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Protein

Sodium/glucose cotransporter 2

Gene

Slc5a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

GO - Molecular functioni

  • glucose:sodium symporter activity Source: RGD

GO - Biological processi

  • glucose transmembrane transport Source: GOC
  • glucose transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 2
Short name:
Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene namesi
Name:Slc5a2
Synonyms:Sglt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620217. Slc5a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4219HelicalSequence analysisAdd
BLAST
Topological domaini43 – 5917ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 10020CytoplasmicSequence analysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence analysisAdd
BLAST
Topological domaini122 – 16645ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 20316CytoplasmicSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Topological domaini225 – 26844ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 31223CytoplasmicSequence analysisAdd
BLAST
Transmembranei313 – 33220HelicalSequence analysisAdd
BLAST
Topological domaini333 – 42189ExtracellularSequence analysisAdd
BLAST
Transmembranei422 – 44120HelicalSequence analysisAdd
BLAST
Topological domaini442 – 45312CytoplasmicSequence analysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence analysisAdd
BLAST
Topological domaini475 – 52450ExtracellularSequence analysisAdd
BLAST
Transmembranei525 – 54521HelicalSequence analysisAdd
BLAST
Topological domaini546 – 648103CytoplasmicSequence analysisAdd
BLAST
Transmembranei649 – 66921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • brush border membrane Source: RGD
  • integral component of membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Sodium/glucose cotransporter 2PRO_0000105375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi248 – 2481N-linked (GlcNAc...)Curated

Post-translational modificationi

Glycosylated at a single site.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP53792.
PRIDEiP53792.

Expressioni

Tissue specificityi

Kidney, in proximal tubule S1 segments.

Developmental stagei

Appears on embryonic day 17 and gradually increases until day 19. Decreases between day 19 and birth.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027265.

Chemistry

BindingDBiP53792.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP53792.
KOiK14382.
PhylomeDBiP53792.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGHVEEGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGRRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAVTSLTV SKDPAVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG GLPWPALLLG LTIVSGWHWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK
360 370 380 390 400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS
410 420 430 440 450
TLFTMDIYTR LRPRAGDREL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL
460 470 480 490 500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLIGG LLMGLARLIP
510 520 530 540 550
EFFFGTGSCV RPSACPAIFC RVHYLYFAII LFFCSGFLTL AISRCTAPIP
560 570 580 590 600
QKHLHRLVFS LRHSKEERED LDAEELEGPA PPPVQNGCQE CAMGIEEVQS
610 620 630 640 650
PAPGLLRQCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPSWARV
660 670
VNLNALLMMT VAVFLWGFYA
Length:670
Mass (Da):72,962
Last modified:October 1, 1996 - v1
Checksum:i0609562861618BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29881 mRNA. Translation: AAC52325.1.
RefSeqiNP_072112.2. NM_022590.2.
UniGeneiRn.5887.

Genome annotation databases

GeneIDi64522.
KEGGirno:64522.
UCSCiRGD:620217. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29881 mRNA. Translation: AAC52325.1.
RefSeqiNP_072112.2. NM_022590.2.
UniGeneiRn.5887.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027265.

Chemistry

BindingDBiP53792.
ChEMBLiCHEMBL4316.

Proteomic databases

PaxDbiP53792.
PRIDEiP53792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64522.
KEGGirno:64522.
UCSCiRGD:620217. rat.

Organism-specific databases

CTDi6524.
RGDi620217. Slc5a2.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP53792.
KOiK14382.
PhylomeDBiP53792.

Miscellaneous databases

PROiP53792.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney."
    You G., Lee W.-S., Barros E.J.G., Kanai Y., Huo T.-L., Khawaja S., Wells R.G., Nigam S.K., Hediger M.A.
    J. Biol. Chem. 270:29365-29371(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiSC5A2_RAT
AccessioniPrimary (citable) accession number: P53792
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.