Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P53805 (RCAN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcipressin-1
Alternative name(s):
Adapt78
Down syndrome critical region protein 1
Myocyte-enriched calcineurin-interacting protein 1
Short name=MCIP1
Regulator of calcineurin 1
Gene names
Name:RCAN1
Synonyms:ADAPT78, CSP1, DSC1, DSCR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

Subunit structure

Interacts with RAF1. Ref.13

Tissue specificity

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Induction

By calcium.

Sequence similarities

Belongs to the RCAN family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processblood circulation

Traceable author statement Ref.1. Source: ProtInc

calcium-mediated signaling

Inferred from electronic annotation. Source: InterPro

central nervous system development

Traceable author statement Ref.1. Source: ProtInc

negative regulation of smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Traceable author statement Ref.1. Source: GOC

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.1. Source: ProtInc

skeletal muscle fiber development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionDNA binding

Traceable author statement Ref.1. Source: ProtInc

identical protein binding

Inferred from physical interaction PubMed 24021800. Source: IntAct

protein binding

Inferred from physical interaction Ref.13PubMed 21965663. Source: IntAct

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dyrk1aQ612145EBI-1541912,EBI-80344From a different organism.
RAF1P040494EBI-1541912,EBI-365996

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P53805-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P53805-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MEDGVAGPQL...DPRVFVDGLC → MHFRNFNYSFSSLIACVANSDIFSESET
Isoform 3 (identifier: P53805-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MEDGVAGPQL...PRVFVDGLCR → MVY
Isoform 4 (identifier: P53805-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Calcipressin-1
PRO_0000211414

Regions

Compositional bias221 – 2299Poly-Glu

Natural variations

Alternative sequence1 – 135135Missing in isoform 4.
VSP_001316
Alternative sequence1 – 8484MEDGV…DGLCR → MVY in isoform 3.
VSP_001315
Alternative sequence1 – 8383MEDGV…VDGLC → MHFRNFNYSFSSLIACVANS DIFSESET in isoform 2.
VSP_001314

Experimental info

Sequence conflict2021H → R in AAK92478. Ref.3
Sequence conflict2141H → Q in AAF21218. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 4.
Checksum: 0B17133D03BD7AFA

FASTA25228,079
        10         20         30         40         50         60 
MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS FIDCEMEEVD 

        70         80         90        100        110        120 
LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF QYFKSFKRVR INFSNPFSAA 

       130        140        150        160        170        180 
DARLQLHKTE FLGKEMKLYF AQTLHIGSSH LAPPNPDKQF LISPPASPPV GWKQVEDATP 

       190        200        210        220        230        240 
VINYDLLYAI SKLGPGEKYE LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ 

       250 
TRRPEYTPIH LS 

« Hide

Isoform 2 [UniParc].

Checksum: 980A1FD7AA54A238
Show »

FASTA19722,767
Isoform 3 [UniParc].

Checksum: 1330107875A36BD9
Show »

FASTA17119,805
Isoform 4 [UniParc].

Checksum: 447ABCBB7DDD4826
Show »

