P53801 (PTTG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pituitary tumor-transforming gene 1 protein-interacting protein

Alternative name(s):
Pituitary tumor-transforming gene protein-binding factor
Short name=PBF
Short name=PTTG-binding factor

Gene names

Name:	PTTG1IP
Synonyms:	C21orf1, C21orf3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May facilitate PTTG1 nuclear translocation.
Subunit structure	Interacts with PTTG1. Ref.2
Subcellular location	Membrane; Single-pass type I membrane protein Potential. Cytoplasm. Nucleus. Note: According to Ref.2, it is found in the cytoplasm and the nucleus. Ref.2
Tissue specificity	Ubiquitous.
Induction	By transcription factor RUNX2. Ref.7
Sequence similarities	Contains 1 PSI domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Domain	Coiled coil Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein import into nucleus Inferred from direct assay Ref.2. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.2. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Non-traceable author statement. Source: UniProtKB nucleus Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 180	148	Pituitary tumor-transforming gene 1 protein-interacting protein		PRO_0000022184
Regions
	Topological domain	33 – 96	64	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Potential
	Topological domain	118 – 180	63	Cytoplasmic Potential
	Domain	39 – 92	54	PSI
	Coiled coil	130 – 165	36	Potential
	Compositional bias	116 – 121	6	Poly-Cys
Amino acid modifications
	Modified residue	174	1	Phosphotyrosine By similarity
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	9 – 19	11	PTPYWRLRLGG → ARRTGGCASV in AAF73770. Ref.2
	Sequence conflict	108 – 114	7	TLLLGIA → NPPPGHC in AAF73770. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P53801 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: F1E66014D49EC1DE	FASTA	180	20,324
	10 20 30 40 50 60 MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSCLWC 70 80 90 100 110 120 NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII TMSVVGGTLL LGIAICCCCC 130 140 150 160 170 180 CRRKRSRKPD RSEEKAMRER EERRIRQEER RAEMKTRHDE IRKKYGLFKE ENPYARFENN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3." Yaspo M.-L., Aaltonen J., Horelli-Kuitunen N., Peltonen L., Lehrach H. Genomics 49:133-136(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymus.
[2]	"A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product." Chien W., Pei L. J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SUBCELLULAR LOCATION, INTERACTION WITH PTTG1.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Lung, Muscle and Ovary.
[7]	"Identification of novel genes of the bone-specific transcription factor Runx2." Stock M., Schafer H., Fliegauf M., Otto F. J. Bone Miner. Res. 19:959-972(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50022 mRNA. Translation: CAA90325.1. AF149785 mRNA. Translation: AAF73770.1. AK315626 mRNA. Translation: BAG37994.1. AL163300 Genomic DNA. Translation: CAB90552.1. CH471079 Genomic DNA. Translation: EAX09386.1. CH471079 Genomic DNA. Translation: EAX09388.1. BC000415 mRNA. Translation: AAH00415.1. BC012858 mRNA. Translation: AAH12858.1. BC019295 mRNA. Translation: AAH19295.1. BC020983 mRNA. Translation: AAH20983.1. BC031097 mRNA. Translation: AAH31097.1. BC034250 mRNA. Translation: AAH34250.1.
IPI	IPI00023974.
RefSeq	NP_004330.1. NM_004339.3.
UniGene	Hs.474010.
3D structure databases
ProteinModelPortal	P53801.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53801. 1 interaction.
STRING	9606.ENSP00000328325.
PTM databases
PhosphoSite	P53801.
Polymorphism databases
DMDM	1711387.
Proteomic databases
PaxDb	P53801.
PRIDE	P53801.
Protocols and materials databases
DNASU	754.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330938; ENSP00000328325; ENSG00000183255.
GeneID	754.
KEGG	hsa:754.
UCSC	uc002zgb.2. human.
Organism-specific databases
CTD	754.
GeneCards	GC21M046269.
HGNC	HGNC:13524. PTTG1IP.
HPA	CAB034146.
MIM	603784. gene.
neXtProt	NX_P53801.
PharmGKB	PA34034.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45904.
HOGENOM	HOG000015370.
HOVERGEN	HBG000902.
InParanoid	P53801.
OMA	ENPYAKF.
OrthoDB	EOG4STS60.
PhylomeDB	P53801.
Gene expression databases
ArrayExpress	P53801.
Bgee	P53801.
CleanEx	HS_PTTG1IP.
Genevestigator	P53801.
GermOnline	ENSG00000183255. Homo sapiens.
Family and domain databases
InterPro	IPR003659. Plexin-like. [Graphical view]
SMART	SM00423. PSI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTTG1IP. human.
GenomeRNAi	754.
NextBio	3052.
SOURCE	Search...

Entry information

Entry name

PTTG_HUMAN

Accession

Primary (citable) accession number: P53801
Secondary accession number(s): B2RDP7, D3DSL9, Q9NS09

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.