P53823 (SNO2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutamine amidotransferase SNO2
EC=2.6.-.-

Gene names

Name:	SNO2
Ordered Locus Names:	YNL334C
ORF Names:	N0285

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be required for the production of pyridoxine (vitamin B6). Ref.3
Sequence similarities	Belongs to the glutamine amidotransferase pdxT/SNO family.

Ontologies

Keywords
Biological process	Pyridoxine biosynthesis
Domain	Glutamine amidotransferase
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutamine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pyridoxine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW thiamine biosynthetic process Inferred from mutant phenotype Ref.3. Source: SGD
Molecular function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Probable glutamine amidotransferase SNO2		PRO_0000135620
Sites
	Active site	91	1	Nucleophile By similarity
	Active site	197	1	By similarity
	Active site	199	1	By similarity
	Binding site	120	1	Glutamine Potential

Sequences

	Sequence		Length	Mass (Da)
	P53823 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6755EE1D826CAABA	FASTA	222	25,208
	10 20 30 40 50 60 MTVVIGVLAL QGAFIEHVRH VEKCIVENRD FYEKKLSVMT VKDKNQLAQC DALIIPGGES 70 80 90 100 110 120 TAMSLIAERT GFYDDLYAFV HNPSKVTWGT CAGMIYISQQ LSNEEKLVKT LNLLKVKVKR 130 140 150 160 170 180 NAFGRQAQSS TRICDFSNFI PHCNDFPATF IRAPVIEEVL DPEHVQVLYK LDGKDNGGQE 190 200 210 220 LIVAAKQKNN ILATSFHPEL AENDIRFHDW FIREFVLKNY SK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed: 9169873] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6." Rodriguez-Navarro S., Llorente B., Rodriguez-Manzaneque M.T., Ramne A., Uber G., Marchesan D., Dujon B., Herrero E., Sunnerhagen P., Perez-Ortin J.E. Yeast 19:1261-1276(2002) [PubMed: 12271461] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71610 Genomic DNA. Translation: CAA96268.1. BK006947 Genomic DNA. Translation: DAA10229.1.
PIR	S63320.
RefSeq	NP_014065.1. NM_001183172.1.
3D structure databases
ProteinModelPortal	P53823.
SMR	P53823. Positions 4-215.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2069N.
IntAct	P53823. 7 interactions.
MINT	MINT-509304.
STRING	P53823.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL334C; YNL334C; YNL334C.
GeneID	855382.
KEGG	sce:YNL334C.
Organism-specific databases
CYGD	YNL334c.
SGD	S000005278. SNO2.
Phylogenomic databases
eggNOG	fuNOG09923.
GeneTree	EFGT00050000003446.
HOGENOM	HBG292341.
OMA	IFMAREV.
OrthoDB	EOG4R2742.
Gene expression databases
Genevestigator	P53823.
GermOnline	YNL334C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR002161. Glutamine_amidoTferase_suPdxT. IPR021196. PdxT/SNO_CS. [Graphical view]
KO	K08681.
Pfam	PF01174. SNO. 1 hit. [Graphical view]
PIRSF	PIRSF005639. Glut_amidoT_SNO. 1 hit.
TIGRFAMs	TIGR03800. PLP_synth_Pdx2. 1 hit.
PROSITE	PS01236. PDXT_SNO_1. 1 hit. PS51130. PDXT_SNO_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	979175.

Entry information

Entry name

SNO2_YEAST

Accession

Primary (citable) accession number: P53823
Secondary accession number(s): D6W0L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program