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Protein

Zinc finger protein GIS2

Gene

GIS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act in the sexual differentiation pathway.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri23 – 40CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri47 – 64CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri92 – 109CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri116 – 133CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • mRNA binding Source: SGD
  • single-stranded DNA binding Source: SGD
  • translation regulator activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • positive regulation of translation Source: SGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GIS2
Gene namesi
Name:GIS2
Ordered Locus Names:YNL255C
ORF Names:N0852
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL255C.
SGDiS000005199. GIS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: SGD
  • cytoplasmic stress granule Source: SGD
  • polysomal ribosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874961 – 153Zinc finger protein GIS2Add BLAST153

Proteomic databases

MaxQBiP53849.
PRIDEiP53849.

Interactioni

Protein-protein interaction databases

BioGridi35584. 1217 interactors.
DIPiDIP-2669N.
IntActiP53849. 20 interactors.
MINTiMINT-2732013.

Structurei

3D structure databases

ProteinModelPortaliP53849.
SMRiP53849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri23 – 40CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri47 – 64CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri92 – 109CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri116 – 133CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri135 – 152CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
InParanoidiP53849.
KOiK09250.
OMAiRLCYNCN.
OrthoDBiEOG092C2J4N.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 3 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKACYVCG KIGHLAEDCD SERLCYNCNK PGHVQTDCTM PRTVEFKQCY
60 70 80 90 100
NCGETGHVRS ECTVQRCFNC NQTGHISREC PEPKKTSRFS KVSCYKCGGP
110 120 130 140 150
NHMAKDCMKE DGISGLKCYT CGQAGHMSRD CQNDRLCYNC NETGHISKDC

PKA
Length:153
Mass (Da):17,103
Last modified:October 1, 1996 - v1
Checksum:iE72696428F85CA3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA. Translation: CAA65489.1.
Z71531 Genomic DNA. Translation: CAA96162.1.
AY558002 Genomic DNA. Translation: AAS56328.1.
BK006947 Genomic DNA. Translation: DAA10304.1.
PIRiS63228.
RefSeqiNP_014144.1. NM_001183093.1.

Genome annotation databases

EnsemblFungiiYNL255C; YNL255C; YNL255C.
GeneIDi855466.
KEGGisce:YNL255C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA. Translation: CAA65489.1.
Z71531 Genomic DNA. Translation: CAA96162.1.
AY558002 Genomic DNA. Translation: AAS56328.1.
BK006947 Genomic DNA. Translation: DAA10304.1.
PIRiS63228.
RefSeqiNP_014144.1. NM_001183093.1.

3D structure databases

ProteinModelPortaliP53849.
SMRiP53849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35584. 1217 interactors.
DIPiDIP-2669N.
IntActiP53849. 20 interactors.
MINTiMINT-2732013.

Proteomic databases

MaxQBiP53849.
PRIDEiP53849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL255C; YNL255C; YNL255C.
GeneIDi855466.
KEGGisce:YNL255C.

Organism-specific databases

EuPathDBiFungiDB:YNL255C.
SGDiS000005199. GIS2.

Phylogenomic databases

GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
InParanoidiP53849.
KOiK09250.
OMAiRLCYNCN.
OrthoDBiEOG092C2J4N.

Enzyme and pathway databases

BioCyciYEAST:G3O-33252-MONOMER.

Miscellaneous databases

PROiP53849.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 3 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIS2_YEAST
AccessioniPrimary (citable) accession number: P53849
Secondary accession number(s): D6W0T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 96655 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.