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Protein

Calcipressin-1

Gene

RCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calcium-dependent protein serine/threonine phosphatase regulator activity Source: GO_Central
  • DNA binding Source: ProtInc
  • DNA binding transcription factor activity Source: ProtInc
  • identical protein binding Source: IntAct

GO - Biological processi

  • blood circulation Source: ProtInc
  • calcineurin-NFAT signaling cascade Source: InterPro
  • central nervous system development Source: ProtInc
  • negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
  • regulation of calcineurin-NFAT signaling cascade Source: GO_Central
  • signal transduction Source: ProtInc

Enzyme and pathway databases

SIGNORiP53805

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Adapt78
Down syndrome critical region protein 1
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
Gene namesi
Name:RCAN1
Synonyms:ADAPT78, CSP1, DSC1, DSCR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000159200.17
HGNCiHGNC:3040 RCAN1
MIMi602917 gene
neXtProtiNX_P53805

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi163S → A: Loss of phosphorylation, no loss of interaction with PPP3CA and PPP3R1, reduced ability to inhibit calcineurin and increased protein half-life; alone or when associated with A-167. 1 Publication1
Mutagenesisi163S → E: No loss of phosphorylation and no effect on protein half-life; alone or when associated with E-167. 1 Publication1
Mutagenesisi167S → A: Loss of phosphorylation, no loss of interaction with PPP3CA and PPP3R1, reduced ability to inhibit calcineurin and increased protein half-life; alone or when associated with A-163. 1 Publication1
Mutagenesisi167S → E: No loss of phosphorylation and no effect on protein half-life; alone or when associated with E-163. 1 Publication1

Organism-specific databases

DisGeNETi1827
OpenTargetsiENSG00000159200
PharmGKBiPA162400946

Polymorphism and mutation databases

DMDMi215274235

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114141 – 252Calcipressin-1Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163Phosphoserine1 Publication1
Modified residuei167Phosphoserine1 Publication1
Modified residuei218PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53805
MaxQBiP53805
PaxDbiP53805
PeptideAtlasiP53805
PRIDEiP53805

PTM databases

iPTMnetiP53805
PhosphoSitePlusiP53805

Expressioni

Tissue specificityi

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Inductioni

By calcium.

Gene expression databases

BgeeiENSG00000159200
CleanExiHS_DSC1
ExpressionAtlasiP53805 baseline and differential
GenevisibleiP53805 HS

Organism-specific databases

HPAiCAB037218

Interactioni

Subunit structurei

Interacts with RAF1 (PubMed:15935327). Interacts with PPP3CA and PPP3R1 (PubMed:12809556).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi108161, 27 interactors
CORUMiP53805
IntActiP53805, 6 interactors
MINTiP53805
STRINGi9606.ENSP00000320768

Structurei

3D structure databases

ProteinModelPortaliP53805
SMRiP53805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 229Poly-Glu9

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019 Eukaryota
ENOG4111I50 LUCA
GeneTreeiENSGT00400000022053
HOVERGENiHBG018932
InParanoidiP53805
KOiK17901
OMAiVQFQYFR
PhylomeDBiP53805
TreeFamiTF313579

Family and domain databases

CDDicd12708 RRM_RCAN1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006931 Calcipressin
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR031271 RCAN1
IPR034906 RCAN1_RRM
PANTHERiPTHR10300 PTHR10300, 1 hit
PTHR10300:SF4 PTHR10300:SF4, 1 hit
PfamiView protein in Pfam
PF04847 Calcipressin, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P53805-1) [UniParc]FASTAAdd to basket
Also known as: CALP1-L1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS
60 70 80 90 100
FIDCEMEEVD LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF
110 120 130 140 150
QYFKSFKRVR INFSNPFSAA DARLQLHKTE FLGKEMKLYF AQTLHIGSSH
160 170 180 190 200
LAPPNPDKQF LISPPASPPV GWKQVEDATP VINYDLLYAI SKLGPGEKYE
210 220 230 240 250
LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ TRRPEYTPIH

LS
Length:252
Mass (Da):28,079
Last modified:November 25, 2008 - v4
Checksum:i0B17133D03BD7AFA
GO
Isoform 2 (identifier: P53805-2) [UniParc]FASTAAdd to basket
Also known as: CALP1-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MEDGVAGPQL...DPRVFVDGLC → MHFRNFNYSFSSLIACVANSDIFSESET

Show »
Length:197
Mass (Da):22,767
Checksum:i980A1FD7AA54A238
GO
Isoform 3 (identifier: P53805-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MEDGVAGPQL...PRVFVDGLCR → MVY

Show »
Length:171
Mass (Da):19,805
Checksum:i1330107875A36BD9
GO
Isoform 4 (identifier: P53805-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Show »
Length:117
Mass (Da):13,291
Checksum:i447ABCBB7DDD4826
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202H → R in AAK92478 (PubMed:12809556).Curated1
Sequence conflicti214H → Q in AAF21218 (PubMed:10830953).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0013161 – 135Missing in isoform 4. 2 PublicationsAdd BLAST135
Alternative sequenceiVSP_0013151 – 84MEDGV…DGLCR → MVY in isoform 3. 3 PublicationsAdd BLAST84
Alternative sequenceiVSP_0013141 – 83MEDGV…VDGLC → MHFRNFNYSFSSLIACVANS DIFSESET in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28833 mRNA Translation: AAB81557.1
U85265 mRNA Translation: AAB84370.1
U85266 mRNA Translation: AAB84371.2
U85267 mRNA Translation: AAB84372.1
AY325903 mRNA Translation: AAP96743.1
AF400429 mRNA Translation: AAK92478.1
AK092184 mRNA Translation: BAG52494.1
CR456878 mRNA Translation: CAG33159.1
AP000326 Genomic DNA No translation available.
AP000327 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09779.1
CH471079 Genomic DNA Translation: EAX09782.1
U53821 Genomic DNA Translation: AAF21218.1
BC002864 mRNA Translation: AAH02864.1
BT007363 mRNA Translation: AAP36027.1
CCDSiCCDS13637.1 [P53805-1]
CCDS33551.1 [P53805-2]
CCDS42921.1 [P53805-4]
CCDS74790.1 [P53805-3]
RefSeqiNP_001272318.1, NM_001285389.2 [P53805-3]
NP_001272320.2, NM_001285391.2
NP_001272321.1, NM_001285392.2 [P53805-4]
NP_001272322.1, NM_001285393.2 [P53805-4]
NP_004405.3, NM_004414.6 [P53805-1]
NP_981962.1, NM_203417.2 [P53805-4]
NP_981963.1, NM_203418.2 [P53805-2]
UniGeneiHs.282326

Genome annotation databases

EnsembliENST00000313806; ENSP00000320768; ENSG00000159200 [P53805-1]
ENST00000381132; ENSP00000370524; ENSG00000159200 [P53805-2]
ENST00000399272; ENSP00000382214; ENSG00000159200 [P53805-3]
ENST00000443408; ENSP00000392438; ENSG00000159200 [P53805-4]
ENST00000482533; ENSP00000419624; ENSG00000159200 [P53805-4]
ENST00000487990; ENSP00000419252; ENSG00000159200 [P53805-4]
ENST00000620920; ENSP00000477646; ENSG00000159200 [P53805-4]
GeneIDi1827
KEGGihsa:1827
UCSCiuc002yuc.5 human [P53805-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRCAN1_HUMAN
AccessioniPrimary (citable) accession number: P53805
Secondary accession number(s): D3DSF9
, O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03, Q9BU69, Q9UF15, Q9UME4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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