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Protein

E3 ubiquitin-protein ligase TTC3

Gene

TTC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1957 – 1997RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein K48-linked ubiquitination Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiP53804.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TTC3 (EC:6.3.2.-)
Alternative name(s):
Protein DCRR1
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3
Short name:
TPR repeat protein 3
Gene namesi
Name:TTC3
Synonyms:DCRR1, RNF105, TPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:12393. TTC3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi378S → A: Abolishes phosphorylation by Akt and impairs ubiquitin ligase activity on Akt. 1 Publication1

Organism-specific databases

DisGeNETi7267.
OpenTargetsiENSG00000182670.
PharmGKBiPA37058.

Polymorphism and mutation databases

BioMutaiTTC3.
DMDMi313104040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063781 – 2025E3 ubiquitin-protein ligase TTC3Add BLAST2025

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei378Phosphoserine; by PKB/AKT21 Publication1
Modified residuei1009PhosphoserineBy similarity1
Modified residuei1061PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP53804.
MaxQBiP53804.
PaxDbiP53804.
PeptideAtlasiP53804.
PRIDEiP53804.

PTM databases

iPTMnetiP53804.
PhosphoSitePlusiP53804.

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

BgeeiENSG00000182670.
CleanExiHS_TTC3.
ExpressionAtlasiP53804. baseline and differential.
GenevisibleiP53804. HS.

Organism-specific databases

HPAiHPA016810.
HPA023964.
HPA036304.

Interactioni

Subunit structurei

Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.2 Publications

Protein-protein interaction databases

BioGridi113118. 26 interactors.
IntActiP53804. 26 interactors.
MINTiMINT-1181179.
STRINGi9606.ENSP00000346791.

Structurei

3D structure databases

ProteinModelPortaliP53804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati231 – 264TPR 1Add BLAST34
Repeati266 – 298TPR 2Add BLAST33
Repeati536 – 572TPR 3Add BLAST37
Repeati576 – 609TPR 4Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi453 – 456Poly-Ser4
Compositional biasi1018 – 1029Arg/Lys-rich (basic)Add BLAST12
Compositional biasi1020 – 1029Poly-Lys10
Compositional biasi1172 – 1185Arg/Lys-rich (basic)Add BLAST14
Compositional biasi1563 – 1579Arg/Lys-rich (basic)Add BLAST17
Compositional biasi1899 – 1902Poly-Lys4

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 4 TPR repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1957 – 1997RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410JR26. Eukaryota.
ENOG41103HK. LUCA.
GeneTreeiENSGT00530000063254.
HOVERGENiHBG007494.
InParanoidiP53804.
KOiK15712.
OMAiSCQFLDD.
OrthoDBiEOG091G00EM.
PhylomeDBiP53804.
TreeFamiTF333981.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform TPRDI (identifier: P53804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV
60 70 80 90 100
QYKDYIQSER NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS
110 120 130 140 150
SVISRLHPCV DANNSRASEI NLKKLQHLEL MEDIVDLAKK VANDSFLIGG
160 170 180 190 200
LLRIGCKIEN KILAMEEALN WIKYAGDVTI LTKLGSIDNC WPMLSIFFTE
210 220 230 240 250
YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE EFSKERFDIA
260 270 280 290 300
IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK
310 320 330 340 350
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI
360 370 380 390 400
EDLQGRTANK DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH
410 420 430 440 450
EMANGGNQNL KVADEALKVD DCDCHPEFSP PSSQPPKHKG KQKSRNNESE
460 470 480 490 500
KFSSSSPLTL PADLKNILEK QFSKSSRAAH QDFANIMKML RSLIQDGYMA
510 520 530 540 550
LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAISLLGIG
560 570 580 590 600
QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE
610 620 630 640 650
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI
660 670 680 690 700
CCYQKCHGYS KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF
710 720 730 740 750
NDKIDKDFLQ GICLTPDCEG VISKIIIFSS GGEVKCEFEH KVIKEKVPPR
760 770 780 790 800
PILKQKCSSL EKLRLKEDKK LKRKIQKKEA KKLAQERMEE DLRESNPPKN
810 820 830 840 850
EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM LLKELLSWKV
860 870 880 890 900
LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE
910 920 930 940 950
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD
960 970 980 990 1000
SIEGKQLDYF SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR
1010 1020 1030 1040 1050
CTVLRKQDSG EAPFSSTKVK NKSKKKKPKD SKPMLVGSGT TSVTSNNEII
1060 1070 1080 1090 1100
TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF EALYDQHSNE YVVRNKKLWD
1110 1120 1130 1140 1150
MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE ETRQILEKAG
1160 1170 1180 1190 1200
GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY
1210 1220 1230 1240 1250
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE
1260 1270 1280 1290 1300
DVKAKPVSDN SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL
1310 1320 1330 1340 1350
EDVKPTYWAQ SHLVTGYCTY LPFQRFDITQ TPPAYINVLP GLPQYTSIYT
1360 1370 1380 1390 1400
PLASLSPEYQ LPRSVPVVPS FVANDRADKN AAAYFEGHHL NAENVAGHQI
1410 1420 1430 1440 1450
ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN SNNKCEVIPE
1460 1470 1480 1490 1500
STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ
1510 1520 1530 1540 1550
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ
1560 1570 1580 1590 1600
DLEREIKKWQ QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL
1610 1620 1630 1640 1650
HLDQSLEISN TLTNEKMKIE EYIKKGKEDY EESHQRAVAA EVSVLENWKE
1660 1670 1680 1690 1700
SEVYKLQIME SQAEAFLKKL GLISRDPAAY PDMESDIRSW ELFLSNVTKE
1710 1720 1730 1740 1750
IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV HPELLPESSG
1760 1770 1780 1790 1800
DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE
1810 1820 1830 1840 1850
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH
1860 1870 1880 1890 1900
LSVVFPCYNS TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK
1910 1920 1930 1940 1950
KKPNPGKDKR TYEPSSATPV TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI
1960 1970 1980 1990 2000
ALGASSCEIC HEVFKSKNVR VLKCGHKYHK GCFKQWLKGQ SACPACQGRD
2010 2020
LLTEESPSGR GWPSQNQELP SCSSR
Length:2,025
Mass (Da):229,869
Last modified:November 30, 2010 - v2
Checksum:iC80BC8E1970B6725
GO
Isoform TPRDII (identifier: P53804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:1,792
Mass (Da):203,189
Checksum:iCCF6AE90171F496F
GO
Isoform TPRDIII (identifier: P53804-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Show »
Length:1,715
Mass (Da):194,059
Checksum:i443B4C9A7FD955B2
GO

Sequence cautioni

The sequence AAH63033 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH92466 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9F → Y in AAH92466 (PubMed:15489334).Curated1
Sequence conflicti121N → D in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti139K → R in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti232E → G in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti276L → P in CAA05057 (PubMed:9503011).Curated1
Sequence conflicti437K → Q in AAH63033 (PubMed:15489334).Curated1
Sequence conflicti495Q → P in BAA23666 (PubMed:9254009).Curated1
Sequence conflicti1700E → V in BAA23666 (PubMed:9254009).Curated1
Sequence conflicti1822A → T in BAA23666 (PubMed:9254009).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020312840M → T.1 PublicationCorresponds to variant rs1053808dbSNPEnsembl.1
Natural variantiVAR_0444281154P → S.Corresponds to variant rs1053840dbSNPEnsembl.1
Natural variantiVAR_0358681289K → M in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0246761751D → H.2 PublicationsCorresponds to variant rs1053966dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065551 – 310Missing in isoform TPRDIII. 1 PublicationAdd BLAST310
Alternative sequenceiVSP_0065541 – 233Missing in isoform TPRDII. 1 PublicationAdd BLAST233

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83077 mRNA. Translation: BAA11769.1.
D84294 mRNA. Translation: BAA12301.1.
D84295 mRNA. Translation: BAA12302.1.
D84296 mRNA. Translation: BAA12303.1.
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1.
CH471079 Genomic DNA. Translation: EAX09717.1.
CH471079 Genomic DNA. Translation: EAX09718.1.
CH471079 Genomic DNA. Translation: EAX09719.1.
CH471079 Genomic DNA. Translation: EAX09720.1.
CH471079 Genomic DNA. Translation: EAX09721.1.
CH471079 Genomic DNA. Translation: EAX09722.1.
CH471079 Genomic DNA. Translation: EAX09723.1.
BC063033 mRNA. Translation: AAH63033.1. Sequence problems.
BC092466 mRNA. Translation: AAH92466.1. Sequence problems.
BC137345 mRNA. Translation: AAI37346.1.
AK291992 mRNA. Translation: BAF84681.1.
D83327 mRNA. Translation: BAA23666.1.
AJ001866 mRNA. Translation: CAA05057.1.
CCDSiCCDS13651.1. [P53804-1]
PIRiJC5020.
RefSeqiNP_001001894.1. NM_001001894.2. [P53804-1]
NP_001307633.1. NM_001320704.1.
NP_001317610.1. NM_001330681.1.
NP_001317611.1. NM_001330682.1.
NP_001317612.1. NM_001330683.1.
NP_003307.3. NM_003316.3. [P53804-1]
XP_011528042.1. XM_011529740.2. [P53804-2]
UniGeneiHs.368214.

