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P53804

- TTC3_HUMAN

UniProt

P53804 - TTC3_HUMAN

Protein

E3 ubiquitin-protein ligase TTC3

Gene

TTC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.2 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1957 – 199741RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. ubiquitin-protein transferase activity Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of cell morphogenesis involved in differentiation Source: Ensembl
    2. negative regulation of neuron differentiation Source: Ensembl
    3. protein K48-linked ubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase TTC3 (EC:6.3.2.-)
    Alternative name(s):
    Protein DCRR1
    RING finger protein 105
    TPR repeat protein D
    Tetratricopeptide repeat protein 3
    Short name:
    TPR repeat protein 3
    Gene namesi
    Name:TTC3
    Synonyms:DCRR1, RNF105, TPRD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:12393. TTC3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: HPA
    2. nucleus Source: UniProtKB
    3. vacuole Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi378 – 3781S → A: Abolishes phosphorylation by Akt and impairs ubiquitin ligase activity on Akt. 1 Publication

    Organism-specific databases

    PharmGKBiPA37058.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20252025E3 ubiquitin-protein ligase TTC3PRO_0000106378Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei378 – 3781Phosphoserine; by PKB/AKT21 Publication

    Post-translational modificationi

    Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53804.
    PaxDbiP53804.
    PRIDEiP53804.

    PTM databases

    PhosphoSiteiP53804.

    Expressioni

    Tissue specificityi

    Found in all tissues examined.

    Gene expression databases

    ArrayExpressiP53804.
    BgeeiP53804.
    CleanExiHS_TTC3.
    GenevestigatoriP53804.

    Organism-specific databases

    HPAiHPA016810.
    HPA023964.

    Interactioni

    Subunit structurei

    Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.2 Publications

    Protein-protein interaction databases

    BioGridi113118. 7 interactions.
    IntActiP53804. 8 interactions.
    MINTiMINT-1181179.

    Structurei

    3D structure databases

    ProteinModelPortaliP53804.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati231 – 26434TPR 1Add
    BLAST
    Repeati266 – 29833TPR 2Add
    BLAST
    Repeati536 – 57237TPR 3Add
    BLAST
    Repeati576 – 60934TPR 4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi453 – 4564Poly-Ser
    Compositional biasi1018 – 102912Arg/Lys-rich (basic)Add
    BLAST
    Compositional biasi1020 – 102910Poly-Lys
    Compositional biasi1172 – 118514Arg/Lys-rich (basic)Add
    BLAST
    Compositional biasi1563 – 157917Arg/Lys-rich (basic)Add
    BLAST
    Compositional biasi1899 – 19024Poly-Lys

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 4 TPR repeats.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1957 – 199741RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, TPR repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG248683.
    HOVERGENiHBG007494.
    InParanoidiP53804.
    KOiK15712.
    OMAiDCEGIIS.
    PhylomeDBiP53804.
    TreeFamiTF333981.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    3.30.40.10. 1 hit.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00515. TPR_1. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform TPRDI (identifier: P53804-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV     50
    QYKDYIQSER NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS 100
    SVISRLHPCV DANNSRASEI NLKKLQHLEL MEDIVDLAKK VANDSFLIGG 150
    LLRIGCKIEN KILAMEEALN WIKYAGDVTI LTKLGSIDNC WPMLSIFFTE 200
    YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE EFSKERFDIA 250
    IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 300
    GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI 350
    EDLQGRTANK DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH 400
    EMANGGNQNL KVADEALKVD DCDCHPEFSP PSSQPPKHKG KQKSRNNESE 450
    KFSSSSPLTL PADLKNILEK QFSKSSRAAH QDFANIMKML RSLIQDGYMA 500
    LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAISLLGIG 550
    QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 600
    KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI 650
    CCYQKCHGYS KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF 700
    NDKIDKDFLQ GICLTPDCEG VISKIIIFSS GGEVKCEFEH KVIKEKVPPR 750
    PILKQKCSSL EKLRLKEDKK LKRKIQKKEA KKLAQERMEE DLRESNPPKN 800
    EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM LLKELLSWKV 850
    LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 900
    PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD 950
    SIEGKQLDYF SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR 1000
    CTVLRKQDSG EAPFSSTKVK NKSKKKKPKD SKPMLVGSGT TSVTSNNEII 1050
    TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF EALYDQHSNE YVVRNKKLWD 1100
    MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE ETRQILEKAG 1150
    GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY 1200
    VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE 1250
    DVKAKPVSDN SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL 1300
    EDVKPTYWAQ SHLVTGYCTY LPFQRFDITQ TPPAYINVLP GLPQYTSIYT 1350
    PLASLSPEYQ LPRSVPVVPS FVANDRADKN AAAYFEGHHL NAENVAGHQI 1400
    ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN SNNKCEVIPE 1450
    STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ 1500
    VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ 1550
    DLEREIKKWQ QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL 1600
    HLDQSLEISN TLTNEKMKIE EYIKKGKEDY EESHQRAVAA EVSVLENWKE 1650
    SEVYKLQIME SQAEAFLKKL GLISRDPAAY PDMESDIRSW ELFLSNVTKE 1700
    IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV HPELLPESSG 1750
    DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE 1800
    ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH 1850
    LSVVFPCYNS TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK 1900
    KKPNPGKDKR TYEPSSATPV TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI 1950
    ALGASSCEIC HEVFKSKNVR VLKCGHKYHK GCFKQWLKGQ SACPACQGRD 2000
    LLTEESPSGR GWPSQNQELP SCSSR 2025
    Length:2,025
    Mass (Da):229,869
    Last modified:November 30, 2010 - v2
    Checksum:iC80BC8E1970B6725
    GO
    Isoform TPRDII (identifier: P53804-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-233: Missing.

    Show »
    Length:1,792
    Mass (Da):203,189
    Checksum:iCCF6AE90171F496F
    GO
    Isoform TPRDIII (identifier: P53804-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-310: Missing.

    Show »
    Length:1,715
    Mass (Da):194,059
    Checksum:i443B4C9A7FD955B2
    GO

    Sequence cautioni

    The sequence AAH63033.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH92466.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91F → Y in AAH92466. (PubMed:15489334)Curated
    Sequence conflicti121 – 1211N → D in CAA05057. (PubMed:9503011)Curated
    Sequence conflicti139 – 1391K → R in CAA05057. (PubMed:9503011)Curated
    Sequence conflicti232 – 2321E → G in CAA05057. (PubMed:9503011)Curated
    Sequence conflicti276 – 2761L → P in CAA05057. (PubMed:9503011)Curated
    Sequence conflicti437 – 4371K → Q in AAH63033. (PubMed:15489334)Curated
    Sequence conflicti495 – 4951Q → P in BAA23666. (PubMed:9254009)Curated
    Sequence conflicti1700 – 17001E → V in BAA23666. (PubMed:9254009)Curated
    Sequence conflicti1822 – 18221A → T in BAA23666. (PubMed:9254009)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti840 – 8401M → T.1 Publication
    Corresponds to variant rs1053808 [ dbSNP | Ensembl ].
    VAR_020312
    Natural varianti1063 – 10631S → T.
    Corresponds to variant rs1133021 [ dbSNP | Ensembl ].
    VAR_044426
    Natural varianti1117 – 11171F → L.
    Corresponds to variant rs1133022 [ dbSNP | Ensembl ].
    VAR_014491
    Natural varianti1128 – 11281N → H.
    Corresponds to variant rs1053833 [ dbSNP | Ensembl ].
    VAR_044427
    Natural varianti1154 – 11541P → S.
    Corresponds to variant rs1053840 [ dbSNP | Ensembl ].
    VAR_044428
    Natural varianti1289 – 12891K → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035868
    Natural varianti1751 – 17511D → H.2 Publications
    Corresponds to variant rs1053966 [ dbSNP | Ensembl ].
    VAR_024676

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 310310Missing in isoform TPRDIII. 1 PublicationVSP_006555Add
    BLAST
    Alternative sequencei1 – 233233Missing in isoform TPRDII. 1 PublicationVSP_006554Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83077 mRNA. Translation: BAA11769.1.
    D84294 mRNA. Translation: BAA12301.1.
    D84295 mRNA. Translation: BAA12302.1.
    D84296 mRNA. Translation: BAA12303.1.
    AP001429 Genomic DNA. No translation available.
    AP001432 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09716.1.
    CH471079 Genomic DNA. Translation: EAX09717.1.
    CH471079 Genomic DNA. Translation: EAX09718.1.
    CH471079 Genomic DNA. Translation: EAX09719.1.
    CH471079 Genomic DNA. Translation: EAX09720.1.
    CH471079 Genomic DNA. Translation: EAX09721.1.
    CH471079 Genomic DNA. Translation: EAX09722.1.
    CH471079 Genomic DNA. Translation: EAX09723.1.
    BC063033 mRNA. Translation: AAH63033.1. Sequence problems.
    BC092466 mRNA. Translation: AAH92466.1. Sequence problems.
    BC137345 mRNA. Translation: AAI37346.1.
    AK291992 mRNA. Translation: BAF84681.1.
    D83327 mRNA. Translation: BAA23666.1.
    AJ001866 mRNA. Translation: CAA05057.1.
    CCDSiCCDS13651.1. [P53804-1]
    PIRiJC5020.
    RefSeqiNP_001001894.1. NM_001001894.1. [P53804-1]
    NP_003307.3. NM_003316.3. [P53804-1]
    UniGeneiHs.368214.