FASTA11713,291

References

« Hide 'large scale' references
[1]"A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart."
Fuentes J.-J., Pritchard M.A., Planas A.M., Bosch A., Ferrer I., Estivill X.
Hum. Mol. Genet. 4:1935-1944(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
[2]"Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene."
Fuentes J.-J., Pritchard M.A., Estivill X.
Genomics 44:358-361(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 48-252 (ISOFORM 1), ALTERNATIVE SPLICING.
[3]"Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life."
Genesca L., Aubareda A., Fuentes J.J., Estivill X., De La Luna S., Perez-Riba M.
Biochem. J. 374:567-575(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart.
[4]Hua F., Wu J., Zhou Y., Zhang B., Peng X., Qiang B., Yuan J., Qiang B.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[7]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"Adapt78, a calcium and oxidant-inducible RNA."
Crawford D.R., Leahy K.P., Davies K.J.A.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-219 (ISOFORM 2).
Tissue: Mammary gland.
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-252 (ISOFORM 1).
Tissue: Lung.
[11]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-252 (ISOFORM 1).
[12]"DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways."
Fuentes J.J., Genesca L., Kingsbury T.J., Cunningham K.W., Perez-Riba M., Estivill X., de la Luna S.
Hum. Mol. Genet. 9:1681-1690(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[13]"Raf-1 is a binding partner of DSCR1."
Cho Y.J., Abe M., Kim S.Y., Sato Y.
Arch. Biochem. Biophys. 439:121-128(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAF1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28833 mRNA. Translation: AAB81557.1.
U85265 mRNA. Translation: AAB84370.1.
U85266 mRNA. Translation: AAB84371.2.
U85267 mRNA. Translation: AAB84372.1.
AY325903 mRNA. Translation: AAP96743.1.
AF400429 mRNA. Translation: AAK92478.1.
AK092184 mRNA. Translation: BAG52494.1.
CR456878 mRNA. Translation: CAG33159.1.
AP000326 Genomic DNA. No translation available.
AP000327 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09779.1.
CH471079 Genomic DNA. Translation: EAX09782.1.
U53821 Genomic DNA. Translation: AAF21218.1.
BC002864 mRNA. Translation: AAH02864.1.
BT007363 mRNA. Translation: AAP36027.1.
CCDSCCDS13637.1. [P53805-1]
CCDS33551.1. [P53805-2]
CCDS42921.1. [P53805-4]
RefSeqNP_001272318.1. NM_001285389.2. [P53805-3]
NP_001272320.2. NM_001285391.2.
NP_001272321.1. NM_001285392.2. [P53805-4]
NP_001272322.1. NM_001285393.2. [P53805-4]
NP_004405.3. NM_004414.6. [P53805-1]
NP_981962.1. NM_203417.2. [P53805-4]
NP_981963.1. NM_203418.2. [P53805-2]
UniGeneHs.282326.

3D structure databases

ProteinModelPortalP53805.
SMRP53805. Positions 66-158.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108161. 12 interactions.
IntActP53805. 5 interactions.
MINTMINT-4824397.

PTM databases

PhosphoSiteP53805.

Polymorphism databases

DMDM215274235.

Proteomic databases

MaxQBP53805.
PaxDbP53805.
PRIDEP53805.

Protocols and materials databases

DNASU1827.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313806; ENSP00000320768; ENSG00000159200. [P53805-1]
ENST00000381132; ENSP00000370524; ENSG00000159200. [P53805-2]
ENST00000399272; ENSP00000382214; ENSG00000159200. [P53805-3]
ENST00000443408; ENSP00000392438; ENSG00000159200. [P53805-4]
ENST00000482533; ENSP00000419624; ENSG00000159200. [P53805-4]
ENST00000487990; ENSP00000419252; ENSG00000159200. [P53805-4]
GeneID1827.
KEGGhsa:1827.
UCSCuc002yuc.3. human. [P53805-3]
uc002yud.3. human. [P53805-4]
uc002yue.3. human. [P53805-1]

Organism-specific databases

CTD1827.
GeneCardsGC21M035885.
HGNCHGNC:3040. RCAN1.
HPACAB037218.
MIM602917. gene.
neXtProtNX_P53805.
PharmGKBPA162400946.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87330.
HOVERGENHBG018932.
InParanoidP53805.
KOK17901.
OMAACVANSE.
OrthoDBEOG715Q51.
PhylomeDBP53805.
TreeFamTF313579.

Gene expression databases

ArrayExpressP53805.
BgeeP53805.
CleanExHS_DSC1.
GenevestigatorP53805.

Family and domain databases

InterProIPR006931. Calcipressin.
[Graphical view]
PANTHERPTHR10300. PTHR10300. 1 hit.
PfamPF04847. Calcipressin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDSCR1.
GenomeRNAi1827.
NextBio7453.
PROP53805.
SOURCESearch...

Entry information

Entry nameRCAN1_HUMAN
AccessionPrimary (citable) accession number: P53805
Secondary accession number(s): D3DSF9 expand/collapse secondary AC list , O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03, Q9BU69, Q9UF15, Q9UME4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM