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Protein

Sodium/glucose cotransporter 1

Gene

Slc5a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43Implicated in sodium couplingBy similarity1
Sitei300Implicated in sodium couplingBy similarity1
Binding sitei457GlucoseBy similarity1
Sitei460Involved in sugar-binding/transport and inhibitor bindingBy similarity1

GO - Molecular functioni

  • glucose:sodium symporter activity Source: RGD

GO - Biological processi

  • glucose transport Source: RGD
  • intestinal absorption Source: RGD
  • intestinal D-glucose absorption Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sugar transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-189200. Hexose transport.
R-RNO-428808. Na+-dependent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 1
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
Gene namesi
Name:Slc5a1
Synonyms:Sglt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi3713. Slc5a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 64CytoplasmicSequence analysisAdd BLAST15
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105ExtracellularSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 142CytoplasmicSequence analysisAdd BLAST16
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 178ExtracellularSequence analysisAdd BLAST15
Transmembranei179 – 201HelicalSequence analysisAdd BLAST23
Topological domaini202 – 208CytoplasmicSequence analysis7
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 277ExtracellularSequence analysisAdd BLAST48
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 313CytoplasmicSequence analysisAdd BLAST15
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 380ExtracellularSequence analysisAdd BLAST46
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 423CytoplasmicSequence analysisAdd BLAST22
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 455ExtracellularSequence analysisAdd BLAST11
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 484CytoplasmicSequence analysis8
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 526ExtracellularSequence analysisAdd BLAST21
Intramembranei527 – 563HelicalSequence analysisAdd BLAST37
Topological domaini564 – 644ExtracellularSequence analysisAdd BLAST81
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • brush border membrane Source: RGD
  • cell-cell junction Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053701 – 665Sodium/glucose cotransporter 1Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi255 ↔ 611By similarity
Modified residuei588PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP53790.
PRIDEiP53790.

PTM databases

iPTMnetiP53790.
PhosphoSitePlusiP53790.

Expressioni

Developmental stagei

Appears on embryonic day 18 and gradually increases until birth.

Gene expression databases

BgeeiENSRNOG00000017775.
GenevisibleiP53790. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024165.

Chemistry databases

BindingDBiP53790.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP53790.
KOiK14158.
OMAiKAGCTLC.
OrthoDBiEOG091G077U.
PhylomeDBiP53790.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSTLSPAV TATDAPIQSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST
60 70 80 90 100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG
110 120 130 140 150
FEWNALVFVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL
160 170 180 190 200
LLYIFTKISA DIFSGAIFIN LALGLDIYLA IFILLAITAL YTITGGLAAV
210 220 230 240 250
IYTDTLQTAI MLVGSFILTG FAFREVGGYE AFMDKYMKAI PTLVSDGNIT
260 270 280 290 300
VKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLSILALWY WCTDQVIVQR
310 320 330 340 350
CLSAKNMSHV KAGCTLCGYL KLLPMFLMVM PGMISRILYT DKIACVLPSE
360 370 380 390 400
CKKYCGTPVG CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDIY TKIRKGASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG
460 470 480 490 500
QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV NEPGAFWGLI LGFLIGISRM
510 520 530 540 550
ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFAISVVT VLVISLLTKP
560 570 580 590 600
IPDVHLYRLC WSLRNSTEER IDLDAGEEEP VEEDPKDTIE IDAEAPQKEK
610 620 630 640 650
GCFRKAYDLF CGLDQDKGPK MTKEEEEAMK LKMTDTSEKP LWRTVVNING
660
IILLAVAVFC HAYFA
Length:665
Mass (Da):73,066
Last modified:October 1, 1996 - v1
Checksum:iA92038D964BFF061
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354Y → H in BAA19172 (PubMed:9214758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03120 mRNA. Translation: AAA19015.1.
D16101 mRNA. Translation: BAA03676.1.
AB000729 mRNA. Translation: BAA19172.1.
BC081827 mRNA. Translation: AAH81827.1.
PIRiA53582.
RefSeqiNP_037165.1. NM_013033.2.
UniGeneiRn.10224.

Genome annotation databases

EnsembliENSRNOT00000024165; ENSRNOP00000024165; ENSRNOG00000017775.
GeneIDi25552.
KEGGirno:25552.
UCSCiRGD:3713. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03120 mRNA. Translation: AAA19015.1.
D16101 mRNA. Translation: BAA03676.1.
AB000729 mRNA. Translation: BAA19172.1.
BC081827 mRNA. Translation: AAH81827.1.
PIRiA53582.
RefSeqiNP_037165.1. NM_013033.2.
UniGeneiRn.10224.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024165.

Chemistry databases

BindingDBiP53790.
ChEMBLiCHEMBL5374.

PTM databases

iPTMnetiP53790.
PhosphoSitePlusiP53790.

Proteomic databases

PaxDbiP53790.
PRIDEiP53790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024165; ENSRNOP00000024165; ENSRNOG00000017775.
GeneIDi25552.
KEGGirno:25552.
UCSCiRGD:3713. rat.

Organism-specific databases

CTDi6523.
RGDi3713. Slc5a1.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiP53790.
KOiK14158.
OMAiKAGCTLC.
OrthoDBiEOG091G077U.
PhylomeDBiP53790.

Enzyme and pathway databases

ReactomeiR-RNO-189200. Hexose transport.
R-RNO-428808. Na+-dependent glucose transporters.

Miscellaneous databases

PROiP53790.

Gene expression databases

BgeeiENSRNOG00000017775.
GenevisibleiP53790. RN.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS00457. NA_SOLUT_SYMP_2. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A1_RAT
AccessioniPrimary (citable) accession number: P53790
Secondary accession number(s): P97787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.