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P53800 (FDFT_NICBE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Squalene synthase

Short name=SQS
Short name=SS
EC=2.5.1.21
Alternative name(s):
FPP:FPP farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
OrganismNicotiana benthamiana
Taxonomic identifier4100 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)+.

Cofactor

Magnesium By similarity.

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Squalene synthase
PRO_0000067456

Regions

Transmembrane281 – 30121Helical; Potential
Transmembrane388 – 40821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P53800 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5DE209E9BB70A42A

FASTA41147,083
        10         20         30         40         50         60 
MGSLRAILKN PEDLYPLVKL KLAARHAEKQ IPPSPNWGFC YSMLHKVSRS FALVIQQLPV 

        70         80         90        100        110        120 
ELRDAVCIFY LVLRALDTVE DDTSIPTDVK VPILISFHQH VYDREWHFSC GTKEYKVLMD 

       130        140        150        160        170        180 
QFHHVSTAFL ELRKHYQQAI EDITMRMGAG MAKFICKEVE TTDDYDEYCH YVAGLVGLGL 

       190        200        210        220        230        240 
SKLFHASEKE DLASDSLSNS MGLFLQKTNI IRDYLEDINE VPKCRMFWPR EIWSKYVNKL 

       250        260        270        280        290        300 
EELKYEDNSA KAVQCLNDMV TNALPHVEDC LTYMSALRDP SIFRFCAIPQ VMAIGTLAMC 

       310        320        330        340        350        360 
YDNIEVFRGV VKMRRGLTAK VIDRTRTIAD VYGAFFDFSC MLKSKVNNND PNATKTLKRL 

       370        380        390        400        410 
EVILKTCRDS GTLNKRKSYI IRSEPNYSPV LIVVIFIILA IILAQLSGNR S 

« Hide

References

[1]"Molecular cloning, in vitro expression and characterization of a plant squalene synthetase cDNA."
Hanley K.M., Nicolas O., Donaldson T.B., Smith-Monroy C., Robinson G.W., Hellmann G.M.
Plant Mol. Biol. 30:1139-1151(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U46000 mRNA. Translation: AAA87048.1.
PIRS71771.

3D structure databases

ProteinModelPortalP53800.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00767; UER00751.

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR002060. Squ/phyt_synthse.
IPR006449. Squal_synth.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
TIGRFAMsTIGR01559. squal_synth. 1 hit.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDFT_NICBE
AccessionPrimary (citable) accession number: P53800
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways