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P53849 (GIS2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein GIS2
Gene names
Name:GIS2
Ordered Locus Names:YNL255C
ORF Names:N0852
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act in the sexual differentiation pathway By similarity. Ref.5

Subcellular location

Cytoplasm Ref.6.

Miscellaneous

Present with 96655 molecules/cell in log phase SD medium.

Sequence similarities

Contains 7 CCHC-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Zinc finger protein GIS2
PRO_0000087496

Regions

Zinc finger4 – 2118CCHC-type 1
Zinc finger23 – 4018CCHC-type 2
Zinc finger47 – 6418CCHC-type 3
Zinc finger65 – 8218CCHC-type 4
Zinc finger92 – 10918CCHC-type 5
Zinc finger116 – 13318CCHC-type 6
Zinc finger135 – 15218CCHC-type 7

Sequences

Sequence LengthMass (Da)Tools
P53849 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E72696428F85CA3F

FASTA15317,103
        10         20         30         40         50         60 
MSQKACYVCG KIGHLAEDCD SERLCYNCNK PGHVQTDCTM PRTVEFKQCY NCGETGHVRS 

        70         80         90        100        110        120 
ECTVQRCFNC NQTGHISREC PEPKKTSRFS KVSCYKCGGP NHMAKDCMKE DGISGLKCYT 

       130        140        150 
CGQAGHMSRD CQNDRLCYNC NETGHISKDC PKA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae."
Sen-Gupta M., Gueldener U., Beinhauer J.D., Fiedler T.A., Hegemann J.H.
Yeast 13:849-860(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells."
Balciunas D., Ronne H.
Mol. Gen. Genet. 262:589-599(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96722 Genomic DNA. Translation: CAA65489.1.
Z71531 Genomic DNA. Translation: CAA96162.1.
AY558002 Genomic DNA. Translation: AAS56328.1.
BK006947 Genomic DNA. Translation: DAA10304.1.
PIRS63228.
RefSeqNP_014144.1. NM_001183093.1.

3D structure databases

ProteinModelPortalP53849.
SMRP53849. Positions 6-39, 67-109, 118-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35584. 1216 interactions.
DIPDIP-2669N.
IntActP53849. 20 interactions.
MINTMINT-2732013.
STRING4932.YNL255C.

Proteomic databases

MaxQBP53849.
PaxDbP53849.
PeptideAtlasP53849.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL255C; YNL255C; YNL255C.
GeneID855466.
KEGGsce:YNL255C.

Organism-specific databases

CYGDYNL255c.
SGDS000005199. GIS2.

Phylogenomic databases

eggNOGCOG5082.
GeneTreeENSGT00510000047065.
HOGENOMHOG000186262.
KOK09250.
OMAQFGHISK.
OrthoDBEOG7GFBDX.

Enzyme and pathway databases

BioCycYEAST:G3O-33252-MONOMER.

Gene expression databases

GenevestigatorP53849.

Family and domain databases

Gene3D4.10.60.10. 4 hits.
InterProIPR001878. Znf_CCHC.
[Graphical view]
PfamPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMSSF57756. SSF57756. 3 hits.
PROSITEPS50158. ZF_CCHC. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio979403.
PROP53849.

Entry information

Entry nameGIS2_YEAST
AccessionPrimary (citable) accession number: P53849
Secondary accession number(s): D6W0T8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families