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Protein

Sodium/glucose cotransporter 1

Gene

Slc5a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Actively transports glucose into cells by Na+ cotransport with a Na+ to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei43Implicated in sodium couplingBy similarity1
Sitei300Implicated in sodium couplingBy similarity1
Binding sitei457GlucoseBy similarity1
Sitei460Involved in sugar-binding/transport and inhibitor bindingBy similarity1

GO - Molecular functioni

  • glucose:sodium symporter activity Source: RGD

GO - Biological processi

  • glucose transmembrane transport Source: RGD
  • intestinal absorption Source: RGD
  • intestinal D-glucose absorption Source: RGD

Keywordsi

Biological processIon transport, Sodium transport, Sugar transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-189200 Cellular hexose transport
R-RNO-8981373 Intestinal hexose absorption

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 1
Short name:
Na(+)/glucose cotransporter 1
Alternative name(s):
High affinity sodium-glucose cotransporter
Solute carrier family 5 member 1
Gene namesi
Name:Slc5a1
Synonyms:Sglt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi3713 Slc5a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 64CytoplasmicSequence analysisAdd BLAST15
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 105ExtracellularSequence analysisAdd BLAST20
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 142CytoplasmicSequence analysisAdd BLAST16
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 178ExtracellularSequence analysisAdd BLAST15
Transmembranei179 – 201HelicalSequence analysisAdd BLAST23
Topological domaini202 – 208CytoplasmicSequence analysis7
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 277ExtracellularSequence analysisAdd BLAST48
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 313CytoplasmicSequence analysisAdd BLAST15
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 380ExtracellularSequence analysisAdd BLAST46
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 423CytoplasmicSequence analysisAdd BLAST22
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 455ExtracellularSequence analysisAdd BLAST11
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 484CytoplasmicSequence analysis8
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 526ExtracellularSequence analysisAdd BLAST21
Intramembranei527 – 563HelicalSequence analysisAdd BLAST37
Topological domaini564 – 644ExtracellularSequence analysisAdd BLAST81
Transmembranei645 – 665HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5374
GuidetoPHARMACOLOGYi915

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053701 – 665Sodium/glucose cotransporter 1Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 611By similarity
Modified residuei588PhosphothreonineBy similarity1

Post-translational modificationi

N-glycosylation is not necessary for the cotransporter function.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP53790
PRIDEiP53790

PTM databases

iPTMnetiP53790
PhosphoSitePlusiP53790

Expressioni

Developmental stagei

Appears on embryonic day 18 and gradually increases until birth.

Gene expression databases

BgeeiENSRNOG00000017775
GenevisibleiP53790 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024165

Chemistry databases

BindingDBiP53790

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000025422
HOVERGENiHBG052859
InParanoidiP53790
KOiK14158
OMAiVEGWILA
OrthoDBiEOG091G077U
PhylomeDBiP53790

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P53790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSTLSPAV TATDAPIQSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST
60 70 80 90 100
NRGTVGGFFL AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG
110 120 130 140 150
FEWNALVFVV VLGWLFVPIY IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL
160 170 180 190 200
LLYIFTKISA DIFSGAIFIN LALGLDIYLA IFILLAITAL YTITGGLAAV
210 220 230 240 250
IYTDTLQTAI MLVGSFILTG FAFREVGGYE AFMDKYMKAI PTLVSDGNIT
260 270 280 290 300
VKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLSILALWY WCTDQVIVQR
310 320 330 340 350
CLSAKNMSHV KAGCTLCGYL KLLPMFLMVM PGMISRILYT DKIACVLPSE
360 370 380 390 400
CKKYCGTPVG CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDIY TKIRKGASEK ELMIAGRLFI LVLIGISIAW VPIVQSAQSG
460 470 480 490 500
QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV NEPGAFWGLI LGFLIGISRM
510 520 530 540 550
ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFAISVVT VLVISLLTKP
560 570 580 590 600
IPDVHLYRLC WSLRNSTEER IDLDAGEEEP VEEDPKDTIE IDAEAPQKEK
610 620 630 640 650
GCFRKAYDLF CGLDQDKGPK MTKEEEEAMK LKMTDTSEKP LWRTVVNING
660
IILLAVAVFC HAYFA
Length:665
Mass (Da):73,066
Last modified:October 1, 1996 - v1
Checksum:iA92038D964BFF061
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354Y → H in BAA19172 (PubMed:9214758).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03120 mRNA Translation: AAA19015.1
D16101 mRNA Translation: BAA03676.1
AB000729 mRNA Translation: BAA19172.1
BC081827 mRNA Translation: AAH81827.1
PIRiA53582
RefSeqiNP_037165.1, NM_013033.2
UniGeneiRn.10224

Genome annotation databases

EnsembliENSRNOT00000024165; ENSRNOP00000024165; ENSRNOG00000017775
GeneIDi25552
KEGGirno:25552
UCSCiRGD:3713 rat

Similar proteinsi

Entry informationi

Entry nameiSC5A1_RAT
AccessioniPrimary (citable) accession number: P53790
Secondary accession number(s): P97787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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