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P53838 (BOR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Boron transporter 1
Gene names
Name:BOR1
Ordered Locus Names:YNL275W
ORF Names:N0626
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole. Ref.3 Ref.5 Ref.6 Ref.8 Ref.9

Subcellular location

Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein Ref.3 Ref.6 Ref.9.

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Boron transporter 1
PRO_0000079243

Regions

Topological domain1 – 8484Cytoplasmic Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 11611Extracellular Potential
Transmembrane117 – 13418Helical; Potential
Topological domain135 – 1406Cytoplasmic Potential
Transmembrane141 – 16020Helical; Potential
Topological domain161 – 1655Extracellular Potential
Transmembrane166 – 18621Helical; Potential
Topological domain187 – 1926Cytoplasmic Potential
Transmembrane193 – 21321Helical; Potential
Topological domain214 – 23522Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 27418Cytoplasmic Potential
Transmembrane275 – 29521Helical; Potential
Topological domain296 – 32934Extracellular Potential
Transmembrane330 – 35021Helical; Potential
Topological domain351 – 37323Cytoplasmic Potential
Transmembrane374 – 39421Helical; Potential
Topological domain395 – 43844Extracellular Potential
Transmembrane439 – 45921Helical; Potential
Topological domain460 – 49536Cytoplasmic Potential
Transmembrane496 – 51621Helical; Potential
Topological domain517 – 5182Extracellular Potential
Transmembrane519 – 53921Helical; Potential
Topological domain540 – 57637Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P53838 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4EA3FFC89F66307A

FASTA57665,028
        10         20         30         40         50         60 
MSNESTRVTV SRGCTASDEC AQALERTNDE LDRESSVSES RSDEESHEKL SRRRFPTLGI 

        70         80         90        100        110        120 
GIWLDLKDRI PYYKSDWVDA FNYRVIPSIV DTYFNNLLPA IAFAQDMFDR TDNSYGVNEV 

       130        140        150        160        170        180 
LLSSAMAGIV FGVLGGQPLC IVGVTGPISI FNYTVYEIIK PLNTSYFGFM FWICMWSMIF 

       190        200        210        220        230        240 
HLVLAFTNAV CLLQYVTTFP CDIFGLFINV VYIQKGIQIL TRQFSAKSGE KSVQDGFASV 

       250        260        270        280        290        300 
VVALVMTAFG LFFKLFHYYP LFSHRIRTFI SDYSTALSVL FWSSFTHFGG YLHDVKFKKL 

       310        320        330        340        350        360 
PITKAFFPTS KVNRPQNTWL AYEPIPVKDV FIALPFGIFL TILFYFDHNV SSLMAQRHQY 

       370        380        390        400        410        420 
KLKKPSSFHY DFALLGLTTC ISGVLGIPAP NGLIPQAPLH TETLLVRDSN QKVISCVEQR 

       430        440        450        460        470        480 
FTNTFQGLMI LGTMTRPLLV CLGEIPQAVL SGLFFIMGIN GLMTNSIIQR LVFLFSDPNR 

       490        500        510        520        530        540 
RDNTSPLMKV SKKSMLIFLS FSLTGFAGEF AITNTIAAIG FPLVLLLSVL VSFSFAYIFP 

       550        560        570 
TEELKILDTN VAQKFTIKNL LLENIRDAKF CDKHED 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Expression and characterization of the anion transporter homologue YNL275w in Saccharomyces cerevisiae."
Zhao R., Reithmeier R.A.F.
Am. J. Physiol. 281:C33-C45(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae."
Nozawa A., Takano J., Kobayashi M., von Wiren N., Fujiwara T.
FEMS Microbiol. Lett. 262:216-222(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast."
Decker B.L., Wickner W.T.
J. Biol. Chem. 281:14523-14528(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[8]"Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p."
Jennings M.L., Howren T.R., Cui J., Winters M., Hannigan R.
Am. J. Physiol. 293:C468-C476(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance."
Takano J., Kobayashi M., Noda Y., Fujiwara T.
FEMS Microbiol. Lett. 267:230-235(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71551 Genomic DNA. Translation: CAA96183.1.
BK006947 Genomic DNA. Translation: DAA10285.1.
PIRS63249.
RefSeqNP_014124.1. NM_001183113.1.

3D structure databases

ProteinModelPortalP53838.
SMRP53838. Positions 69-110.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35565. 20 interactions.
DIPDIP-8001N.
STRING4932.YNL275W.

Protein family/group databases

TCDB2.A.31.3.2. the anion exchanger (ae) family.

Proteomic databases

MaxQBP53838.
PaxDbP53838.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL275W; YNL275W; YNL275W.
GeneID855446.
KEGGsce:YNL275W.

Organism-specific databases

CYGDYNL275w.
SGDS000005219. BOR1.

Phylogenomic databases

eggNOGNOG268067.
GeneTreeENSGT00560000076933.
HOGENOMHOG000197283.
OMAHWDIWLL.
OrthoDBEOG7DRJBV.

Enzyme and pathway databases

BioCycYEAST:G3O-33269-MONOMER.

Gene expression databases

GenevestigatorP53838.

Family and domain databases

InterProIPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
[Graphical view]
PANTHERPTHR11453. PTHR11453. 1 hit.
PfamPF00955. HCO3_cotransp. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio979346.

Entry information

Entry nameBOR1_YEAST
AccessionPrimary (citable) accession number: P53838
Secondary accession number(s): D6W0R9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families