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P53801

- PTTG_HUMAN

UniProt

P53801 - PTTG_HUMAN

Protein

Pituitary tumor-transforming gene 1 protein-interacting protein

Gene

PTTG1IP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May facilitate PTTG1 nuclear translocation.

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: InterPro
    2. protein import into nucleus Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary tumor-transforming gene 1 protein-interacting protein
    Alternative name(s):
    Pituitary tumor-transforming gene protein-binding factor
    Short name:
    PBF
    Short name:
    PTTG-binding factor
    Gene namesi
    Name:PTTG1IP
    Synonyms:C21orf1, C21orf3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:13524. PTTG1IP.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: According to PubMed:10781616, it is found in the cytoplasm and the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34034.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 180148Pituitary tumor-transforming gene 1 protein-interacting proteinPRO_0000022184Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Modified residuei174 – 1741PhosphotyrosineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP53801.
    PaxDbiP53801.
    PRIDEiP53801.

    PTM databases

    PhosphoSiteiP53801.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Inductioni

    By transcription factor RUNX2.1 Publication

    Gene expression databases

    ArrayExpressiP53801.
    BgeeiP53801.
    CleanExiHS_PTTG1IP.
    GenevestigatoriP53801.

    Organism-specific databases

    HPAiCAB034146.

    Interactioni

    Subunit structurei

    Interacts with PTTG1.1 Publication

    Protein-protein interaction databases

    BioGridi107210. 5 interactions.
    IntActiP53801. 1 interaction.
    STRINGi9606.ENSP00000328325.

    Structurei

    3D structure databases

    ProteinModelPortaliP53801.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 9664ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 18063CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 9254PSIAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili130 – 16536Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi116 – 1216Poly-Cys

    Sequence similaritiesi

    Contains 1 PSI domain.Curated

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45904.
    HOGENOMiHOG000015370.
    HOVERGENiHBG000902.
    InParanoidiP53801.
    OMAiLDYPVTK.
    PhylomeDBiP53801.
    TreeFamiTF329310.

    Family and domain databases

    InterProiIPR016201. Plexin-like_fold.
    [Graphical view]
    SMARTiSM00423. PSI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53801-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE    50
    CLKNVSCLWC NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII 100
    TMSVVGGTLL LGIAICCCCC CRRKRSRKPD RSEEKAMRER EERRIRQEER 150
    RAEMKTRHDE IRKKYGLFKE ENPYARFENN 180
    Length:180
    Mass (Da):20,324
    Last modified:October 1, 1996 - v1
    Checksum:iF1E66014D49EC1DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 1911PTPYWRLRLGG → ARRTGGCASV in AAF73770. (PubMed:10781616)CuratedAdd
    BLAST
    Sequence conflicti108 – 1147TLLLGIA → NPPPGHC in AAF73770. (PubMed:10781616)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50022 mRNA. Translation: CAA90325.1.
    AF149785 mRNA. Translation: AAF73770.1.
    AK315626 mRNA. Translation: BAG37994.1.
    AL163300 Genomic DNA. Translation: CAB90552.1.
    CH471079 Genomic DNA. Translation: EAX09386.1.
    CH471079 Genomic DNA. Translation: EAX09388.1.
    BC000415 mRNA. Translation: AAH00415.1.
    BC012858 mRNA. Translation: AAH12858.1.
    BC019295 mRNA. Translation: AAH19295.1.
    BC020983 mRNA. Translation: AAH20983.1.
    BC031097 mRNA. Translation: AAH31097.1.
    BC034250 mRNA. Translation: AAH34250.1.
    CCDSiCCDS13715.1.
    RefSeqiNP_001273751.1. NM_001286822.1.
    NP_004330.1. NM_004339.3.
    UniGeneiHs.474010.

    Genome annotation databases

    EnsembliENST00000330938; ENSP00000328325; ENSG00000183255.
    GeneIDi754.
    KEGGihsa:754.
    UCSCiuc002zgb.2. human.

    Polymorphism databases

    DMDMi1711387.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50022 mRNA. Translation: CAA90325.1 .
    AF149785 mRNA. Translation: AAF73770.1 .
    AK315626 mRNA. Translation: BAG37994.1 .
    AL163300 Genomic DNA. Translation: CAB90552.1 .
    CH471079 Genomic DNA. Translation: EAX09386.1 .
    CH471079 Genomic DNA. Translation: EAX09388.1 .
    BC000415 mRNA. Translation: AAH00415.1 .
    BC012858 mRNA. Translation: AAH12858.1 .
    BC019295 mRNA. Translation: AAH19295.1 .
    BC020983 mRNA. Translation: AAH20983.1 .
    BC031097 mRNA. Translation: AAH31097.1 .
    BC034250 mRNA. Translation: AAH34250.1 .
    CCDSi CCDS13715.1.
    RefSeqi NP_001273751.1. NM_001286822.1.
    NP_004330.1. NM_004339.3.
    UniGenei Hs.474010.

    3D structure databases

    ProteinModelPortali P53801.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107210. 5 interactions.
    IntActi P53801. 1 interaction.
    STRINGi 9606.ENSP00000328325.

    PTM databases

    PhosphoSitei P53801.

    Polymorphism databases

    DMDMi 1711387.

    Proteomic databases

    MaxQBi P53801.
    PaxDbi P53801.
    PRIDEi P53801.

    Protocols and materials databases

    DNASUi 754.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330938 ; ENSP00000328325 ; ENSG00000183255 .
    GeneIDi 754.
    KEGGi hsa:754.
    UCSCi uc002zgb.2. human.

    Organism-specific databases

    CTDi 754.
    GeneCardsi GC21M046269.
    HGNCi HGNC:13524. PTTG1IP.
    HPAi CAB034146.
    MIMi 603784. gene.
    neXtProti NX_P53801.
    PharmGKBi PA34034.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45904.
    HOGENOMi HOG000015370.
    HOVERGENi HBG000902.
    InParanoidi P53801.
    OMAi LDYPVTK.
    PhylomeDBi P53801.
    TreeFami TF329310.

    Miscellaneous databases

    ChiTaRSi PTTG1IP. human.
    GeneWikii PTTG1IP.
    GenomeRNAii 754.
    NextBioi 3052.
    PROi P53801.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53801.
    Bgeei P53801.
    CleanExi HS_PTTG1IP.
    Genevestigatori P53801.

    Family and domain databases

    InterProi IPR016201. Plexin-like_fold.
    [Graphical view ]
    SMARTi SM00423. PSI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3."
      Yaspo M.-L., Aaltonen J., Horelli-Kuitunen N., Peltonen L., Lehrach H.
      Genomics 49:133-136(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."
      Chien W., Pei L.
      J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SUBCELLULAR LOCATION, INTERACTION WITH PTTG1.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon, Lung, Muscle and Ovary.
    7. "Identification of novel genes of the bone-specific transcription factor Runx2."
      Stock M., Schafer H., Fliegauf M., Otto F.
      J. Bone Miner. Res. 19:959-972(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiPTTG_HUMAN
    AccessioniPrimary (citable) accession number: P53801
    Secondary accession number(s): B2RDP7, D3DSL9, Q9NS09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3