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Reviewed, UniProtKB/Swiss-Prot P53794 (SC5A3_HUMAN)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Sodium/myo-inositol cotransporter
Alternative name(s):
    Na(+)/myo-inositol cotransporter
    Solute carrier family 5 member 3
Gene names
Name: SLC5A3
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length718 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

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Ontologies

Keywords

   Biological processIon transport
Sodium transport
Symport
Transport
   Cellular componentMembrane
   DomainTransmembrane
   LigandSodium
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to plasma membrane

Traceable author statement. Source: ProtInc

   Molecular functionmyo-inositol:sodium symporter activity

Traceable author statement. Source: ProtInc

sodium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 718718Sodium/myo-inositol cotransporter
PRO_0000105381

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 2920 Potential
Topological domain30 – 389Extracellular Potential
Transmembrane39 – 5719 Potential
Topological domain58 – 8629Cytoplasmic Potential
Transmembrane87 – 11024 Potential
Topological domain111 – 12313Extracellular Potential
Transmembrane124 – 14421 Potential
Topological domain145 – 15713Cytoplasmic Potential
Transmembrane158 – 18326 Potential
Topological domain184 – 1863Extracellular Potential
Transmembrane187 – 20519 Potential
Topological domain206 – 30398Cytoplasmic Potential
Transmembrane304 – 32421 Potential
Topological domain325 – 35329Extracellular Potential
Transmembrane354 – 37623 Potential
Topological domain377 – 40630Cytoplasmic Potential
Transmembrane407 – 43024 Potential
Topological domain431 – 44313Extracellular Potential
Transmembrane444 – 46219 Potential
Topological domain463 – 51048Cytoplasmic Potential
Transmembrane511 – 53222 Potential
Topological domain533 – 695163Cytoplasmic Potential
Transmembrane696 – 71621 Potential

Sites

Site241Implicated in sodium coupling By similarity
Site2851Implicated in sodium coupling By similarity

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict311S → C in AAC41747. Ref.1
Sequence conflict501T → A in AAC41747. Ref.1
Sequence conflict5661Q → K in AAC41747. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P53794-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 73A9697FC910363F

FASTA71879,694
        10         20         30         40         50         60 
MRAVLDTADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVT IGASLFVSNI 

        70         80         90        100        110        120 
GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI YIRSGVYTMP EYLSKRFGGH 

       130        140        150        160        170        180 
RIQVYFAALS LILYIFTKLS VDLYSGALFI QESLGWNLYV SVILLIGMTA LLTVTGGLVA 

       190        200        210        220        230        240 
VIYTDTLQAL LMIIGALTLM IISIMEIGGF EEVKRRYMLA SPDVTSILLT YNLSNTNSCN 

       250        260        270        280        290        300 
VSPKKEALKM LRNPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL 

       310        320        330        340        350        360 
MAGFLKLLPM FIIVVPGMIS RILFTDDIAC INPEHCMLVC GSRAGCSNIA YPRLVMKLVP 

       370        380        390        400        410        420 
VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK SASSRELMIV GRIFVAFMVV 

       430        440        450        460        470        480 
ISIAWVPIIV EMQGGQMYLY IQEVADYLTP PVAALFLLAI FWKRCNEQGA FYGGMAGFVL 

       490        500        510        520        530        540 
GAVRLILAFA YRAPECDQPD NRPGFIKDIH YMYVATGLFW VTGLITVIVS LLTPPPTKEQ 

       550        560        570        580        590        600 
IRTTTFWSKK NLVVKENCSP KEEPYQMQEK SILRCSENNE TINHIIPNGK SEDSIKGLQP 

       610        620        630        640        650        660 
EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETDD GGRYWKFIDW 

       670        680        690        700        710 
FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE TRQVKVILNI GLFAVCSLGI FMFVYFSL

« Hide

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References

« Hide 'large scale' references
[1]"The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21."
Berry G.T., Mallee J.J., Kwon H.M., Rim J.S., Mulla W.R., Muenke M., Spinner N.B.
Genomics 25:507-513(1995) [PubMed: 7789985] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]Berry G.T., Mallee J.J., Kwon H.M., Rim J.S., Mulla W.R., Muenke M., Spinner N.B.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 50 AND 566.
[3]"The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter."
Mallee J.J., Atta M.G., Lorica V., Rim J.S., Kwon H.M., Lucente A.D., Wang Y., Berry G.T.
Genomics 46:459-465(1997) [PubMed: 9441750] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed: 10830953] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

L38500 Genomic DNA. Translation: AAC41747.2.
AF027153 Genomic DNA. Translation: AAC39548.1.
AP001719 Genomic DNA. No translation available.
PIRA56851.
RefSeqNP_008864.3.
UniGeneHs.302742

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP53794.

Genome annotation databases

EnsemblENSG00000198743. Homo sapiens. [Contig view]
GeneID6526.
KEGGhsa:6526.

Organism-specific databases

HGNCHGNC:11038. SLC5A3.
MIM600444. gene.
PharmGKBPA35903.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP53794.
HOVERGENP53794.

Gene expression databases

ArrayExpressP53794.
GermOnlineENSG00000198743. Homo sapiens.

Family and domain databases

InterProIPR001734. Na/solut_symport.
[Graphical view]
PANTHERPTHR11819. Na/solut_symport. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio25391.
SOURCESearch...

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Entry information

Entry nameSC5A3_HUMAN
AccessionPrimary (citable) accession number: P53794
Secondary accession number(s): O43489
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 25, 2008
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents