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Protein

Boron transporter 1

Gene

BOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole.5 Publications

GO - Molecular functioni

  1. borate efflux transmembrane transporter activity Source: SGD
  2. inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  1. borate transmembrane transport Source: GOC
  2. borate transport Source: SGD
  3. protein targeting to vacuole Source: SGD
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33269-MONOMER.
ReactomeiREACT_285129. Bicarbonate transporters.
REACT_316736. Erythrocytes take up carbon dioxide and release oxygen.
REACT_342481. Erythrocytes take up oxygen and release carbon dioxide.

Protein family/group databases

TCDBi2.A.31.3.2. the anion exchanger (ae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Boron transporter 1
Gene namesi
Name:BOR1
Ordered Locus Names:YNL275W
ORF Names:N0626
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIV

Organism-specific databases

CYGDiYNL275w.
SGDiS000005219. BOR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 11611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13418HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 1406CytoplasmicSequence Analysis
Transmembranei141 – 16020HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 1655ExtracellularSequence Analysis
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 1926CytoplasmicSequence Analysis
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 23522ExtracellularSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 27418CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei275 – 29521HelicalSequence AnalysisAdd
BLAST
Topological domaini296 – 32934ExtracellularSequence AnalysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence AnalysisAdd
BLAST
Topological domaini351 – 37323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence AnalysisAdd
BLAST
Topological domaini395 – 43844ExtracellularSequence AnalysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence AnalysisAdd
BLAST
Topological domaini460 – 49536CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei496 – 51621HelicalSequence AnalysisAdd
BLAST
Topological domaini517 – 5182ExtracellularSequence Analysis
Transmembranei519 – 53921HelicalSequence AnalysisAdd
BLAST
Topological domaini540 – 57637CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. fungal-type vacuole Source: SGD
  2. integral component of membrane Source: SGD
  3. plasma membrane Source: SGD
  4. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Boron transporter 1PRO_0000079243Add
BLAST

Proteomic databases

MaxQBiP53838.
PaxDbiP53838.

Expressioni

Gene expression databases

GenevestigatoriP53838.

Interactioni

Protein-protein interaction databases

BioGridi35565. 20 interactions.
DIPiDIP-8001N.
STRINGi4932.YNL275W.

Structurei

3D structure databases

ProteinModelPortaliP53838.
SMRiP53838. Positions 69-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000197283.
InParanoidiP53838.
OMAiQFFERTV.
OrthoDBiEOG7DRJBV.

Family and domain databases

InterProiIPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF00955. HCO3_cotransp. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNESTRVTV SRGCTASDEC AQALERTNDE LDRESSVSES RSDEESHEKL
60 70 80 90 100
SRRRFPTLGI GIWLDLKDRI PYYKSDWVDA FNYRVIPSIV DTYFNNLLPA
110 120 130 140 150
IAFAQDMFDR TDNSYGVNEV LLSSAMAGIV FGVLGGQPLC IVGVTGPISI
160 170 180 190 200
FNYTVYEIIK PLNTSYFGFM FWICMWSMIF HLVLAFTNAV CLLQYVTTFP
210 220 230 240 250
CDIFGLFINV VYIQKGIQIL TRQFSAKSGE KSVQDGFASV VVALVMTAFG
260 270 280 290 300
LFFKLFHYYP LFSHRIRTFI SDYSTALSVL FWSSFTHFGG YLHDVKFKKL
310 320 330 340 350
PITKAFFPTS KVNRPQNTWL AYEPIPVKDV FIALPFGIFL TILFYFDHNV
360 370 380 390 400
SSLMAQRHQY KLKKPSSFHY DFALLGLTTC ISGVLGIPAP NGLIPQAPLH
410 420 430 440 450
TETLLVRDSN QKVISCVEQR FTNTFQGLMI LGTMTRPLLV CLGEIPQAVL
460 470 480 490 500
SGLFFIMGIN GLMTNSIIQR LVFLFSDPNR RDNTSPLMKV SKKSMLIFLS
510 520 530 540 550
FSLTGFAGEF AITNTIAAIG FPLVLLLSVL VSFSFAYIFP TEELKILDTN
560 570
VAQKFTIKNL LLENIRDAKF CDKHED
Length:576
Mass (Da):65,028
Last modified:September 30, 1996 - v1
Checksum:i4EA3FFC89F66307A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71551 Genomic DNA. Translation: CAA96183.1.
BK006947 Genomic DNA. Translation: DAA10285.1.
PIRiS63249.
RefSeqiNP_014124.1. NM_001183113.1.

Genome annotation databases

EnsemblFungiiYNL275W; YNL275W; YNL275W.
GeneIDi855446.
KEGGisce:YNL275W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71551 Genomic DNA. Translation: CAA96183.1.
BK006947 Genomic DNA. Translation: DAA10285.1.
PIRiS63249.
RefSeqiNP_014124.1. NM_001183113.1.

3D structure databases

ProteinModelPortaliP53838.
SMRiP53838. Positions 69-110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35565. 20 interactions.
DIPiDIP-8001N.
STRINGi4932.YNL275W.

Protein family/group databases

TCDBi2.A.31.3.2. the anion exchanger (ae) family.

Proteomic databases

MaxQBiP53838.
PaxDbiP53838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL275W; YNL275W; YNL275W.
GeneIDi855446.
KEGGisce:YNL275W.

Organism-specific databases

CYGDiYNL275w.
SGDiS000005219. BOR1.

Phylogenomic databases

eggNOGiNOG268067.
GeneTreeiENSGT00760000119021.
HOGENOMiHOG000197283.
InParanoidiP53838.
OMAiQFFERTV.
OrthoDBiEOG7DRJBV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33269-MONOMER.
ReactomeiREACT_285129. Bicarbonate transporters.
REACT_316736. Erythrocytes take up carbon dioxide and release oxygen.
REACT_342481. Erythrocytes take up oxygen and release carbon dioxide.

Miscellaneous databases

NextBioi979346.

Gene expression databases

GenevestigatoriP53838.

Family and domain databases

InterProiIPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF00955. HCO3_cotransp. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Expression and characterization of the anion transporter homologue YNL275w in Saccharomyces cerevisiae."
    Zhao R., Reithmeier R.A.F.
    Am. J. Physiol. 281:C33-C45(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae."
    Nozawa A., Takano J., Kobayashi M., von Wiren N., Fujiwara T.
    FEMS Microbiol. Lett. 262:216-222(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast."
    Decker B.L., Wickner W.T.
    J. Biol. Chem. 281:14523-14528(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  8. "Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p."
    Jennings M.L., Howren T.R., Cui J., Winters M., Hannigan R.
    Am. J. Physiol. 293:C468-C476(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance."
    Takano J., Kobayashi M., Noda Y., Fujiwara T.
    FEMS Microbiol. Lett. 267:230-235(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiBOR1_YEAST
AccessioniPrimary (citable) accession number: P53838
Secondary accession number(s): D6W0R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1996
Last sequence update: September 30, 1996
Last modified: March 31, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.