    Genome annotation databases

    EnsembliENST00000354749; ENSP00000346791; ENSG00000182670. [P53804-1]
    ENST00000355666; ENSP00000347889; ENSG00000182670. [P53804-1]
    ENST00000399017; ENSP00000381981; ENSG00000182670. [P53804-1]
    GeneIDi7267.
    KEGGihsa:7267.
    UCSCiuc002yvz.3. human. [P53804-1]

    Polymorphism databases

    DMDMi313104040.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83077 mRNA. Translation: BAA11769.1 .
    D84294 mRNA. Translation: BAA12301.1 .
    D84295 mRNA. Translation: BAA12302.1 .
    D84296 mRNA. Translation: BAA12303.1 .
    AP001429 Genomic DNA. No translation available.
    AP001432 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09716.1 .
    CH471079 Genomic DNA. Translation: EAX09717.1 .
    CH471079 Genomic DNA. Translation: EAX09718.1 .
    CH471079 Genomic DNA. Translation: EAX09719.1 .
    CH471079 Genomic DNA. Translation: EAX09720.1 .
    CH471079 Genomic DNA. Translation: EAX09721.1 .
    CH471079 Genomic DNA. Translation: EAX09722.1 .
    CH471079 Genomic DNA. Translation: EAX09723.1 .
    BC063033 mRNA. Translation: AAH63033.1 . Sequence problems.
    BC092466 mRNA. Translation: AAH92466.1 . Sequence problems.
    BC137345 mRNA. Translation: AAI37346.1 .
    AK291992 mRNA. Translation: BAF84681.1 .
    D83327 mRNA. Translation: BAA23666.1 .
    AJ001866 mRNA. Translation: CAA05057.1 .
    CCDSi CCDS13651.1. [P53804-1 ]
    PIRi JC5020.
    RefSeqi NP_001001894.1. NM_001001894.1. [P53804-1 ]
    NP_003307.3. NM_003316.3. [P53804-1 ]
    UniGenei Hs.368214.

    3D structure databases

    ProteinModelPortali P53804.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113118. 7 interactions.
    IntActi P53804. 8 interactions.
    MINTi MINT-1181179.

    PTM databases

    PhosphoSitei P53804.

    Polymorphism databases

    DMDMi 313104040.

    Proteomic databases

    MaxQBi P53804.
    PaxDbi P53804.
    PRIDEi P53804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354749 ; ENSP00000346791 ; ENSG00000182670 . [P53804-1 ]
    ENST00000355666 ; ENSP00000347889 ; ENSG00000182670 . [P53804-1 ]
    ENST00000399017 ; ENSP00000381981 ; ENSG00000182670 . [P53804-1 ]
    GeneIDi 7267.
    KEGGi hsa:7267.
    UCSCi uc002yvz.3. human. [P53804-1 ]

    Organism-specific databases

    CTDi 7267.
    GeneCardsi GC21P038445.
    H-InvDB HIX0027791.
    HIX0041033.
    HIX0148527.
    HGNCi HGNC:12393. TTC3.
    HPAi HPA016810.
    HPA023964.
    MIMi 602259. gene.
    neXtProti NX_P53804.
    PharmGKBi PA37058.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248683.
    HOVERGENi HBG007494.
    InParanoidi P53804.
    KOi K15712.
    OMAi DCEGIIS.
    PhylomeDBi P53804.
    TreeFami TF333981.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi TTC3. human.
    GeneWikii TTC3.
    GenomeRNAii 7267.
    NextBioi 28411.
    PROi P53804.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53804.
    Bgeei P53804.
    CleanExi HS_TTC3.
    Genevestigatori P53804.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    3.30.40.10. 1 hit.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00515. TPR_1. 1 hit.
    PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21."
      Ohira M., Ootsuyama A., Suzuki E., Ichikawa H., Seki N., Nagase T., Nomura N., Ohki M.
      DNA Res. 3:9-16(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TPRDI), VARIANT HIS-1751.
      Tissue: Brain.
    2. "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2."
      Tsukahara F., Hattori M., Muraki T., Sakaki Y.
      J. Biochem. 120:820-827(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TPRDI; TPRDII AND TPRDIII), VARIANT HIS-1751.
      Tissue: Fetal brain and Placenta.
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM TPRDI).
      Tissue: Testis.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-627 (ISOFORM TPRDI).
      Tissue: Small intestine.
    7. "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2."
      Eki T., Abe M., Naitou M., Sasanuma S.I., Nohata J., Kawashima K., Ahmad I., Hanaoka F., Murakami Y.
      DNA Seq. 7:153-164(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-2025 (ISOFORM TPRDI), VARIANT THR-840.
    8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-616 (ISOFORM TPRDI).
      Tissue: Fetal brain.
    9. "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase."
      Berto G., Camera P., Fusco C., Imarisio S., Ambrogio C., Chiarle R., Silengo L., Di Cunto F.
      J. Cell Sci. 120:1859-1867(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CIT.
    10. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1; AKT2 AND AKT3, PHOSPHORYLATION AT SER-378, MUTAGENESIS OF SER-378.
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-1289.

    Entry informationi

    Entry nameiTTC3_HUMAN
    AccessioniPrimary (citable) accession number: P53804
    Secondary accession number(s): A8K7H7
    , B2RPA7, D3DSG9, D3DSH2, D3DSH3, O60767, P78476, P78477, Q569I2, Q6P578, Q9UEK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3