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Protein

Phosphatidylcholine transfer protein

Gene

Pctp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721PhosphatidylcholineBy similarity
Binding sitei78 – 781PhosphatidylcholineBy similarity
Binding sitei157 – 1571PhosphatidylcholineBy similarity

GO - Molecular functioni

GO - Biological processi

  • cholesterol metabolic process Source: MGI
  • phospholipid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

SABIO-RKP53808.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine transfer protein
Short name:
PC-TP
Alternative name(s):
START domain-containing protein 2
Short name:
StARD2
StAR-related lipid transfer protein 2
Gene namesi
Name:Pctp
Synonyms:Stard2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107375. Pctp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Phosphatidylcholine transfer proteinPRO_0000220659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP53808.
PaxDbiP53808.
PRIDEiP53808.

PTM databases

PhosphoSiteiP53808.

Expressioni

Tissue specificityi

Abundant in liver of pups but levels in liver decrease 10-fold about 2 weeks after birth. In adult, highly expressed in epididymis, testis, kidney and bone-marrow derived mast cells.1 Publication

Gene expression databases

CleanExiMM_PCTP.
GenevisibleiP53808. MM.

Interactioni

Subunit structurei

Interacts with ACOT13/THEM2.1 Publication

Protein-protein interaction databases

BioGridi202066. 2 interactions.
STRINGi10090.ENSMUSP00000020864.

Structurei

3D structure databases

ProteinModelPortaliP53808.
SMRiP53808. Positions 8-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 212212STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG264966.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiP53808.
PhylomeDBiP53808.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAACCFSD EQFREACAEL QKPALTGADW QLLVEASGIT IYRLLDQPSG
60 70 80 90 100
LYEYKVFGVL EGCSPALLTD VYMDLDYRKQ WDQYVKELYE KESDEQMVAY
110 120 130 140 150
WEVKYPFPLS NRDYVYTRQR RDLDVDRRKI YVVLAQSISA PQFPEKSGVI
160 170 180 190 200
RVKQYKQSLA IESDGKKGSR VFMYYFDNPG GQIPSWLINW AAKNGVPNFL
210
KDMVKACQNY HKKT
Length:214
Mass (Da):24,785
Last modified:August 14, 2001 - v2
Checksum:i8BE2B046314DAE70
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901E → D in AAF08346 (PubMed:10542325).Curated
Sequence conflicti127 – 1271R → G in AAF08346 (PubMed:10542325).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151639 mRNA. Translation: AAF02537.1.
Z50024 mRNA. Translation: CAA90328.1.
AF114437 mRNA. Translation: AAF08346.1.
CCDSiCCDS25238.1.
PIRiS68246.
RefSeqiNP_032822.2. NM_008796.2.
UniGeneiMm.5062.

Genome annotation databases

GeneIDi18559.
KEGGimmu:18559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151639 mRNA. Translation: AAF02537.1.
Z50024 mRNA. Translation: CAA90328.1.
AF114437 mRNA. Translation: AAF08346.1.
CCDSiCCDS25238.1.
PIRiS68246.
RefSeqiNP_032822.2. NM_008796.2.
UniGeneiMm.5062.

3D structure databases

ProteinModelPortaliP53808.
SMRiP53808. Positions 8-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202066. 2 interactions.
STRINGi10090.ENSMUSP00000020864.

PTM databases

PhosphoSiteiP53808.

Proteomic databases

MaxQBiP53808.
PaxDbiP53808.
PRIDEiP53808.

Protocols and materials databases

DNASUi18559.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18559.
KEGGimmu:18559.

Organism-specific databases

CTDi58488.
MGIiMGI:107375. Pctp.

Phylogenomic databases

eggNOGiNOG264966.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiP53808.
PhylomeDBiP53808.

Enzyme and pathway databases

SABIO-RKP53808.

Miscellaneous databases

NextBioi294384.
PROiP53808.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PCTP.
GenevisibleiP53808. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: 129/Ola.
    Tissue: Liver.
  2. "cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene."
    Geijtenbeek T.B.H., Smith A.J., Borst P., Wirtz K.W.A.
    Biochem. J. 316:49-55(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-214.
    Tissue: Lung.
  3. "Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein."
    Cohen D.E., Green R.M., Wu M.K., Beier D.R.
    Biochim. Biophys. Acta 1447:265-270(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-214.
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  4. "Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2."
    Kanno K., Wu M.K., Agate D.S., Fanelli B.J., Wagle N., Scapa E.F., Ukomadu C., Cohen D.E.
    J. Biol. Chem. 282:30728-30736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACOT13/THEM2 AND PAX3.

Entry informationi

Entry nameiPPCT_MOUSE
AccessioniPrimary (citable) accession number: P53808
Secondary accession number(s): Q9QZX0, Q9R058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 14, 2001
Last modified: June 24, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.