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Protein

Protein CAF40

Gene

CAF40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.

Miscellaneous

Present with 18800 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33278-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CAF40
Alternative name(s):
40 kDa CCR4-associated factor
Gene namesi
Name:CAF40
Ordered Locus Names:YNL288W
ORF Names:N0540
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL288W
SGDiS000005232 CAF40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002033751 – 373Protein CAF40Add BLAST373

Proteomic databases

MaxQBiP53829
PaxDbiP53829
PRIDEiP53829

Interactioni

Subunit structurei

Subunit of the 1.0 MDa CCR4-NOT core complex that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and CAF130. In the complex interacts with NOT1. The core complex probably is part of a less characterized 1.9 MDa CCR4-NOT complex.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35549, 155 interactors
DIPiDIP-1995N
IntActiP53829, 71 interactors
MINTiP53829
STRINGi4932.YNL288W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CV5X-ray3.81B/D54-373[»]
ProteinModelPortaliP53829
SMRiP53829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNOT9 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001225
HOGENOMiHOG000192069
InParanoidiP53829
KOiK12606
OMAiMVTKRCL
OrthoDBiEOG092C42ZN

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

P53829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG
60 70 80 90 100
GPMLMGNTPN NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA
110 120 130 140 150
LDDPNVYHWI CQLTYGPQKE QALLELGRKR EQFDDLAVVL WSSFGVMTSL
160 170 180 190 200
LNEIISVYPM LQPQMLSNNL SNRVCNALVL LQCVASHPET KHLFLQAHIP
210 220 230 240 250
LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT FLLRTDIVPL
260 270 280 290 300
CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM
310 320 330 340 350
VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV
360 370
LRDDVGSKRC LAQLLLTLNE ETS
Length:373
Mass (Da):41,155
Last modified:October 1, 1996 - v1
Checksum:iF3DBABE6AD3C7F3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71564 Genomic DNA Translation: CAA96205.1
BK006947 Genomic DNA Translation: DAA10271.1
PIRiS63262
RefSeqiNP_014111.1, NM_001183126.1

Genome annotation databases

EnsemblFungiiYNL288W; YNL288W; YNL288W
GeneIDi855428
KEGGisce:YNL288W

Similar proteinsi

Entry informationi

Entry nameiCAF40_YEAST
AccessioniPrimary (citable) accession number: P53829
Secondary accession number(s): D6W0Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health