Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P53808

- PPCT_MOUSE

UniProt

P53808 - PPCT_MOUSE

Protein

Phosphatidylcholine transfer protein

Gene

Pctp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721PhosphatidylcholineBy similarity
    Binding sitei78 – 781PhosphatidylcholineBy similarity
    Binding sitei157 – 1571PhosphatidylcholineBy similarity

    GO - Molecular functioni

    1. phosphatidylcholine binding Source: UniProtKB
    2. phosphatidylcholine transporter activity Source: UniProtKB

    GO - Biological processi

    1. cholesterol metabolic process Source: MGI
    2. phospholipid transport Source: UniProtKB

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    SABIO-RKP53808.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylcholine transfer protein
    Short name:
    PC-TP
    Alternative name(s):
    START domain-containing protein 2
    Short name:
    StARD2
    StAR-related lipid transfer protein 2
    Gene namesi
    Name:Pctp
    Synonyms:Stard2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107375. Pctp.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Phosphatidylcholine transfer proteinPRO_0000220659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP53808.
    PaxDbiP53808.
    PRIDEiP53808.

    PTM databases

    PhosphoSiteiP53808.

    Expressioni

    Tissue specificityi

    Abundant in liver of pups but levels in liver decrease 10-fold about 2 weeks after birth. In adult, highly expressed in epididymis, testis, kidney and bone-marrow derived mast cells.1 Publication

    Gene expression databases

    CleanExiMM_PCTP.
    GenevestigatoriP53808.

    Interactioni

    Subunit structurei

    Interacts with ACOT13/THEM2.1 Publication

    Protein-protein interaction databases

    BioGridi202066. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP53808.
    SMRiP53808. Positions 8-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 212212STARTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 START domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG264966.
    HOGENOMiHOG000261644.
    HOVERGENiHBG008237.
    InParanoidiP53808.
    PhylomeDBiP53808.

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view]
    PfamiPF01852. START. 1 hit.
    [Graphical view]
    SMARTiSM00234. START. 1 hit.
    [Graphical view]
    PROSITEiPS50848. START. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53808-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGAACCFSD EQFREACAEL QKPALTGADW QLLVEASGIT IYRLLDQPSG    50
    LYEYKVFGVL EGCSPALLTD VYMDLDYRKQ WDQYVKELYE KESDEQMVAY 100
    WEVKYPFPLS NRDYVYTRQR RDLDVDRRKI YVVLAQSISA PQFPEKSGVI 150
    RVKQYKQSLA IESDGKKGSR VFMYYFDNPG GQIPSWLINW AAKNGVPNFL 200
    KDMVKACQNY HKKT 214
    Length:214
    Mass (Da):24,785
    Last modified:August 14, 2001 - v2
    Checksum:i8BE2B046314DAE70
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901E → D in AAF08346. (PubMed:10542325)Curated
    Sequence conflicti127 – 1271R → G in AAF08346. (PubMed:10542325)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151639 mRNA. Translation: AAF02537.1.
    Z50024 mRNA. Translation: CAA90328.1.
    AF114437 mRNA. Translation: AAF08346.1.
    CCDSiCCDS25238.1.
    PIRiS68246.
    RefSeqiNP_032822.2. NM_008796.2.
    UniGeneiMm.5062.

    Genome annotation databases

    GeneIDi18559.
    KEGGimmu:18559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151639 mRNA. Translation: AAF02537.1 .
    Z50024 mRNA. Translation: CAA90328.1 .
    AF114437 mRNA. Translation: AAF08346.1 .
    CCDSi CCDS25238.1.
    PIRi S68246.
    RefSeqi NP_032822.2. NM_008796.2.
    UniGenei Mm.5062.

    3D structure databases

    ProteinModelPortali P53808.
    SMRi P53808. Positions 8-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202066. 2 interactions.

    PTM databases

    PhosphoSitei P53808.

    Proteomic databases

    MaxQBi P53808.
    PaxDbi P53808.
    PRIDEi P53808.

    Protocols and materials databases

    DNASUi 18559.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 18559.
    KEGGi mmu:18559.

    Organism-specific databases

    CTDi 58488.
    MGIi MGI:107375. Pctp.

    Phylogenomic databases

    eggNOGi NOG264966.
    HOGENOMi HOG000261644.
    HOVERGENi HBG008237.
    InParanoidi P53808.
    PhylomeDBi P53808.

    Enzyme and pathway databases

    SABIO-RK P53808.

    Miscellaneous databases

    NextBioi 294384.
    PROi P53808.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PCTP.
    Genevestigatori P53808.

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view ]
    Pfami PF01852. START. 1 hit.
    [Graphical view ]
    SMARTi SM00234. START. 1 hit.
    [Graphical view ]
    PROSITEi PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: 129/Ola.
      Tissue: Liver.
    2. "cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene."
      Geijtenbeek T.B.H., Smith A.J., Borst P., Wirtz K.W.A.
      Biochem. J. 316:49-55(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-214.
      Tissue: Lung.
    3. "Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein."
      Cohen D.E., Green R.M., Wu M.K., Beier D.R.
      Biochim. Biophys. Acta 1447:265-270(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-214.
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    4. "Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2."
      Kanno K., Wu M.K., Agate D.S., Fanelli B.J., Wagle N., Scapa E.F., Ukomadu C., Cohen D.E.
      J. Biol. Chem. 282:30728-30736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ACOT13/THEM2 AND PAX3.

    Entry informationi

    Entry nameiPPCT_MOUSE
    AccessioniPrimary (citable) accession number: P53808
    Secondary accession number(s): Q9QZX0, Q9R058
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3