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Protein

Zinc finger protein GIS2

Gene

GIS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act in the sexual differentiation pathway.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri23 – 4018CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 6418CCHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri65 – 8218CCHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 10918CCHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 13318CCHC-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri135 – 15218CCHC-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • mRNA binding Source: SGD
  • single-stranded DNA binding Source: SGD
  • translation regulator activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • positive regulation of translation Source: SGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-33252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GIS2
Gene namesi
Name:GIS2
Ordered Locus Names:YNL255C
ORF Names:N0852
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIV

Organism-specific databases

CYGDiYNL255c.
EuPathDBiFungiDB:YNL255C.
SGDiS000005199. GIS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic mRNA processing body Source: SGD
  • cytoplasmic stress granule Source: SGD
  • polysomal ribosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Zinc finger protein GIS2PRO_0000087496Add
BLAST

Proteomic databases

MaxQBiP53849.
PaxDbiP53849.
PeptideAtlasiP53849.

Interactioni

Protein-protein interaction databases

BioGridi35584. 1218 interactions.
DIPiDIP-2669N.
IntActiP53849. 20 interactions.
MINTiMINT-2732013.
STRINGi4932.YNL255C.

Structurei

3D structure databases

ProteinModelPortaliP53849.
SMRiP53849. Positions 6-39, 67-109, 118-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 7 CCHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2118CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri23 – 4018CCHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri47 – 6418CCHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri65 – 8218CCHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 10918CCHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 13318CCHC-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri135 – 15218CCHC-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5082.
GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
InParanoidiP53849.
KOiK09250.
OMAiQFGHISK.
OrthoDBiEOG7GFBDX.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 3 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKACYVCG KIGHLAEDCD SERLCYNCNK PGHVQTDCTM PRTVEFKQCY
60 70 80 90 100
NCGETGHVRS ECTVQRCFNC NQTGHISREC PEPKKTSRFS KVSCYKCGGP
110 120 130 140 150
NHMAKDCMKE DGISGLKCYT CGQAGHMSRD CQNDRLCYNC NETGHISKDC

PKA
Length:153
Mass (Da):17,103
Last modified:October 1, 1996 - v1
Checksum:iE72696428F85CA3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA. Translation: CAA65489.1.
Z71531 Genomic DNA. Translation: CAA96162.1.
AY558002 Genomic DNA. Translation: AAS56328.1.
BK006947 Genomic DNA. Translation: DAA10304.1.
PIRiS63228.
RefSeqiNP_014144.1. NM_001183093.1.

Genome annotation databases

EnsemblFungiiYNL255C; YNL255C; YNL255C.
GeneIDi855466.
KEGGisce:YNL255C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96722 Genomic DNA. Translation: CAA65489.1.
Z71531 Genomic DNA. Translation: CAA96162.1.
AY558002 Genomic DNA. Translation: AAS56328.1.
BK006947 Genomic DNA. Translation: DAA10304.1.
PIRiS63228.
RefSeqiNP_014144.1. NM_001183093.1.

3D structure databases

ProteinModelPortaliP53849.
SMRiP53849. Positions 6-39, 67-109, 118-151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35584. 1218 interactions.
DIPiDIP-2669N.
IntActiP53849. 20 interactions.
MINTiMINT-2732013.
STRINGi4932.YNL255C.

Proteomic databases

MaxQBiP53849.
PaxDbiP53849.
PeptideAtlasiP53849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL255C; YNL255C; YNL255C.
GeneIDi855466.
KEGGisce:YNL255C.

Organism-specific databases

CYGDiYNL255c.
EuPathDBiFungiDB:YNL255C.
SGDiS000005199. GIS2.

Phylogenomic databases

eggNOGiCOG5082.
GeneTreeiENSGT00510000047065.
HOGENOMiHOG000186262.
InParanoidiP53849.
KOiK09250.
OMAiQFGHISK.
OrthoDBiEOG7GFBDX.

Enzyme and pathway databases

BioCyciYEAST:G3O-33252-MONOMER.

Miscellaneous databases

NextBioi979403.
PROiP53849.

Family and domain databases

Gene3Di4.10.60.10. 4 hits.
InterProiIPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 7 hits.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 7 hits.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 3 hits.
PROSITEiPS50158. ZF_CCHC. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae."
    Sen-Gupta M., Gueldener U., Beinhauer J.D., Fiedler T.A., Hegemann J.H.
    Yeast 13:849-860(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells."
    Balciunas D., Ronne H.
    Mol. Gen. Genet. 262:589-599(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIS2_YEAST
AccessioniPrimary (citable) accession number: P53849
Secondary accession number(s): D6W0T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 96655 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.