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Protein

Autophagy-related protein 2

Gene

ATG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cytoplasm to vacuole transport (Cvt) vesicle and autophagosome completion. Necessary for the localization of ATG18 to the preautophagosomal structure (PAS) and the binding of ATG18 to ATG9. Involved in correct ATG9 trafficking through the preautophagosomal structure and in peroxisome degradation. ATG2 is the most downstream ATG protein in the preautophagosomal structure organization process. Plays a significant role in life span extension.14 Publications

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • autophagosome assembly Source: SGD
  • autophagy Source: UniProtKB
  • autophagy of mitochondrion Source: SGD
  • autophagy of peroxisome Source: SGD
  • late nucleophagy Source: SGD
  • piecemeal microautophagy of the nucleus Source: SGD
  • protein localization by the Cvt pathway Source: SGD
  • protein transport Source: UniProtKB-KW
  • reticulophagy Source: SGD

Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33239-MONOMER

Protein family/group databases

TCDBi9.A.15.1.1 the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2
Alternative name(s):
Sporulation-specific protein 72
Gene namesi
Name:ATG2
Synonyms:APG2, AUT8, SPO72
Ordered Locus Names:YNL242W
ORF Names:N1106
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YNL242W
SGDiS000005186 ATG2

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83G → E: Leads to a severely reduced activity of autophagy and a dispersed localization in the cytoplasm. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158361 – 1592Autophagy-related protein 2Add BLAST1592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53855
PaxDbiP53855
PRIDEiP53855

PTM databases

iPTMnetiP53855

Interactioni

Subunit structurei

Interacts with ATG18.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG18P436015EBI-29212,EBI-22968

Protein-protein interaction databases

BioGridi35597, 181 interactors
DIPiDIP-2620N
IntActiP53855, 5 interactors
MINTiP53855
STRINGi4932.YNL242W

Structurei

3D structure databases

ProteinModelPortaliP53855
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1049 – 1075Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00620000087966
HOGENOMiHOG000034152
InParanoidiP53855
KOiK17906
OMAiWMPQNIQ
OrthoDBiEOG092C02NM

Family and domain databases

InterProiView protein in InterPro
IPR026849 ATG2
IPR026885 ATG2_CAD_motif
IPR026886 ATG2_fungi/plants
IPR015412 Autophagy-rel_C
PANTHERiPTHR13190 PTHR13190, 3 hits
PTHR13190:SF1 PTHR13190:SF1, 3 hits
PfamiView protein in Pfam
PF13329 ATG2_CAD, 1 hit
PF09333 ATG_C, 1 hit

Sequencei

Sequence statusi: Complete.

P53855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFWLPQNIQ KRLLLYVLQQ ISLFSNIDLS NLDVSIGSKS HFSFHDVNLS
60 70 80 90 100
LDDLNIPNVQ INEGIVDELV LKLTVSGGVE IDGSGLRFIM TPLYSSGSQE
110 120 130 140 150
LHSDFLVKSI QDLTNSMLQF SDPLTTYNRY KEDDISSSDS SSDLNSNIEA
160 170 180 190 200
SKPAANGSYT LQNMRNKALN VALAKLKIAL KDVTIRFIVN DRDPSDNIVE
210 220 230 240 250
VHLESIQLIT TDANLRHINI ENITISSIQK QAVPDSPVHP FNNDDLSQSV
260 270 280 290 300
YLSKMEATSL YMSAMEEQSN EDPSEPQVTQ EEQENDKCKE SLMEINNLNI
310 320 330 340 350
AFKGLSSVND LRMSNIVIDI QDVHLAIHKI VEIKNSTLKN IIDIIVTHLD
360 370 380 390 400
ANESFSCQDS QSPSPDKQEP SALSSVDIKC IYLNLGQDIT VILKSFKLEQ
410 420 430 440 450
KENNSLAFSL GSFYSNSSPL TISHKTKPLL TGEQTPQSIA LNMGDELDII
460 470 480 490 500
ISHDGIAHFF KIFQFVSKCM SFYQNKSKGM MPQIASDTKR TVQLTSKAVK
510 520 530 540 550
LSLKFPYFLL CFQVSPFIYD SNRELYIELV DVFKKLPSRC TKILTMSSIT
560 570 580 590 600
ISNLQSPLQL GSYDDTLKEA LIYSSVHAII KEVIFNEEYS GIVQLVEDIS
610 620 630 640 650
AFGKLFTDSK NSECTGKSKS KRGSFLQRSV RVLNSSRFVY KQSLSANFSL
660 670 680 690 700
KIDSMKLKVS EIIGPQFGSV EALLSNNFFA ITDDSQIVYF TKNLKVERKT
710 720 730 740 750
PSLLEPQEIM SVVLNKAVNE PVLYVHRRAN GKLKVIFNNI RIHYYARWLE
760 770 780 790 800
ILKKNIGPDN ASSKDEPVSQ KLSKKQPTSG FPWELKCLDC SLILHPFRLK
810 820 830 840 850
SVMVIVLDNL TTGGSSFIPQ AKLLSKANTL FLIDDYQNFK IQKDKNWPSL
860 870 880 890 900
INFYAGQGFS AIGKIDTLNF LINKSDGALL LDCKIEQVGL SLCADSFQTF
910 920 930 940 950
CQLCIDLKYP QTFPDEEKFR TQLKNPIDVF KDIDCDLFNS AFIRENNHQN
960 970 980 990 1000
DYDSVHLVDS FLDKTHEFNN GARSKLSSQG SYEMDSSSGT ATGGILLPHE
1010 1020 1030 1040 1050
SYLDSAQPKE EDTPPIASKE QERDVDIRGS IDVEKVVIKL FDGYDWKYTR
1060 1070 1080 1090 1100
KFIANTVEKL DKELSKAEAS SSKSNVPQSE ANIFDSIYIS ANKNNVTDLR
1110 1120 1130 1140 1150
RNLDGEIQGV QNSFSDVSKV NLRPSKHYKA LIQLNKVHVN LKNYRVDEPD
1160 1170 1180 1190 1200
ESNSDNSTDV LNRCVVSIYE FEIIDNVPTS TWNKFVTLLK HEPWPHSSPM
1210 1220 1230 1240 1250
FLLDLEFIRP IDFLQAVELV MQLNVAPLRL HVDQDTLEFL IRFLGFKDKR
1260 1270 1280 1290 1300
FELIDEYPDI VFIQKFSTNS IKLRLDYKPK KVDYAGLRSG QTSELMNFFT
1310 1320 1330 1340 1350
LDGSKIILKS VVLYGLNGFD ELNNKLKAIW TPDITKKQLP GVLEGLAPVR
1360 1370 1380 1390 1400
SFMAIGSGVK TLVTVLMSEY RQEGHLGRSL KKGGNVFLKT TTGDFVKLGV
1410 1420 1430 1440 1450
KLTSGTQAIL ENTEELFGGV GSNGRVYDAS KFGSADGADS DTAAVLDLDT
1460 1470 1480 1490 1500
LFEEDQLVGS KYSRIRDHEP TAVVIDMSSP GDHNEPTIVS LYADQPLDLP
1510 1520 1530 1540 1550
TGLKEAYSSL EKHMHIAYDA VWRAKGQMKD DKRGGPSAAA VYVARAAPVA
1560 1570 1580 1590
IIRPLIGATE AVSKTLQGIA NQVDKTHNEQ INDKYKSNRT DS
Length:1,592
Mass (Da):178,414
Last modified:October 1, 1996 - v1
Checksum:i54FDDF56297FFF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA Translation: CAA93356.1
Z71518 Genomic DNA Translation: CAA96147.1
BK006947 Genomic DNA Translation: DAA10317.1
PIRiS63208
RefSeqiNP_014157.1, NM_001183080.1

Genome annotation databases

EnsemblFungiiYNL242W; YNL242W; YNL242W
GeneIDi855479
KEGGisce:YNL242W

Entry informationi

Entry nameiATG2_YEAST
AccessioniPrimary (citable) accession number: P53855
Secondary accession number(s): D6W0V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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