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Protein

Glyoxylate reductase 1

Gene

GOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversibly reduces glyoxylate to glycolate.1 Publication

Miscellaneous

Present with 3280 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Glycolate + NAD+ = glyoxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei254By similarity1
Binding sitei278NADBy similarity1
Active sitei283By similarity1
Active sitei301Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi173 – 174NADBy similarity2
Nucleotide bindingi252 – 254NADBy similarity3
Nucleotide bindingi301 – 304NADBy similarity4

GO - Molecular functioni

GO - Biological processi

  • glyoxylate catabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:G3O-33268-MONOMER
YEAST:G3O-33268-MONOMER
ReactomeiR-SCE-389661 Glyoxylate metabolism and glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase 1 (EC:1.1.1.26)
Gene namesi
Name:GOR1
Ordered Locus Names:YNL274C
ORF Names:N0631
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL274C
SGDiS000005218 GOR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760401 – 350Glyoxylate reductase 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53839
PaxDbiP53839
PRIDEiP53839

PTM databases

iPTMnetiP53839

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35566, 22 interactors
IntActiP53839, 5 interactors
MINTiP53839
STRINGi4932.YNL274C

Structurei

3D structure databases

ProteinModelPortaliP53839
SMRiP53839
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000046913
InParanoidiP53839
KOiK00015
OMAiVISCHSA
OrthoDBiEOG092C4Y4L

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

P53839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKPIVLKL GKDAFGDQAW GELEKIADVI TIPESTTREQ FLREVKDPQN
60 70 80 90 100
KLSQVQVITR TARSVKNTGR FDEELALALP SSVVAVCHTG AGYDQIDVEP
110 120 130 140 150
FKKRHIQVAN VPDLVSNATA DTHVFLLLGA LRNFGIGNRR LIEGNWPEAG
160 170 180 190 200
PACGSPFGYD PEGKTVGILG LGRIGRCILE RLKPFGFENF IYHNRHQLPS
210 220 230 240 250
EEEHGCEYVG FEEFLKRSDI VSVNVPLNHN THHLINAETI EKMKDGVVIV
260 270 280 290 300
NTARGAVIDE QAMTDALRSG KIRSAGLDVF EYEPKISKEL LSMSQVLGLP
310 320 330 340 350
HMGTHSVETR KKMEELVVEN AKNVILTGKV LTIVPELQNE DWPNESKPLV
Length:350
Mass (Da):38,831
Last modified:October 1, 1996 - v1
Checksum:i5E934D00E8A9BB13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71550 Genomic DNA Translation: CAA96182.1
AY692660 Genomic DNA Translation: AAT92679.1
BK006947 Genomic DNA Translation: DAA10286.1
PIRiS63248
RefSeqiNP_014125.1, NM_001183112.1

Genome annotation databases

EnsemblFungiiYNL274C; YNL274C; YNL274C
GeneIDi855447
KEGGisce:YNL274C

Similar proteinsi

Entry informationi

Entry nameiGOR1_YEAST
AccessioniPrimary (citable) accession number: P53839
Secondary accession number(s): D6W0S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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