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Protein

Phosphatidylinositol transfer protein PDR16

Gene

PDR16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover.2 Publications

GO - Molecular functioni

  • phosphatidylinositol transporter activity Source: SGD

GO - Biological processi

  • negative regulation of sexual sporulation resulting in formation of a cellular spore Source: SGD
  • phospholipid biosynthetic process Source: SGD
  • phospholipid transport Source: SGD
  • response to drug Source: SGD
  • sterol biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33231-MONOMER.

Chemistry databases

SwissLipidsiSLP:000000356.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein PDR16
Short name:
PITP
Alternative name(s):
Pleiotropic drug resistance protein 16
SEC14 homolog 3
Gene namesi
Name:PDR16
Synonyms:SFH3
Ordered Locus Names:YNL231C
ORF Names:N1158
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL231C.
SGDiS000005175. PDR16.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • lipid particle Source: SGD
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107451 – 351Phosphatidylinositol transfer protein PDR16Add BLAST351

Proteomic databases

MaxQBiP53860.
PRIDEiP53860.

PTM databases

iPTMnetiP53860.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-29195,EBI-29195

Protein-protein interaction databases

BioGridi35607. 29 interactors.
DIPiDIP-5449N.
IntActiP53860. 2 interactors.
MINTiMINT-539790.

Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 21Combined sources3
Helixi42 – 56Combined sources15
Beta strandi61 – 64Combined sources4
Beta strandi74 – 76Combined sources3
Helixi79 – 84Combined sources6
Helixi87 – 96Combined sources10
Turni97 – 99Combined sources3
Helixi101 – 118Combined sources18
Helixi125 – 127Combined sources3
Helixi133 – 136Combined sources4
Helixi137 – 140Combined sources4
Beta strandi144 – 150Combined sources7
Beta strandi156 – 160Combined sources5
Helixi162 – 164Combined sources3
Helixi171 – 186Combined sources16
Beta strandi195 – 200Combined sources6
Helixi221 – 231Combined sources11
Beta strandi237 – 244Combined sources8
Helixi247 – 256Combined sources10
Helixi257 – 259Combined sources3
Helixi262 – 265Combined sources4
Beta strandi268 – 272Combined sources5
Helixi274 – 276Combined sources3
Helixi280 – 282Combined sources3
Helixi285 – 287Combined sources3
Beta strandi289 – 293Combined sources5
Helixi297 – 321Combined sources25
Helixi330 – 333Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FMMX-ray2.34A/B1-351[»]
4J7PX-ray2.00A/B2-351[»]
4J7QX-ray1.55A/B15-345[»]
4M8ZX-ray1.93A/B1-351[»]
ProteinModelPortaliP53860.
SMRiP53860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 295CRAL-TRIOPROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018675.
HOGENOMiHOG000176881.
InParanoidiP53860.
OMAiVWMLERT.
OrthoDBiEOG092C2TLF.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKRFSKKKE APEDPKNLIN IDKPIKELPA SIAIPKEKPL TGEQQKMYDE
60 70 80 90 100
VLKHFSNPDL KVYTSEKNKS EDDLKPLEEE EKAWLTRECF LRYLRATKWV
110 120 130 140 150
LKDCIDRITM TLAWRREFGI SHLGEEHGDK ITADLVAVEN ESGKQVILGY
160 170 180 190 200
ENDARPILYL KPGRQNTKTS HRQVQHLVFM LERVIDFMPA GQDSLALLID
210 220 230 240 250
FKDYPDVPKV PGNSKIPPIG VGKEVLHILQ THYPERLGKA LLTNIPWLAW
260 270 280 290 300
TFLKLIHPFI DPLTREKLVF DEPFVKYVPK NELDSLYGGD LKFKYNHDVY
310 320 330 340 350
WPALVETARE KRDHYFKRFQ SFGGIVGLSE VDLRGTHEKL LYPVKSESST

V
Length:351
Mass (Da):40,714
Last modified:October 1, 1996 - v1
Checksum:i24C5B3262016F037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA. Translation: CAA93367.1.
Z71507 Genomic DNA. Translation: CAA96136.1.
AY558020 Genomic DNA. Translation: AAS56346.1.
BK006947 Genomic DNA. Translation: DAA10327.1.
PIRiS63197.
RefSeqiNP_014168.1. NM_001183069.1.

Genome annotation databases

EnsemblFungiiYNL231C; YNL231C; YNL231C.
GeneIDi855490.
KEGGisce:YNL231C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA. Translation: CAA93367.1.
Z71507 Genomic DNA. Translation: CAA96136.1.
AY558020 Genomic DNA. Translation: AAS56346.1.
BK006947 Genomic DNA. Translation: DAA10327.1.
PIRiS63197.
RefSeqiNP_014168.1. NM_001183069.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FMMX-ray2.34A/B1-351[»]
4J7PX-ray2.00A/B2-351[»]
4J7QX-ray1.55A/B15-345[»]
4M8ZX-ray1.93A/B1-351[»]
ProteinModelPortaliP53860.
SMRiP53860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35607. 29 interactors.
DIPiDIP-5449N.
IntActiP53860. 2 interactors.
MINTiMINT-539790.

Chemistry databases

SwissLipidsiSLP:000000356.

PTM databases

iPTMnetiP53860.

Proteomic databases

MaxQBiP53860.
PRIDEiP53860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL231C; YNL231C; YNL231C.
GeneIDi855490.
KEGGisce:YNL231C.

Organism-specific databases

EuPathDBiFungiDB:YNL231C.
SGDiS000005175. PDR16.

Phylogenomic databases

GeneTreeiENSGT00390000018675.
HOGENOMiHOG000176881.
InParanoidiP53860.
OMAiVWMLERT.
OrthoDBiEOG092C2TLF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33231-MONOMER.

Miscellaneous databases

PROiP53860.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDR16_YEAST
AccessioniPrimary (citable) accession number: P53860
Secondary accession number(s): D6W0W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 15361 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.