Reviewed, UniProtKB/Swiss-Prot P53844 (PDR17_YEAST)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol transfer protein PDR17
      Short name=PITP
Alternative name(s):
    Phosphatidylserine transport B pathway protein 2
    Pleiotropic drug resistance protein 17
    SEC14 homolog 3

Gene names

Name:	PDR17
Synonyms:	ISS1, PSTB2, SFH4
Ordered Locus Names:	YNL264C
ORF Names:	N0815

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Contributes to efficient phospholipase D1 activation and phospholipase B1 inhibition in the regulation of phospholipid turnover. Ref.4 Ref.5 Ref.6
Subcellular location	Cytoplasm Ref.7 Ref.8.
Miscellaneous	Present with 5040 molecules/cell in log phase SD medium. Ref.9
Sequence similarities	Contains 1 CRAL-TRIO domain.

Ontologies

Keywords
Biological process	Lipid transport Transport
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Ref.4 Inferred from mutant phenotype. Source: SGD phospholipid transport Ref.6 Inferred from direct assay. Source: SGD response to drug Ref.4 Inferred from genetic interaction. Source: SGD
Cellular component	cytoplasm Ref.8 Inferred from direct assay. Source: SGD
Molecular function	phosphatidylinositol transporter activity Ref.6 Inferred from direct assay. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P38800	1	EBI-2076838,EBI-24597
PMP3	P87284	1	EBI-2076838,EBI-13555

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Phosphatidylinositol transfer protein PDR17		PRO_0000210746
Regions
	Domain	139 – 297	159	CRAL-TRIO

Sequences

	Sequence		Length	Mass (Da)
	P53844-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C18F0D225A69DB86	FASTA	350	40,678
	10 20 30 40 50 60 MGLFSRKRDH TPAVPKEKLI PCDKIFLDPP AKYGNAPLLE PISEDQNEKY RAVLRHFQDD 70 80 90 100 110 120 DLKLPENLND LDNGTHANDR PLSDWEKFWL SRECFLRYLR ANKWNTANAI KGLTKTLVWR 130 140 150 160 170 180 REIGLTHGKE DKDPLTADKV AVENETGKQV ILGFDNAKRP LYYMKNGRQN TESSFRQVQE 190 200 210 220 230 240 LVYMMETATT VAPQGVEKIT VLVDFKSYKE PGIITDKAPP ISIARMCLNV MQDHYPERLA 250 260 270 280 290 300 KCVLINIPWF AWAFLKMMYP FLDPATKAKA IFDEPFENHI EPSQLDALYN GLLDFKYKHE 310 320 330 340 350 VYWPDMVKKV DDLRLKRFDR FLKFGGIVGL SEYDTKGQHD ELKYPVDMVI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes." Sen-Gupta M., Lyck R., Fleig U., Niedenthal R.K., Hegemann J.H. Yeast 12:505-514(1996) [PubMed: 8740425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs." van den Hazel H.B., Pichler H., do Valle Matta M.A., Leitner E., Goffeau A., Daum G. J. Biol. Chem. 274:1934-1941(1999) [PubMed: 9890948] [Abstract] Cited for: FUNCTION.
[5]	"A new gene involved in the transport-dependent metabolism of phosphatidylserine, PSTB2/PDR17, shares sequence similarity with the gene encoding the phosphatidylinositol/phosphatidylcholine transfer protein, SEC14." Wu W.-I., Routt S.M., Bankaitis V.A., Voelker D.R. J. Biol. Chem. 275:14446-14456(2000) [PubMed: 10799527] [Abstract] Cited for: FUNCTION.
[6]	"Identification of a novel family of nonclassic yeast phosphatidylinositol transfer proteins whose function modulates phospholipase D activity and Sec14p-independent cell growth." Li X., Routt S.M., Xie Z., Cui X., Fang M., Kearns M.A., Bard M., Kirsch D.R., Bankaitis V.A. Mol. Biol. Cell 11:1989-2005(2000) [PubMed: 10848624] [Abstract] Cited for: FUNCTION.
[7]	"Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover." Schnabl M., Oskolkova O.V., Holic R., Brezna B., Pichler H., Zagorsek M., Kohlwein S.D., Paltauf F., Daum G., Griac P. Eur. J. Biochem. 270:3133-3145(2003) [PubMed: 12869188] [Abstract] Cited for: SUBCELLULAR LOCATION.
[8]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[9]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X92494 Genomic DNA. Translation: CAA63233.1. Z71540 Genomic DNA. Translation: CAA96171.1. AY692928 Genomic DNA. Translation: AAT92947.1.
PIR	S60917.
RefSeq	NP_014135.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2580N.
IntAct	P53844. 2 interactions.
STRING	P53844.
Proteomic databases
PeptideAtlas	P53844.
Genome annotation databases
Ensembl	YNL264C; YNL264C; YNL264C; Saccharomyces cerevisiae. [Genome view]
GeneID	855457.
KEGG	sce:YNL264C.
NMPDR	fig|4932.3.peg.5200.
Organism-specific databases
CYGD	YNL264c.
SGD	S000005208. PDR17.
Phylogenomic databases
HOGENOM	HBG327719.
OMA	KNGRQNT.
OrthoDB	EOG90GF7B.
Gene expression databases
ArrayExpress	P53844.
Genevestigator	P53844.
GermOnline	YNL264C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001251. CRAL_bd_TRIO_C. IPR008273. CRAL_bd_TRIO_N. IPR011074. Sec14p-like_N. [Graphical view]
Gene3D	G3DSA:3.40.525.10. CRAL_bd_TRIO_C. 1 hit.
Pfam	PF00650. CRAL_TRIO. 1 hit. PF03765. CRAL_TRIO_N. 1 hit. [Graphical view]
SMART	SM00516. SEC14. 1 hit. [Graphical view]
PROSITE	PS50191. CRAL_TRIO. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	979376.

Entry information

Entry name

PDR17_YEAST

Accession

Primary (citable) accession number: P53844

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 15, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)