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Protein

Pituitary tumor-transforming gene 1 protein-interacting protein

Gene

PTTG1IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May facilitate PTTG1 nuclear translocation.

GO - Molecular functioni

  • p53 binding Source: MGI

GO - Biological processi

  • negative regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
  • positive regulation of cellular protein catabolic process Source: MGI
  • positive regulation of protein ubiquitination Source: MGI
  • protein import into nucleus Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32035-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary tumor-transforming gene 1 protein-interacting protein
Alternative name(s):
Pituitary tumor-transforming gene protein-binding factor
Short name:
PBF
Short name:
PTTG-binding factor
Gene namesi
Name:PTTG1IP
Synonyms:C21orf1, C21orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:13524. PTTG1IP.

Subcellular locationi

  • Membrane Curated; Single-pass type I membrane protein Curated
  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: According to PubMed:10781616, it is found in the cytoplasm and the nucleus.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 96ExtracellularSequence analysisAdd BLAST64
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Topological domaini118 – 180CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi754.
OpenTargetsiENSG00000183255.
PharmGKBiPA34034.

Polymorphism and mutation databases

BioMutaiPTTG1IP.
DMDMi1711387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000002218433 – 180Pituitary tumor-transforming gene 1 protein-interacting proteinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Modified residuei174PhosphotyrosineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP53801.
MaxQBiP53801.
PaxDbiP53801.
PeptideAtlasiP53801.
PRIDEiP53801.

PTM databases

iPTMnetiP53801.
PhosphoSitePlusiP53801.
SwissPalmiP53801.

Expressioni

Tissue specificityi

Ubiquitous.

Inductioni

By transcription factor RUNX2.1 Publication

Gene expression databases

BgeeiENSG00000183255.
CleanExiHS_PTTG1IP.
ExpressionAtlasiP53801. baseline and differential.
GenevisibleiP53801. HS.

Organism-specific databases

HPAiCAB034146.
HPA061827.

Interactioni

Subunit structurei

Interacts with PTTG1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CLEC7AQ9BXN23EBI-3906138,EBI-3939278
LDLRAD1Q5T7003EBI-3906138,EBI-10173166

GO - Molecular functioni

  • p53 binding Source: MGI

Protein-protein interaction databases

BioGridi107210. 7 interactors.
IntActiP53801. 11 interactors.
STRINGi9606.ENSP00000328325.

Structurei

3D structure databases

ProteinModelPortaliP53801.
SMRiP53801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 92PSIAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 165Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 121Poly-Cys6

Sequence similaritiesi

Contains 1 PSI domain.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXF7. Eukaryota.
ENOG4111WR4. LUCA.
GeneTreeiENSGT00390000004977.
HOGENOMiHOG000015370.
HOVERGENiHBG000902.
InParanoidiP53801.
OMAiELSSARW.
OrthoDBiEOG091G0X6V.
PhylomeDBiP53801.
TreeFamiTF329310.

Family and domain databases

InterProiIPR016201. PSI.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE
60 70 80 90 100
CLKNVSCLWC NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII
110 120 130 140 150
TMSVVGGTLL LGIAICCCCC CRRKRSRKPD RSEEKAMRER EERRIRQEER
160 170 180
RAEMKTRHDE IRKKYGLFKE ENPYARFENN
Length:180
Mass (Da):20,324
Last modified:October 1, 1996 - v1
Checksum:iF1E66014D49EC1DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 19PTPYWRLRLGG → ARRTGGCASV in AAF73770 (PubMed:10781616).CuratedAdd BLAST11
Sequence conflicti108 – 114TLLLGIA → NPPPGHC in AAF73770 (PubMed:10781616).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50022 mRNA. Translation: CAA90325.1.
AF149785 mRNA. Translation: AAF73770.1.
AK315626 mRNA. Translation: BAG37994.1.
AL163300 Genomic DNA. Translation: CAB90552.1.
CH471079 Genomic DNA. Translation: EAX09386.1.
CH471079 Genomic DNA. Translation: EAX09388.1.
BC000415 mRNA. Translation: AAH00415.1.
BC012858 mRNA. Translation: AAH12858.1.
BC019295 mRNA. Translation: AAH19295.1.
BC020983 mRNA. Translation: AAH20983.1.
BC031097 mRNA. Translation: AAH31097.1.
BC034250 mRNA. Translation: AAH34250.1.
CCDSiCCDS13715.1.
RefSeqiNP_001273751.1. NM_001286822.1.
NP_004330.1. NM_004339.3.
UniGeneiHs.474010.

Genome annotation databases

EnsembliENST00000330938; ENSP00000328325; ENSG00000183255.
GeneIDi754.
KEGGihsa:754.
UCSCiuc002zgb.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50022 mRNA. Translation: CAA90325.1.
AF149785 mRNA. Translation: AAF73770.1.
AK315626 mRNA. Translation: BAG37994.1.
AL163300 Genomic DNA. Translation: CAB90552.1.
CH471079 Genomic DNA. Translation: EAX09386.1.
CH471079 Genomic DNA. Translation: EAX09388.1.
BC000415 mRNA. Translation: AAH00415.1.
BC012858 mRNA. Translation: AAH12858.1.
BC019295 mRNA. Translation: AAH19295.1.
BC020983 mRNA. Translation: AAH20983.1.
BC031097 mRNA. Translation: AAH31097.1.
BC034250 mRNA. Translation: AAH34250.1.
CCDSiCCDS13715.1.
RefSeqiNP_001273751.1. NM_001286822.1.
NP_004330.1. NM_004339.3.
UniGeneiHs.474010.

3D structure databases

ProteinModelPortaliP53801.
SMRiP53801.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107210. 7 interactors.
IntActiP53801. 11 interactors.
STRINGi9606.ENSP00000328325.

PTM databases

iPTMnetiP53801.
PhosphoSitePlusiP53801.
SwissPalmiP53801.

Polymorphism and mutation databases

BioMutaiPTTG1IP.
DMDMi1711387.

Proteomic databases

EPDiP53801.
MaxQBiP53801.
PaxDbiP53801.
PeptideAtlasiP53801.
PRIDEiP53801.

Protocols and materials databases

DNASUi754.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330938; ENSP00000328325; ENSG00000183255.
GeneIDi754.
KEGGihsa:754.
UCSCiuc002zgb.3. human.

Organism-specific databases

CTDi754.
DisGeNETi754.
GeneCardsiPTTG1IP.
HGNCiHGNC:13524. PTTG1IP.
HPAiCAB034146.
HPA061827.
MIMi603784. gene.
neXtProtiNX_P53801.
OpenTargetsiENSG00000183255.
PharmGKBiPA34034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXF7. Eukaryota.
ENOG4111WR4. LUCA.
GeneTreeiENSGT00390000004977.
HOGENOMiHOG000015370.
HOVERGENiHBG000902.
InParanoidiP53801.
OMAiELSSARW.
OrthoDBiEOG091G0X6V.
PhylomeDBiP53801.
TreeFamiTF329310.

Enzyme and pathway databases

BioCyciZFISH:G66-32035-MONOMER.

Miscellaneous databases

ChiTaRSiPTTG1IP. human.
GeneWikiiPTTG1IP.
GenomeRNAii754.
PROiP53801.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183255.
CleanExiHS_PTTG1IP.
ExpressionAtlasiP53801. baseline and differential.
GenevisibleiP53801. HS.

Family and domain databases

InterProiIPR016201. PSI.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTTG_HUMAN
AccessioniPrimary (citable) accession number: P53801
Secondary accession number(s): B2RDP7, D3DSL9, Q9NS09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.