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Protein

Probable pyridoxal 5'-phosphate synthase subunit SNZ2

Gene

SNZ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.By similarity

Catalytic activityi

D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate.By similarity

Pathwayi: pyridoxal 5'-phosphate biosynthesis

This protein is involved in the pathway pyridoxal 5'-phosphate biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway pyridoxal 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21D-ribose 5-phosphateBy similarity1
Active sitei78Schiff-base intermediate with D-ribose 5-phosphateBy similarity1
Binding sitei150D-ribose 5-phosphate; via amide nitrogenBy similarity1
Binding sitei213D-ribose 5-phosphate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • pyridoxal phosphate biosynthetic process Source: UniProtKB-UniPathway
  • pyridoxine biosynthetic process Source: SGD

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate, Schiff base

Enzyme and pathway databases

BioCyciYEAST:G3O-33316-MONOMER
UniPathwayiUPA00245

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pyridoxal 5'-phosphate synthase subunit SNZ2 (EC:4.3.3.6)
Short name:
PLP synthase subunit SNZ2
Alternative name(s):
PDX1 homolog 2
Short name:
Pdx1.2
Gene namesi
Name:SNZ2
Ordered Locus Names:YNL333W
ORF Names:N0290
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL333W
SGDiS000005277 SNZ2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001093591 – 298Probable pyridoxal 5'-phosphate synthase subunit SNZ2Add BLAST298

Proteomic databases

MaxQBiP53824
PaxDbiP53824
PRIDEiP53824

Expressioni

Inductioni

By the absence of external thiamine.1 Publication

Interactioni

Subunit structurei

Homohexamer (By similarity). Interacts with THI11 (PubMed:12271461).By similarity1 Publication

Protein-protein interaction databases

BioGridi35508, 24 interactors
DIPiDIP-1695N
IntActiP53824, 12 interactors
MINTiP53824
STRINGi4932.YNL333W

Structurei

3D structure databases

ProteinModelPortaliP53824
SMRiP53824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 235D-ribose 5-phosphate bindingBy similarity2

Sequence similaritiesi

Belongs to the PdxS/SNZ family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000018460
HOGENOMiHOG000227586
InParanoidiP53824
KOiK06215
OMAiKEIRAPV
OrthoDBiEOG092C3P5O

Family and domain databases

CDDicd04727 pdxS, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01824 PdxS, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001852 PdxS/SNZ
IPR033755 PdxS/SNZ_N
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR31829 PTHR31829, 1 hit
PfamiView protein in Pfam
PF01680 SOR_SNZ, 1 hit
PIRSFiPIRSF029271 Pdx1, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR00343 TIGR00343, 1 hit
PROSITEiView protein in PROSITE
PS01235 PDXS_SNZ_1, 1 hit
PS51129 PDXS_SNZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

P53824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEFKVKTGL AQMLKGGVIM DVVTPEQAII AERAGACAVM ALERIPADMR
60 70 80 90 100
KSGQVCRMSD PRMIKEIMEA VSIPVMAKVR IGHFVEAQIL EELQVDYIDE
110 120 130 140 150
SEVLTPADWT HHIEKHNFKV PFVCGAKDLG EALRRINEGA AMIRTKGEAG
160 170 180 190 200
TGDVSEAVKH ITKIKAEIQQ YKENLKTESD FAAKATELRV PVDLLKTTLS
210 220 230 240 250
EGKLPVVNFA AGGVATPADA ALLMQLGCEG VFVGSGIFKS SDPEKLACAI
260 270 280 290
VEATTHYDNP AKLLQISSDL GDLMGGISIQ SINEAGGKNG ARLSEIGW
Length:298
Mass (Da):32,033
Last modified:October 1, 1996 - v1
Checksum:iEE02E7C546C460AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71608 Genomic DNA Translation: CAA96266.1
Z71609 Genomic DNA Translation: CAA96267.1
AY692873 Genomic DNA Translation: AAT92892.1
BK006947 Genomic DNA Translation: DAA10230.1
RefSeqiNP_014066.1, NM_001183171.1

Genome annotation databases

EnsemblFungiiYNL333W; YNL333W; YNL333W
GeneIDi855383
KEGGisce:YNL333W

Similar proteinsi

Entry informationi

Entry nameiSNZ2_YEAST
AccessioniPrimary (citable) accession number: P53824
Secondary accession number(s): D6W0L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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