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P53829 (CAF40_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CAF40
Alternative name(s):
40 kDa CCR4-associated factor
Gene names
Name:CAF40
Ordered Locus Names:YNL288W
ORF Names:N0540
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

Subunit structure

Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex. Ref.3

Subcellular location

Cytoplasm Probable. Nucleus Probable.

Miscellaneous

Present with 18800 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the RCD1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Protein CAF40
PRO_0000203375

Sequences

Sequence LengthMass (Da)Tools
P53829 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F3DBABE6AD3C7F3C

FASTA37341,155
        10         20         30         40         50         60 
MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG GPMLMGNTPN 

        70         80         90        100        110        120 
NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA LDDPNVYHWI CQLTYGPQKE 

       130        140        150        160        170        180 
QALLELGRKR EQFDDLAVVL WSSFGVMTSL LNEIISVYPM LQPQMLSNNL SNRVCNALVL 

       190        200        210        220        230        240 
LQCVASHPET KHLFLQAHIP LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT 

       250        260        270        280        290        300 
FLLRTDIVPL CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM 

       310        320        330        340        350        360 
VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV LRDDVGSKRC 

       370 
LAQLLLTLNE ETS 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex."
Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.
J. Mol. Biol. 314:683-694(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, INTERACTION WITH NOT1.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71564 Genomic DNA. Translation: CAA96205.1.
BK006947 Genomic DNA. Translation: DAA10271.1.
PIRS63262.
RefSeqNP_014111.1. NM_001183126.1.

3D structure databases

ProteinModelPortalP53829.
SMRP53829. Positions 106-370.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35549. 106 interactions.
DIPDIP-1995N.
IntActP53829. 45 interactions.
MINTMINT-393536.
STRING4932.YNL288W.

Proteomic databases

PaxDbP53829.
PeptideAtlasP53829.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL288W; YNL288W; YNL288W.
GeneID855428.
KEGGsce:YNL288W.

Organism-specific databases

CYGDYNL288w.
SGDS000005232. CAF40.

Phylogenomic databases

eggNOGCOG5209.
GeneTreeENSGT00390000001225.
HOGENOMHOG000192069.
KOK12606.
OMACVASHND.
OrthoDBEOG7S7SR3.

Enzyme and pathway databases

BioCycYEAST:G3O-33278-MONOMER.

Gene expression databases

GenevestigatorP53829.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR007216. Rcd1.
[Graphical view]
PANTHERPTHR12262. PTHR12262. 1 hit.
PfamPF04078. Rcd1. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

NextBio979301.
PROP53829.

Entry information

Entry nameCAF40_YEAST
AccessionPrimary (citable) accession number: P53829
Secondary accession number(s): D6W0Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families