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P53808 (PPCT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylcholine transfer protein

Short name=PC-TP
Alternative name(s):
START domain-containing protein 2
Short name=StARD2
StAR-related lipid transfer protein 2
Gene names
Name:Pctp
Synonyms:Stard2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.

Subunit structure

Interacts with ACOT13/THEM2. Ref.4

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Abundant in liver of pups but levels in liver decrease 10-fold about 2 weeks after birth. In adult, highly expressed in epididymis, testis, kidney and bone-marrow derived mast cells. Ref.1

Sequence similarities

Contains 1 START domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Phosphatidylcholine transfer protein
PRO_0000220659

Regions

Domain1 – 212212START

Sites

Binding site721Phosphatidylcholine By similarity
Binding site781Phosphatidylcholine By similarity
Binding site1571Phosphatidylcholine By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict901E → D in AAF08346. Ref.3
Sequence conflict1271R → G in AAF08346. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P53808 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 8BE2B046314DAE70

FASTA21424,785
        10         20         30         40         50         60 
MAGAACCFSD EQFREACAEL QKPALTGADW QLLVEASGIT IYRLLDQPSG LYEYKVFGVL 

        70         80         90        100        110        120 
EGCSPALLTD VYMDLDYRKQ WDQYVKELYE KESDEQMVAY WEVKYPFPLS NRDYVYTRQR 

       130        140        150        160        170        180 
RDLDVDRRKI YVVLAQSISA PQFPEKSGVI RVKQYKQSLA IESDGKKGSR VFMYYFDNPG 

       190        200        210 
GQIPSWLINW AAKNGVPNFL KDMVKACQNY HKKT 

« Hide

References

[1]"Mice without phosphatidylcholine transfer protein have no defects in the secretion of PC into bile or into the lung airspaces."
van Helvoort A., de Brouwer A., Ottenhoff R., Brouwers J.F.H.M., Wijnholds J., Beijnen J.H., Rijneveld A., van der Poll T., van der Valk M.A., Majoor D., Voorhout W., Wirtz K.W.A., Oude Elferink R.P.J., Borst P.
Proc. Natl. Acad. Sci. U.S.A. 96:11501-11506(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: 129/Ola.
Tissue: Liver.
[2]"cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene."
Geijtenbeek T.B.H., Smith A.J., Borst P., Wirtz K.W.A.
Biochem. J. 316:49-55(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-214.
Tissue: Lung.
[3]"Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein."
Cohen D.E., Green R.M., Wu M.K., Beier D.R.
Biochim. Biophys. Acta 1447:265-270(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-214.
Strain: C57BL/6 X CBA.
Tissue: Liver.
[4]"Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2."
Kanno K., Wu M.K., Agate D.S., Fanelli B.J., Wagle N., Scapa E.F., Ukomadu C., Cohen D.E.
J. Biol. Chem. 282:30728-30736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ACOT13/THEM2 AND PAX3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151639 mRNA. Translation: AAF02537.1.
Z50024 mRNA. Translation: CAA90328.1.
AF114437 mRNA. Translation: AAF08346.1.
CCDSCCDS25238.1.
PIRS68246.
RefSeqNP_032822.2. NM_008796.2.
UniGeneMm.5062.

3D structure databases

ProteinModelPortalP53808.
SMRP53808. Positions 8-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202066. 2 interactions.

PTM databases

PhosphoSiteP53808.

Proteomic databases

MaxQBP53808.
PaxDbP53808.
PRIDEP53808.

Protocols and materials databases

DNASU18559.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID18559.
KEGGmmu:18559.

Organism-specific databases

CTD58488.
MGIMGI:107375. Pctp.

Phylogenomic databases

eggNOGNOG264966.
HOGENOMHOG000261644.
HOVERGENHBG008237.
InParanoidP53808.
PhylomeDBP53808.

Enzyme and pathway databases

SABIO-RKP53808.

Gene expression databases

CleanExMM_PCTP.
GenevestigatorP53808.

Family and domain databases

Gene3D3.30.530.20. 1 hit.
InterProIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamPF01852. START. 1 hit.
[Graphical view]
SMARTSM00234. START. 1 hit.
[Graphical view]
PROSITEPS50848. START. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294384.
PROP53808.
SOURCESearch...

Entry information

Entry namePPCT_MOUSE
AccessionPrimary (citable) accession number: P53808
Secondary accession number(s): Q9QZX0, Q9R058
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 14, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot