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P53860

- PDR16_YEAST

UniProt

P53860 - PDR16_YEAST

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Protein
Phosphatidylinositol transfer protein PDR16
Gene
PDR16, SFH3, YNL231C, N1158
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover.2 Publications

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. phosphatidylinositol transporter activity Source: SGD

GO - Biological processi

  1. negative regulation of sexual sporulation resulting in formation of a cellular spore Source: SGD
  2. phospholipid biosynthetic process Source: SGD
  3. phospholipid transport Source: SGD
  4. response to drug Source: SGD
  5. sterol biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33231-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein PDR16
Short name:
PITP
Alternative name(s):
Pleiotropic drug resistance protein 16
SEC14 homolog 3
Gene namesi
Name:PDR16
Synonyms:SFH3
Ordered Locus Names:YNL231C
ORF Names:N1158
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL231c.
SGDiS000005175. PDR16.

Subcellular locationi

Lipid droplet. Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein Reviewed prediction 2 Publications

GO - Cellular componenti

  1. cell periphery Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. lipid particle Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Phosphatidylinositol transfer protein PDR16
PRO_0000210745Add
BLAST

Proteomic databases

MaxQBiP53860.
PaxDbiP53860.
PeptideAtlasiP53860.

Expressioni

Gene expression databases

GenevestigatoriP53860.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-29195,EBI-29195

Protein-protein interaction databases

BioGridi35607. 28 interactions.
DIPiDIP-5449N.
IntActiP53860. 2 interactions.
MINTiMINT-539790.
STRINGi4932.YNL231C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 213
Helixi42 – 5615
Beta strandi61 – 644
Beta strandi74 – 763
Helixi79 – 846
Helixi87 – 9610
Helixi101 – 11818
Helixi125 – 1273
Helixi133 – 1364
Helixi137 – 1404
Beta strandi144 – 1507
Beta strandi156 – 1605
Helixi162 – 1643
Helixi171 – 18616
Beta strandi195 – 2006
Helixi221 – 23111
Beta strandi237 – 2448
Helixi247 – 25610
Helixi257 – 2593
Helixi262 – 2654
Beta strandi268 – 2725
Helixi274 – 2763
Helixi280 – 2823
Helixi285 – 2873
Beta strandi289 – 2935
Helixi297 – 32125
Helixi330 – 3334

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FMMX-ray2.34A/B1-351[»]
4J7PX-ray2.00A/B2-351[»]
4J7QX-ray1.55A/B15-345[»]
ProteinModelPortaliP53860.
SMRiP53860. Positions 16-345.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 295161CRAL-TRIO
Add
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.

Phylogenomic databases

eggNOGiNOG242743.
GeneTreeiENSGT00390000018675.
HOGENOMiHOG000176881.
OMAiNEACLVR.
OrthoDBiEOG70PC7T.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53860-1 [UniParc]FASTAAdd to Basket

« Hide

MFKRFSKKKE APEDPKNLIN IDKPIKELPA SIAIPKEKPL TGEQQKMYDE    50
VLKHFSNPDL KVYTSEKNKS EDDLKPLEEE EKAWLTRECF LRYLRATKWV 100
LKDCIDRITM TLAWRREFGI SHLGEEHGDK ITADLVAVEN ESGKQVILGY 150
ENDARPILYL KPGRQNTKTS HRQVQHLVFM LERVIDFMPA GQDSLALLID 200
FKDYPDVPKV PGNSKIPPIG VGKEVLHILQ THYPERLGKA LLTNIPWLAW 250
TFLKLIHPFI DPLTREKLVF DEPFVKYVPK NELDSLYGGD LKFKYNHDVY 300
WPALVETARE KRDHYFKRFQ SFGGIVGLSE VDLRGTHEKL LYPVKSESST 350
V 351
Length:351
Mass (Da):40,714
Last modified:October 1, 1996 - v1
Checksum:i24C5B3262016F037
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69381 Genomic DNA. Translation: CAA93367.1.
Z71507 Genomic DNA. Translation: CAA96136.1.
AY558020 Genomic DNA. Translation: AAS56346.1.
BK006947 Genomic DNA. Translation: DAA10327.1.
PIRiS63197.
RefSeqiNP_014168.1. NM_001183069.1.

Genome annotation databases

EnsemblFungiiYNL231C; YNL231C; YNL231C.
GeneIDi855490.
KEGGisce:YNL231C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z69381 Genomic DNA. Translation: CAA93367.1 .
Z71507 Genomic DNA. Translation: CAA96136.1 .
AY558020 Genomic DNA. Translation: AAS56346.1 .
BK006947 Genomic DNA. Translation: DAA10327.1 .
PIRi S63197.
RefSeqi NP_014168.1. NM_001183069.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FMM X-ray 2.34 A/B 1-351 [» ]
4J7P X-ray 2.00 A/B 2-351 [» ]
4J7Q X-ray 1.55 A/B 15-345 [» ]
ProteinModelPortali P53860.
SMRi P53860. Positions 16-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35607. 28 interactions.
DIPi DIP-5449N.
IntActi P53860. 2 interactions.
MINTi MINT-539790.
STRINGi 4932.YNL231C.

Proteomic databases

MaxQBi P53860.
PaxDbi P53860.
PeptideAtlasi P53860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL231C ; YNL231C ; YNL231C .
GeneIDi 855490.
KEGGi sce:YNL231C.

Organism-specific databases

CYGDi YNL231c.
SGDi S000005175. PDR16.

Phylogenomic databases

eggNOGi NOG242743.
GeneTreei ENSGT00390000018675.
HOGENOMi HOG000176881.
OMAi NEACLVR.
OrthoDBi EOG70PC7T.

Enzyme and pathway databases

BioCyci YEAST:G3O-33231-MONOMER.

Miscellaneous databases

NextBioi 979472.

Gene expression databases

Genevestigatori P53860.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view ]
Pfami PF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view ]
SMARTi SM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of cosmid 14-5 from chromosome XIV reveals 21 open reading frames including a novel gene encoding a globin-like domain."
    Pandolfo D., de Antoni A., Lanfranchi G., Valle G.
    Yeast 12:1071-1076(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Bienvenut W.V., Peters C.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 240-292 AND 319-334, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs."
    van den Hazel H.B., Pichler H., do Valle Matta M.A., Leitner E., Goffeau A., Daum G.
    J. Biol. Chem. 274:1934-1941(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth."
    Li X., Routt S.M., Xie Z., Cui X., Fang M., Kearns M.A., Bard M., Kirsch D.R., Bankaitis V.A.
    Mol. Biol. Cell 11:1989-2005(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover."
    Schnabl M., Oskolkova O.V., Holic R., Brezna B., Pichler H., Zagorsek M., Kohlwein S.D., Paltauf F., Daum G., Griac P.
    Eur. J. Biochem. 270:3133-3145(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  11. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  12. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDR16_YEAST
AccessioniPrimary (citable) accession number: P53860
Secondary accession number(s): D6W0W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 15361 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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