P53819 (YRF16_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Y' element ATP-dependent helicase protein 1 copy 6
EC=3.6.4.12

Gene names

Name:	YRF1-6
Ordered Locus Names:	YNL339C
ORF Names:	N0152

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	1859 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance. Ref.3
Catalytic activity	ATP + H2O = ADP + phosphate.
Induction	Induced in absence of telomerase TLC1. Ref.3
Sequence similarities	Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	telomere maintenance via recombination Inferred from genetic interaction Ref.3. Source: SGD
Cellular_component	nucleus Inferred by curator Ref.3. Source: SGD
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro DNA helicase activity Inferred from direct assay Ref.3. Source: SGD nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1859	1859	Y' element ATP-dependent helicase protein 1 copy 6		PRO_0000102205
Regions
	Domain	861 – 1038	178	Helicase ATP-binding
	Domain	1095 – 1244	150	Helicase C-terminal
	Nucleotide binding	874 – 881	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P53819 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 6210C19E166D40D7	FASTA	1,859	211,099
	10 20 30 40 50 60 MEIENEQICT CIAQILHLLN SLIITFLDDD KTETGQSFVY IDGFLVKKHN NQHTIVNFET 70 80 90 100 110 120 YKNKMKVSDR RKFEKANFDE FESALNNKND LVHCPSITLF ESIPTEVRSF YEDEKSGLIK 130 140 150 160 170 180 VVKFRTGAMD RKRSFEKIVV SVMVGKNVQK FLTFVEDEPD FQGGPIPSKY LIPKKINLMV 190 200 210 220 230 240 YTLFQVHTLK FNRKDYDTLS LFYLNRGYYN ELSFRVLERC YEIASARPND SSTMRTFTDF 250 260 270 280 290 300 VSGTPIVRGL QKSTIRKYGY NLAPYMFLLL HVDELSIFSA YQASLPGEKK VDTERLKRDL 310 320 330 340 350 360 CPRKPTEIKY FSQICNDMMN KKDRLGDILH IILRACALNF GAGPRGGAGD EEDRSITNEE 370 380 390 400 410 420 PIIPSVDEHG LKVCKLRSPN TPRRLRKTLD AVKALLVSSC ACTARDLDIF DDNNGVAMWK 430 440 450 460 470 480 WIKILYHEVA QETALKDSYR ITLVPSSDGV SVCGKLFNRE YVRGFYFACK AQFDNLWEEL 490 500 510 520 530 540 NDCFYMPTVV DIASLILRNR EVLFREPKRG IDEYLENDSF LQMIPVKYRE IVLPKLRRDT 550 560 570 580 590 600 NKMTAALKNK VTVAIDELTV PLMWMIHFAV GYPYRYPELQ LLAFAGPQRN VYVDDTTRRI 610 620 630 640 650 660 QLYTDYNKNG SSEPRLKTLD GLTSDYVFYF VTVLRQMQIC ALGNSYDAFN HDPWMDVVGF 670 680 690 700 710 720 EDPDQVTNRD ISRIVLYSYM FLNTAKGCLV EYATFRQYMR ELPKNAPQKL NFREMRQGLI 730 740 750 760 770 780 ALGRHCVGSR FETDLYESAT SELMANHSVQ TGRNIYGVDS FSLTSVSGTT ATLLQERASE 790 800 810 820 830 840 RWIQWLGLES DYHCSFSSTR NAEDVVAGEA ASSDHHQKIS RVTRKRPREP KSTNDILVAG 850 860 870 880 890 900 QKLFGSSFEF RDLHQLRLCH EIYMADTPSV AVQAPPGYGK TELFHLPLIA LASKGDVKYV 910 920 930 940 950 960 SFLFVPYTVL LANCMIRLSR CGCLNVAPVR NFIEEGCDGV TDLYVGIYDD LASTNFTDRI 970 980 990 1000 1010 1020 AAWENIVECT FRTNNVKLGY LIVDEFHNFE TEVYRQSQFG GITNLDFDAF