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Protein

Protein transport protein YIF1

Gene

YIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases.1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein YIF1
Alternative name(s):
YIP1-interacting factor 1
Gene namesi
Name:YIF1
Ordered Locus Names:YNL263C
ORF Names:N0820
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL263C.
SGDiS000005207. YIF1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 153CytoplasmicSequence analysisAdd BLAST152
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 188LumenalSequence analysisAdd BLAST14
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 217CytoplasmicSequence analysis8
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 243LumenalSequence analysis5
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 293CytoplasmicSequence analysisAdd BLAST29
Transmembranei294 – 313HelicalSequence analysisAdd BLAST20
Topological domaini314LumenalSequence analysis1

GO - Cellular componenti

  • endoplasmic reticulum-Golgi intermediate compartment Source: GO_Central
  • endoplasmic reticulum membrane Source: SGD
  • ER to Golgi transport vesicle Source: SGD
  • integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002033812 – 314Protein transport protein YIF1Add BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53845.
PRIDEiP53845.

Interactioni

Subunit structurei

Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1. The complex interacts with the ER to Golgi SNAREs BOS1 and SEC22. Interacts with the YIP1 family members YIP4 and YIP5, and with the Rab GTPases SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52. Interacts with BTN2 and SNX3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTN2P532862EBI-28230,EBI-3796
SEC4P075602EBI-28230,EBI-16858
VAM7P329123EBI-28230,EBI-20232
VPS17P329132EBI-28230,EBI-20366
YIP1P530396EBI-28230,EBI-25295
YIP4P530932EBI-28230,EBI-24124
YPT1P011233EBI-28230,EBI-29496
YPT10P381462EBI-28230,EBI-29357
YPT31P385553EBI-28230,EBI-29379
YPT32P519962EBI-28230,EBI-29384
YPT35P388154EBI-28230,EBI-24665
YPT53P360192EBI-28230,EBI-29415
YPT7P329392EBI-28230,EBI-29509

Protein-protein interaction databases

BioGridi35576. 58 interactors.
DIPiDIP-1729N.
IntActiP53845. 29 interactors.
MINTiMINT-388912.

Structurei

3D structure databases

ProteinModelPortaliP53845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIF1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009423.
HOGENOMiHOG000201672.
InParanoidiP53845.
KOiK20362.
OMAiYILIWNT.
OrthoDBiEOG092C4SQZ.

Family and domain databases

InterProiIPR005578. Yif1_fam.
[Graphical view]
PANTHERiPTHR14083. PTHR14083. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYNPYAYAT SEQNGVNDRF SHTPQQQRPM QIPRNTPVNG QGNANMNANV
60 70 80 90 100
NGSGGGFPFQ DPRGSMAFQL GQSAFSNFIG QDNFNQFQET VNKATANAAG
110 120 130 140 150
SQQISTYFQV STRYVINKLK LILVPFLNGT KNWQRIMDSG NFLPPRDDVN
160 170 180 190 200
SPDMYMPIMG LVTYILIWNT QQGLKGSFNP EDLYYKLSST LAFVCLDLLI
210 220 230 240 250
LKLGLYLLID SKIPSFSLVE LLCYVGYKFV PLILAQLLTN VTMPFNLNIL
260 270 280 290 300
IKFYLFIAFG VFLLRSVKFN LLSRSGAEDD DIHVSISKST VKKCNYFLFV
310
YGFIWQNVLM WLMG
Length:314
Mass (Da):35,498
Last modified:October 1, 1996 - v1
Checksum:i3D1550C65A7D0A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92494 Genomic DNA. Translation: CAA63234.1.
Z71539 Genomic DNA. Translation: CAA96170.1.
BK006947 Genomic DNA. Translation: DAA10296.1.
PIRiS60918.
RefSeqiNP_014136.1. NM_001183101.1.

Genome annotation databases

EnsemblFungiiYNL263C; YNL263C; YNL263C.
GeneIDi855458.
KEGGisce:YNL263C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92494 Genomic DNA. Translation: CAA63234.1.
Z71539 Genomic DNA. Translation: CAA96170.1.
BK006947 Genomic DNA. Translation: DAA10296.1.
PIRiS60918.
RefSeqiNP_014136.1. NM_001183101.1.

3D structure databases

ProteinModelPortaliP53845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35576. 58 interactors.
DIPiDIP-1729N.
IntActiP53845. 29 interactors.
MINTiMINT-388912.

Proteomic databases

MaxQBiP53845.
PRIDEiP53845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL263C; YNL263C; YNL263C.
GeneIDi855458.
KEGGisce:YNL263C.

Organism-specific databases

EuPathDBiFungiDB:YNL263C.
SGDiS000005207. YIF1.

Phylogenomic databases

GeneTreeiENSGT00390000009423.
HOGENOMiHOG000201672.
InParanoidiP53845.
KOiK20362.
OMAiYILIWNT.
OrthoDBiEOG092C4SQZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-33259-MONOMER.

Miscellaneous databases

PROiP53845.

Family and domain databases

InterProiIPR005578. Yif1_fam.
[Graphical view]
PANTHERiPTHR14083. PTHR14083. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYIF1_YEAST
AccessioniPrimary (citable) accession number: P53845
Secondary accession number(s): D6W0T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.