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Reviewed, UniProtKB/Swiss-Prot P53822 (COS1_YEAST)

Last modified November 24, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein COS1
Gene names
Name: COS1
Ordered Locus Names: YNL336W
ORF Names: N0275
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 1730 molecules/cell in log phase SD medium. Ref.2

Sequence similarities

Belongs to the DUP/COS family.

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Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentfungal-type vacuole

Inferred from direct assay. Source: SGD

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Protein COS1
PRO_0000207513

Regions

Topological domain1 – 4242Cytoplasmic Potential
Transmembrane43 – 6321 Potential
Topological domain64 – 729Extracellular Potential
Transmembrane73 – 9321 Potential
Topological domain94 – 231138Cytoplasmic Potential
Transmembrane232 – 25221 Potential
Topological domain253 – 2542Extracellular Potential
Transmembrane255 – 27521 Potential
Topological domain276 – 381106Cytoplasmic Potential

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Sequences

Sequence LengthMass (Da)Tools
P53822-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F9AF930CB1935131

FASTA38145,288
        10         20         30         40         50         60 
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS 

        70         80         90        100        110        120 
VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS KQLIQFCKEV TENTPSSDPH 

       130        140        150        160        170        180 
DWEVVAANLN SYLYENKAWN TKYFFFNAMV CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV 

       190        200        210        220        230        240 
PYIEEALGVY FREVEKQWKL FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI 

       250        260        270        280        290        300 
PFLNFLCCIY VSRGMCLLLR TFYLGWILFM LVQGFQNMRM IVLSVKMEHK MQFLSTIINE 

       310        320        330        340        350        360 
QESGANGWDE IAKKMNRYLF EKKVWKNEEF FFDGIDCEWF FSHFFYRVLS AKKSMRALSL 

       370        380 
NVELWPYIKE AQLSCSEESL A

« Hide

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References

[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed: 9169873] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z71612 Genomic DNA. Translation: CAA96270.1.
PIRS63322.
RefSeqNP_014063.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:7523N.
IntActP53822. 20 interactions.
STRINGP53822.

Genome annotation databases

EnsemblYNL336W; YNL336W; YNL336W; Saccharomyces cerevisiae. [Genome view]
GeneID855380.
KEGGsce:YNL336W.
NMPDRfig|4932.3.peg.5125.

Organism-specific databases

CYGDYNL336w.
SGDS000005280. COS1.

Phylogenomic databases

HOGENOMP53822.

Gene expression databases

GenevestigatorP53822.
GermOnlineYNL336W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001142. DUP.
[Graphical view]
PfamPF00674. DUP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio979169.

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Entry information

Entry nameCOS1_YEAST
AccessionPrimary (citable) accession number: P53822
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 24, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents