Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53804

- TTC3_HUMAN

UniProt

P53804 - TTC3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

E3 ubiquitin-protein ligase TTC3

Gene

TTC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1957 – 199741RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of cell morphogenesis involved in differentiation Source: Ensembl
  2. negative regulation of neuron differentiation Source: Ensembl
  3. protein K48-linked ubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TTC3 (EC:6.3.2.-)
Alternative name(s):
Protein DCRR1
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3
Short name:
TPR repeat protein 3
Gene namesi
Name:TTC3
Synonyms:DCRR1, RNF105, TPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:12393. TTC3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: UniProtKB
  3. vacuole Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi378 – 3781S → A: Abolishes phosphorylation by Akt and impairs ubiquitin ligase activity on Akt. 1 Publication

Organism-specific databases

PharmGKBiPA37058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20252025E3 ubiquitin-protein ligase TTC3PRO_0000106378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei378 – 3781Phosphoserine; by PKB/AKT21 Publication

Post-translational modificationi

Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53804.
PaxDbiP53804.
PRIDEiP53804.

PTM databases

PhosphoSiteiP53804.

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

BgeeiP53804.
CleanExiHS_TTC3.
ExpressionAtlasiP53804. baseline and differential.
GenevestigatoriP53804.

Organism-specific databases

HPAiHPA016810.
HPA023964.

Interactioni

Subunit structurei

Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.2 Publications

Protein-protein interaction databases

BioGridi113118. 7 interactions.
IntActiP53804. 8 interactions.
MINTiMINT-1181179.

Structurei

3D structure databases

ProteinModelPortaliP53804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati231 – 26434TPR 1Add
BLAST
Repeati266 – 29833TPR 2Add
BLAST
Repeati536 – 57237TPR 3Add
BLAST
Repeati576 – 60934TPR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi453 – 4564Poly-Ser
Compositional biasi1018 – 102912Arg/Lys-rich (basic)Add
BLAST
Compositional biasi1020 – 102910Poly-Lys
Compositional biasi1172 – 118514Arg/Lys-rich (basic)Add
BLAST
Compositional biasi1563 – 157917Arg/Lys-rich (basic)Add
BLAST
Compositional biasi1899 – 19024Poly-Lys

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 4 TPR repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1957 – 199741RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG248683.
GeneTreeiENSGT00530000063254.
HOVERGENiHBG007494.
InParanoidiP53804.
KOiK15712.
OMAiDCEGIIS.
PhylomeDBiP53804.
TreeFamiTF333981.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform TPRDI (identifier: P53804-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV
60 70 80 90 100
QYKDYIQSER NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS
110 120 130 140 150
SVISRLHPCV DANNSRASEI NLKKLQHLEL MEDIVDLAKK VANDSFLIGG
160 170 180 190 200
LLRIGCKIEN KILAMEEALN WIKYAGDVTI LTKLGSIDNC WPMLSIFFTE
210 220 230 240 250
YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE EFSKERFDIA
260 270 280 290 300
IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK
310 320 330 340 350
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI
360 370 380 390 400
EDLQGRTANK DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH
410 420 430 440 450
EMANGGNQNL KVADEALKVD DCDCHPEFSP PSSQPPKHKG KQKSRNNESE
460 470 480 490 500
KFSSSSPLTL PADLKNILEK QFSKSSRAAH QDFANIMKML RSLIQDGYMA
510 520 530 540 550
LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAISLLGIG
560 570 580 590 600
QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE
610 620 630 640 650
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI
660 670 680 690 700
CCYQKCHGYS KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF
710 720 730 740 750
NDKIDKDFLQ GICLTPDCEG VISKIIIFSS GGEVKCEFEH KVIKEKVPPR
760 770 780 790 800
PILKQKCSSL EKLRLKEDKK LKRKIQKKEA KKLAQERMEE DLRESNPPKN
810 820 830 840 850
EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM LLKELLSWKV
860 870 880 890 900
LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE
910 920 930 940 950
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD
960 970 980 990 1000
SIEGKQLDYF SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR
1010 1020 1030 1040 1050
CTVLRKQDSG EAPFSSTKVK NKSKKKKPKD SKPMLVGSGT TSVTSNNEII
1060 1070 1080 1090 1100
TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF EALYDQHSNE YVVRNKKLWD
1110 1120 1130 1140 1150
MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE ETRQILEKAG
1160 1170 1180 1190 1200
GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY
1210 1220 1230 1240 1250
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE
1260 1270 1280 1290 1300
DVKAKPVSDN SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL
1310 1320 1330 1340 1350
EDVKPTYWAQ SHLVTGYCTY LPFQRFDITQ TPPAYINVLP GLPQYTSIYT
1360 1370 1380 1390 1400
PLASLSPEYQ LPRSVPVVPS FVANDRADKN AAAYFEGHHL NAENVAGHQI
1410 1420 1430 1440 1450
ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN SNNKCEVIPE
1460 1470 1480 1490 1500
STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ
1510 1520 1530 1540 1550
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ
1560 1570 1580 1590 1600
DLEREIKKWQ QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL
1610 1620 1630 1640 1650
HLDQSLEISN TLTNEKMKIE EYIKKGKEDY EESHQRAVAA EVSVLENWKE
1660 1670 1680 1690 1700
SEVYKLQIME SQAEAFLKKL GLISRDPAAY PDMESDIRSW ELFLSNVTKE
1710 1720 1730 1740 1750
IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV HPELLPESSG
1760 1770 1780 1790 1800
DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE
1810 1820 1830 1840 1850
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH
1860 1870 1880 1890 1900
LSVVFPCYNS TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK
1910 1920 1930 1940 1950
KKPNPGKDKR TYEPSSATPV TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI
1960 1970 1980 1990 2000
ALGASSCEIC HEVFKSKNVR VLKCGHKYHK GCFKQWLKGQ SACPACQGRD
2010 2020
LLTEESPSGR GWPSQNQELP SCSSR
Length:2,025
Mass (Da):229,869
Last modified:November 30, 2010 - v2
Checksum:iC80BC8E1970B6725
GO
Isoform TPRDII (identifier: P53804-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:1,792
Mass (Da):203,189
Checksum:iCCF6AE90171F496F
GO
Isoform TPRDIII (identifier: P53804-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Show »
Length:1,715
Mass (Da):194,059
Checksum:i443B4C9A7FD955B2
GO

