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Protein

Sodium/glucose cotransporter 2

Gene

Slc5a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium-dependent glucose transporter. Has a Na+ to glucose coupling ratio of 1:1.
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

GO - Molecular functioni

  • glucose:sodium symporter activity Source: RGD

GO - Biological processi

  • glucose transmembrane transport Source: RGD

Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 2
Short name:
Na(+)/glucose cotransporter 2
Alternative name(s):
Low affinity sodium-glucose cotransporter
Solute carrier family 5 member 2
Gene namesi
Name:Slc5a2
Synonyms:Sglt21 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620217 Slc5a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 42HelicalSequence analysisAdd BLAST19
Topological domaini43 – 59ExtracellularSequence analysisAdd BLAST17
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 100CytoplasmicSequence analysisAdd BLAST20
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 166ExtracellularSequence analysisAdd BLAST45
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 203CytoplasmicSequence analysisAdd BLAST16
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 268ExtracellularSequence analysisAdd BLAST44
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 312CytoplasmicSequence analysisAdd BLAST23
Transmembranei313 – 332HelicalSequence analysisAdd BLAST20
Topological domaini333 – 421ExtracellularSequence analysisAdd BLAST89
Transmembranei422 – 441HelicalSequence analysisAdd BLAST20
Topological domaini442 – 453CytoplasmicSequence analysisAdd BLAST12
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 524ExtracellularSequence analysisAdd BLAST50
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 648CytoplasmicSequence analysisAdd BLAST103
Transmembranei649 – 669HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4316
GuidetoPHARMACOLOGYi916

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053751 – 670Sodium/glucose cotransporter 2Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...) asparagineCurated1

Post-translational modificationi

Glycosylated at a single site.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP53792
PRIDEiP53792

Expressioni

Tissue specificityi

Kidney, in proximal tubule S1 segments.

Developmental stagei

Appears on embryonic day 17 and gradually increases until day 19. Decreases between day 19 and birth.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027265

Chemistry databases

BindingDBiP53792

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiP53792
KOiK14382
PhylomeDBiP53792

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P53792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGHVEEGSE LGEQKVLIDN PADILVIAAY FLLVIGVGLW SMFRTNRGTV
60 70 80 90 100
GGYFLAGRSM VWWPVGASLF ASNIGSGHFV GLAGTGAASG LAVAGFEWNA
110 120 130 140 150
LFVVLLLGWL FVPVYLTAGV ITMPQYLRKR FGGRRIRLYL SVLSLFLYIF
160 170 180 190 200
TKISVDMFSG AVFIQQALGW NIYASVIALL GITMIYTVTG GLAALMYTDT
210 220 230 240 250
VQTFVILAGA FILTGYAFHE VGGYSGLFDK YLGAVTSLTV SKDPAVGNIS
260 270 280 290 300
STCYQPRPDS YHLLRDPVTG GLPWPALLLG LTIVSGWHWC SDQVIVQRCL
310 320 330 340 350
AGKNLTHIKA GCILCGYLKL MPMFLMVMPG MISRILYPDE VACVVPEVCK
360 370 380 390 400
RVCGTEVGCS NIAYPRLVVK LMPNGLRGLM LAVMLAALMS SLASIFNSSS
410 420 430 440 450
TLFTMDIYTR LRPRAGDREL LLVGRLWVVF IVAVSVAWLP VVQAAQGGQL
460 470 480 490 500
FDYIQSVSSY LAPPVSAVFV LALFVPRVNE KGAFWGLIGG LLMGLARLIP
510 520 530 540 550
EFFFGTGSCV RPSACPAIFC RVHYLYFAII LFFCSGFLTL AISRCTAPIP
560 570 580 590 600
QKHLHRLVFS LRHSKEERED LDAEELEGPA PPPVQNGCQE CAMGIEEVQS
610 620 630 640 650
PAPGLLRQCL LWFCGMSKSG SGSPPPTTEE VAATTRRLED ISEDPSWARV
660 670
VNLNALLMMT VAVFLWGFYA
Length:670
Mass (Da):72,962
Last modified:October 1, 1996 - v1
Checksum:i0609562861618BB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29881 mRNA Translation: AAC52325.1
RefSeqiNP_072112.2, NM_022590.2
UniGeneiRn.5887

Genome annotation databases

GeneIDi64522
KEGGirno:64522
UCSCiRGD:620217 rat

Similar proteinsi

Entry informationi

Entry nameiSC5A2_RAT
AccessioniPrimary (citable) accession number: P53792
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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