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Reviewed, UniProtKB/Swiss-Prot P53829 (CAF40_YEAST)

Last modified November 24, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein CAF40
Alternative name(s):
    40 kDa CCR4-associated factor
Gene names
Name: CAF40
Ordered Locus Names: YNL288W
ORF Names: N0540
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

Subunit structure

Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex. Ref.2

Subcellular location

Cytoplasm Probable. Nucleus Probable.

Miscellaneous

Present with 18800 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the RCD1 family.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   Molecular functionActivator
Repressor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription from RNA polymerase II promoter Ref.2

Inferred from physical interaction. Source: SGD

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentCCR4-NOT core complex Ref.2

Inferred from physical interaction. Source: SGD

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionidentical protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Protein CAF40
PRO_0000203375

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Sequences

Sequence LengthMass (Da)Tools
P53829-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F3DBABE6AD3C7F3C

FASTA37341,155
        10         20         30         40         50         60 
MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG GPMLMGNTPN 

        70         80         90        100        110        120 
NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA LDDPNVYHWI CQLTYGPQKE 

       130        140        150        160        170        180 
QALLELGRKR EQFDDLAVVL WSSFGVMTSL LNEIISVYPM LQPQMLSNNL SNRVCNALVL 

       190        200        210        220        230        240 
LQCVASHPET KHLFLQAHIP LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT 

       250        260        270        280        290        300 
FLLRTDIVPL CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM 

       310        320        330        340        350        360 
VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV LRDDVGSKRC 

       370 
LAQLLLTLNE ETS

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed: 9169873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex."
Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.
J. Mol. Biol. 314:683-694(2001) [PubMed: 11733989] [Abstract]
Cited for: IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, INTERACTION WITH NOT1.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z71564 Genomic DNA. Translation: CAA96205.1.
PIRS63262.
RefSeqNP_014111.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1995N.
IntActP53829. 54 interactions.
STRINGP53829.

Proteomic databases

PeptideAtlasP53829.

Genome annotation databases

EnsemblYNL288W; YNL288W; YNL288W; Saccharomyces cerevisiae. [Genome view]
GeneID855428.
KEGGsce:YNL288W.
NMPDRfig|4932.3.peg.5173.

Organism-specific databases

CYGDYNL288w.
SGDS000005232. CAF40.

Phylogenomic databases

HOGENOMP53829.
OMARSFEYLR
OrthoDBEOG9XPRZ8

Gene expression databases

ArrayExpressP53829.
GenevestigatorP53829.
GermOnlineYNL288W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR007216. Cell_differentiation_Rcd1.
[Graphical view]
PANTHERPTHR12262. Rcd1. 1 hit.
PfamPF04078. Rcd1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio979301.

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Entry information

Entry nameCAF40_YEAST
AccessionPrimary (citable) accession number: P53829
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents