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P53845

- YIF1_YEAST

UniProt

P53845 - YIF1_YEAST

Protein

Protein transport protein YIF1

Gene

YIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33259-MONOMER.
    ReactomeiREACT_188969. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein YIF1
    Alternative name(s):
    YIP1-interacting factor 1
    Gene namesi
    Name:YIF1
    Ordered Locus Names:YNL263C
    ORF Names:N0820
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL263c.
    SGDiS000005207. YIF1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. ER to Golgi transport vesicle Source: SGD
    3. integral component of Golgi membrane Source: SGD

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 314313Protein transport protein YIF1PRO_0000203381Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP53845.
    PaxDbiP53845.

    Expressioni

    Gene expression databases

    GenevestigatoriP53845.

    Interactioni

    Subunit structurei

    Component of the YIP1-YIF1 complex, composed of at least YIF1, YIP1 and YOS1. The complex interacts with the ER to Golgi SNAREs BOS1 and SEC22. Interacts with the YIP1 family members YIP4 and YIP5, and with the Rab GTPases SEC4, YPT1, YPT6, YPT7, YPT10, YPT11, YPT31, YPT32 and YPT52. Interacts with BTN2 and SNX3.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BTN2P532862EBI-28230,EBI-3796
    SEC4P075602EBI-28230,EBI-16858
    VAM7P329123EBI-28230,EBI-20232
    VPS17P329132EBI-28230,EBI-20366
    YIP1P530396EBI-28230,EBI-25295
    YIP4P530932EBI-28230,EBI-24124
    YPT1P011233EBI-28230,EBI-29496
    YPT10P381462EBI-28230,EBI-29357
    YPT31P385553EBI-28230,EBI-29379
    YPT32P519962EBI-28230,EBI-29384
    YPT35P388154EBI-28230,EBI-24665
    YPT53P360192EBI-28230,EBI-29415
    YPT7P329392EBI-28230,EBI-29509

    Protein-protein interaction databases

    BioGridi35576. 53 interactions.
    DIPiDIP-1729N.
    IntActiP53845. 29 interactions.
    MINTiMINT-388912.
    STRINGi4932.YNL263C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53845.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 153152CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 18814LumenalSequence AnalysisAdd
    BLAST
    Topological domaini210 – 2178CytoplasmicSequence Analysis
    Topological domaini239 – 2435LumenalSequence Analysis
    Topological domaini265 – 29329CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini314 – 3141LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei154 – 17421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31320HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YIF1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5197.
    GeneTreeiENSGT00390000009423.
    HOGENOMiHOG000201672.
    OMAiKCNYFLF.
    OrthoDBiEOG7B5X74.

    Family and domain databases

    InterProiIPR005578. Hrf1.
    [Graphical view]
    PANTHERiPTHR14083. PTHR14083. 1 hit.
    PfamiPF03878. YIF1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53845-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYNPYAYAT SEQNGVNDRF SHTPQQQRPM QIPRNTPVNG QGNANMNANV    50
    NGSGGGFPFQ DPRGSMAFQL GQSAFSNFIG QDNFNQFQET VNKATANAAG 100
    SQQISTYFQV STRYVINKLK LILVPFLNGT KNWQRIMDSG NFLPPRDDVN 150
    SPDMYMPIMG LVTYILIWNT QQGLKGSFNP EDLYYKLSST LAFVCLDLLI 200
    LKLGLYLLID SKIPSFSLVE LLCYVGYKFV PLILAQLLTN VTMPFNLNIL 250
    IKFYLFIAFG VFLLRSVKFN LLSRSGAEDD DIHVSISKST VKKCNYFLFV 300
    YGFIWQNVLM WLMG 314
    Length:314
    Mass (Da):35,498
    Last modified:October 1, 1996 - v1
    Checksum:i3D1550C65A7D0A92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92494 Genomic DNA. Translation: CAA63234.1.
    Z71539 Genomic DNA. Translation: CAA96170.1.
    BK006947 Genomic DNA. Translation: DAA10296.1.
    PIRiS60918.
    RefSeqiNP_014136.1. NM_001183101.1.

    Genome annotation databases

    EnsemblFungiiYNL263C; YNL263C; YNL263C.
    GeneIDi855458.
    KEGGisce:YNL263C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92494 Genomic DNA. Translation: CAA63234.1 .
    Z71539 Genomic DNA. Translation: CAA96170.1 .
    BK006947 Genomic DNA. Translation: DAA10296.1 .
    PIRi S60918.
    RefSeqi NP_014136.1. NM_001183101.1.

    3D structure databases

    ProteinModelPortali P53845.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35576. 53 interactions.
    DIPi DIP-1729N.
    IntActi P53845. 29 interactions.
    MINTi MINT-388912.
    STRINGi 4932.YNL263C.

    Proteomic databases

    MaxQBi P53845.
    PaxDbi P53845.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL263C ; YNL263C ; YNL263C .
    GeneIDi 855458.
    KEGGi sce:YNL263C.

    Organism-specific databases

    CYGDi YNL263c.
    SGDi S000005207. YIF1.

    Phylogenomic databases

    eggNOGi COG5197.
    GeneTreei ENSGT00390000009423.
    HOGENOMi HOG000201672.
    OMAi KCNYFLF.
    OrthoDBi EOG7B5X74.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33259-MONOMER.
    Reactomei REACT_188969. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 979379.
    PROi P53845.

    Gene expression databases

    Genevestigatori P53845.

    Family and domain databases

    InterProi IPR005578. Hrf1.
    [Graphical view ]
    PANTHERi PTHR14083. PTHR14083. 1 hit.
    Pfami PF03878. YIF1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes."
      Sen-Gupta M., Lyck R., Fleig U., Niedenthal R.K., Hegemann J.H.
      Yeast 12:505-514(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting."
      Matern H.T., Yang X., Andrulis E., Sternglanz R., Trepte H.-H., Gallwitz D.
      EMBO J. 19:4485-4492(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH YIP1, TOPOLOGY.
    5. "Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex."
      Otte S., Belden W.J., Heidtman M., Liu J., Jensen O.N., Barlowe C.
      J. Cell Biol. 152:503-518(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    6. "Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors."
      Calero M., Winand N.J., Collins R.N.
      FEBS Lett. 515:89-98(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SEC4; YIP4; YIP5; YPT1; YPT6; YPT7; YPT10; YPT11; YPT31; YPT32 AND YPT52.
    7. "The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p."
      Chattopadhyay S., Roberts P.M., Pearce D.A.
      Biochem. Biophys. Res. Commun. 302:534-538(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BTN2.
    8. "The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles."
      Barrowman J., Wang W., Zhang Y., Ferro-Novick S.
      J. Biol. Chem. 278:19878-19884(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BOS1; SEC22 AND YPT1.
    9. "The phox homology (PX) domain protein interaction network in yeast."
      Vollert C.S., Uetz P.
      Mol. Cell. Proteomics 3:1053-1064(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNX3.
    10. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYIF1_YEAST
    AccessioniPrimary (citable) accession number: P53845
    Secondary accession number(s): D6W0T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3