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P53800

- FDFT_NICBE

UniProt

P53800 - FDFT_NICBE

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Protein

Squalene synthase

Gene
N/A
Organism
Nicotiana benthamiana
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. farnesyl-diphosphate farnesyltransferase activity Source: UniProtKB-EC
  2. oxidoreductase activity Source: UniProtKB-KW
  3. squalene synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Magnesium, NADP

Enzyme and pathway databases

UniPathwayiUPA00767; UER00751.

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene synthase (EC:2.5.1.21)
Short name:
SQS
Short name:
SS
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
OrganismiNicotiana benthamiana
Taxonomic identifieri4100 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Squalene synthasePRO_0000067456Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP53800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phytoene/squalene synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR01559. squal_synth. 1 hit.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53800-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLRAILKN PEDLYPLVKL KLAARHAEKQ IPPSPNWGFC YSMLHKVSRS
60 70 80 90 100
FALVIQQLPV ELRDAVCIFY LVLRALDTVE DDTSIPTDVK VPILISFHQH
110 120 130 140 150
VYDREWHFSC GTKEYKVLMD QFHHVSTAFL ELRKHYQQAI EDITMRMGAG
160 170 180 190 200
MAKFICKEVE TTDDYDEYCH YVAGLVGLGL SKLFHASEKE DLASDSLSNS
210 220 230 240 250
MGLFLQKTNI IRDYLEDINE VPKCRMFWPR EIWSKYVNKL EELKYEDNSA
260 270 280 290 300
KAVQCLNDMV TNALPHVEDC LTYMSALRDP SIFRFCAIPQ VMAIGTLAMC
310 320 330 340 350
YDNIEVFRGV VKMRRGLTAK VIDRTRTIAD VYGAFFDFSC MLKSKVNNND
360 370 380 390 400
PNATKTLKRL EVILKTCRDS GTLNKRKSYI IRSEPNYSPV LIVVIFIILA
410
IILAQLSGNR S
Length:411
Mass (Da):47,083
Last modified:October 1, 1996 - v1
Checksum:i5DE209E9BB70A42A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46000 mRNA. Translation: AAA87048.1.
PIRiS71771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46000 mRNA. Translation: AAA87048.1 .
PIRi S71771.

3D structure databases

ProteinModelPortali P53800.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00767 ; UER00751 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR01559. squal_synth. 1 hit.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, in vitro expression and characterization of a plant squalene synthetase cDNA."
    Hanley K.M., Nicolas O., Donaldson T.B., Smith-Monroy C., Robinson G.W., Hellmann G.M.
    Plant Mol. Biol. 30:1139-1151(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFDFT_NICBE
AccessioniPrimary (citable) accession number: P53800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3