Genome annotation databases

EnsembliENST00000354749; ENSP00000346791; ENSG00000182670. [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670. [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670. [P53804-1]
GeneIDi7267.
KEGGihsa:7267.
UCSCiuc002yvz.4. human. [P53804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83077 mRNA. Translation: BAA11769.1.
D84294 mRNA. Translation: BAA12301.1.
D84295 mRNA. Translation: BAA12302.1.
D84296 mRNA. Translation: BAA12303.1.
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1.
CH471079 Genomic DNA. Translation: EAX09717.1.
CH471079 Genomic DNA. Translation: EAX09718.1.
CH471079 Genomic DNA. Translation: EAX09719.1.
CH471079 Genomic DNA. Translation: EAX09720.1.
CH471079 Genomic DNA. Translation: EAX09721.1.
CH471079 Genomic DNA. Translation: EAX09722.1.
CH471079 Genomic DNA. Translation: EAX09723.1.
BC063033 mRNA. Translation: AAH63033.1. Sequence problems.
BC092466 mRNA. Translation: AAH92466.1. Sequence problems.
BC137345 mRNA. Translation: AAI37346.1.
AK291992 mRNA. Translation: BAF84681.1.
D83327 mRNA. Translation: BAA23666.1.
AJ001866 mRNA. Translation: CAA05057.1.
CCDSiCCDS13651.1. [P53804-1]
PIRiJC5020.
RefSeqiNP_001001894.1. NM_001001894.2. [P53804-1]
NP_001307633.1. NM_001320704.1.
NP_001317610.1. NM_001330681.1.
NP_001317611.1. NM_001330682.1.
NP_001317612.1. NM_001330683.1.
NP_003307.3. NM_003316.3. [P53804-1]
XP_011528042.1. XM_011529740.2. [P53804-2]
UniGeneiHs.368214.

3D structure databases

ProteinModelPortaliP53804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113118. 26 interactors.
IntActiP53804. 26 interactors.
MINTiMINT-1181179.
STRINGi9606.ENSP00000346791.

PTM databases

iPTMnetiP53804.
PhosphoSitePlusiP53804.

Polymorphism and mutation databases

BioMutaiTTC3.
DMDMi313104040.

Proteomic databases

EPDiP53804.
MaxQBiP53804.
PaxDbiP53804.
PeptideAtlasiP53804.
PRIDEiP53804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354749; ENSP00000346791; ENSG00000182670. [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670. [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670. [P53804-1]
GeneIDi7267.
KEGGihsa:7267.
UCSCiuc002yvz.4. human. [P53804-1]

Organism-specific databases

CTDi7267.
DisGeNETi7267.
GeneCardsiTTC3.
H-InvDBHIX0027791.
HIX0041033.
HIX0148527.
HGNCiHGNC:12393. TTC3.
HPAiHPA016810.
HPA023964.
HPA036304.
MIMi602259. gene.
neXtProtiNX_P53804.
OpenTargetsiENSG00000182670.
PharmGKBiPA37058.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JR26. Eukaryota.
ENOG41103HK. LUCA.
GeneTreeiENSGT00530000063254.
HOVERGENiHBG007494.
InParanoidiP53804.
KOiK15712.
OMAiSCQFLDD.
OrthoDBiEOG091G00EM.
PhylomeDBiP53804.
TreeFamiTF333981.

Enzyme and pathway databases

UniPathwayiUPA00143.
SIGNORiP53804.

Miscellaneous databases

ChiTaRSiTTC3. human.
GeneWikiiTTC3.
GenomeRNAii7267.
PROiP53804.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182670.
CleanExiHS_TTC3.
ExpressionAtlasiP53804. baseline and differential.
GenevisibleiP53804. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC3_HUMAN
AccessioniPrimary (citable) accession number: P53804
Secondary accession number(s): A8K7H7
, B2RPA7, D3DSG9, D3DSH2, D3DSH3, O60767, P78476, P78477, Q569I2, Q6P578, Q9UEK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.