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P53801 (PTTG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pituitary tumor-transforming gene 1 protein-interacting protein
Alternative name(s):
Pituitary tumor-transforming gene protein-binding factor
Short name=PBF
Short name=PTTG-binding factor
Gene names
Name:PTTG1IP
Synonyms:C21orf1, C21orf3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May facilitate PTTG1 nuclear translocation.

Subunit structure

Interacts with PTTG1. Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein Potential. Cytoplasm. Nucleus. Note: According to Ref.2, it is found in the cytoplasm and the nucleus. Ref.2

Tissue specificity

Ubiquitous.

Induction

By transcription factor RUNX2. Ref.7

Sequence similarities

Contains 1 PSI domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Chain33 – 180148Pituitary tumor-transforming gene 1 protein-interacting protein
PRO_0000022184

Regions

Topological domain33 – 9664Extracellular Potential
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 18063Cytoplasmic Potential
Domain39 – 9254PSI
Coiled coil130 – 16536 Potential
Compositional bias116 – 1216Poly-Cys

Amino acid modifications

Modified residue1741Phosphotyrosine By similarity
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation541N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict9 – 1911PTPYWRLRLGG → ARRTGGCASV in AAF73770. Ref.2
Sequence conflict108 – 1147TLLLGIA → NPPPGHC in AAF73770. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P53801 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: F1E66014D49EC1DE

FASTA18020,324
        10         20         30         40         50         60 
MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSCLWC 

        70         80         90        100        110        120 
NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII TMSVVGGTLL LGIAICCCCC 

       130        140        150        160        170        180 
CRRKRSRKPD RSEEKAMRER EERRIRQEER RAEMKTRHDE IRKKYGLFKE ENPYARFENN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3."
Yaspo M.-L., Aaltonen J., Horelli-Kuitunen N., Peltonen L., Lehrach H.
Genomics 49:133-136(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
[2]"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."
Chien W., Pei L.
J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SUBCELLULAR LOCATION, INTERACTION WITH PTTG1.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Lung, Muscle and Ovary.
[7]"Identification of novel genes of the bone-specific transcription factor Runx2."
Stock M., Schafer H., Fliegauf M., Otto F.
J. Bone Miner. Res. 19:959-972(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z50022 mRNA. Translation: CAA90325.1.
AF149785 mRNA. Translation: AAF73770.1.
AK315626 mRNA. Translation: BAG37994.1.
AL163300 Genomic DNA. Translation: CAB90552.1.
CH471079 Genomic DNA. Translation: EAX09386.1.
CH471079 Genomic DNA. Translation: EAX09388.1.
BC000415 mRNA. Translation: AAH00415.1.
BC012858 mRNA. Translation: AAH12858.1.
BC019295 mRNA. Translation: AAH19295.1.
BC020983 mRNA. Translation: AAH20983.1.
BC031097 mRNA. Translation: AAH31097.1.
BC034250 mRNA. Translation: AAH34250.1.
CCDSCCDS13715.1.
RefSeqNP_001273751.1. NM_001286822.1.
NP_004330.1. NM_004339.3.
UniGeneHs.474010.

3D structure databases

ProteinModelPortalP53801.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107210. 5 interactions.
IntActP53801. 1 interaction.
STRING9606.ENSP00000328325.

PTM databases

PhosphoSiteP53801.

Polymorphism databases

DMDM1711387.

Proteomic databases

MaxQBP53801.
PaxDbP53801.
PRIDEP53801.

Protocols and materials databases

DNASU754.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330938; ENSP00000328325; ENSG00000183255.
GeneID754.
KEGGhsa:754.
UCSCuc002zgb.2. human.

Organism-specific databases

CTD754.
GeneCardsGC21M046269.
HGNCHGNC:13524. PTTG1IP.
HPACAB034146.
MIM603784. gene.
neXtProtNX_P53801.
PharmGKBPA34034.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45904.
HOGENOMHOG000015370.
HOVERGENHBG000902.
InParanoidP53801.
OMALDYPVTK.
PhylomeDBP53801.
TreeFamTF329310.

Gene expression databases

ArrayExpressP53801.
BgeeP53801.
CleanExHS_PTTG1IP.
GenevestigatorP53801.

Family and domain databases

InterProIPR016201. Plexin-like_fold.
[Graphical view]
SMARTSM00423. PSI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTTG1IP. human.
GeneWikiPTTG1IP.
GenomeRNAi754.
NextBio3052.
PROP53801.
SOURCESearch...

Entry information

Entry namePTTG_HUMAN
AccessionPrimary (citable) accession number: P53801
Secondary accession number(s): B2RDP7, D3DSL9, Q9NS09
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM