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Protein

Phosphatidylinositol transfer protein alpha isoform

Gene

Pitpna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei61Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei86Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei90Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei97Phosphatidylinositol lipid headgroupBy similarity1
Binding sitei195Phosphatidylinositol lipid headgroupBy similarity1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: BHF-UCL
  • phospholipid transport Source: MGI
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-418890. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein alpha isoform
Short name:
PI-TP-alpha
Short name:
PtdIns transfer protein alpha
Short name:
PtdInsTP alpha
Gene namesi
Name:Pitpna
Synonyms:Pitpn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99887. Pitpna.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: MGI
  • integral component of membrane Source: MGI
  • myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001916402 – 271Phosphatidylinositol transfer protein alpha isoformAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP53810.
PaxDbiP53810.
PeptideAtlasiP53810.
PRIDEiP53810.

2D gel databases

REPRODUCTION-2DPAGEP53810.

PTM databases

iPTMnetiP53810.
PhosphoSitePlusiP53810.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017781.
CleanExiMM_PITPNA.
ExpressionAtlasiP53810. baseline and differential.
GenevisibleiP53810. MM.

Interactioni

Protein-protein interaction databases

IntActiP53810. 1 interactor.
MINTiMINT-4107643.
STRINGi10090.ENSMUSP00000115723.

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Helixi15 – 30Combined sources16
Turni36 – 39Combined sources4
Beta strandi40 – 49Combined sources10
Beta strandi55 – 64Combined sources10
Helixi66 – 68Combined sources3
Helixi71 – 74Combined sources4
Turni79 – 82Combined sources4
Beta strandi83 – 91Combined sources9
Beta strandi94 – 101Combined sources8
Turni102 – 104Combined sources3
Helixi105 – 107Combined sources3
Beta strandi108 – 121Combined sources14
Helixi131 – 134Combined sources4
Beta strandi138 – 142Combined sources5
Helixi147 – 149Combined sources3
Helixi152 – 154Combined sources3
Helixi157 – 159Combined sources3
Turni161 – 163Combined sources3
Turni167 – 169Combined sources3
Helixi178 – 182Combined sources5
Beta strandi191 – 201Combined sources11
Helixi207 – 231Combined sources25
Helixi233 – 236Combined sources4
Helixi241 – 253Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCMX-ray2.00A2-271[»]
ProteinModelPortaliP53810.
SMRiP53810.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53810.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00760000119216.
HOGENOMiHOG000174733.
HOVERGENiHBG058915.
InParanoidiP53810.
PhylomeDBiP53810.
TreeFamiTF313279.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiPF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK
60 70 80 90 100
DDGEKGQYTH KIYHLQSKVP TFVRMLAPEG ALNIHEKAWN AYPYCRTVIT
110 120 130 140 150
NEYMKEDFLI KIETWHKPDL GTQENVHKLE PEAWKHVEAI YIDIADRSQV
160 170 180 190 200
LSKDYKAEED PAKFKSVKTG RGPLGPNWKQ ELVNQKDCPY MCAYKLVTVK
210 220 230 240 250
FKWWGLQNKV ENFIHKQEKR LFTNFHRQLF CWLDKWVDLT MDDIRRMEEE
260 270
TKRQLDEMRQ KDPVKGMTAD D
Length:271
Mass (Da):31,893
Last modified:January 23, 2007 - v2
Checksum:iE9561EE5BBBADC3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72681 mRNA. Translation: AAC60690.1.
U96725 mRNA. Translation: AAC53266.1.
U96726 Genomic DNA. Translation: AAC60756.1.
BC056171 mRNA. Translation: AAH56171.1.
CCDSiCCDS25052.1.
RefSeqiNP_032876.1. NM_008850.2.
UniGeneiMm.3128.

Genome annotation databases

EnsembliENSMUST00000143219; ENSMUSP00000115723; ENSMUSG00000017781.
GeneIDi18738.
KEGGimmu:18738.
UCSCiuc007kei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72681 mRNA. Translation: AAC60690.1.
U96725 mRNA. Translation: AAC53266.1.
U96726 Genomic DNA. Translation: AAC60756.1.
BC056171 mRNA. Translation: AAH56171.1.
CCDSiCCDS25052.1.
RefSeqiNP_032876.1. NM_008850.2.
UniGeneiMm.3128.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KCMX-ray2.00A2-271[»]
ProteinModelPortaliP53810.
SMRiP53810.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53810. 1 interactor.
MINTiMINT-4107643.
STRINGi10090.ENSMUSP00000115723.

PTM databases

iPTMnetiP53810.
PhosphoSitePlusiP53810.

2D gel databases

REPRODUCTION-2DPAGEP53810.

Proteomic databases

EPDiP53810.
PaxDbiP53810.
PeptideAtlasiP53810.
PRIDEiP53810.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143219; ENSMUSP00000115723; ENSMUSG00000017781.
GeneIDi18738.
KEGGimmu:18738.
UCSCiuc007kei.1. mouse.

Organism-specific databases

CTDi5306.
MGIiMGI:99887. Pitpna.

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00760000119216.
HOGENOMiHOG000174733.
HOVERGENiHBG058915.
InParanoidiP53810.
PhylomeDBiP53810.
TreeFamiTF313279.

Enzyme and pathway databases

ReactomeiR-MMU-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiPitpna. mouse.
EvolutionaryTraceiP53810.
PROiP53810.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017781.
CleanExiMM_PITPNA.
ExpressionAtlasiP53810. baseline and differential.
GenevisibleiP53810. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiPF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.
ProtoNetiSearch...

Entry informationi

Entry nameiPIPNA_MOUSE
AccessioniPrimary (citable) accession number: P53810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.