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Protein

Calcipressin-1

Gene

RCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. identical protein binding Source: IntAct
  3. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. blood circulation Source: ProtInc
  2. calcium-mediated signaling Source: InterPro
  3. central nervous system development Source: ProtInc
  4. regulation of transcription, DNA-templated Source: GOC
  5. signal transduction Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Adapt78
Down syndrome critical region protein 1
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
Gene namesi
Name:RCAN1
Synonyms:ADAPT78, CSP1, DSC1, DSCR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:3040. RCAN1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Calcipressin-1PRO_0000211414Add
BLAST

Proteomic databases

MaxQBiP53805.
PaxDbiP53805.
PRIDEiP53805.

PTM databases

PhosphoSiteiP53805.

Expressioni

Tissue specificityi

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Inductioni

By calcium.

Gene expression databases

BgeeiP53805.
CleanExiHS_DSC1.
ExpressionAtlasiP53805. baseline and differential.
GenevestigatoriP53805.

Organism-specific databases

HPAiCAB037218.

Interactioni

Subunit structurei

Interacts with RAF1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dyrk1aQ612145EBI-1541912,EBI-80344From a different organism.
RAF1P040494EBI-1541912,EBI-365996

Protein-protein interaction databases

BioGridi108161. 14 interactions.
IntActiP53805. 5 interactions.
MINTiMINT-4824397.

Structurei

3D structure databases

ProteinModelPortaliP53805.
SMRiP53805. Positions 66-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2299Poly-Glu

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiNOG87330.
GeneTreeiENSGT00400000022053.
HOVERGENiHBG018932.
InParanoidiP53805.
KOiK17901.
OMAiGKYELHA.
OrthoDBiEOG715Q51.
PhylomeDBiP53805.
TreeFamiTF313579.

Family and domain databases

InterProiIPR006931. Calcipressin.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P53805-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS
60 70 80 90 100
FIDCEMEEVD LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF
110 120 130 140 150
QYFKSFKRVR INFSNPFSAA DARLQLHKTE FLGKEMKLYF AQTLHIGSSH
160 170 180 190 200
LAPPNPDKQF LISPPASPPV GWKQVEDATP VINYDLLYAI SKLGPGEKYE
210 220 230 240 250
LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ TRRPEYTPIH

LS
Length:252
Mass (Da):28,079
Last modified:November 25, 2008 - v4
Checksum:i0B17133D03BD7AFA
GO
Isoform 2 (identifier: P53805-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MEDGVAGPQL...DPRVFVDGLC → MHFRNFNYSFSSLIACVANSDIFSESET

Show »
Length:197
Mass (Da):22,767
Checksum:i980A1FD7AA54A238
GO
Isoform 3 (identifier: P53805-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MEDGVAGPQL...PRVFVDGLCR → MVY

Show »
Length:171
Mass (Da):19,805
Checksum:i1330107875A36BD9
GO
Isoform 4 (identifier: P53805-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:117
Mass (Da):13,291
Checksum:i447ABCBB7DDD4826
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021H → R in AAK92478 (PubMed:12809556).Curated
Sequence conflicti214 – 2141H → Q in AAF21218 (PubMed:10830953).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 135135Missing in isoform 4. 2 PublicationsVSP_001316Add
BLAST
Alternative sequencei1 – 8484MEDGV…DGLCR → MVY in isoform 3. 3 PublicationsVSP_001315Add
BLAST
Alternative sequencei1 – 8383MEDGV…VDGLC → MHFRNFNYSFSSLIACVANS DIFSESET in isoform 2. 1 PublicationVSP_001314Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28833 mRNA. Translation: AAB81557.1.
U85265 mRNA. Translation: AAB84370.1.
U85266 mRNA. Translation: AAB84371.2.
U85267 mRNA. Translation: AAB84372.1.
AY325903 mRNA. Translation: AAP96743.1.
AF400429 mRNA. Translation: AAK92478.1.
AK092184 mRNA. Translation: BAG52494.1.
CR456878 mRNA. Translation: CAG33159.1.
AP000326 Genomic DNA. No translation available.
AP000327 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09779.1.
CH471079 Genomic DNA. Translation: EAX09782.1.
U53821 Genomic DNA. Translation: AAF21218.1.
BC002864 mRNA. Translation: AAH02864.1.
BT007363 mRNA. Translation: AAP36027.1.
CCDSiCCDS13637.1. [P53805-1]
CCDS33551.1. [P53805-2]
CCDS42921.1. [P53805-4]
CCDS74790.1. [P53805-3]
RefSeqiNP_001272318.1. NM_001285389.2. [P53805-3]
NP_001272320.2. NM_001285391.2.
NP_001272321.1. NM_001285392.2. [P53805-4]
NP_001272322.1. NM_001285393.2. [P53805-4]
NP_004405.3. NM_004414.6. [P53805-1]
NP_981962.1. NM_203417.2. [P53805-4]
NP_981963.1. NM_203418.2. [P53805-2]
UniGeneiHs.282326.

Genome annotation databases

EnsembliENST00000313806; ENSP00000320768; ENSG00000159200. [P53805-1]
ENST00000381132; ENSP00000370524; ENSG00000159200. [P53805-2]
ENST00000399272; ENSP00000382214; ENSG00000159200. [P53805-3]
ENST00000443408; ENSP00000392438; ENSG00000159200. [P53805-4]
ENST00000482533; ENSP00000419624; ENSG00000159200. [P53805-4]
ENST00000487990; ENSP00000419252; ENSG00000159200. [P53805-4]
ENST00000620920; ENSP00000477646; ENSG00000159200. [P53805-4]
GeneIDi1827.
KEGGihsa:1827.
UCSCiuc002yuc.3. human. [P53805-3]
uc002yud.3. human. [P53805-4]
uc002yue.3. human. [P53805-1]

Polymorphism databases

DMDMi215274235.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28833 mRNA. Translation: AAB81557.1.
U85265 mRNA. Translation: AAB84370.1.
U85266 mRNA. Translation: AAB84371.2.
U85267 mRNA. Translation: AAB84372.1.
AY325903 mRNA. Translation: AAP96743.1.
AF400429 mRNA. Translation: AAK92478.1.
AK092184 mRNA. Translation: BAG52494.1.
CR456878 mRNA. Translation: CAG33159.1.
AP000326 Genomic DNA. No translation available.
AP000327 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09779.1.
CH471079 Genomic DNA. Translation: EAX09782.1.
U53821 Genomic DNA. Translation: AAF21218.1.
BC002864 mRNA. Translation: AAH02864.1.
BT007363 mRNA. Translation: AAP36027.1.
CCDSiCCDS13637.1. [P53805-1]
CCDS33551.1. [P53805-2]
CCDS42921.1. [P53805-4]
CCDS74790.1. [P53805-3]
RefSeqiNP_001272318.1. NM_001285389.2. [P53805-3]
NP_001272320.2. NM_001285391.2.
NP_001272321.1. NM_001285392.2. [P53805-4]
NP_001272322.1. NM_001285393.2. [P53805-4]
NP_004405.3. NM_004414.6. [P53805-1]
NP_981962.1. NM_203417.2. [P53805-4]
NP_981963.1. NM_203418.2. [P53805-2]
UniGeneiHs.282326.

3D structure databases

ProteinModelPortaliP53805.
SMRiP53805. Positions 66-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108161. 14 interactions.
IntActiP53805. 5 interactions.
MINTiMINT-4824397.

PTM databases

PhosphoSiteiP53805.

Polymorphism databases

DMDMi215274235.

Proteomic databases

MaxQBiP53805.
PaxDbiP53805.
PRIDEiP53805.

Protocols and materials databases

DNASUi1827.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313806; ENSP00000320768; ENSG00000159200. [P53805-1]
ENST00000381132; ENSP00000370524; ENSG00000159200. [P53805-2]
ENST00000399272; ENSP00000382214; ENSG00000159200. [P53805-3]
ENST00000443408; ENSP00000392438; ENSG00000159200. [P53805-4]
ENST00000482533; ENSP00000419624; ENSG00000159200. [P53805-4]
ENST00000487990; ENSP00000419252; ENSG00000159200. [P53805-4]
ENST00000620920; ENSP00000477646; ENSG00000159200. [P53805-4]
GeneIDi1827.
KEGGihsa:1827.
UCSCiuc002yuc.3. human. [P53805-3]
uc002yud.3. human. [P53805-4]
uc002yue.3. human. [P53805-1]

Organism-specific databases

CTDi1827.
GeneCardsiGC21M035885.
HGNCiHGNC:3040. RCAN1.
HPAiCAB037218.
MIMi602917. gene.
neXtProtiNX_P53805.
PharmGKBiPA162400946.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87330.
GeneTreeiENSGT00400000022053.
HOVERGENiHBG018932.
InParanoidiP53805.
KOiK17901.
OMAiGKYELHA.
OrthoDBiEOG715Q51.
PhylomeDBiP53805.
TreeFamiTF313579.

Miscellaneous databases

ChiTaRSiRCAN1. human.
GeneWikiiDSCR1.
GenomeRNAii1827.
NextBioi7453.
PROiP53805.
SOURCEiSearch...

Gene expression databases

BgeeiP53805.
CleanExiHS_DSC1.
ExpressionAtlasiP53805. baseline and differential.
GenevestigatoriP53805.

Family and domain databases

InterProiIPR006931. Calcipressin.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart."
    Fuentes J.-J., Pritchard M.A., Planas A.M., Bosch A., Ferrer I., Estivill X.
    Hum. Mol. Genet. 4:1935-1944(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  2. "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene."
    Fuentes J.-J., Pritchard M.A., Estivill X.
    Genomics 44:358-361(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 48-252 (ISOFORM 1), ALTERNATIVE SPLICING.
  3. "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life."
    Genesca L., Aubareda A., Fuentes J.J., Estivill X., De La Luna S., Perez-Riba M.
    Biochem. J. 374:567-575(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  4. Hua F., Wu J., Zhou Y., Zhang B., Peng X., Qiang B., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  7. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "Adapt78, a calcium and oxidant-inducible RNA."
    Crawford D.R., Leahy K.P., Davies K.J.A.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-219 (ISOFORM 2).
    Tissue: Mammary gland.
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-252 (ISOFORM 1).
    Tissue: Lung.
  11. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-252 (ISOFORM 1).
  12. "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways."
    Fuentes J.J., Genesca L., Kingsbury T.J., Cunningham K.W., Perez-Riba M., Estivill X., de la Luna S.
    Hum. Mol. Genet. 9:1681-1690(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  13. Cited for: INTERACTION WITH RAF1.

Entry informationi

Entry nameiRCAN1_HUMAN
AccessioniPrimary (citable) accession number: P53805
Secondary accession number(s): D3DSF9
, O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03, Q9BU69, Q9UF15, Q9UME4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: January 7, 2015
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.