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Protein

Plasma membrane fusion protein PRM1

Gene

PRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.5 Publications

GO - Biological processi

  • plasma membrane fusion involved in cytogamy Source: SGD
Complete GO annotation...

Keywords - Biological processi

Conjugation

Enzyme and pathway databases

BioCyciYEAST:G3O-33271-MONOMER.

Protein family/group databases

TCDBi9.B.63.1.1. the yeast pheromone-induced plasma membrane mating cell fusion protein (prm1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane fusion protein PRM1
Alternative name(s):
Pheromone-regulated membrane protein 1
Gene namesi
Name:PRM1
Ordered Locus Names:YNL279W
ORF Names:N0605
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL279W.
SGDiS000005223. PRM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 10568CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 296170ExtracellularSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 424107CytoplasmicSequence analysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST
Topological domaini446 – 629184ExtracellularSequence analysisAdd
BLAST
Transmembranei630 – 65021HelicalSequence analysisAdd
BLAST
Topological domaini651 – 66111CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: SGD
  • mating projection tip Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661Plasma membrane fusion protein PRM1PRO_0000203377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence analysis
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence analysis
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi512 – 5121N-linked (GlcNAc...)Sequence analysis
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence analysis
Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence analysis
Glycosylationi587 – 5871N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By pheromones during mating, through the regulation by the STE12 transcription factor. Also induced in respiratory-deficient cells.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi35562. 17 interactions.
DIPiDIP-1385N.
IntActiP53835. 3 interactions.
MINTiMINT-384905.

Structurei

3D structure databases

ProteinModelPortaliP53835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000115701.
InParanoidiP53835.
OMAiLTWVHDH.
OrthoDBiEOG092C1WXV.

Family and domain databases

InterProiIPR026777. PRM1.
[Graphical view]
PANTHERiPTHR31030. PTHR31030. 2 hits.

Sequencei

Sequence statusi: Complete.

P53835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFKCYLQL GDRLSQIWLN KYTLVLLLAM LKLLFFSKSI QHAIEVSETY
60 70 80 90 100
ILSNCYSIDS LYSKMTDNTP HYLGIMGNYL IEKGMEETVK ATLETLSLIV
110 120 130 140 150
YASEGLVNFA IDLYLGTYAC LIVSAVDGTV DVATNITEKL ISLVNDTVSS
160 170 180 190 200
VANELDTGLN DISKIINKVI KAASKVENFF TGDDDDSNMT SSIKSVNLTI
210 220 230 240 250
SALHNLYIPS SINDKLEELS AKTPDFAQVK NTTKNLISVP FNEVRKNIKA
260 270 280 290 300
VNASNIIGDT SVLYVPPVSL DNSTGICSSN QSEILAFYSI LGHVLKIATV
310 320 330 340 350
VCITVLICFA VGAMAPVAWN EIKLWRRLCG MRDHYMLSRQ DSYTSFSSEN
360 370 380 390 400
THELKDPFRD PPIQNGQYDV IASYQQCFQT WNTRIAGWMT NLVTFGKSPE
410 420 430 440 450
NIDPKTKQKI EWVVAYMTSE RALCVLGIGL LGILVCICQF VMIALLKHKI
460 470 480 490 500
SHSLTSNDGD GVQNLLKSST AVDIENQMSL WSVQTNKYIN TTETNINQEV
510 520 530 540 550
FGWINTTTLS VNNTVATMIS DIDTTLADVF NGTLLYNPMK TVVGCAIENK
560 570 580 590 600
LYTIEKAMTW IHDKAQLHIP RINGTQIKQA LAKQTDNSTI PTASSTSAAT
610 620 630 640 650
ENLLENLVND MREGLLKILR AYHRITLGEL TVALVILAVW LVQLPIALVI
660
LRLRLRKATF D
Length:661
Mass (Da):73,353
Last modified:October 1, 1996 - v1
Checksum:i2038CACDCEDD927D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71555 Genomic DNA. Translation: CAA96191.1.
BK006947 Genomic DNA. Translation: DAA10281.1.
PIRiS63253.
RefSeqiNP_014120.1. NM_001183117.1.

Genome annotation databases

EnsemblFungiiYNL279W; YNL279W; YNL279W.
GeneIDi855442.
KEGGisce:YNL279W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71555 Genomic DNA. Translation: CAA96191.1.
BK006947 Genomic DNA. Translation: DAA10281.1.
PIRiS63253.
RefSeqiNP_014120.1. NM_001183117.1.

3D structure databases

ProteinModelPortaliP53835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35562. 17 interactions.
DIPiDIP-1385N.
IntActiP53835. 3 interactions.
MINTiMINT-384905.

Protein family/group databases

TCDBi9.B.63.1.1. the yeast pheromone-induced plasma membrane mating cell fusion protein (prm1) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL279W; YNL279W; YNL279W.
GeneIDi855442.
KEGGisce:YNL279W.

Organism-specific databases

EuPathDBiFungiDB:YNL279W.
SGDiS000005223. PRM1.

Phylogenomic databases

HOGENOMiHOG000115701.
InParanoidiP53835.
OMAiLTWVHDH.
OrthoDBiEOG092C1WXV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33271-MONOMER.

Miscellaneous databases

PROiP53835.

Family and domain databases

InterProiIPR026777. PRM1.
[Graphical view]
PANTHERiPTHR31030. PTHR31030. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPRM1_YEAST
AccessioniPrimary (citable) accession number: P53835
Secondary accession number(s): D6W0R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.