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Protein

Cell wall integrity and stress response component 2

Gene

WSC2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: SGD

GO - Biological processi

  • fungal-type cell wall organization Source: SGD
  • response to heat Source: SGD
  • Rho protein signal transduction Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-33274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell wall integrity and stress response component 2
Gene namesi
Name:WSC2
Ordered Locus Names:YNL283C
ORF Names:N0583
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL283C.
SGDiS000005227. WSC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 325302ExtracellularSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Topological domaini347 – 503157CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cellular bud Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB-SubCell
  • site of polarized growth Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 503480Cell wall integrity and stress response component 2PRO_0000041484Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021PhosphothreonineCombined sources
Modified residuei455 – 4551PhosphoserineCombined sources
Modified residuei458 – 4581PhosphoserineCombined sources

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP53832.

PTM databases

iPTMnetiP53832.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself1EBI-2055941,EBI-2055941
FLC2P397191EBI-2055941,EBI-20703
GPA2P108231EBI-2055941,EBI-7382
HNM1P198071EBI-2055941,EBI-8409
MID2P360271EBI-2055941,EBI-10901
MUP1P502761EBI-2055941,EBI-11624
OSH7P387551EBI-2055941,EBI-12641
PDR12Q027851EBI-2055941,EBI-13065
PLM2Q043831EBI-2055941,EBI-2079237
PST2Q123351EBI-2055941,EBI-14064
RFS1P382341EBI-2055941,EBI-21445
ROM2P518621EBI-2055941,EBI-15702
SFK1P357351EBI-2055941,EBI-26678
SYP1P256231EBI-2055941,EBI-21900
TCB3Q036401EBI-2055941,EBI-27872
WSC3Q122151EBI-2055941,EBI-20551

Protein-protein interaction databases

BioGridi35558. 47 interactions.
IntActiP53832. 17 interactions.
MINTiMINT-4500766.

Structurei

3D structure databases

ProteinModelPortaliP53832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11894WSCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi121 – 319199Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 WSC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000112583.
InParanoidiP53832.
KOiK11244.
OrthoDBiEOG79GTJ6.

Family and domain databases

InterProiIPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF01822. WSC. 1 hit.
[Graphical view]
SMARTiSM00321. WSC. 1 hit.
[Graphical view]
PROSITEiPS51212. WSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLDLIHKSF ILVWLIYIRA ALADQFTYKA CYSASDIRKL GLTYKGVYEY
60 70 80 90 100
QSVSYCQNEC PGQAVVALFN GTGCYCGGSV AQLQSLTQVD SSKCDVSCAG
110 120 130 140 150
WPYQNCGGSS AMNVYINNAA STADSTSSTA TSTSTTSSSS TSVSSKTSTK
160 170 180 190 200
LDTKTSTSSS ATHSSSSSST TSTTTSSSET TTSSSSSSSS SSTSTTSTTS
210 220 230 240 250
TTSSTTSTSS SPSTTSSSTS ASSSSETSST QATSSSTTST SSSTSTATVT
260 270 280 290 300
STPSSTSIGT STHYTTRVVT QSVVSQANQQ ASTIFTTRTS VYATVSSTSS
310 320 330 340 350
STSSLLNGKS SSSKSKGLSG GAIAGVVVGV VCGTVALLAL ALFFFVWKKR
360 370 380 390 400
RQSSQHVDLE ETKQYQPYSL GDADANPVIP PSASSTNWHI PSRNNTALSK
410 420 430 440 450
NTASTFATYD LPTRAPGGRD SIITGDAHNI SKRSHFPSVV YEEPPSIYNG
460 470 480 490 500
NQRFSATSLP DMMEERQLHI VNPDNVSSNI GSNVSDGDDD YDDAKDSNNS

SLR
Length:503
Mass (Da):52,292
Last modified:October 1, 1996 - v1
Checksum:iF2392A73C5CBAB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71559 Genomic DNA. Translation: CAA96195.1.
BK006947 Genomic DNA. Translation: DAA10277.1.
PIRiS63257.
RefSeqiNP_014116.1. NM_001183121.1.

Genome annotation databases

EnsemblFungiiYNL283C; YNL283C; YNL283C.
GeneIDi855438.
KEGGisce:YNL283C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71559 Genomic DNA. Translation: CAA96195.1.
BK006947 Genomic DNA. Translation: DAA10277.1.
PIRiS63257.
RefSeqiNP_014116.1. NM_001183121.1.

3D structure databases

ProteinModelPortaliP53832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35558. 47 interactions.
IntActiP53832. 17 interactions.
MINTiMINT-4500766.

PTM databases

iPTMnetiP53832.

Proteomic databases

MaxQBiP53832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL283C; YNL283C; YNL283C.
GeneIDi855438.
KEGGisce:YNL283C.

Organism-specific databases

EuPathDBiFungiDB:YNL283C.
SGDiS000005227. WSC2.

Phylogenomic databases

GeneTreeiENSGT00730000112583.
InParanoidiP53832.
KOiK11244.
OrthoDBiEOG79GTJ6.

Enzyme and pathway databases

BioCyciYEAST:G3O-33274-MONOMER.

Miscellaneous databases

PROiP53832.

Family and domain databases

InterProiIPR002889. WSC_carb-bd.
[Graphical view]
PfamiPF01822. WSC. 1 hit.
[Graphical view]
SMARTiSM00321. WSC. 1 hit.
[Graphical view]
PROSITEiPS51212. WSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455 AND SER-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  4. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes."
    Kung L.A., Tao S.-C., Qian J., Smith M.G., Snyder M., Zhu H.
    Mol. Syst. Biol. 5:308-308(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-402; SER-455 AND SER-458, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWSC2_YEAST
AccessioniPrimary (citable) accession number: P53832
Secondary accession number(s): D6W0R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.