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Protein

Plasma membrane fusion protein PRM1

Gene

PRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.5 Publications

GO - Biological processi

  • plasma membrane fusion involved in cytogamy Source: SGD
Complete GO annotation...

Keywords - Biological processi

Conjugation

Enzyme and pathway databases

BioCyciYEAST:G3O-33271-MONOMER.

Protein family/group databases

TCDBi9.B.63.1.1. the yeast pheromone-induced plasma membrane mating cell fusion protein (prm1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane fusion protein PRM1
Alternative name(s):
Pheromone-regulated membrane protein 1
Gene namesi
Name:PRM1
Ordered Locus Names:YNL279W
ORF Names:N0605
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL279W.
SGDiS000005223. PRM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 105CytoplasmicSequence analysisAdd BLAST68
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 296ExtracellularSequence analysisAdd BLAST170
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 424CytoplasmicSequence analysisAdd BLAST107
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 629ExtracellularSequence analysisAdd BLAST184
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Topological domaini651 – 661CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • integral component of membrane Source: SGD
  • mating projection tip Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033771 – 661Plasma membrane fusion protein PRM1Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi490N-linked (GlcNAc...)Sequence analysis1
Glycosylationi505N-linked (GlcNAc...)Sequence analysis1
Glycosylationi512N-linked (GlcNAc...)Sequence analysis1
Glycosylationi531N-linked (GlcNAc...)Sequence analysis1
Glycosylationi573N-linked (GlcNAc...)Sequence analysis1
Glycosylationi587N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP53835.

Expressioni

Inductioni

By pheromones during mating, through the regulation by the STE12 transcription factor. Also induced in respiratory-deficient cells.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi35562. 17 interactors.
DIPiDIP-1385N.
IntActiP53835. 3 interactors.
MINTiMINT-384905.

Structurei

3D structure databases

ProteinModelPortaliP53835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PRM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000115701.
InParanoidiP53835.
OMAiLTWVHDH.
OrthoDBiEOG092C1WXV.

Family and domain databases

InterProiIPR026777. PRM1.
[Graphical view]
PANTHERiPTHR31030. PTHR31030. 2 hits.

Sequencei

Sequence statusi: Complete.

P53835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFKCYLQL GDRLSQIWLN KYTLVLLLAM LKLLFFSKSI QHAIEVSETY
60 70 80 90 100
ILSNCYSIDS LYSKMTDNTP HYLGIMGNYL IEKGMEETVK ATLETLSLIV
110 120 130 140 150
YASEGLVNFA IDLYLGTYAC LIVSAVDGTV DVATNITEKL ISLVNDTVSS
160 170 180 190 200
VANELDTGLN DISKIINKVI KAASKVENFF TGDDDDSNMT SSIKSVNLTI
210 220 230 240 250
SALHNLYIPS SINDKLEELS AKTPDFAQVK NTTKNLISVP FNEVRKNIKA
260 270 280 290 300
VNASNIIGDT SVLYVPPVSL DNSTGICSSN QSEILAFYSI LGHVLKIATV
310 320 330 340 350
VCITVLICFA VGAMAPVAWN EIKLWRRLCG MRDHYMLSRQ DSYTSFSSEN
360 370 380 390 400
THELKDPFRD PPIQNGQYDV IASYQQCFQT WNTRIAGWMT NLVTFGKSPE
410 420 430 440 450
NIDPKTKQKI EWVVAYMTSE RALCVLGIGL LGILVCICQF VMIALLKHKI
460 470 480 490 500
SHSLTSNDGD GVQNLLKSST AVDIENQMSL WSVQTNKYIN TTETNINQEV
510 520 530 540 550
FGWINTTTLS VNNTVATMIS DIDTTLADVF NGTLLYNPMK TVVGCAIENK
560 570 580 590 600
LYTIEKAMTW IHDKAQLHIP RINGTQIKQA LAKQTDNSTI PTASSTSAAT
610 620 630 640 650
ENLLENLVND MREGLLKILR AYHRITLGEL TVALVILAVW LVQLPIALVI
660
LRLRLRKATF D
Length:661
Mass (Da):73,353
Last modified:October 1, 1996 - v1
Checksum:i2038CACDCEDD927D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71555 Genomic DNA. Translation: CAA96191.1.
BK006947 Genomic DNA. Translation: DAA10281.1.
PIRiS63253.
RefSeqiNP_014120.1. NM_001183117.1.

Genome annotation databases

EnsemblFungiiYNL279W; YNL279W; YNL279W.
GeneIDi855442.
KEGGisce:YNL279W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71555 Genomic DNA. Translation: CAA96191.1.
BK006947 Genomic DNA. Translation: DAA10281.1.
PIRiS63253.
RefSeqiNP_014120.1. NM_001183117.1.

3D structure databases

ProteinModelPortaliP53835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35562. 17 interactors.
DIPiDIP-1385N.
IntActiP53835. 3 interactors.
MINTiMINT-384905.

Protein family/group databases

TCDBi9.B.63.1.1. the yeast pheromone-induced plasma membrane mating cell fusion protein (prm1) family.

Proteomic databases

PRIDEiP53835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL279W; YNL279W; YNL279W.
GeneIDi855442.
KEGGisce:YNL279W.

Organism-specific databases

EuPathDBiFungiDB:YNL279W.
SGDiS000005223. PRM1.

Phylogenomic databases

HOGENOMiHOG000115701.
InParanoidiP53835.
OMAiLTWVHDH.
OrthoDBiEOG092C1WXV.

Enzyme and pathway databases

BioCyciYEAST:G3O-33271-MONOMER.

Miscellaneous databases

PROiP53835.

Family and domain databases

InterProiIPR026777. PRM1.
[Graphical view]
PANTHERiPTHR31030. PTHR31030. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPRM1_YEAST
AccessioniPrimary (citable) accession number: P53835
Secondary accession number(s): D6W0R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.