EKAIFLSGTA 1030 1040 1050 1060 1070 1080 PEAVADAALQ RIGLTGLAKK SMDINELKRS EDLSRGLSSY PTRMFNLIKE KSEVPLGHVH 1090 1100 1110 1120 1130 1140 KIWKKVESQP EEALKLLLAL FEIEPESKAI VVASTTNEVE ELACSWRKYF RVVWIHGKLG 1150 1160 1170 1180 1190 1200 AAEKVSRTKE FVTDGSMRVL IGTKLVTEGI DIKQLMMVIM LDNRLNIIEL IQGVGRLRDG 1210 1220 1230 1240 1250 1260 GLCYLLSRKN SWAARNRKGE LPPIKEGCIT EQVREFYGLE SKKGKKGQHV GCCGSRTDLS 1270 1280 1290 1300 1310 1320 ADTVELIERM DRLAEKQATA SMSIVALPSS FQESNSSDRC RKYCSSDEDS DTCIHGSANA 1330 1340 1350 1360 1370 1380 STNATTNSST NATTTASTNV RTSATTTASI NVRTSATTTE STNSSTNATT TASTNVRTSA 1390 1400 1410 1420 1430 1440 TTTASINVRT SATTTESTNS NTSATTTEST DSNTSATTTE STDSNTSATT TASTNSSTNA 1450 1460 1470 1480 1490 1500 TTTASTNSST NATTTESTNA SAKEDANKDG NAEDNRFHPV TDINKESYKR KGSQMVLLER 1510 1520 1530 1540 1550 1560 KKLKAQFPNT SENMNVLQFL GFRSDEIKHL FLYGIDVYFC PEGVFTQYGL CKGCQKMFEL 1570 1580 1590 1600 1610 1620 CVCWAGQKVS YRRMAWEALA VERMLRNDEE YKEYLEDIEP YHGDPVGYLK FFSVKRGEIY 1630 1640 1650 1660 1670 1680 SQIQRNYAWY LAITRRRETI SVLDSTRGKQ GSQVFRMSGR QIKELYYKVW SNLRESKTEV 1690 1700 1710 1720 1730 1740 LQYFLNWDEK KCREEWEAKD DTVFVEALEK VGVFQRLRSM TSAGLQGPQY VKLQFSRHHR 1750 1760 1770 1780 1790 1800 QLRSRYELSL GMHLRDQLAL GVTPSKVPHW TAFLSMLIGL FCNKTFRQKL EYLLEQISEV 1810 1820 1830 1840 1850 WLLPHWLDLA NVEVLAADNT RVPLYMLMVA VHKELDSDDV PDGRFDILLC RDSSREVGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications." Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J. Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase." Yamada M., Hayatsu N., Matsuura A., Ishikawa F. J. Biol. Chem. 273:33360-33366(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z71615 Genomic DNA. Translation: CAA96276.1. Z71614 Genomic DNA. Translation: CAA96275.1. BK006947 Genomic DNA. Translation: DAA10226.1.
PIR	S63325.
RefSeq	NP_014060.1. NM_001183177.1.
3D structure databases
ProteinModelPortal	P53819.
SMR	P53819. Positions 963-1196.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7312N.
IntAct	P53819. 2 interactions.
STRING	4932.YPL283C.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YNL339C; YNL339C; YNL339C.
GeneID	855377.
KEGG	sce:YNL339C.
Organism-specific databases
CYGD	YNL339c.
SGD	S000005283. YRF1-6.
Phylogenomic databases
GeneTree	ENSGT00440000033744.
HOGENOM	HOG000155528.
OrthoDB	EOG4V9Z0T.
Enzyme and pathway databases
BioCyc	YEAST:G3O-33320-MONOMER.
Gene expression databases
Genevestigator	P53819.
GermOnline	YNL339C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	979166.

Entry information

Entry name

YRF16_YEAST

Accession

Primary (citable) accession number: P53819
Secondary accession number(s): D6W0L0, O94144

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program