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P53849

- GIS2_YEAST

UniProt

P53849 - GIS2_YEAST

Protein

Zinc finger protein GIS2

Gene

GIS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May act in the sexual differentiation pathway.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri23 – 4018CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri47 – 6418CCHC-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri65 – 8218CCHC-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 10918CCHC-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri116 – 13318CCHC-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri135 – 15218CCHC-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. mRNA binding Source: SGD
    2. single-stranded DNA binding Source: SGD
    3. translation regulator activity Source: SGD
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of translation Source: SGD

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33252-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein GIS2
    Gene namesi
    Name:GIS2
    Ordered Locus Names:YNL255C
    ORF Names:N0852
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL255c.
    SGDiS000005199. GIS2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasmic mRNA processing body Source: SGD
    2. cytoplasmic stress granule Source: SGD
    3. polysomal ribosome Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Zinc finger protein GIS2PRO_0000087496Add
    BLAST

    Proteomic databases

    MaxQBiP53849.
    PaxDbiP53849.
    PeptideAtlasiP53849.

    Expressioni

    Gene expression databases

    GenevestigatoriP53849.

    Interactioni

    Protein-protein interaction databases

    BioGridi35584. 1216 interactions.
    DIPiDIP-2669N.
    IntActiP53849. 20 interactions.
    MINTiMINT-2732013.
    STRINGi4932.YNL255C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53849.
    SMRiP53849. Positions 6-39, 67-109, 118-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri23 – 4018CCHC-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri47 – 6418CCHC-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri65 – 8218CCHC-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri92 – 10918CCHC-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri116 – 13318CCHC-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri135 – 15218CCHC-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5082.
    GeneTreeiENSGT00510000047065.
    HOGENOMiHOG000186262.
    KOiK09250.
    OMAiQFGHISK.
    OrthoDBiEOG7GFBDX.

    Family and domain databases

    Gene3Di4.10.60.10. 4 hits.
    InterProiIPR001878. Znf_CCHC.
    [Graphical view]
    PfamiPF00098. zf-CCHC. 7 hits.
    [Graphical view]
    SMARTiSM00343. ZnF_C2HC. 7 hits.
    [Graphical view]
    SUPFAMiSSF57756. SSF57756. 3 hits.
    PROSITEiPS50158. ZF_CCHC. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53849-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQKACYVCG KIGHLAEDCD SERLCYNCNK PGHVQTDCTM PRTVEFKQCY    50
    NCGETGHVRS ECTVQRCFNC NQTGHISREC PEPKKTSRFS KVSCYKCGGP 100
    NHMAKDCMKE DGISGLKCYT CGQAGHMSRD CQNDRLCYNC NETGHISKDC 150
    PKA 153
    Length:153
    Mass (Da):17,103
    Last modified:October 1, 1996 - v1
    Checksum:iE72696428F85CA3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96722 Genomic DNA. Translation: CAA65489.1.
    Z71531 Genomic DNA. Translation: CAA96162.1.
    AY558002 Genomic DNA. Translation: AAS56328.1.
    BK006947 Genomic DNA. Translation: DAA10304.1.
    PIRiS63228.
    RefSeqiNP_014144.1. NM_001183093.1.

    Genome annotation databases

    EnsemblFungiiYNL255C; YNL255C; YNL255C.
    GeneIDi855466.
    KEGGisce:YNL255C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X96722 Genomic DNA. Translation: CAA65489.1 .
    Z71531 Genomic DNA. Translation: CAA96162.1 .
    AY558002 Genomic DNA. Translation: AAS56328.1 .
    BK006947 Genomic DNA. Translation: DAA10304.1 .
    PIRi S63228.
    RefSeqi NP_014144.1. NM_001183093.1.

    3D structure databases

    ProteinModelPortali P53849.
    SMRi P53849. Positions 6-39, 67-109, 118-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35584. 1216 interactions.
    DIPi DIP-2669N.
    IntActi P53849. 20 interactions.
    MINTi MINT-2732013.
    STRINGi 4932.YNL255C.

    Proteomic databases

    MaxQBi P53849.
    PaxDbi P53849.
    PeptideAtlasi P53849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL255C ; YNL255C ; YNL255C .
    GeneIDi 855466.
    KEGGi sce:YNL255C.

    Organism-specific databases

    CYGDi YNL255c.
    SGDi S000005199. GIS2.

    Phylogenomic databases

    eggNOGi COG5082.
    GeneTreei ENSGT00510000047065.
    HOGENOMi HOG000186262.
    KOi K09250.
    OMAi QFGHISK.
    OrthoDBi EOG7GFBDX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33252-MONOMER.

    Miscellaneous databases

    NextBioi 979403.
    PROi P53849.

    Gene expression databases

    Genevestigatori P53849.

    Family and domain databases

    Gene3Di 4.10.60.10. 4 hits.
    InterProi IPR001878. Znf_CCHC.
    [Graphical view ]
    Pfami PF00098. zf-CCHC. 7 hits.
    [Graphical view ]
    SMARTi SM00343. ZnF_C2HC. 7 hits.
    [Graphical view ]
    SUPFAMi SSF57756. SSF57756. 3 hits.
    PROSITEi PS50158. ZF_CCHC. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae."
      Sen-Gupta M., Gueldener U., Beinhauer J.D., Fiedler T.A., Hegemann J.H.
      Yeast 13:849-860(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells."
      Balciunas D., Ronne H.
      Mol. Gen. Genet. 262:589-599(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIS2_YEAST
    AccessioniPrimary (citable) accession number: P53849
    Secondary accession number(s): D6W0T8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 96655 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3