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P53838

- BOR1_YEAST

UniProt

P53838 - BOR1_YEAST

Protein

Boron transporter 1

Gene

BOR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole.5 Publications

    GO - Molecular functioni

    1. borate efflux transmembrane transporter activity Source: SGD
    2. inorganic anion exchanger activity Source: InterPro

    GO - Biological processi

    1. borate transmembrane transport Source: GOC
    2. borate transport Source: SGD
    3. protein targeting to vacuole Source: SGD

    Keywords - Biological processi

    Anion exchange, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33269-MONOMER.

    Protein family/group databases

    TCDBi2.A.31.3.2. the anion exchanger (ae) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Boron transporter 1
    Gene namesi
    Name:BOR1
    Ordered Locus Names:YNL275W
    ORF Names:N0626
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL275w.
    SGDiS000005219. BOR1.

    Subcellular locationi

    GO - Cellular componenti

    1. fungal-type vacuole Source: SGD
    2. integral component of membrane Source: SGD
    3. plasma membrane Source: SGD
    4. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Boron transporter 1PRO_0000079243Add
    BLAST

    Proteomic databases

    MaxQBiP53838.
    PaxDbiP53838.

    Expressioni

    Gene expression databases

    GenevestigatoriP53838.

    Interactioni

    Protein-protein interaction databases

    BioGridi35565. 20 interactions.
    DIPiDIP-8001N.
    STRINGi4932.YNL275W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53838.
    SMRiP53838. Positions 69-110.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8484CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 11611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1406CytoplasmicSequence Analysis
    Topological domaini161 – 1655ExtracellularSequence Analysis
    Topological domaini187 – 1926CytoplasmicSequence Analysis
    Topological domaini214 – 23522ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 27418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 32934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini351 – 37323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini395 – 43844ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini460 – 49536CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini517 – 5182ExtracellularSequence Analysis
    Topological domaini540 – 57637CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13418HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei496 – 51621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei519 – 53921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268067.
    GeneTreeiENSGT00560000076933.
    HOGENOMiHOG000197283.
    OMAiHWDIWLL.
    OrthoDBiEOG7DRJBV.

    Family and domain databases

    InterProiIPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    [Graphical view]
    PANTHERiPTHR11453. PTHR11453. 1 hit.
    PfamiPF00955. HCO3_cotransp. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53838-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNESTRVTV SRGCTASDEC AQALERTNDE LDRESSVSES RSDEESHEKL    50
    SRRRFPTLGI GIWLDLKDRI PYYKSDWVDA FNYRVIPSIV DTYFNNLLPA 100
    IAFAQDMFDR TDNSYGVNEV LLSSAMAGIV FGVLGGQPLC IVGVTGPISI 150
    FNYTVYEIIK PLNTSYFGFM FWICMWSMIF HLVLAFTNAV CLLQYVTTFP 200
    CDIFGLFINV VYIQKGIQIL TRQFSAKSGE KSVQDGFASV VVALVMTAFG 250
    LFFKLFHYYP LFSHRIRTFI SDYSTALSVL FWSSFTHFGG YLHDVKFKKL 300
    PITKAFFPTS KVNRPQNTWL AYEPIPVKDV FIALPFGIFL TILFYFDHNV 350
    SSLMAQRHQY KLKKPSSFHY DFALLGLTTC ISGVLGIPAP NGLIPQAPLH 400
    TETLLVRDSN QKVISCVEQR FTNTFQGLMI LGTMTRPLLV CLGEIPQAVL 450
    SGLFFIMGIN GLMTNSIIQR LVFLFSDPNR RDNTSPLMKV SKKSMLIFLS 500
    FSLTGFAGEF AITNTIAAIG FPLVLLLSVL VSFSFAYIFP TEELKILDTN 550
    VAQKFTIKNL LLENIRDAKF CDKHED 576
    Length:576
    Mass (Da):65,028
    Last modified:October 1, 1996 - v1
    Checksum:i4EA3FFC89F66307A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71551 Genomic DNA. Translation: CAA96183.1.
    BK006947 Genomic DNA. Translation: DAA10285.1.
    PIRiS63249.
    RefSeqiNP_014124.1. NM_001183113.1.

    Genome annotation databases

    EnsemblFungiiYNL275W; YNL275W; YNL275W.
    GeneIDi855446.
    KEGGisce:YNL275W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71551 Genomic DNA. Translation: CAA96183.1 .
    BK006947 Genomic DNA. Translation: DAA10285.1 .
    PIRi S63249.
    RefSeqi NP_014124.1. NM_001183113.1.

    3D structure databases

    ProteinModelPortali P53838.
    SMRi P53838. Positions 69-110.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35565. 20 interactions.
    DIPi DIP-8001N.
    STRINGi 4932.YNL275W.

    Protein family/group databases

    TCDBi 2.A.31.3.2. the anion exchanger (ae) family.

    Proteomic databases

    MaxQBi P53838.
    PaxDbi P53838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL275W ; YNL275W ; YNL275W .
    GeneIDi 855446.
    KEGGi sce:YNL275W.

    Organism-specific databases

    CYGDi YNL275w.
    SGDi S000005219. BOR1.

    Phylogenomic databases

    eggNOGi NOG268067.
    GeneTreei ENSGT00560000076933.
    HOGENOMi HOG000197283.
    OMAi HWDIWLL.
    OrthoDBi EOG7DRJBV.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33269-MONOMER.

    Miscellaneous databases

    NextBioi 979346.

    Gene expression databases

    Genevestigatori P53838.

    Family and domain databases

    InterProi IPR011531. HCO3_transpt_C.
    IPR003020. HCO3_transpt_euk.
    [Graphical view ]
    PANTHERi PTHR11453. PTHR11453. 1 hit.
    Pfami PF00955. HCO3_cotransp. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Expression and characterization of the anion transporter homologue YNL275w in Saccharomyces cerevisiae."
      Zhao R., Reithmeier R.A.F.
      Am. J. Physiol. 281:C33-C45(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae."
      Nozawa A., Takano J., Kobayashi M., von Wiren N., Fujiwara T.
      FEMS Microbiol. Lett. 262:216-222(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast."
      Decker B.L., Wickner W.T.
      J. Biol. Chem. 281:14523-14528(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    8. "Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p."
      Jennings M.L., Howren T.R., Cui J., Winters M., Hannigan R.
      Am. J. Physiol. 293:C468-C476(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance."
      Takano J., Kobayashi M., Noda Y., Fujiwara T.
      FEMS Microbiol. Lett. 267:230-235(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiBOR1_YEAST
    AccessioniPrimary (citable) accession number: P53838
    Secondary accession number(s): D6W0R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 195 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3