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P53805

- RCAN1_HUMAN

UniProt

P53805 - RCAN1_HUMAN

Protein

Calcipressin-1

Gene

RCAN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 4 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. identical protein binding Source: IntAct
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. blood circulation Source: ProtInc
    2. calcium-mediated signaling Source: InterPro
    3. central nervous system development Source: ProtInc
    4. negative regulation of smooth muscle cell differentiation Source: Ensembl
    5. regulation of phosphoprotein phosphatase activity Source: Ensembl
    6. regulation of transcription, DNA-templated Source: GOC
    7. response to estrogen Source: Ensembl
    8. response to mechanical stimulus Source: Ensembl
    9. signal transduction Source: ProtInc
    10. skeletal muscle fiber development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcipressin-1
    Alternative name(s):
    Adapt78
    Down syndrome critical region protein 1
    Myocyte-enriched calcineurin-interacting protein 1
    Short name:
    MCIP1
    Regulator of calcineurin 1
    Gene namesi
    Name:RCAN1
    Synonyms:ADAPT78, CSP1, DSC1, DSCR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:3040. RCAN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Calcipressin-1PRO_0000211414Add
    BLAST

    Proteomic databases

    MaxQBiP53805.
    PaxDbiP53805.
    PRIDEiP53805.

    PTM databases

    PhosphoSiteiP53805.

    Expressioni

    Tissue specificityi

    Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

    Inductioni

    By calcium.

    Gene expression databases

    ArrayExpressiP53805.
    BgeeiP53805.
    CleanExiHS_DSC1.
    GenevestigatoriP53805.

    Organism-specific databases

    HPAiCAB037218.

    Interactioni

    Subunit structurei

    Interacts with RAF1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dyrk1aQ612145EBI-1541912,EBI-80344From a different organism.
    RAF1P040494EBI-1541912,EBI-365996

    Protein-protein interaction databases

    BioGridi108161. 12 interactions.
    IntActiP53805. 5 interactions.
    MINTiMINT-4824397.

    Structurei

    3D structure databases

    ProteinModelPortaliP53805.
    SMRiP53805. Positions 66-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 2299Poly-Glu

    Sequence similaritiesi

    Belongs to the RCAN family.Curated

    Phylogenomic databases

    eggNOGiNOG87330.
    HOVERGENiHBG018932.
    InParanoidiP53805.
    KOiK17901.
    OMAiACVANSE.
    OrthoDBiEOG715Q51.
    PhylomeDBiP53805.
    TreeFamiTF313579.

    Family and domain databases

    InterProiIPR006931. Calcipressin.
    [Graphical view]
    PANTHERiPTHR10300. PTHR10300. 1 hit.
    PfamiPF04847. Calcipressin. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P53805-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDGVAGPQL GAAAEAAEAA EARARPGVTL RPFAPLSGAA EADEGGGDWS    50
    FIDCEMEEVD LQDLPSATIA CHLDPRVFVD GLCRAKFESL FRTYDKDITF 100
    QYFKSFKRVR INFSNPFSAA DARLQLHKTE FLGKEMKLYF AQTLHIGSSH 150
    LAPPNPDKQF LISPPASPPV GWKQVEDATP VINYDLLYAI SKLGPGEKYE 200
    LHAATDTTPS VVVHVCESDQ EKEEEEEMER MRRPKPKIIQ TRRPEYTPIH 250
    LS 252
    Length:252
    Mass (Da):28,079
    Last modified:November 25, 2008 - v4
    Checksum:i0B17133D03BD7AFA
    GO
    Isoform 2 (identifier: P53805-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: MEDGVAGPQL...DPRVFVDGLC → MHFRNFNYSFSSLIACVANSDIFSESET

    Show »
    Length:197
    Mass (Da):22,767
    Checksum:i980A1FD7AA54A238
    GO
    Isoform 3 (identifier: P53805-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: MEDGVAGPQL...PRVFVDGLCR → MVY

    Show »
    Length:171
    Mass (Da):19,805
    Checksum:i1330107875A36BD9
    GO
    Isoform 4 (identifier: P53805-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: Missing.

