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P53829

- CAF40_YEAST

UniProt

P53829 - CAF40_YEAST

Protein

Protein CAF40

Gene

CAF40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. positive regulation of transcription elongation from RNA polymerase II promoter Source: SGD
    2. regulation of transcription from RNA polymerase II promoter Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33278-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CAF40
    Alternative name(s):
    40 kDa CCR4-associated factor
    Gene namesi
    Name:CAF40
    Ordered Locus Names:YNL288W
    ORF Names:N0540
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL288w.
    SGDiS000005232. CAF40.

    Subcellular locationi

    Cytoplasm Curated. Nucleus Curated

    GO - Cellular componenti

    1. CCR4-NOT core complex Source: SGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Protein CAF40PRO_0000203375Add
    BLAST

    Proteomic databases

    MaxQBiP53829.
    PaxDbiP53829.
    PeptideAtlasiP53829.

    Expressioni

    Gene expression databases

    GenevestigatoriP53829.

    Interactioni

    Subunit structurei

    Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCR4P313848EBI-28306,EBI-4396
    CDC39P256559EBI-28306,EBI-12139
    MOT2P349095EBI-28306,EBI-12174
    NOT3P061023EBI-28306,EBI-12165
    NOT5Q125143EBI-28306,EBI-12184
    NST1P539353EBI-28306,EBI-28788
    POP2P390088EBI-28306,EBI-13629

    Protein-protein interaction databases

    BioGridi35549. 107 interactions.
    DIPiDIP-1995N.
    IntActiP53829. 45 interactions.
    MINTiMINT-393536.
    STRINGi4932.YNL288W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CV5X-ray3.81B/D54-373[»]
    ProteinModelPortaliP53829.
    SMRiP53829. Positions 106-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RCD1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5209.
    GeneTreeiENSGT00390000001225.
    HOGENOMiHOG000192069.
    KOiK12606.
    OMAiCVASHND.
    OrthoDBiEOG7S7SR3.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR007216. Rcd1.
    [Graphical view]
    PANTHERiPTHR12262. PTHR12262. 1 hit.
    PfamiPF04078. Rcd1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P53829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG    50
    GPMLMGNTPN NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA 100
    LDDPNVYHWI CQLTYGPQKE QALLELGRKR EQFDDLAVVL WSSFGVMTSL 150
    LNEIISVYPM LQPQMLSNNL SNRVCNALVL LQCVASHPET KHLFLQAHIP 200
    LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT FLLRTDIVPL 250
    CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM 300
    VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV 350
    LRDDVGSKRC LAQLLLTLNE ETS 373
    Length:373
    Mass (Da):41,155
    Last modified:October 1, 1996 - v1
    Checksum:iF3DBABE6AD3C7F3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71564 Genomic DNA. Translation: CAA96205.1.
    BK006947 Genomic DNA. Translation: DAA10271.1.
    PIRiS63262.
    RefSeqiNP_014111.1. NM_001183126.1.

    Genome annotation databases

    EnsemblFungiiYNL288W; YNL288W; YNL288W.
    GeneIDi855428.
    KEGGisce:YNL288W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71564 Genomic DNA. Translation: CAA96205.1 .
    BK006947 Genomic DNA. Translation: DAA10271.1 .
    PIRi S63262.
    RefSeqi NP_014111.1. NM_001183126.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CV5 X-ray 3.81 B/D 54-373 [» ]
    ProteinModelPortali P53829.
    SMRi P53829. Positions 106-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35549. 107 interactions.
    DIPi DIP-1995N.
    IntActi P53829. 45 interactions.
    MINTi MINT-393536.
    STRINGi 4932.YNL288W.

    Proteomic databases

    MaxQBi P53829.
    PaxDbi P53829.
    PeptideAtlasi P53829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL288W ; YNL288W ; YNL288W .
    GeneIDi 855428.
    KEGGi sce:YNL288W.

    Organism-specific databases

    CYGDi YNL288w.
    SGDi S000005232. CAF40.

    Phylogenomic databases

    eggNOGi COG5209.
    GeneTreei ENSGT00390000001225.
    HOGENOMi HOG000192069.
    KOi K12606.
    OMAi CVASHND.
    OrthoDBi EOG7S7SR3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33278-MONOMER.

    Miscellaneous databases

    NextBioi 979301.
    PROi P53829.

    Gene expression databases

    Genevestigatori P53829.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR007216. Rcd1.
    [Graphical view ]
    PANTHERi PTHR12262. PTHR12262. 1 hit.
    Pfami PF04078. Rcd1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex."
      Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.
      J. Mol. Biol. 314:683-694(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, INTERACTION WITH NOT1.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAF40_YEAST
    AccessioniPrimary (citable) accession number: P53829
    Secondary accession number(s): D6W0Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 18800 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3