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Protein

Phosphatidylcholine transfer protein

Gene

Pctp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lipid transfer protein that promotes intermembrane transfer of phosphatidylcholines but no other phospholipids. Binds a single lipid molecule. May play a role in hepatocellular selection and transport of phosphatidylcholines during bile formation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721PhosphatidylcholineBy similarity
Binding sitei78 – 781PhosphatidylcholineBy similarity
Binding sitei157 – 1571PhosphatidylcholineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine transfer protein
Short name:
PC-TP
Alternative name(s):
START domain-containing protein 2
Short name:
StARD2
StAR-related lipid transfer protein 2
Gene namesi
Name:Pctp
Synonyms:Stard2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3276. Pctp.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Phosphatidylcholine transfer proteinPRO_0000220660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP53809.
PRIDEiP53809.

Expressioni

Gene expression databases

GenevisibleiP53809. RN.

Interactioni

Subunit structurei

Interacts with ACOT13/THEM2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003295.

Structurei

3D structure databases

ProteinModelPortaliP53809.
SMRiP53809. Positions 8-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 212212STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPC9. Eukaryota.
ENOG4111CP6. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiP53809.
OMAiCADVYMD.
OrthoDBiEOG70KGQK.
PhylomeDBiP53809.
TreeFamiTF320705.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAAHFSD EQFREACAEL QKPALTGADW QLLVEASGIT IYRLLDQSTG
60 70 80 90 100
LYEYKVFGVL ESCIPSLLAD VYMDLDYRKK WDQYVKELYE KSFDGQMVAY
110 120 130 140 150
WEVKYPFPLS NRDYVYTRQR RDLDVDGRKI YVVLAQNISV PQFPEKSGVI
160 170 180 190 200
RVKQYKQSLA IESDGKKGSR VFMYYFDNPG GQIPSWLINW AAKNGVPSFL
210
KDMVKACQNY HKKT
Length:214
Mass (Da):24,734
Last modified:May 15, 2002 - v2
Checksum:i35D26960235C2374
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021E → Q in CAA90329 (PubMed:8645232).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040267
, AF040262, AF040263, AF040264, AF040265, AF040266 Genomic DNA. Translation: AAC98930.1.
AF040261 mRNA. Translation: AAC98929.1.
BC078854 mRNA. Translation: AAH78854.1.
Z50025 mRNA. Translation: CAA90329.1.
RefSeqiNP_058921.1. NM_017225.3.
UniGeneiRn.9487.

Genome annotation databases

EnsembliENSRNOT00000003295; ENSRNOP00000003295; ENSRNOG00000002425.
GeneIDi29510.
KEGGirno:29510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040267
, AF040262, AF040263, AF040264, AF040265, AF040266 Genomic DNA. Translation: AAC98930.1.
AF040261 mRNA. Translation: AAC98929.1.
BC078854 mRNA. Translation: AAH78854.1.
Z50025 mRNA. Translation: CAA90329.1.
RefSeqiNP_058921.1. NM_017225.3.
UniGeneiRn.9487.

3D structure databases

ProteinModelPortaliP53809.
SMRiP53809. Positions 8-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003295.

Proteomic databases

PaxDbiP53809.
PRIDEiP53809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003295; ENSRNOP00000003295; ENSRNOG00000002425.
GeneIDi29510.
KEGGirno:29510.

Organism-specific databases

CTDi58488.
RGDi3276. Pctp.

Phylogenomic databases

eggNOGiENOG410IPC9. Eukaryota.
ENOG4111CP6. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiP53809.
OMAiCADVYMD.
OrthoDBiEOG70KGQK.
PhylomeDBiP53809.
TreeFamiTF320705.

Miscellaneous databases

PROiP53809.

Gene expression databases

GenevisibleiP53809. RN.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and gene structure of rat phosphatidylcholine transfer protein, Pctp."
    Wu M.K., Boylan M.O., Cohen D.E.
    Gene 235:111-120(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene."
    Geijtenbeek T.B.H., Smith A.J., Borst P., Wirtz K.W.A.
    Biochem. J. 316:49-55(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-179.
    Tissue: Liver.

Entry informationi

Entry nameiPPCT_RAT
AccessioniPrimary (citable) accession number: P53809
Secondary accession number(s): Q9Z2N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 15, 2002
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.