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P53845

- YIF1_YEAST

UniProt

P53845 - YIF1_YEAST

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Protein
Protein transport protein YIF1
Gene
YIF1, YNL263C, N0820
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33259-MONOMER.
ReactomeiREACT_188969. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein YIF1
Alternative name(s):
YIP1-interacting factor 1
Gene namesi
Name:YIF1
Ordered Locus Names:YNL263C
ORF Names:N0820
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL263c.
SGDiS000005207. YIF1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicleCOPII-coated vesicle
Note: Also found in ER-derived COPII-coated vesicles.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 153152Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST
Topological domaini175 – 18814Lumenal Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 2178Cytoplasmic Reviewed prediction
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Topological domaini239 – 2435Lumenal Reviewed prediction
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST
Topological domaini265 – 29329Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei294 – 31320Helical; Reviewed prediction
Add
BLAST
Topological domaini314 – 3141Lumenal Reviewed prediction

GO - Cellular componenti

  1. ER to Golgi transport vesicle Source: SGD
  2. endoplasmic reticulum membrane Source: SGD
  3. integral component of Golgi membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 314313Protein transport protein YIF1
PRO_0000203381Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53845.
PaxDbiP53845.

Expressioni

Gene expression databases

GenevestigatoriP53845.

Interactioni

Subunit structurei

Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1. The complex interacts with the ER to Golgi SNAREs BOS1 and SEC22. Interacts with the YIP1 family members YIP4 and YIP5, and with the Rab GTPases SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52. Interacts with BTN2 and SNX3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BTN2P532862EBI-28230,EBI-3796
SEC4P075602EBI-28230,EBI-16858
VAM7P329123EBI-28230,EBI-20232
VPS17P329132EBI-28230,EBI-20366
YIP1P530396EBI-28230,EBI-25295
YIP4P530932EBI-28230,EBI-24124
YPT1P011233EBI-28230,EBI-29496
YPT10P381462EBI-28230,EBI-29357
YPT31P385553EBI-28230,EBI-29379
YPT32P519962EBI-28230,EBI-29384
YPT35P388154EBI-28230,EBI-24665
YPT53P360192EBI-28230,EBI-29415
YPT7P329392EBI-28230,EBI-29509

Protein-protein interaction databases

BioGridi35576. 53 interactions.
DIPiDIP-1729N.
IntActiP53845. 29 interactions.
MINTiMINT-388912.
STRINGi4932.YNL263C.

Structurei

3D structure databases

ProteinModelPortaliP53845.

Family & Domainsi

Sequence similaritiesi

Belongs to the YIF1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5197.
GeneTreeiENSGT00390000009423.
HOGENOMiHOG000201672.
OMAiKCNYFLF.
OrthoDBiEOG7B5X74.

Family and domain databases

InterProiIPR005578. Hrf1.
[Graphical view]
PANTHERiPTHR14083. PTHR14083. 1 hit.
PfamiPF03878. YIF1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53845-1 [UniParc]FASTAAdd to Basket

« Hide

MSYNPYAYAT SEQNGVNDRF SHTPQQQRPM QIPRNTPVNG QGNANMNANV    50
NGSGGGFPFQ DPRGSMAFQL GQSAFSNFIG QDNFNQFQET VNKATANAAG 100
SQQISTYFQV STRYVINKLK LILVPFLNGT KNWQRIMDSG NFLPPRDDVN 150
SPDMYMPIMG LVTYILIWNT QQGLKGSFNP EDLYYKLSST LAFVCLDLLI 200
LKLGLYLLID SKIPSFSLVE LLCYVGYKFV PLILAQLLTN VTMPFNLNIL 250
IKFYLFIAFG VFLLRSVKFN LLSRSGAEDD DIHVSISKST VKKCNYFLFV 300
YGFIWQNVLM WLMG 314
Length:314
Mass (Da):35,498
Last modified:October 1, 1996 - v1
Checksum:i3D1550C65A7D0A92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92494 Genomic DNA. Translation: CAA63234.1.
Z71539 Genomic DNA. Translation: CAA96170.1.
BK006947 Genomic DNA. Translation: DAA10296.1.
PIRiS60918.
RefSeqiNP_014136.1. NM_001183101.1.

Genome annotation databases

EnsemblFungiiYNL263C; YNL263C; YNL263C.
GeneIDi855458.
KEGGisce:YNL263C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92494 Genomic DNA. Translation: CAA63234.1 .
Z71539 Genomic DNA. Translation: CAA96170.1 .
BK006947 Genomic DNA. Translation: DAA10296.1 .
PIRi S60918.
RefSeqi NP_014136.1. NM_001183101.1.

3D structure databases

ProteinModelPortali P53845.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35576. 53 interactions.
DIPi DIP-1729N.
IntActi P53845. 29 interactions.
MINTi MINT-388912.
STRINGi 4932.YNL263C.

Proteomic databases

MaxQBi P53845.
PaxDbi P53845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL263C ; YNL263C ; YNL263C .
GeneIDi 855458.
KEGGi sce:YNL263C.

Organism-specific databases

CYGDi YNL263c.
SGDi S000005207. YIF1.

Phylogenomic databases

eggNOGi COG5197.
GeneTreei ENSGT00390000009423.
HOGENOMi HOG000201672.
OMAi KCNYFLF.
OrthoDBi EOG7B5X74.

Enzyme and pathway databases

BioCyci YEAST:G3O-33259-MONOMER.
Reactomei REACT_188969. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 979379.
PROi P53845.

Gene expression databases

Genevestigatori P53845.

Family and domain databases

InterProi IPR005578. Hrf1.
[Graphical view ]
PANTHERi PTHR14083. PTHR14083. 1 hit.
Pfami PF03878. YIF1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes."
    Sen-Gupta M., Lyck R., Fleig U., Niedenthal R.K., Hegemann J.H.
    Yeast 12:505-514(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting."
    Matern H.T., Yang X., Andrulis E., Sternglanz R., Trepte H.-H., Gallwitz D.
    EMBO J. 19:4485-4492(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIP1, TOPOLOGY.
  5. "Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
    Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
    J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors."
    Calero M., Winand N.J., Collins R.N.
    FEBS Lett. 515:89-98(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEC4; YIP4; YIP5; YPT1; YPT6; YPT7; YPT10; YPT11; YPT31; YPT32 AND YPT52.
  7. "The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p."
    Chattopadhyay S., Roberts P.M., Pearce D.A.
    Biochem. Biophys. Res. Commun. 302:534-538(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BTN2.
  8. "The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles."
    Barrowman J., Wang W., Zhang Y., Ferro-Novick S.
    J. Biol. Chem. 278:19878-19884(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BOS1; SEC22 AND YPT1.
  9. "The phox homology (PX) domain protein interaction network in yeast."
    Vollert C.S., Uetz P.
    Mol. Cell. Proteomics 3:1053-1064(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNX3.
  10. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYIF1_YEAST
AccessioniPrimary (citable) accession number: P53845
Secondary accession number(s): D6W0T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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