protein SQS1Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei345PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53866
PaxDbiP53866
PRIDEiP53866

PTM databases

iPTMnetiP53866

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35612, 101 interactors
DIPiDIP-6728N
IntActiP53866, 24 interactors
MINTiP53866
STRINGi4932.YNL224C

Structurei

3D structure databases

ProteinModelPortaliP53866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini594 – 656R3HAdd BLAST63
Domaini720 – 767G-patchPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Belongs to the SQS1 family.Curated

Phylogenomic databases

HOGENOMiHOG000154406
InParanoidiP53866
OMAiESEPEYG
OrthoDBiEOG092C3CYC

Family and domain databases

CDDicd02646 R3H_G-patch, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034082 R3H_G-patch
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF01424 R3H, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

Sequencei

Sequence statusi: Complete.

P53866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRHSHYQG SRRRHARGSN SKKAGRGNAK GIQGRKIKKK PTPTNSWHNS
60 70 80 90 100
SIPLGEGDLD DVGADFNPGR AFISPKTIED YYFGRDAKSR SMKMGGLRPG
110 120 130 140 150
NRYDSSTDLQ AGRAAFRKRP MQFVKAKEVY DPSHNMIQKL RAKNETKNSE
160 170 180 190 200
EIVEREADVF EEPGKMTSDV EYINNEDSEN EDDDSQNSPS TDHSLSSNES
210 220 230 240 250
KVEDGDLFFV DEEAQQSPDL TKIKRVCIEE IARPREVAIE FDPILTIGKV
260 270 280 290 300
ELSVSEGNES KEISVDVPNK GNKTYHPFAG YISNVLHGMH TSDSDNDELD
310 320 330 340 350
YEIETENNSE PLYESSASSE VDQGFNYVGQ RHNSRADNNL LPSPSPQLTE
360 370 380 390 400
DIKCLSINGT KTFEGNNDNL PSPASEELEF GFKEEDFVIN TNDIVVSNIR
410 420 430 440 450
MGGVDNSYYL RCYRLLGDYD FHWIDQDLLT DFVVDELGLP EDRLPAYLNF
460 470 480 490 500
IKNSLIPKIE PAEPTYSDIP ISDSSDEGDS YEGDSYEDDE DMASSVVHSD
510 520 530 540 550
IEEGLDDLIA YTLKHDTERF KTFETKSLET KGKGKKKKLL IDDALALDTE
560 570 580 590 600
TLETLQSKFS KRIETKAKKR KAKEDFIDQE NRNSNDMLKK YPYGLHIQNI
610 620 630 640 650
KDEFESFLSR NNDRLTFPPL DPHGNKTVMK IAKHYNMKSS KIGKANHTSV
660 670 680 690 700
VVEKIKKTKW SSPNYSLIDQ LMRQRPVFMR IDIRRPREEQ AAFERTKTIR
710 720 730 740 750
GKFHVKEGEI VGQNAPEIGN ENIGRRMLEK LGWKSGEGLG IQGNKGISEP
760
IFAKIKKNRS GLRHSES
Length:767
Mass (Da):86,950
Last modified:October 1, 1996 - v1
Checksum:iCE5650B8679BF8C0
GO

Sequence cautioni

The sequence AAA86499 differs from that shown. Reason: Frameshift at position 257.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA Translation: CAA93374.1
Z71500 Genomic DNA Translation: CAA96127.1
U20390 Genomic DNA Translation: AAA86499.1 Frameshift.
BK006947 Genomic DNA Translation: DAA10332.1
PIRiS63182
RefSeqiNP_014175.1, NM_001183062.1

Genome annotation databases

EnsemblFungiiYNL224C; YNL224C; YNL224C
GeneIDi855497
KEGGisce:YNL224C

Similar proteinsi

Entry informationi

Entry nameiSQS1_YEAST
AccessioniPrimary (citable) accession number: P53866
Secondary accession number(s): D6W0W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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