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Protein

Sodium/myo-inositol cotransporter

Gene

SLC5A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Implicated in sodium couplingBy similarity1
Sitei285Implicated in sodium couplingBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:G66-33037-MONOMER.
ReactomeiR-HSA-189200. Hexose transport.
R-HSA-428808. Na+-dependent glucose transporters.
R-HSA-429593. Inositol transporters.

Protein family/group databases

TCDBi2.A.21.3.14. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/myo-inositol cotransporter
Short name:
Na(+)/myo-inositol cotransporter
Alternative name(s):
Sodium/myo-inositol transporter 1
Short name:
SMIT1
Solute carrier family 5 member 3
Gene namesi
Name:SLC5A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11038. SLC5A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 29HelicalSequence analysisAdd BLAST20
Topological domaini30 – 38CytoplasmicSequence analysis9
Transmembranei39 – 57HelicalSequence analysisAdd BLAST19
Topological domaini58 – 86ExtracellularSequence analysisAdd BLAST29
Transmembranei87 – 110HelicalSequence analysisAdd BLAST24
Topological domaini111 – 123CytoplasmicSequence analysisAdd BLAST13
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 157ExtracellularSequence analysisAdd BLAST13
Transmembranei158 – 183HelicalSequence analysisAdd BLAST26
Topological domaini184 – 186CytoplasmicSequence analysis3
Transmembranei187 – 205HelicalSequence analysisAdd BLAST19
Topological domaini206 – 303ExtracellularSequence analysisAdd BLAST98
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 353CytoplasmicSequence analysisAdd BLAST29
Transmembranei354 – 376HelicalSequence analysisAdd BLAST23
Topological domaini377 – 406ExtracellularSequence analysisAdd BLAST30
Transmembranei407 – 430HelicalSequence analysisAdd BLAST24
Topological domaini431 – 443CytoplasmicSequence analysisAdd BLAST13
Transmembranei444 – 462HelicalSequence analysisAdd BLAST19
Topological domaini463 – 510ExtracellularSequence analysisAdd BLAST48
Transmembranei511 – 532HelicalSequence analysisAdd BLAST22
Topological domaini533 – 695CytoplasmicSequence analysisAdd BLAST163
Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Topological domaini717 – 718ExtracellularSequence analysis2

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6526.
PharmGKBiPA35903.

Polymorphism and mutation databases

BioMutaiSLC5A3.
DMDMi3334498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053811 – 718Sodium/myo-inositol cotransporterAdd BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Modified residuei594PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP53794.
MaxQBiP53794.
PaxDbiP53794.
PeptideAtlasiP53794.
PRIDEiP53794.

PTM databases

iPTMnetiP53794.
PhosphoSitePlusiP53794.

Expressioni

Gene expression databases

GenevisibleiP53794. HS.

Organism-specific databases

HPAiHPA029791.

Interactioni

Protein-protein interaction databases

IntActiP53794. 4 interactors.
MINTiMINT-4657416.
STRINGi9606.ENSP00000370543.

Structurei

3D structure databases

ProteinModelPortaliP53794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP53794.
OrthoDBiEOG091G077U.
PhylomeDBiP53794.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVLDTADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVT
60 70 80 90 100
IGASLFVSNI GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI
110 120 130 140 150
YIRSGVYTMP EYLSKRFGGH RIQVYFAALS LILYIFTKLS VDLYSGALFI
160 170 180 190 200
QESLGWNLYV SVILLIGMTA LLTVTGGLVA VIYTDTLQAL LMIIGALTLM
210 220 230 240 250
IISIMEIGGF EEVKRRYMLA SPDVTSILLT YNLSNTNSCN VSPKKEALKM
260 270 280 290 300
LRNPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL
310 320 330 340 350
MAGFLKLLPM FIIVVPGMIS RILFTDDIAC INPEHCMLVC GSRAGCSNIA
360 370 380 390 400
YPRLVMKLVP VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK
410 420 430 440 450
SASSRELMIV GRIFVAFMVV ISIAWVPIIV EMQGGQMYLY IQEVADYLTP
460 470 480 490 500
PVAALFLLAI FWKRCNEQGA FYGGMAGFVL GAVRLILAFA YRAPECDQPD
510 520 530 540 550
NRPGFIKDIH YMYVATGLFW VTGLITVIVS LLTPPPTKEQ IRTTTFWSKK
560 570 580 590 600
NLVVKENCSP KEEPYQMQEK SILRCSENNE TINHIIPNGK SEDSIKGLQP
610 620 630 640 650
EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETDD
660 670 680 690 700
GGRYWKFIDW FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE TRQVKVILNI
710
GLFAVCSLGI FMFVYFSL
Length:718
Mass (Da):79,694
Last modified:July 15, 1998 - v2
Checksum:i73A9697FC910363F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31S → C in AAC41747 (PubMed:7789985).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06187550T → A.1 PublicationCorresponds to variant rs8129891dbSNPEnsembl.1
Natural variantiVAR_061876566Q → K.1 PublicationCorresponds to variant rs4817617dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38500 Genomic DNA. Translation: AAC41747.2.
AF027153 Genomic DNA. Translation: AAC39548.1.
AP001719 Genomic DNA. No translation available.
CCDSiCCDS33549.1.
PIRiA56851.
UniGeneiHs.302742.

Genome annotation databases

EnsembliENST00000381151; ENSP00000370543; ENSG00000198743.
UCSCiuc002yto.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38500 Genomic DNA. Translation: AAC41747.2.
AF027153 Genomic DNA. Translation: AAC39548.1.
AP001719 Genomic DNA. No translation available.
CCDSiCCDS33549.1.
PIRiA56851.
UniGeneiHs.302742.

3D structure databases

ProteinModelPortaliP53794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53794. 4 interactors.
MINTiMINT-4657416.
STRINGi9606.ENSP00000370543.

Protein family/group databases

TCDBi2.A.21.3.14. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiP53794.
PhosphoSitePlusiP53794.

Polymorphism and mutation databases

BioMutaiSLC5A3.
DMDMi3334498.

Proteomic databases

EPDiP53794.
MaxQBiP53794.
PaxDbiP53794.
PeptideAtlasiP53794.
PRIDEiP53794.

Protocols and materials databases

DNASUi6526.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381151; ENSP00000370543; ENSG00000198743.
UCSCiuc002yto.4. human.

Organism-specific databases

DisGeNETi6526.
GeneCardsiSLC5A3.
HGNCiHGNC:11038. SLC5A3.
HPAiHPA029791.
MIMi600444. gene.
neXtProtiNX_P53794.
PharmGKBiPA35903.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP53794.
OrthoDBiEOG091G077U.
PhylomeDBiP53794.
TreeFamiTF352855.

Enzyme and pathway databases

BioCyciZFISH:G66-33037-MONOMER.
ReactomeiR-HSA-189200. Hexose transport.
R-HSA-428808. Na+-dependent glucose transporters.
R-HSA-429593. Inositol transporters.

Miscellaneous databases

ChiTaRSiSLC5A3. human.
PROiP53794.
SOURCEiSearch...

Gene expression databases

GenevisibleiP53794. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A3_HUMAN
AccessioniPrimary (citable) accession number: P53794
Secondary accession number(s): O43489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.