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Protein

Phosphatidylinositol transfer protein alpha isoform

Gene

Pitpna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Phosphatidylinositol lipid headgroupBy similarity
Binding sitei61 – 611Phosphatidylinositol lipid headgroupBy similarity
Binding sitei86 – 861Phosphatidylinositol lipid headgroupBy similarity
Binding sitei90 – 901Phosphatidylinositol lipid headgroupBy similarity
Binding sitei97 – 971Phosphatidylinositol lipid headgroupBy similarity
Binding sitei195 – 1951Phosphatidylinositol lipid headgroupBy similarity

GO - Molecular functioni

  • lipid binding Source: MGI
  • phospholipid binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-418890. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein alpha isoform
Short name:
PI-TP-alpha
Short name:
PtdIns transfer protein alpha
Short name:
PtdInsTP alpha
Gene namesi
Name:Pitpna
Synonyms:Pitpn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99887. Pitpna.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: MGI
  • integral component of membrane Source: MGI
  • myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in Pitpna are the cause of the vibrator phenotype which is characterized by early-onset progressive action tremor, degeneration of brain stem and spinal cord neurons, and juvenile death. The mutation is due to the insertion of an intracisternal A particle retrotransposon in intron 4 which results in a 5-fold reduction in protein levels.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 271270Phosphatidylinositol transfer protein alpha isoformPRO_0000191640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP53810.
PaxDbiP53810.
PeptideAtlasiP53810.
PRIDEiP53810.

2D gel databases

REPRODUCTION-2DPAGEP53810.

PTM databases

iPTMnetiP53810.
PhosphoSiteiP53810.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017781.
CleanExiMM_PITPNA.
ExpressionAtlasiP53810. baseline and differential.
GenevisibleiP53810. MM.

Interactioni

Protein-protein interaction databases

IntActiP53810. 1 interaction.
MINTiMINT-4107643.
STRINGi10090.ENSMUSP00000115723.

Structurei

Secondary structure

1
271
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1311Combined sources
Helixi15 – 3016Combined sources
Turni36 – 394Combined sources
Beta strandi40 – 4910Combined sources
Beta strandi55 – 6410Combined sources
Helixi66 – 683Combined sources
Helixi71 – 744Combined sources
Turni79 – 824Combined sources
Beta strandi83 – 919Combined sources
Beta strandi94 – 1018Combined sources
Turni102 – 1043Combined sources
Helixi105 – 1073Combined sources
Beta strandi108 – 12114Combined sources
Helixi131 – 1344Combined sources
Beta strandi138 – 1425Combined sources
Helixi147 – 1493Combined sources
Helixi152 – 1543Combined sources
Helixi157 – 1593Combined sources
Turni161 – 1633Combined sources
Turni167 – 1693Combined sources
Helixi178 – 1825Combined sources
Beta strandi191 – 20111Combined sources
Helixi207 – 23125Combined sources
Helixi233 – 2364Combined sources
Helixi241 – 25313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KCMX-ray2.00A2-271[»]
ProteinModelPortaliP53810.
SMRiP53810. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP53810.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
HOGENOMiHOG000174733.
HOVERGENiHBG058915.
InParanoidiP53810.
PhylomeDBiP53810.
TreeFamiTF313279.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiPF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK
60 70 80 90 100
DDGEKGQYTH KIYHLQSKVP TFVRMLAPEG ALNIHEKAWN AYPYCRTVIT
110 120 130 140 150
NEYMKEDFLI KIETWHKPDL GTQENVHKLE PEAWKHVEAI YIDIADRSQV
160 170 180 190 200
LSKDYKAEED PAKFKSVKTG RGPLGPNWKQ ELVNQKDCPY MCAYKLVTVK
210 220 230 240 250
FKWWGLQNKV ENFIHKQEKR LFTNFHRQLF CWLDKWVDLT MDDIRRMEEE
260 270
TKRQLDEMRQ KDPVKGMTAD D
Length:271
Mass (Da):31,893
Last modified:January 23, 2007 - v2
Checksum:iE9561EE5BBBADC3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72681 mRNA. Translation: AAC60690.1.
U96725 mRNA. Translation: AAC53266.1.
U96726 Genomic DNA. Translation: AAC60756.1.
BC056171 mRNA. Translation: AAH56171.1.
CCDSiCCDS25052.1.
RefSeqiNP_032876.1. NM_008850.2.
UniGeneiMm.3128.

Genome annotation databases

EnsembliENSMUST00000143219; ENSMUSP00000115723; ENSMUSG00000017781.
GeneIDi18738.
KEGGimmu:18738.
UCSCiuc007kei.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72681 mRNA. Translation: AAC60690.1.
U96725 mRNA. Translation: AAC53266.1.
U96726 Genomic DNA. Translation: AAC60756.1.
BC056171 mRNA. Translation: AAH56171.1.
CCDSiCCDS25052.1.
RefSeqiNP_032876.1. NM_008850.2.
UniGeneiMm.3128.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KCMX-ray2.00A2-271[»]
ProteinModelPortaliP53810.
SMRiP53810. Positions 2-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53810. 1 interaction.
MINTiMINT-4107643.
STRINGi10090.ENSMUSP00000115723.

PTM databases

iPTMnetiP53810.
PhosphoSiteiP53810.

2D gel databases

REPRODUCTION-2DPAGEP53810.

Proteomic databases

EPDiP53810.
PaxDbiP53810.
PeptideAtlasiP53810.
PRIDEiP53810.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000143219; ENSMUSP00000115723; ENSMUSG00000017781.
GeneIDi18738.
KEGGimmu:18738.
UCSCiuc007kei.1. mouse.

Organism-specific databases

CTDi5306.
MGIiMGI:99887. Pitpna.

Phylogenomic databases

eggNOGiKOG3668. Eukaryota.
COG5083. LUCA.
HOGENOMiHOG000174733.
HOVERGENiHBG058915.
InParanoidiP53810.
PhylomeDBiP53810.
TreeFamiTF313279.

Enzyme and pathway databases

ReactomeiR-MMU-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiPitpna. mouse.
EvolutionaryTraceiP53810.
PROiP53810.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017781.
CleanExiMM_PITPNA.
ExpressionAtlasiP53810. baseline and differential.
GenevisibleiP53810. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR001666. PI_transfer.
IPR023393. START-like_dom.
[Graphical view]
PANTHERiPTHR10658. PTHR10658. 1 hit.
PfamiPF02121. IP_trans. 1 hit.
[Graphical view]
PRINTSiPR00391. PITRANSFER.
ProtoNetiSearch...

Entry informationi

Entry nameiPIPNA_MOUSE
AccessioniPrimary (citable) accession number: P53810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.