Sequence cautioni

The sequence AAH63033.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH92466.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91F → Y in AAH92466. (PubMed:15489334)Curated
Sequence conflicti121 – 1211N → D in CAA05057. (PubMed:9503011)Curated
Sequence conflicti139 – 1391K → R in CAA05057. (PubMed:9503011)Curated
Sequence conflicti232 – 2321E → G in CAA05057. (PubMed:9503011)Curated
Sequence conflicti276 – 2761L → P in CAA05057. (PubMed:9503011)Curated
Sequence conflicti437 – 4371K → Q in AAH63033. (PubMed:15489334)Curated
Sequence conflicti495 – 4951Q → P in BAA23666. (PubMed:9254009)Curated
Sequence conflicti1700 – 17001E → V in BAA23666. (PubMed:9254009)Curated
Sequence conflicti1822 – 18221A → T in BAA23666. (PubMed:9254009)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti840 – 8401M → T.1 Publication
Corresponds to variant rs1053808 [ dbSNP | Ensembl ].
VAR_020312
Natural varianti1063 – 10631S → T.
Corresponds to variant rs1133021 [ dbSNP | Ensembl ].
VAR_044426
Natural varianti1117 – 11171F → L.
Corresponds to variant rs1133022 [ dbSNP | Ensembl ].
VAR_014491
Natural varianti1128 – 11281N → H.
Corresponds to variant rs1053833 [ dbSNP | Ensembl ].
VAR_044427
Natural varianti1154 – 11541P → S.
Corresponds to variant rs1053840 [ dbSNP | Ensembl ].
VAR_044428
Natural varianti1289 – 12891K → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_035868
Natural varianti1751 – 17511D → H.2 Publications
Corresponds to variant rs1053966 [ dbSNP | Ensembl ].
VAR_024676

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 310310Missing in isoform TPRDIII. 1 PublicationVSP_006555Add
BLAST
Alternative sequencei1 – 233233Missing in isoform TPRDII. 1 PublicationVSP_006554Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83077 mRNA. Translation: BAA11769.1.
D84294 mRNA. Translation: BAA12301.1.
D84295 mRNA. Translation: BAA12302.1.
D84296 mRNA. Translation: BAA12303.1.
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1.
CH471079 Genomic DNA. Translation: EAX09717.1.
CH471079 Genomic DNA. Translation: EAX09718.1.
CH471079 Genomic DNA. Translation: EAX09719.1.
CH471079 Genomic DNA. Translation: EAX09720.1.
CH471079 Genomic DNA. Translation: EAX09721.1.
CH471079 Genomic DNA. Translation: EAX09722.1.
CH471079 Genomic DNA. Translation: EAX09723.1.
BC063033 mRNA. Translation: AAH63033.1. Sequence problems.
BC092466 mRNA. Translation: AAH92466.1. Sequence problems.
BC137345 mRNA. Translation: AAI37346.1.
AK291992 mRNA. Translation: BAF84681.1.
D83327 mRNA. Translation: BAA23666.1.
AJ001866 mRNA. Translation: CAA05057.1.
CCDSiCCDS13651.1. [P53804-1]
PIRiJC5020.
RefSeqiNP_001001894.1. NM_001001894.1. [P53804-1]
NP_003307.3. NM_003316.3. [P53804-1]
UniGeneiHs.368214.

Genome annotation databases

EnsembliENST00000354749; ENSP00000346791; ENSG00000182670. [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670. [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670. [P53804-1]
GeneIDi7267.
KEGGihsa:7267.
UCSCiuc002yvz.3. human. [P53804-1]

Polymorphism databases

DMDMi313104040.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83077 mRNA. Translation: BAA11769.1 .
D84294 mRNA. Translation: BAA12301.1 .
D84295 mRNA. Translation: BAA12302.1 .
D84296 mRNA. Translation: BAA12303.1 .
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1 .
CH471079 Genomic DNA. Translation: EAX09717.1 .
CH471079 Genomic DNA. Translation: EAX09718.1 .
CH471079 Genomic DNA. Translation: EAX09719.1 .
CH471079 Genomic DNA. Translation: EAX09720.1 .
CH471079 Genomic DNA. Translation: EAX09721.1 .
CH471079 Genomic DNA. Translation: EAX09722.1 .
CH471079 Genomic DNA. Translation: EAX09723.1 .
BC063033 mRNA. Translation: AAH63033.1 . Sequence problems.
BC092466 mRNA. Translation: AAH92466.1 . Sequence problems.
BC137345 mRNA. Translation: AAI37346.1 .
AK291992 mRNA. Translation: BAF84681.1 .
D83327 mRNA. Translation: BAA23666.1 .
AJ001866 mRNA. Translation: CAA05057.1 .
CCDSi CCDS13651.1. [P53804-1 ]
PIRi JC5020.
RefSeqi NP_001001894.1. NM_001001894.1. [P53804-1 ]
NP_003307.3. NM_003316.3. [P53804-1 ]
UniGenei Hs.368214.

3D structure databases

ProteinModelPortali P53804.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113118. 7 interactions.
IntActi P53804. 8 interactions.
MINTi MINT-1181179.

PTM databases

PhosphoSitei P53804.

Polymorphism databases

DMDMi 313104040.

Proteomic databases

MaxQBi P53804.
PaxDbi P53804.
PRIDEi P53804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354749 ; ENSP00000346791 ; ENSG00000182670 . [P53804-1 ]
ENST00000355666 ; ENSP00000347889 ; ENSG00000182670 . [P53804-1 ]
ENST00000399017 ; ENSP00000381981 ; ENSG00000182670 . [P53804-1 ]
GeneIDi 7267.
KEGGi hsa:7267.
UCSCi uc002yvz.3. human. [P53804-1 ]

Organism-specific databases

CTDi 7267.
GeneCardsi GC21P038445.
H-InvDB HIX0027791.
HIX0041033.
HIX0148527.
HGNCi HGNC:12393. TTC3.
HPAi HPA016810.
HPA023964.
MIMi 602259. gene.
neXtProti NX_P53804.
PharmGKBi PA37058.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248683.
GeneTreei ENSGT00530000063254.
HOVERGENi HBG007494.
InParanoidi P53804.
KOi K15712.
OMAi DCEGIIS.
PhylomeDBi P53804.
TreeFami TF333981.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi TTC3. human.
GeneWikii TTC3.
GenomeRNAii 7267.
NextBioi 28411.
PROi P53804.
SOURCEi Search...

Gene expression databases

Bgeei P53804.
CleanExi HS_TTC3.
ExpressionAtlasi P53804. baseline and differential.
Genevestigatori P53804.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21."
    Ohira M., Ootsuyama A., Suzuki E., Ichikawa H., Seki N., Nagase T., Nomura N., Ohki M.
    DNA Res. 3:9-16(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TPRDI), VARIANT HIS-1751.
    Tissue: Brain.
  2. "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2."
    Tsukahara F., Hattori M., Muraki T., Sakaki Y.
    J. Biochem. 120:820-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TPRDI; TPRDII AND TPRDIII), VARIANT HIS-1751.
    Tissue: Fetal brain and Placenta.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM TPRDI).
    Tissue: Testis.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-627 (ISOFORM TPRDI).
    Tissue: Small intestine.
  7. "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2."
    Eki T., Abe M., Naitou M., Sasanuma S.I., Nohata J., Kawashima K., Ahmad I., Hanaoka F., Murakami Y.
    DNA Seq. 7:153-164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-2025 (ISOFORM TPRDI), VARIANT THR-840.
  8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-616 (ISOFORM TPRDI).
    Tissue: Fetal brain.
  9. "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase."
    Berto G., Camera P., Fusco C., Imarisio S., Ambrogio C., Chiarle R., Silengo L., Di Cunto F.
    J. Cell Sci. 120:1859-1867(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CIT.
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1; AKT2 AND AKT3, PHOSPHORYLATION AT SER-378, MUTAGENESIS OF SER-378.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-1289.

Entry informationi

Entry nameiTTC3_HUMAN
AccessioniPrimary (citable) accession number: P53804
Secondary accession number(s): A8K7H7
, B2RPA7, D3DSG9, D3DSH2, D3DSH3, O60767, P78476, P78477, Q569I2, Q6P578, Q9UEK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3