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P53804

- TTC3_HUMAN

UniProt

P53804 - TTC3_HUMAN

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Protein
E3 ubiquitin-protein ligase TTC3
Gene
TTC3, DCRR1, RNF105, TPRD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1957 – 199741RING-type
Add
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. ubiquitin-protein transferase activity Source: UniProtKB
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. negative regulation of cell morphogenesis involved in differentiation Source: Ensembl
  2. negative regulation of neuron differentiation Source: Ensembl
  3. protein K48-linked ubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TTC3 (EC:6.3.2.-)
Alternative name(s):
Protein DCRR1
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3
Short name:
TPR repeat protein 3
Gene namesi
Name:TTC3
Synonyms:DCRR1, RNF105, TPRD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:12393. TTC3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: UniProtKB
  3. vacuole Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi378 – 3781S → A: Abolishes phosphorylation by Akt and impairs ubiquitin ligase activity on Akt. 1 Publication

Organism-specific databases

PharmGKBiPA37058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20252025E3 ubiquitin-protein ligase TTC3
PRO_0000106378Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei378 – 3781Phosphoserine; by PKB/AKT21 Publication

Post-translational modificationi

Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53804.
PaxDbiP53804.
PRIDEiP53804.

PTM databases

PhosphoSiteiP53804.

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

ArrayExpressiP53804.
BgeeiP53804.
CleanExiHS_TTC3.
GenevestigatoriP53804.

Organism-specific databases

HPAiHPA016810.
HPA023964.

Interactioni

Subunit structurei

Interacts (when phosphorylated on Ser-378) with AKT1, AKT2 and AKT3 (when phosphorylated). Interacts with CIT.2 Publications

Protein-protein interaction databases

BioGridi113118. 7 interactions.
IntActiP53804. 8 interactions.
MINTiMINT-1181179.

Structurei

3D structure databases

ProteinModelPortaliP53804.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati231 – 26434TPR 1
Add
BLAST
Repeati266 – 29833TPR 2
Add
BLAST
Repeati536 – 57237TPR 3
Add
BLAST
Repeati576 – 60934TPR 4
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi453 – 4564Poly-Ser
Compositional biasi1018 – 102912Arg/Lys-rich (basic)
Add
BLAST
Compositional biasi1020 – 102910Poly-Lys
Compositional biasi1172 – 118514Arg/Lys-rich (basic)
Add
BLAST
Compositional biasi1563 – 157917Arg/Lys-rich (basic)
Add
BLAST
Compositional biasi1899 – 19024Poly-Lys

Sequence similaritiesi

Contains 4 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG248683.
HOVERGENiHBG007494.
InParanoidiP53804.
KOiK15712.
OMAiDCEGIIS.
PhylomeDBiP53804.
TreeFamiTF333981.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform TPRDI (identifier: P53804-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDNFAEGDFT VADYALLEDC PHVDDCVFAA EFMSNDYVRV TQLYCDGVGV     50
QYKDYIQSER NLEFDICSIW CSKPISVLQD YCDAIKINIF WPLLFQHQNS 100
SVISRLHPCV DANNSRASEI NLKKLQHLEL MEDIVDLAKK VANDSFLIGG 150
LLRIGCKIEN KILAMEEALN WIKYAGDVTI LTKLGSIDNC WPMLSIFFTE 200
YKYHITKIVM EDCNLLEELK TQSCMDCIEE GELMKMKGNE EFSKERFDIA 250
IIYYTRAIEY RPENYLLYGN RALCFLRTGQ FRNALGDGKR ATILKNTWPK 300
GHYRYCDALS MLGEYDWALQ ANIKAQKLCK NDPEGIKDLI QQHVKLQKQI 350
EDLQGRTANK DPIKAFYENR AYTPRSLSAP IFTTSLNFVE KERDFRKINH 400
EMANGGNQNL KVADEALKVD DCDCHPEFSP PSSQPPKHKG KQKSRNNESE 450
KFSSSSPLTL PADLKNILEK QFSKSSRAAH QDFANIMKML RSLIQDGYMA 500
LLEQRCRSAA QAFTELLNGL DPQKIKQLNL AMINYVLVVY GLAISLLGIG 550
QPEELSEAEN QFKRIIEHYP SEGLDCLAYC GIGKVYLKKN RFLEALNHFE 600
KARTLIYRLP GVLTWPTSNV IIEESQPQKI KMLLEKFVEE CKFPPVPDAI 650
CCYQKCHGYS KIQIYITDPD FKGFIRISCC QYCKIEFHMN CWKKLKTTTF 700
NDKIDKDFLQ GICLTPDCEG VISKIIIFSS GGEVKCEFEH KVIKEKVPPR 750
PILKQKCSSL EKLRLKEDKK LKRKIQKKEA KKLAQERMEE DLRESNPPKN 800
EEQKETVDNV QRCQFLDDRI LQCIKQYADK IKSGIQNTAM LLKELLSWKV 850
LSTEDYTTCF SSRNFLNEAV DYVIRHLIQE NNRVKTRIFL HVLSELKEVE 900
PKLAAWIQKL NSFGLDATGT FFSRYGASLK LLDFSIMTFL WNEKYGHKLD 950
SIEGKQLDYF SEPASLKEAR CLIWLLEEHR DKFPALHSAL DEFFDIMDSR 1000
CTVLRKQDSG EAPFSSTKVK NKSKKKKPKD SKPMLVGSGT TSVTSNNEII 1050
TSSEDHSNRN SDSAGPFAVP DHLRQDVEEF EALYDQHSNE YVVRNKKLWD 1100
MNPKQKCSTL YDYFSQFLEE HGPLDMSNKM FSAEYEFFPE ETRQILEKAG 1150
GLKPFLLGCP RFVVIDNCIA LKKVASRLKK KRKKKNIKTK VEEISKAGEY 1200
VRVKLQLNPA AREFKPDVKS KPVSDSSSAP AFENVKPKPV SANSPKPACE 1250
DVKAKPVSDN SSRQVSEDGQ PKGVSSNSPK PGSEDANYKR VSCNSPKPVL 1300
EDVKPTYWAQ SHLVTGYCTY LPFQRFDITQ TPPAYINVLP GLPQYTSIYT 1350
PLASLSPEYQ LPRSVPVVPS FVANDRADKN AAAYFEGHHL NAENVAGHQI 1400
ASETQILEGS LGISVKSHCS TGDAHTVLSE SNRNDEHCGN SNNKCEVIPE 1450
STSAVTNIPH VQMVAIQVSW NIIHQEVNTE PYNPFEERQG EISRIEKEHQ 1500
VLQDQLQEVY ENYEQIKLKG LEETRDLEEK LKRHLEENKI SKTELDWFLQ 1550
DLEREIKKWQ QEKKEIQERL KSLKKKIKKV SNASEMYTQK NDGKEKEHEL 1600
HLDQSLEISN TLTNEKMKIE EYIKKGKEDY EESHQRAVAA EVSVLENWKE 1650
SEVYKLQIME SQAEAFLKKL GLISRDPAAY PDMESDIRSW ELFLSNVTKE 1700
IEKAKSQFEE QIKAIKNGSR LSELSKVQIS ELSFPACNTV HPELLPESSG 1750
DDGQGLVTSA SDVTGNHAAL HRDPSVFSAG DSPGEAPSAL LPGPPPGQPE 1800
ATQLTGPKRA GQAALSERSP VADRKQPVPP GRAARSSQSP KKPFNSIIEH 1850
LSVVFPCYNS TELAGFIKKV RSKNKNSLSG LSIDEIVQRV TEHILDEQKK 1900
KKPNPGKDKR TYEPSSATPV TRSSQGSPSV VVAPSPKTKG QKAEDVPVRI 1950
ALGASSCEIC HEVFKSKNVR VLKCGHKYHK GCFKQWLKGQ SACPACQGRD 2000
LLTEESPSGR GWPSQNQELP SCSSR 2025
Length:2,025
Mass (Da):229,869
Last modified:November 30, 2010 - v2
Checksum:iC80BC8E1970B6725
GO
Isoform TPRDII (identifier: P53804-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.

