Reviewed, UniProtKB/Swiss-Prot P53824 (SNZ2_YEAST)

Names and origin

Protein names

Recommended name:
    Probable pyridoxine biosynthesis protein SNZ2
Alternative name(s):
    PDX1 homolog 2

Gene names

Name:	SNZ2
Ordered Locus Names:	YNL333W
ORF Names:	N0290

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be required for the production of pyridoxine (vitamin B6). Ref.3
Subunit structure	Interacts with THI11. Ref.3
Induction	By the absence of external thiamine. Ref.3
Sequence similarities	Belongs to the pdxS/SNZ family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW thiamin biosynthetic process Ref.3 Inferred from mutant phenotype. Source: SGD
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein binding Ref.3 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SNO1	Q03144	3	EBI-17623,EBI-28190
SNO2	P53823	1	EBI-17623,EBI-28424
SNO3	P43544	2	EBI-17623,EBI-22871
SNZ1	Q03148	1	EBI-17623,EBI-17618
SNZ3	P43545	1	EBI-17623,EBI-17629

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Probable pyridoxine biosynthesis protein SNZ2		PRO_0000109359

Sequences

	Sequence		Length	Mass (Da)
	P53824-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: EE02E7C546C460AC	FASTA	298	32,033
	10 20 30 40 50 60 MSEFKVKTGL AQMLKGGVIM DVVTPEQAII AERAGACAVM ALERIPADMR KSGQVCRMSD 70 80 90 100 110 120 PRMIKEIMEA VSIPVMAKVR IGHFVEAQIL EELQVDYIDE SEVLTPADWT HHIEKHNFKV 130 140 150 160 170 180 PFVCGAKDLG EALRRINEGA AMIRTKGEAG TGDVSEAVKH ITKIKAEIQQ YKENLKTESD 190 200 210 220 230 240 FAAKATELRV PVDLLKTTLS EGKLPVVNFA AGGVATPADA ALLMQLGCEG VFVGSGIFKS 250 260 270 280 290 SDPEKLACAI VEATTHYDNP AKLLQISSDL GDLMGGISIQ SINEAGGKNG ARLSEIGW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6." Rodriguez-Navarro S., Llorente B., Rodriguez-Manzaneque M.T., Ramne A., Uber G., Marchesan D., Dujon B., Herrero E., Sunnerhagen P., Perez-Ortin J.E. Yeast 19:1261-1276(2002) [PubMed: 12271461] [Abstract] Cited for: PROBABLE FUNCTION, INDUCTION, INTERACTION WITH THI11.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z71608 Genomic DNA. Translation: CAA96266.1. Z71609 Genomic DNA. Translation: CAA96267.1. AY692873 Genomic DNA. Translation: AAT92892.1.
RefSeq	NP_014066.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1695N.
IntAct	P53824. 13 interactions.
STRING	P53824.
Genome annotation databases
Ensembl	YNL333W; YNL333W; YNL333W; Saccharomyces cerevisiae. [Genome view]
GeneID	855383.
KEGG	sce:YNL333W.
Organism-specific databases
CYGD	YNL333w.
SGD	S000005277. SNZ2.
Phylogenomic databases
HOGENOM	P53824.
OrthoDB	EOG93N8WC
Gene expression databases
Genevestigator	P53824.
GermOnline	YNL333W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011060. RibuloseP-bd_barrel. IPR001852. Snz1p/Sor1. [Graphical view]
Pfam	PF01680. SOR_SNZ. 1 hit. [Graphical view]
PIRSF	PIRSF029271. Pdx1. 1 hit.
TIGRFAMs	TIGR00343. Snz1p/Sor1. 1 hit.
PROSITE	PS01235. PDXS_SNZ_1. 1 hit. PS51129. PDXS_SNZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	979178.

Entry information

Entry name

SNZ2_YEAST

Accession

Primary (citable) accession number: P53824

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)