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Protein

Squalene synthase

Gene
N/A
Organism
Nicotiana benthamiana
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi: lanosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Squalene synthase
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMultifunctional enzyme, Transferase
Biological processIsoprene biosynthesis
LigandMagnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
OrganismiNicotiana benthamiana
Taxonomic identifieri4100 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674561 – 411Squalene synthaseAdd BLAST411

Structurei

3D structure databases

ProteinModelPortaliP53800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd00683 Trans_IPPS_HH, 1 hit
Gene3Di1.10.600.10, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR002060 Squ/phyt_synthse
IPR006449 Squal_synth-like
IPR019845 Squalene/phytoene_synthase_CS
IPR033904 Trans_IPPS_HH
PfamiView protein in Pfam
PF00494 SQS_PSY, 1 hit
SUPFAMiSSF48576 SSF48576, 1 hit
TIGRFAMsiTIGR01559 squal_synth, 1 hit
PROSITEiView protein in PROSITE
PS01044 SQUALEN_PHYTOEN_SYN_1, 1 hit
PS01045 SQUALEN_PHYTOEN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P53800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLRAILKN PEDLYPLVKL KLAARHAEKQ IPPSPNWGFC YSMLHKVSRS
60 70 80 90 100
FALVIQQLPV ELRDAVCIFY LVLRALDTVE DDTSIPTDVK VPILISFHQH
110 120 130 140 150
VYDREWHFSC GTKEYKVLMD QFHHVSTAFL ELRKHYQQAI EDITMRMGAG
160 170 180 190 200
MAKFICKEVE TTDDYDEYCH YVAGLVGLGL SKLFHASEKE DLASDSLSNS
210 220 230 240 250
MGLFLQKTNI IRDYLEDINE VPKCRMFWPR EIWSKYVNKL EELKYEDNSA
260 270 280 290 300
KAVQCLNDMV TNALPHVEDC LTYMSALRDP SIFRFCAIPQ VMAIGTLAMC
310 320 330 340 350
YDNIEVFRGV VKMRRGLTAK VIDRTRTIAD VYGAFFDFSC MLKSKVNNND
360 370 380 390 400
PNATKTLKRL EVILKTCRDS GTLNKRKSYI IRSEPNYSPV LIVVIFIILA
410
IILAQLSGNR S
Length:411
Mass (Da):47,083
Last modified:October 1, 1996 - v1
Checksum:i5DE209E9BB70A42A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46000 mRNA Translation: AAA87048.1
PIRiS71771

Similar proteinsi

Entry informationi

Entry nameiFDFT_NICBE
AccessioniPrimary (citable) accession number: P53800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health