Show »
Length:1,792
Mass (Da):203,189
Checksum:iCCF6AE90171F496F
GO
Isoform TPRDIII (identifier: P53804-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Show »
Length:1,715
Mass (Da):194,059
Checksum:i443B4C9A7FD955B2
GO

Sequence cautioni

The sequence AAH63033.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH92466.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti840 – 8401M → T.1 Publication
Corresponds to variant rs1053808 [ dbSNP | Ensembl ].
VAR_020312
Natural varianti1063 – 10631S → T.
Corresponds to variant rs1133021 [ dbSNP | Ensembl ].
VAR_044426
Natural varianti1117 – 11171F → L.
Corresponds to variant rs1133022 [ dbSNP | Ensembl ].
VAR_014491
Natural varianti1128 – 11281N → H.
Corresponds to variant rs1053833 [ dbSNP | Ensembl ].
VAR_044427
Natural varianti1154 – 11541P → S.
Corresponds to variant rs1053840 [ dbSNP | Ensembl ].
VAR_044428
Natural varianti1289 – 12891K → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_035868
Natural varianti1751 – 17511D → H.2 Publications
Corresponds to variant rs1053966 [ dbSNP | Ensembl ].
VAR_024676

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 310310Missing in isoform TPRDIII.
VSP_006555Add
BLAST
Alternative sequencei1 – 233233Missing in isoform TPRDII.
VSP_006554Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91F → Y in AAH92466. 1 Publication
Sequence conflicti121 – 1211N → D in CAA05057. 1 Publication
Sequence conflicti139 – 1391K → R in CAA05057. 1 Publication
Sequence conflicti232 – 2321E → G in CAA05057. 1 Publication
Sequence conflicti276 – 2761L → P in CAA05057. 1 Publication
Sequence conflicti437 – 4371K → Q in AAH63033. 1 Publication
Sequence conflicti495 – 4951Q → P in BAA23666. 1 Publication
Sequence conflicti1700 – 17001E → V in BAA23666. 1 Publication
Sequence conflicti1822 – 18221A → T in BAA23666. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83077 mRNA. Translation: BAA11769.1.
D84294 mRNA. Translation: BAA12301.1.
D84295 mRNA. Translation: BAA12302.1.
D84296 mRNA. Translation: BAA12303.1.
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1.
CH471079 Genomic DNA. Translation: EAX09717.1.
CH471079 Genomic DNA. Translation: EAX09718.1.
CH471079 Genomic DNA. Translation: EAX09719.1.
CH471079 Genomic DNA. Translation: EAX09720.1.
CH471079 Genomic DNA. Translation: EAX09721.1.
CH471079 Genomic DNA. Translation: EAX09722.1.
CH471079 Genomic DNA. Translation: EAX09723.1.
BC063033 mRNA. Translation: AAH63033.1. Sequence problems.
BC092466 mRNA. Translation: AAH92466.1. Sequence problems.
BC137345 mRNA. Translation: AAI37346.1.
AK291992 mRNA. Translation: BAF84681.1.
D83327 mRNA. Translation: BAA23666.1.
AJ001866 mRNA. Translation: CAA05057.1.
CCDSiCCDS13651.1. [P53804-1]
PIRiJC5020.
RefSeqiNP_001001894.1. NM_001001894.1. [P53804-1]
NP_003307.3. NM_003316.3. [P53804-1]
UniGeneiHs.368214.

Genome annotation databases

EnsembliENST00000354749; ENSP00000346791; ENSG00000182670. [P53804-1]
ENST00000355666; ENSP00000347889; ENSG00000182670. [P53804-1]
ENST00000399017; ENSP00000381981; ENSG00000182670. [P53804-1]
GeneIDi7267.
KEGGihsa:7267.
UCSCiuc002yvz.3. human. [P53804-1]

Polymorphism databases

DMDMi313104040.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83077 mRNA. Translation: BAA11769.1 .
D84294 mRNA. Translation: BAA12301.1 .
D84295 mRNA. Translation: BAA12302.1 .
D84296 mRNA. Translation: BAA12303.1 .
AP001429 Genomic DNA. No translation available.
AP001432 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09716.1 .
CH471079 Genomic DNA. Translation: EAX09717.1 .
CH471079 Genomic DNA. Translation: EAX09718.1 .
CH471079 Genomic DNA. Translation: EAX09719.1 .
CH471079 Genomic DNA. Translation: EAX09720.1 .
CH471079 Genomic DNA. Translation: EAX09721.1 .
CH471079 Genomic DNA. Translation: EAX09722.1 .
CH471079 Genomic DNA. Translation: EAX09723.1 .
BC063033 mRNA. Translation: AAH63033.1 . Sequence problems.
BC092466 mRNA. Translation: AAH92466.1 . Sequence problems.
BC137345 mRNA. Translation: AAI37346.1 .
AK291992 mRNA. Translation: BAF84681.1 .
D83327 mRNA. Translation: BAA23666.1 .
AJ001866 mRNA. Translation: CAA05057.1 .
CCDSi CCDS13651.1. [P53804-1 ]
PIRi JC5020.
RefSeqi NP_001001894.1. NM_001001894.1. [P53804-1 ]
NP_003307.3. NM_003316.3. [P53804-1 ]
UniGenei Hs.368214.

3D structure databases

ProteinModelPortali P53804.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113118. 7 interactions.
IntActi P53804. 8 interactions.
MINTi MINT-1181179.

PTM databases

PhosphoSitei P53804.

Polymorphism databases

DMDMi 313104040.

Proteomic databases

MaxQBi P53804.
PaxDbi P53804.
PRIDEi P53804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354749 ; ENSP00000346791 ; ENSG00000182670 . [P53804-1 ]
ENST00000355666 ; ENSP00000347889 ; ENSG00000182670 . [P53804-1 ]
ENST00000399017 ; ENSP00000381981 ; ENSG00000182670 . [P53804-1 ]
GeneIDi 7267.
KEGGi hsa:7267.
UCSCi uc002yvz.3. human. [P53804-1 ]

Organism-specific databases

CTDi 7267.
GeneCardsi GC21P038445.
H-InvDB HIX0027791.
HIX0041033.
HIX0148527.
HGNCi HGNC:12393. TTC3.
HPAi HPA016810.
HPA023964.
MIMi 602259. gene.
neXtProti NX_P53804.
PharmGKBi PA37058.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248683.
HOVERGENi HBG007494.
InParanoidi P53804.
KOi K15712.
OMAi DCEGIIS.
PhylomeDBi P53804.
TreeFami TF333981.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi TTC3. human.
GeneWikii TTC3.
GenomeRNAii 7267.
NextBioi 28411.
PROi P53804.
SOURCEi Search...

Gene expression databases

ArrayExpressi P53804.
Bgeei P53804.
CleanExi HS_TTC3.
Genevestigatori P53804.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
3.30.40.10. 1 hit.
InterProi IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00515. TPR_1. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21."
    Ohira M., Ootsuyama A., Suzuki E., Ichikawa H., Seki N., Nagase T., Nomura N., Ohki M.
    DNA Res. 3:9-16(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TPRDI), VARIANT HIS-1751.
    Tissue: Brain.
  2. "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2."
    Tsukahara F., Hattori M., Muraki T., Sakaki Y.
    J. Biochem. 120:820-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TPRDI; TPRDII AND TPRDIII), VARIANT HIS-1751.
    Tissue: Fetal brain and Placenta.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM TPRDI).
    Tissue: Testis.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-627 (ISOFORM TPRDI).
    Tissue: Small intestine.
  7. "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2."
    Eki T., Abe M., Naitou M., Sasanuma S.I., Nohata J., Kawashima K., Ahmad I., Hanaoka F., Murakami Y.
    DNA Seq. 7:153-164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-2025 (ISOFORM TPRDI), VARIANT THR-840.
  8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-616 (ISOFORM TPRDI).
    Tissue: Fetal brain.
  9. "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase."
    Berto G., Camera P., Fusco C., Imarisio S., Ambrogio C., Chiarle R., Silengo L., Di Cunto F.
    J. Cell Sci. 120:1859-1867(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CIT.
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AKT1; AKT2 AND AKT3, PHOSPHORYLATION AT SER-378, MUTAGENESIS OF SER-378.
  11. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-1289.

Entry informationi

Entry nameiTTC3_HUMAN
AccessioniPrimary (citable) accession number: P53804
Secondary accession number(s): A8K7H7
, B2RPA7, D3DSG9, D3DSH2, D3DSH3, O60767, P78476, P78477, Q569I2, Q6P578, Q9UEK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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