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P53784

- SOX3_MOUSE

UniProt

P53784 - SOX3_MOUSE

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Protein

Transcription factor SOX-3

Gene

Sox3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi69 – 13769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  3. RNA polymerase II transcription corepressor activity Source: UniProtKB
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. face development Source: UniProtKB
  2. forebrain development Source: MGI
  3. hypothalamus development Source: UniProtKB
  4. negative regulation of neuron differentiation Source: UniProtKB
  5. negative regulation of transcription from RNA polymerase II promoter Source: GOC
  6. neuron development Source: InterPro
  7. organ morphogenesis Source: MGI
  8. pituitary gland development Source: UniProtKB
  9. sensory organ development Source: UniProtKB
  10. Sertoli cell development Source: UniProtKB
  11. sex determination Source: UniProtKB
  12. spermatid differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-3
Gene namesi
Name:Sox3
Synonyms:Sox-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:98365. Sox3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Transcription factor SOX-3PRO_0000048721Add
BLAST

Proteomic databases

MaxQBiP53784.
PaxDbiP53784.
PRIDEiP53784.

PTM databases

PhosphoSiteiP53784.

Expressioni

Tissue specificityi

Mainly in the developing central nervous system. Expressed in developing urogenital ridge.

Gene expression databases

BgeeiP53784.
CleanExiMM_SOX3.
ExpressionAtlasiP53784. baseline and differential.
GenevestigatoriP53784.

Interactioni

Subunit structurei

Interacts with SOX2 and FGFR1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP53784.
SMRiP53784. Positions 67-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 6310Poly-Gly
Compositional biasi164 – 17714Poly-AlaAdd
BLAST
Compositional biasi219 – 2235Poly-Pro
Compositional biasi252 – 2598Poly-Ala
Compositional biasi269 – 2768Poly-Ala
Compositional biasi282 – 29312Poly-AlaAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG321816.
HOGENOMiHOG000231647.
HOVERGENiHBG105663.
InParanoidiP53784.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029550. SOX-3.
IPR022097. TF_SOX.
[Graphical view]
PANTHERiPTHR10270:SF111. PTHR10270:SF111. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53784-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSLLETELK NPVGPPTPAA GTGVPAAPGA AGKSGANPAG GANAGNGGSG
60 70 80 90 100
GANGGGGGGG GGGSDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS
110 120 130 140 150
KRLGADWKLL TDAEKRPFID EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK
160 170 180 190 200
DKYSLPGGLL PPGAAAAAAA AAAAAAASSP VGVGQRLDTY THVNGWANGA
210 220 230 240 250
YSLVQEQLGY AQPPSMSSPP PPPALPQMHR YDMAGLQYSP MMPPGAQSYM
260 270 280 290 300
NAAAAAAAAS GYGGMAPSAA AAAAAAYGQQ PATAAAAAAA AAAMSLGPMG
310 320 330 340 350
SVVKSEPSSP PPAIASHSQR ACLGDLRDMI SMYLPPGGDA ADAASPLPGG
360 370
RLHGVHQHYQ GAGTAVNGTV PLTHI
Length:375
Mass (Da):37,789
Last modified:July 27, 2011 - v2
Checksum:i3E117E20D40BFE34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601L → P in CAA63845. (PubMed:8625802)Curated
Sequence conflicti160 – 1601L → P in AAL40744. (PubMed:12748963)Curated
Sequence conflicti315 – 3151A → R in CAA63845. (PubMed:8625802)Curated
Sequence conflicti315 – 3151A → R in AAL40744. (PubMed:12748963)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94125 Genomic DNA. Translation: CAA63845.1.
AF434675 Genomic DNA. Translation: AAL40744.1.
AB108674 mRNA. Translation: BAC75669.1.
PIRiS10948.
UniGeneiMm.35784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94125 Genomic DNA. Translation: CAA63845.1 .
AF434675 Genomic DNA. Translation: AAL40744.1 .
AB108674 mRNA. Translation: BAC75669.1 .
PIRi S10948.
UniGenei Mm.35784.

3D structure databases

ProteinModelPortali P53784.
SMRi P53784. Positions 67-145.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P53784.

Proteomic databases

MaxQBi P53784.
PaxDbi P53784.
PRIDEi P53784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98365. Sox3.

Phylogenomic databases

eggNOGi NOG321816.
HOGENOMi HOG000231647.
HOVERGENi HBG105663.
InParanoidi P53784.

Miscellaneous databases

ChiTaRSi Sox3. mouse.
PROi P53784.
SOURCEi Search...

Gene expression databases

Bgeei P53784.
CleanExi MM_SOX3.
ExpressionAtlasi P53784. baseline and differential.
Genevestigatori P53784.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR029550. SOX-3.
IPR022097. TF_SOX.
[Graphical view ]
PANTHERi PTHR10270:SF111. PTHR10270:SF111. 1 hit.
Pfami PF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2."
    Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M., Norris D., Rastan S., Stevanovic M., Goodfellow P.N., Lovell-Badge R.
    Development 122:509-520(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Expression of Sox3 throughout the developing central nervous system is dependent on the combined action of discrete, evolutionarily conserved regulatory elements."
    Brunelli S., Silva Casey E., Bell D., Harland R., Lovell-Badge R.
    Genesis 36:12-24(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells."
    Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H.
    Mol. Cell. Biol. 24:8834-8846(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Ola.
  4. "SOX3 is required during the formation of the hypothalamo-pituitary axis."
    Rizzoti K., Brunelli S., Carmignac D., Thomas P.Q., Robinson I.C., Lovell-Badge R.
    Nat. Genet. 36:247-255(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis."
    Rizzoti K., Lovell-Badge R.
    Development 134:3437-3448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SOX2 AND FGFR1.
  6. Cited for: FUNCTION.

Entry informationi

Entry nameiSOX3_MOUSE
AccessioniPrimary (citable) accession number: P53784
Secondary accession number(s): Q80XF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3