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P53801

- PTTG_HUMAN

UniProt

P53801 - PTTG_HUMAN

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Protein

Pituitary tumor-transforming gene 1 protein-interacting protein

Gene

PTTG1IP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May facilitate PTTG1 nuclear translocation.

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: InterPro
  2. protein import into nucleus Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary tumor-transforming gene 1 protein-interacting protein
Alternative name(s):
Pituitary tumor-transforming gene protein-binding factor
Short name:
PBF
Short name:
PTTG-binding factor
Gene namesi
Name:PTTG1IP
Synonyms:C21orf1, C21orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:13524. PTTG1IP.

Subcellular locationi

Membrane Curated; Single-pass type I membrane protein Curated. Cytoplasm 1 Publication. Nucleus 1 Publication
Note: According to PubMed:10781616, it is found in the cytoplasm and the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: UniProtKB
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 180148Pituitary tumor-transforming gene 1 protein-interacting proteinPRO_0000022184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Modified residuei174 – 1741PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP53801.
PaxDbiP53801.
PRIDEiP53801.

PTM databases

PhosphoSiteiP53801.

Expressioni

Tissue specificityi

Ubiquitous.

Inductioni

By transcription factor RUNX2.1 Publication

Gene expression databases

BgeeiP53801.
CleanExiHS_PTTG1IP.
ExpressionAtlasiP53801. baseline and differential.
GenevestigatoriP53801.

Organism-specific databases

HPAiCAB034146.

Interactioni

Subunit structurei

Interacts with PTTG1.1 Publication

Protein-protein interaction databases

BioGridi107210. 6 interactions.
IntActiP53801. 1 interaction.
STRINGi9606.ENSP00000328325.

Structurei

3D structure databases

ProteinModelPortaliP53801.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 9664ExtracellularSequence AnalysisAdd
BLAST
Topological domaini118 – 18063CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 9254PSIAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 16536Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi116 – 1216Poly-Cys

Sequence similaritiesi

Contains 1 PSI domain.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45904.
GeneTreeiENSGT00390000004977.
HOGENOMiHOG000015370.
HOVERGENiHBG000902.
InParanoidiP53801.
OMAiLDYPVTK.
PhylomeDBiP53801.
TreeFamiTF329310.

Family and domain databases

InterProiIPR016201. Plexin-like_fold.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53801-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE
60 70 80 90 100
CLKNVSCLWC NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII
110 120 130 140 150
TMSVVGGTLL LGIAICCCCC CRRKRSRKPD RSEEKAMRER EERRIRQEER
160 170 180
RAEMKTRHDE IRKKYGLFKE ENPYARFENN
Length:180
Mass (Da):20,324
Last modified:October 1, 1996 - v1
Checksum:iF1E66014D49EC1DE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 1911PTPYWRLRLGG → ARRTGGCASV in AAF73770. (PubMed:10781616)CuratedAdd
BLAST
Sequence conflicti108 – 1147TLLLGIA → NPPPGHC in AAF73770. (PubMed:10781616)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50022 mRNA. Translation: CAA90325.1.
AF149785 mRNA. Translation: AAF73770.1.
AK315626 mRNA. Translation: BAG37994.1.
AL163300 Genomic DNA. Translation: CAB90552.1.
CH471079 Genomic DNA. Translation: EAX09386.1.
CH471079 Genomic DNA. Translation: EAX09388.1.
BC000415 mRNA. Translation: AAH00415.1.
BC012858 mRNA. Translation: AAH12858.1.
BC019295 mRNA. Translation: AAH19295.1.
BC020983 mRNA. Translation: AAH20983.1.
BC031097 mRNA. Translation: AAH31097.1.
BC034250 mRNA. Translation: AAH34250.1.
CCDSiCCDS13715.1.
RefSeqiNP_001273751.1. NM_001286822.1.
NP_004330.1. NM_004339.3.
UniGeneiHs.474010.

Genome annotation databases

EnsembliENST00000330938; ENSP00000328325; ENSG00000183255.
GeneIDi754.
KEGGihsa:754.
UCSCiuc002zgb.2. human.

Polymorphism databases

DMDMi1711387.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50022 mRNA. Translation: CAA90325.1 .
AF149785 mRNA. Translation: AAF73770.1 .
AK315626 mRNA. Translation: BAG37994.1 .
AL163300 Genomic DNA. Translation: CAB90552.1 .
CH471079 Genomic DNA. Translation: EAX09386.1 .
CH471079 Genomic DNA. Translation: EAX09388.1 .
BC000415 mRNA. Translation: AAH00415.1 .
BC012858 mRNA. Translation: AAH12858.1 .
BC019295 mRNA. Translation: AAH19295.1 .
BC020983 mRNA. Translation: AAH20983.1 .
BC031097 mRNA. Translation: AAH31097.1 .
BC034250 mRNA. Translation: AAH34250.1 .
CCDSi CCDS13715.1.
RefSeqi NP_001273751.1. NM_001286822.1.
NP_004330.1. NM_004339.3.
UniGenei Hs.474010.

3D structure databases

ProteinModelPortali P53801.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107210. 6 interactions.
IntActi P53801. 1 interaction.
STRINGi 9606.ENSP00000328325.

PTM databases

PhosphoSitei P53801.

Polymorphism databases

DMDMi 1711387.

Proteomic databases

MaxQBi P53801.
PaxDbi P53801.
PRIDEi P53801.

Protocols and materials databases

DNASUi 754.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330938 ; ENSP00000328325 ; ENSG00000183255 .
GeneIDi 754.
KEGGi hsa:754.
UCSCi uc002zgb.2. human.

Organism-specific databases

CTDi 754.
GeneCardsi GC21M046269.
HGNCi HGNC:13524. PTTG1IP.
HPAi CAB034146.
MIMi 603784. gene.
neXtProti NX_P53801.
PharmGKBi PA34034.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45904.
GeneTreei ENSGT00390000004977.
HOGENOMi HOG000015370.
HOVERGENi HBG000902.
InParanoidi P53801.
OMAi LDYPVTK.
PhylomeDBi P53801.
TreeFami TF329310.

Miscellaneous databases

ChiTaRSi PTTG1IP. human.
GeneWikii PTTG1IP.
GenomeRNAii 754.
NextBioi 3052.
PROi P53801.
SOURCEi Search...

Gene expression databases

Bgeei P53801.
CleanExi HS_PTTG1IP.
ExpressionAtlasi P53801. baseline and differential.
Genevestigatori P53801.

Family and domain databases

InterProi IPR016201. Plexin-like_fold.
[Graphical view ]
SMARTi SM00423. PSI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3."
    Yaspo M.-L., Aaltonen J., Horelli-Kuitunen N., Peltonen L., Lehrach H.
    Genomics 49:133-136(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."
    Chien W., Pei L.
    J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SUBCELLULAR LOCATION, INTERACTION WITH PTTG1.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Lung, Muscle and Ovary.
  7. "Identification of novel genes of the bone-specific transcription factor Runx2."
    Stock M., Schafer H., Fliegauf M., Otto F.
    J. Bone Miner. Res. 19:959-972(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiPTTG_HUMAN
AccessioniPrimary (citable) accession number: P53801
Secondary accession number(s): B2RDP7, D3DSL9, Q9NS09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3