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Protein

Autophagy-related protein 2

Gene

ATG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytoplasm to vacuole transport (Cvt) vesicle and autophagosome completion. Necessary for the localization of ATG18 to the preautophagosomal structure (PAS) and the binding of ATG18 to ATG9. Involved in correct ATG9 trafficking through the preautophagosomal structure and in peroxisome degradation. ATG2 is the most downstream ATG protein in the preautophagosomal structure organization process. Plays a significant role in life span extension.14 Publications

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD

GO - Biological processi

  • autophagosome assembly Source: SGD
  • autophagy Source: UniProtKB
  • CVT pathway Source: SGD
  • late nucleophagy Source: SGD
  • mitophagy Source: SGD
  • pexophagy Source: SGD
  • piecemeal microautophagy of nucleus Source: SGD
  • reticulophagy Source: SGD
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33239-MONOMER.

Protein family/group databases

TCDBi9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2
Alternative name(s):
Sporulation-specific protein 72
Gene namesi
Name:ATG2
Synonyms:APG2, AUT8, SPO72
Ordered Locus Names:YNL242W
ORF Names:N1106
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL242W.
SGDiS000005186. ATG2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • extrinsic component of membrane Source: SGD
  • extrinsic component of pre-autophagosomal structure membrane Source: UniProtKB
  • pre-autophagosomal structure Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi83G → E: Leads to a severely reduced activity of autophagy and a dispersed localization in the cytoplasm. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158361 – 1592Autophagy-related protein 2Add BLAST1592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53855.
PRIDEiP53855.

PTM databases

iPTMnetiP53855.

Interactioni

Subunit structurei

Interacts with ATG18.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG18P436015EBI-29212,EBI-22968

Protein-protein interaction databases

BioGridi35597. 42 interactors.
DIPiDIP-2620N.
IntActiP53855. 5 interactors.
MINTiMINT-426483.

Structurei

3D structure databases

ProteinModelPortaliP53855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1049 – 1075Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034152.
InParanoidiP53855.
KOiK17906.
OMAiYSNQPEN.
OrthoDBiEOG092C02NM.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 2 hits.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFWLPQNIQ KRLLLYVLQQ ISLFSNIDLS NLDVSIGSKS HFSFHDVNLS
60 70 80 90 100
LDDLNIPNVQ INEGIVDELV LKLTVSGGVE IDGSGLRFIM TPLYSSGSQE
110 120 130 140 150
LHSDFLVKSI QDLTNSMLQF SDPLTTYNRY KEDDISSSDS SSDLNSNIEA
160 170 180 190 200
SKPAANGSYT LQNMRNKALN VALAKLKIAL KDVTIRFIVN DRDPSDNIVE
210 220 230 240 250
VHLESIQLIT TDANLRHINI ENITISSIQK QAVPDSPVHP FNNDDLSQSV
260 270 280 290 300
YLSKMEATSL YMSAMEEQSN EDPSEPQVTQ EEQENDKCKE SLMEINNLNI
310 320 330 340 350
AFKGLSSVND LRMSNIVIDI QDVHLAIHKI VEIKNSTLKN IIDIIVTHLD
360 370 380 390 400
ANESFSCQDS QSPSPDKQEP SALSSVDIKC IYLNLGQDIT VILKSFKLEQ
410 420 430 440 450
KENNSLAFSL GSFYSNSSPL TISHKTKPLL TGEQTPQSIA LNMGDELDII
460 470 480 490 500
ISHDGIAHFF KIFQFVSKCM SFYQNKSKGM MPQIASDTKR TVQLTSKAVK
510 520 530 540 550
LSLKFPYFLL CFQVSPFIYD SNRELYIELV DVFKKLPSRC TKILTMSSIT
560 570 580 590 600
ISNLQSPLQL GSYDDTLKEA LIYSSVHAII KEVIFNEEYS GIVQLVEDIS
610 620 630 640 650
AFGKLFTDSK NSECTGKSKS KRGSFLQRSV RVLNSSRFVY KQSLSANFSL
660 670 680 690 700
KIDSMKLKVS EIIGPQFGSV EALLSNNFFA ITDDSQIVYF TKNLKVERKT
710 720 730 740 750
PSLLEPQEIM SVVLNKAVNE PVLYVHRRAN GKLKVIFNNI RIHYYARWLE
760 770 780 790 800
ILKKNIGPDN ASSKDEPVSQ KLSKKQPTSG FPWELKCLDC SLILHPFRLK
810 820 830 840 850
SVMVIVLDNL TTGGSSFIPQ AKLLSKANTL FLIDDYQNFK IQKDKNWPSL
860 870 880 890 900
INFYAGQGFS AIGKIDTLNF LINKSDGALL LDCKIEQVGL SLCADSFQTF
910 920 930 940 950
CQLCIDLKYP QTFPDEEKFR TQLKNPIDVF KDIDCDLFNS AFIRENNHQN
960 970 980 990 1000
DYDSVHLVDS FLDKTHEFNN GARSKLSSQG SYEMDSSSGT ATGGILLPHE
1010 1020 1030 1040 1050
SYLDSAQPKE EDTPPIASKE QERDVDIRGS IDVEKVVIKL FDGYDWKYTR
1060 1070 1080 1090 1100
KFIANTVEKL DKELSKAEAS SSKSNVPQSE ANIFDSIYIS ANKNNVTDLR
1110 1120 1130 1140 1150
RNLDGEIQGV QNSFSDVSKV NLRPSKHYKA LIQLNKVHVN LKNYRVDEPD
1160 1170 1180 1190 1200
ESNSDNSTDV LNRCVVSIYE FEIIDNVPTS TWNKFVTLLK HEPWPHSSPM
1210 1220 1230 1240 1250
FLLDLEFIRP IDFLQAVELV MQLNVAPLRL HVDQDTLEFL IRFLGFKDKR
1260 1270 1280 1290 1300
FELIDEYPDI VFIQKFSTNS IKLRLDYKPK KVDYAGLRSG QTSELMNFFT
1310 1320 1330 1340 1350
LDGSKIILKS VVLYGLNGFD ELNNKLKAIW TPDITKKQLP GVLEGLAPVR
1360 1370 1380 1390 1400
SFMAIGSGVK TLVTVLMSEY RQEGHLGRSL KKGGNVFLKT TTGDFVKLGV
1410 1420 1430 1440 1450
KLTSGTQAIL ENTEELFGGV GSNGRVYDAS KFGSADGADS DTAAVLDLDT
1460 1470 1480 1490 1500
LFEEDQLVGS KYSRIRDHEP TAVVIDMSSP GDHNEPTIVS LYADQPLDLP
1510 1520 1530 1540 1550
TGLKEAYSSL EKHMHIAYDA VWRAKGQMKD DKRGGPSAAA VYVARAAPVA
1560 1570 1580 1590
IIRPLIGATE AVSKTLQGIA NQVDKTHNEQ INDKYKSNRT DS
Length:1,592
Mass (Da):178,414
Last modified:October 1, 1996 - v1
Checksum:i54FDDF56297FFF99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA. Translation: CAA93356.1.
Z71518 Genomic DNA. Translation: CAA96147.1.
BK006947 Genomic DNA. Translation: DAA10317.1.
PIRiS63208.
RefSeqiNP_014157.1. NM_001183080.1.

Genome annotation databases

EnsemblFungiiYNL242W; YNL242W; YNL242W.
GeneIDi855479.
KEGGisce:YNL242W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69381 Genomic DNA. Translation: CAA93356.1.
Z71518 Genomic DNA. Translation: CAA96147.1.
BK006947 Genomic DNA. Translation: DAA10317.1.
PIRiS63208.
RefSeqiNP_014157.1. NM_001183080.1.

3D structure databases

ProteinModelPortaliP53855.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35597. 42 interactors.
DIPiDIP-2620N.
IntActiP53855. 5 interactors.
MINTiMINT-426483.

Protein family/group databases

TCDBi9.A.15.1.1. the autophagy-related phagophore-formation transporter (apt) family.

PTM databases

iPTMnetiP53855.

Proteomic databases

MaxQBiP53855.
PRIDEiP53855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL242W; YNL242W; YNL242W.
GeneIDi855479.
KEGGisce:YNL242W.

Organism-specific databases

EuPathDBiFungiDB:YNL242W.
SGDiS000005186. ATG2.

Phylogenomic databases

GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034152.
InParanoidiP53855.
KOiK17906.
OMAiYSNQPEN.
OrthoDBiEOG092C02NM.

Enzyme and pathway databases

BioCyciYEAST:G3O-33239-MONOMER.

Miscellaneous databases

PROiP53855.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 2 hits.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG2_YEAST
AccessioniPrimary (citable) accession number: P53855
Secondary accession number(s): D6W0V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 876 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.