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P53804 (TTC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
E3 ubiquitin-protein ligase TTC3

EC=6.3.2.-
Alternative name(s):
Protein DCRR1
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3
Short name=TPR repeat protein 3
Gene names
Name:TTC3
Synonyms:DCRR1, RNF105, TPRD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2025 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. Ref.9 Ref.10

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT. Ref.9 Ref.10

Subcellular location

Nucleus Ref.10.

Tissue specificity

Found in all tissues examined.

Post-translational modification

Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.

Sequence similarities

Contains 1 RING-type zinc finger.

Contains 4 TPR repeats.

Sequence caution

The sequence AAH63033.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH92466.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform TPRDI (identifier: P53804-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform TPRDII (identifier: P53804-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.
Isoform TPRDIII (identifier: P53804-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20252025E3 ubiquitin-protein ligase TTC3
PRO_0000106378

Regions

Repeat231 – 26434TPR 1
Repeat266 – 29833TPR 2
Repeat536 – 57237TPR 3
Repeat576 – 60934TPR 4
Zinc finger1957 – 199741RING-type
Compositional bias453 – 4564Poly-Ser
Compositional bias1018 – 102912Arg/Lys-rich (basic)
Compositional bias1020 – 102910Poly-Lys
Compositional bias1172 – 118514Arg/Lys-rich (basic)
Compositional bias1563 – 157917Arg/Lys-rich (basic)
Compositional bias1899 – 19024Poly-Lys

Amino acid modifications

Modified residue3781Phosphoserine; by PKB/AKT2 Ref.10

Natural variations

Alternative sequence1 – 310310Missing in isoform TPRDIII.
VSP_006555
Alternative sequence1 – 233233Missing in isoform TPRDII.
VSP_006554
Natural variant8401M → T. Ref.7
Corresponds to variant rs1053808 [ dbSNP | Ensembl ].
VAR_020312
Natural variant10631S → T.
Corresponds to variant rs1133021 [ dbSNP | Ensembl ].
VAR_044426
Natural variant11171F → L.
Corresponds to variant rs1133022 [ dbSNP | Ensembl ].
VAR_014491
Natural variant11281N → H.
Corresponds to variant rs1053833 [ dbSNP | Ensembl ].
VAR_044427
Natural variant11541P → S.
Corresponds to variant rs1053840 [ dbSNP | Ensembl ].
VAR_044428
Natural variant12891K → M in a breast cancer sample; somatic mutation. Ref.11
VAR_035868
Natural variant17511D → H. Ref.1 Ref.2
Corresponds to variant rs1053966 [ dbSNP | Ensembl ].
VAR_024676

Experimental info

Mutagenesis3781S → A: Abolishes phosphorylation by Akt and impairs ubiquitin ligase activity on Akt. Ref.10
Sequence conflict91F → Y in AAH92466. Ref.5
Sequence conflict1211N → D in CAA05057. Ref.8
Sequence conflict1391K → R in CAA05057. Ref.8
Sequence conflict2321E → G in CAA05057. Ref.8
Sequence conflict2761L → P in CAA05057. Ref.8
Sequence conflict4371K → Q in AAH63033. Ref.5
Sequence conflict4951Q → P in BAA23666. Ref.7
Sequence conflict17001E → V in BAA23666. Ref.7
Sequence conflict18221A → T in BAA23666. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Isoform TPRDI [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: C80BC8E1970B6725

FASTA2,025229,869
        10         20         30         40         50         60 
MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV QYKDYIQSER 

        70         80         90        100        110        120 
NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS SVISRLHPCV DANNSRASEI 

       130        140        150        160        170        180 
NLKKLQHLEL MEDIVDLAKK VANDSFLIGG LLRIGCKIEN KILAMEEALN WIKYAGDVTI 

       190        200        210        220        230        240 
LTKLGSIDNC WPMLSIFFTE YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE 

       250        260        270        280        290        300 
EFSKERFDIA IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 

       310        320        330        340        350        360 
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI EDLQGRTANK 

       370        380        390        400        410        420 
DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH EMANGGNQNL KVADEALKVD 

       430        440        450        460        470        480 
DCDCHPEFSP PSSQPPKHKG KQKSRNNESE KFSSSSPLTL PADLKNILEK QFSKSSRAAH 

       490        500        510        520        530        540 
QDFANIMKML RSLIQDGYMA LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY 

       550        560        570        580        590        600 
GLAISLLGIG QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 

       610        620        630        640        650        660 
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI CCYQKCHGYS 

       670        680        690        700        710        720 
KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF NDKIDKDFLQ GICLTPDCEG 

       730        740        750        760        770        780 
VISKIIIFSS GGEVKCEFEH KVIKEKVPPR PILKQKCSSL EKLRLKEDKK LKRKIQKKEA 

       790        800        810        820        830        840 
KKLAQERMEE DLRESNPPKN EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM 

       850        860        870        880        890        900 
LLKELLSWKV LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 

       910        920        930        940        950        960 
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD SIEGKQLDYF 

       970        980        990       1000       1010       1020 
SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR CTVLRKQDSG EAPFSSTKVK 

      1030       1040       1050       1060       1070       1080 
NKSKKKKPKD SKPMLVGSGT TSVTSNNEII TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF 

      1090       1100       1110       1120       1130       1140 
EALYDQHSNE YVVRNKKLWD MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE 

      1150       1160       1170       1180       1190       1200 
ETRQILEKAG GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY 

      1210       1220       1230       1240       1250       1260 
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE DVKAKPVSDN 

      1270       1280       1290       1300       1310       1320 
SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL EDVKPTYWAQ SHLVTGYCTY 

      1330       1340       1350       1360       1370       1380 
LPFQRFDITQ TPPAYINVLP GLPQYTSIYT PLASLSPEYQ LPRSVPVVPS FVANDRADKN 

      1390       1400       1410       1420       1430       1440 
AAAYFEGHHL NAENVAGHQI ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN 

      1450       1460       1470       1480       1490       1500 
SNNKCEVIPE STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ 

      1510       1520       1530       1540       1550       1560 
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ DLEREIKKWQ 

      1570       1580       1590       1600       1610       1620 
QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL HLDQSLEISN TLTNEKMKIE 

      1630       1640       1650       1660       1670       1680 
EYIKKGKEDY EESHQRAVAA EVSVLENWKE SEVYKLQIME SQAEAFLKKL GLISRDPAAY 

      1690       1700       1710       1720       1730       1740 
PDMESDIRSW ELFLSNVTKE IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV 

      1750       1760       1770       1780       1790       1800 
HPELLPESSG DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE 

      1810       1820       1830       1840       1850       1860 
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH LSVVFPCYNS 

      1870       1880       1890       1900       1910       1920 
TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK KKPNPGKDKR TYEPSSATPV 

      1930       1940       1950       1960       1970       1980 
TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI ALGASSCEIC HEVFKSKNVR VLKCGHKYHK 

      1990       2000       2010       2020 
GCFKQWLKGQ SACPACQGRD LLTEESPSGR GWPSQNQELP SCSSR 

« Hide

Isoform TPRDII [UniParc].

Checksum: CCF6AE90171F496F
Show »

FASTA1,792203,189
Isoform TPRDIII [UniParc].

Checksum: 443B4C9A7FD955B2
Show »

FASTA1,715194,059

References

« Hide 'large scale' references
[1]"Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21."
Ohira M., Ootsuyama A., Suzuki E., Ichikawa H., Seki N., Nagase T., Nomura N., Ohki M.
DNA Res. 3:9-16(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TPRDI), VARIANT HIS-1751.
Tissue: Brain.
[2]"Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2."
Tsukahara F., Hattori M., Muraki T., Sakaki Y.
J. Biochem. 120:820-827(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TPRDI; TPRDII AND TPRDIII), VARIANT HIS-1751.
Tissue: Fetal brain and Placenta.
[3]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM TPRDI).
Tissue: Testis.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-627 (ISOFORM TPRDI).
Tissue: Small intestine.
[7]"Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2."
Eki T., Abe M., Naitou M., Sasanuma S.I., Nohata J., Kawashima K., Ahmad I., Hanaoka F., Murakami Y.
DNA Seq. 7:153-164(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-2025 (ISOFORM TPRDI), VARIANT THR-840.
[8]"Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome."
Dahmane N., Ait-Ghezala G., Gosset P., Chamoun Z., Dufresne-Zacharia M.-C., Lopes C., Rabatel N., Gassanova-Maugenre S., Chettouh Z., Abramowski V., Fayet E., Yaspo M.-L., Korn B., Blouin J.-L., Lehrach H., Poustka A., Antonarakis S.E., Sinet P.-M., Creau N., Delabar J.-M.
Genomics 48:12-23(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-616 (ISOFORM TPRDI).
Tissue: Fetal brain.
[9]"The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase."
Berto G., Camera P., Fusco C., Imarisio S., Ambrogio C., Chiarle R., Silengo L., Di Cunto F.
J. Cell Sci. 120:1859-1867(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CIT.
[10]"The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt."
Suizu F., Hiramuki Y., Okumura F., Matsuda M., Okumura A.J., Hirata N., Narita M., Kohno T., Yokota J., Bohgaki M., Obuse C., Hatakeyama S., Obata T., Noguchi M.
Dev. Cell 17:800-810(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1; AKT2 AND AKT3, PHOSPHORYLATION AT SER-378, MUTAGENESIS OF SER-378.
[11]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-1289.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83077 mRNA. Translation: BAA11769.1.
D84294 mRNA. Translation: BAA12301.1.
D84295 mRNA. Translation: BAA12302.1.
D84296 mRNA. Translation: BAA12303.1.
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1.
CH471079 Genomic DNA. Translation: EAX09717.1.
CH471079 Genomic DNA. Translation: EAX09718.1.
CH471079 Genomic DNA. Translation: EAX09719.1.
CH471079 Genomic DNA. Translation: EAX09720.1.
CH471079 Genomic DNA. Translation: EAX09721.1.
CH471079 Genomic DNA. Translation: EAX09722.1.
CH471079 Genomic DNA. Translation: EAX09723.1.
BC063033 mRNA. Translation: AAH63033.1. Sequence problems.
BC092466 mRNA. Translation: AAH92466.1. Sequence problems.
BC137345 mRNA. Translation: AAI37346.1.
AK291992 mRNA. Translation: BAF84681.1.
D83327 mRNA. Translation: BAA23666.1.
AJ001866 mRNA. Translation: CAA05057.1.
PIRJC5020.
RefSeqNP_001001894.1. NM_001001894.1.
NP_003307.3. NM_003316.3.
UniGeneHs.368214.

3D structure databases

ProteinModelPortalP53804.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113118. 7 interactions.
IntActP53804. 8 interactions.
MINTMINT-1181179.

PTM databases

PhosphoSiteP53804.

Polymorphism databases

DMDM313104040.

Proteomic databases

PaxDbP53804.
PRIDEP53804.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354749; ENSP00000346791; ENSG00000182670. [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670. [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670. [P53804-1]
GeneID7267.
KEGGhsa:7267.
UCSCuc002yvz.3. human. [P53804-1]

Organism-specific databases

CTD7267.
GeneCardsGC21P038445.
H-InvDBHIX0027791.
HIX0041033.
HIX0148527.
HGNCHGNC:12393. TTC3.
HPAHPA016810.
HPA023964.
MIM602259. gene.
neXtProtNX_P53804.
PharmGKBPA37058.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248683.
HOVERGENHBG007494.
InParanoidP53804.
KOK15712.
OMADCEGIIS.
PhylomeDBP53804.
TreeFamTF333981.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressP53804.
BgeeP53804.
CleanExHS_TTC3.
GenevestigatorP53804.

Family and domain databases

Gene3D1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00515. TPR_1. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTTC3. human.
GeneWikiTTC3.
GenomeRNAi7267.
NextBio28411.
PROP53804.
SOURCESearch...

Entry information

Entry nameTTC3_HUMAN
AccessionPrimary (citable) accession number: P53804
Secondary accession number(s): A8K7H7 expand/collapse secondary AC list , B2RPA7, D3DSG9, D3DSH2, D3DSH3, O60767, P78476, P78477, Q569I2, Q6P578, Q9UEK4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM