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Protein

Glyoxylate reductase 1

Gene

GOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversibly reduces glyoxylate to glycolate.1 Publication

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei254 – 2541By similarity
Binding sitei278 – 2781NADBy similarity
Active sitei283 – 2831By similarity
Active sitei301 – 3011Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi173 – 1742NADBy similarity
Nucleotide bindingi252 – 2543NADBy similarity
Nucleotide bindingi301 – 3044NADBy similarity

GO - Molecular functioni

  • glyoxylate reductase activity Source: SGD
  • NAD binding Source: InterPro
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: SGD

GO - Biological processi

  • glyoxylate catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17244.
YEAST:G3O-33268-MONOMER.
ReactomeiR-SCE-389661. Glyoxylate metabolism and glycine degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase 1 (EC:1.1.1.26)
Gene namesi
Name:GOR1
Ordered Locus Names:YNL274C
ORF Names:N0631
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL274C.
SGDiS000005218. GOR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Glyoxylate reductase 1PRO_0000076040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53839.
PeptideAtlasiP53839.

PTM databases

iPTMnetiP53839.

Interactioni

Protein-protein interaction databases

BioGridi35566. 13 interactions.
IntActiP53839. 5 interactions.
MINTiMINT-2493973.

Structurei

3D structure databases

ProteinModelPortaliP53839.
SMRiP53839. Positions 8-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000046913.
InParanoidiP53839.
OMAiDIICISI.
OrthoDBiEOG7C5MKX.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPIVLKL GKDAFGDQAW GELEKIADVI TIPESTTREQ FLREVKDPQN
60 70 80 90 100
KLSQVQVITR TARSVKNTGR FDEELALALP SSVVAVCHTG AGYDQIDVEP
110 120 130 140 150
FKKRHIQVAN VPDLVSNATA DTHVFLLLGA LRNFGIGNRR LIEGNWPEAG
160 170 180 190 200
PACGSPFGYD PEGKTVGILG LGRIGRCILE RLKPFGFENF IYHNRHQLPS
210 220 230 240 250
EEEHGCEYVG FEEFLKRSDI VSVNVPLNHN THHLINAETI EKMKDGVVIV
260 270 280 290 300
NTARGAVIDE QAMTDALRSG KIRSAGLDVF EYEPKISKEL LSMSQVLGLP
310 320 330 340 350
HMGTHSVETR KKMEELVVEN AKNVILTGKV LTIVPELQNE DWPNESKPLV
Length:350
Mass (Da):38,831
Last modified:October 1, 1996 - v1
Checksum:i5E934D00E8A9BB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71550 Genomic DNA. Translation: CAA96182.1.
AY692660 Genomic DNA. Translation: AAT92679.1.
BK006947 Genomic DNA. Translation: DAA10286.1.
PIRiS63248.
RefSeqiNP_014125.1. NM_001183112.1.

Genome annotation databases

EnsemblFungiiYNL274C; YNL274C; YNL274C.
GeneIDi855447.
KEGGisce:YNL274C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71550 Genomic DNA. Translation: CAA96182.1.
AY692660 Genomic DNA. Translation: AAT92679.1.
BK006947 Genomic DNA. Translation: DAA10286.1.
PIRiS63248.
RefSeqiNP_014125.1. NM_001183112.1.

3D structure databases

ProteinModelPortaliP53839.
SMRiP53839. Positions 8-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35566. 13 interactions.
IntActiP53839. 5 interactions.
MINTiMINT-2493973.

PTM databases

iPTMnetiP53839.

Proteomic databases

MaxQBiP53839.
PeptideAtlasiP53839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL274C; YNL274C; YNL274C.
GeneIDi855447.
KEGGisce:YNL274C.

Organism-specific databases

EuPathDBiFungiDB:YNL274C.
SGDiS000005218. GOR1.

Phylogenomic databases

GeneTreeiENSGT00510000046913.
InParanoidiP53839.
OMAiDIICISI.
OrthoDBiEOG7C5MKX.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17244.
YEAST:G3O-33268-MONOMER.
ReactomeiR-SCE-389661. Glyoxylate metabolism and glycine degradation.

Miscellaneous databases

PROiP53839.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  7. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. "The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae."
    Rintala E., Pitkanen J.P., Vehkomaki M.L., Penttila M., Ruohonen L.
    Yeast 24:129-136(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGOR1_YEAST
AccessioniPrimary (citable) accession number: P53839
Secondary accession number(s): D6W0S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.