    Show »
    Length:117
    Mass (Da):13,291
    Checksum:i447ABCBB7DDD4826
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti202 – 2021H → R in AAK92478. (PubMed:12809556)Curated
    Sequence conflicti214 – 2141H → Q in AAF21218. (PubMed:10830953)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 135135Missing in isoform 4. 2 PublicationsVSP_001316Add
    BLAST
    Alternative sequencei1 – 8484MEDGV…DGLCR → MVY in isoform 3. 3 PublicationsVSP_001315Add
    BLAST
    Alternative sequencei1 – 8383MEDGV…VDGLC → MHFRNFNYSFSSLIACVANS DIFSESET in isoform 2. 1 PublicationVSP_001314Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28833 mRNA. Translation: AAB81557.1.
    U85265 mRNA. Translation: AAB84370.1.
    U85266 mRNA. Translation: AAB84371.2.
    U85267 mRNA. Translation: AAB84372.1.
    AY325903 mRNA. Translation: AAP96743.1.
    AF400429 mRNA. Translation: AAK92478.1.
    AK092184 mRNA. Translation: BAG52494.1.
    CR456878 mRNA. Translation: CAG33159.1.
    AP000326 Genomic DNA. No translation available.
    AP000327 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09779.1.
    CH471079 Genomic DNA. Translation: EAX09782.1.
    U53821 Genomic DNA. Translation: AAF21218.1.
    BC002864 mRNA. Translation: AAH02864.1.
    BT007363 mRNA. Translation: AAP36027.1.
    CCDSiCCDS13637.1. [P53805-1]
    CCDS33551.1. [P53805-2]
    CCDS42921.1. [P53805-4]
    RefSeqiNP_001272318.1. NM_001285389.2. [P53805-3]
    NP_001272320.2. NM_001285391.2.
    NP_001272321.1. NM_001285392.2. [P53805-4]
    NP_001272322.1. NM_001285393.2. [P53805-4]
    NP_004405.3. NM_004414.6. [P53805-1]
    NP_981962.1. NM_203417.2. [P53805-4]
    NP_981963.1. NM_203418.2. [P53805-2]
    UniGeneiHs.282326.

    Genome annotation databases

    EnsembliENST00000313806; ENSP00000320768; ENSG00000159200. [P53805-1]
    ENST00000381132; ENSP00000370524; ENSG00000159200. [P53805-2]
    ENST00000399272; ENSP00000382214; ENSG00000159200. [P53805-3]
    ENST00000443408; ENSP00000392438; ENSG00000159200. [P53805-4]
    ENST00000482533; ENSP00000419624; ENSG00000159200. [P53805-4]
    ENST00000487990; ENSP00000419252; ENSG00000159200. [P53805-4]
    GeneIDi1827.
    KEGGihsa:1827.
    UCSCiuc002yuc.3. human. [P53805-3]
    uc002yud.3. human. [P53805-4]
    uc002yue.3. human. [P53805-1]

    Polymorphism databases

    DMDMi215274235.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28833 mRNA. Translation: AAB81557.1 .
    U85265 mRNA. Translation: AAB84370.1 .
    U85266 mRNA. Translation: AAB84371.2 .
    U85267 mRNA. Translation: AAB84372.1 .
    AY325903 mRNA. Translation: AAP96743.1 .
    AF400429 mRNA. Translation: AAK92478.1 .
    AK092184 mRNA. Translation: BAG52494.1 .
    CR456878 mRNA. Translation: CAG33159.1 .
    AP000326 Genomic DNA. No translation available.
    AP000327 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09779.1 .
    CH471079 Genomic DNA. Translation: EAX09782.1 .
    U53821 Genomic DNA. Translation: AAF21218.1 .
    BC002864 mRNA. Translation: AAH02864.1 .
    BT007363 mRNA. Translation: AAP36027.1 .
    CCDSi CCDS13637.1. [P53805-1 ]
    CCDS33551.1. [P53805-2 ]
    CCDS42921.1. [P53805-4 ]
    RefSeqi NP_001272318.1. NM_001285389.2. [P53805-3 ]
    NP_001272320.2. NM_001285391.2.
    NP_001272321.1. NM_001285392.2. [P53805-4 ]
    NP_001272322.1. NM_001285393.2. [P53805-4 ]
    NP_004405.3. NM_004414.6. [P53805-1 ]
    NP_981962.1. NM_203417.2. [P53805-4 ]
    NP_981963.1. NM_203418.2. [P53805-2 ]
    UniGenei Hs.282326.

    3D structure databases

    ProteinModelPortali P53805.
    SMRi P53805. Positions 66-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108161. 12 interactions.
    IntActi P53805. 5 interactions.
    MINTi MINT-4824397.

    PTM databases

    PhosphoSitei P53805.

    Polymorphism databases

    DMDMi 215274235.

    Proteomic databases

    MaxQBi P53805.
    PaxDbi P53805.
    PRIDEi P53805.

    Protocols and materials databases

    DNASUi 1827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313806 ; ENSP00000320768 ; ENSG00000159200 . [P53805-1 ]
    ENST00000381132 ; ENSP00000370524 ; ENSG00000159200 . [P53805-2 ]
    ENST00000399272 ; ENSP00000382214 ; ENSG00000159200 . [P53805-3 ]
    ENST00000443408 ; ENSP00000392438 ; ENSG00000159200 . [P53805-4 ]
    ENST00000482533 ; ENSP00000419624 ; ENSG00000159200 . [P53805-4 ]
    ENST00000487990 ; ENSP00000419252 ; ENSG00000159200 . [P53805-4 ]
    GeneIDi 1827.
    KEGGi hsa:1827.
    UCSCi uc002yuc.3. human. [P53805-3 ]
    uc002yud.3. human. [P53805-4 ]
    uc002yue.3. human. [P53805-1 ]

    Organism-specific databases

    CTDi 1827.
    GeneCardsi GC21M035885.
    HGNCi HGNC:3040. RCAN1.
    HPAi CAB037218.
    MIMi 602917. gene.
    neXtProti NX_P53805.
    PharmGKBi PA162400946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87330.
    HOVERGENi HBG018932.
    InParanoidi P53805.
    KOi K17901.
    OMAi ACVANSE.
    OrthoDBi EOG715Q51.
    PhylomeDBi P53805.
    TreeFami TF313579.

    Miscellaneous databases

    GeneWikii DSCR1.
    GenomeRNAii 1827.
    NextBioi 7453.
    PROi P53805.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53805.
    Bgeei P53805.
    CleanExi HS_DSC1.
    Genevestigatori P53805.

    Family and domain databases

    InterProi IPR006931. Calcipressin.
    [Graphical view ]
    PANTHERi PTHR10300. PTHR10300. 1 hit.
    Pfami PF04847. Calcipressin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart."
      Fuentes J.-J., Pritchard M.A., Planas A.M., Bosch A., Ferrer I., Estivill X.
      Hum. Mol. Genet. 4:1935-1944(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    2. "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene."
      Fuentes J.-J., Pritchard M.A., Estivill X.
      Genomics 44:358-361(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 48-252 (ISOFORM 1), ALTERNATIVE SPLICING.
    3. "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life."
      Genesca L., Aubareda A., Fuentes J.J., Estivill X., De La Luna S., Perez-Riba M.
      Biochem. J. 374:567-575(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    4. Hua F., Wu J., Zhou Y., Zhang B., Peng X., Qiang B., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    7. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "Adapt78, a calcium and oxidant-inducible RNA."
      Crawford D.R., Leahy K.P., Davies K.J.A.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-219 (ISOFORM 2).
      Tissue: Mammary gland.
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-252 (ISOFORM 1).
      Tissue: Lung.
    11. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-252 (ISOFORM 1).
    12. "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways."
      Fuentes J.J., Genesca L., Kingsbury T.J., Cunningham K.W., Perez-Riba M., Estivill X., de la Luna S.
      Hum. Mol. Genet. 9:1681-1690(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    13. Cited for: INTERACTION WITH RAF1.

    Entry informationi

    Entry nameiRCAN1_HUMAN
    AccessioniPrimary (citable) accession number: P53805
    Secondary accession number(s): D3DSF9
    , O00582, O00583, Q53XT0, Q6IBC6, Q7Z555, Q96R03, Q9BU69, Q9UF15, Q9UME4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 126 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3