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P53784

- SOX3_MOUSE

UniProt

P53784 - SOX3_MOUSE

Protein

Transcription factor SOX-3

Gene

Sox3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi69 – 13769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
    3. RNA polymerase II transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. face development Source: UniProtKB
    2. forebrain development Source: MGI
    3. hypothalamus development Source: UniProtKB
    4. negative regulation of neuron differentiation Source: UniProtKB
    5. negative regulation of transcription from RNA polymerase II promoter Source: GOC
    6. organ morphogenesis Source: MGI
    7. pituitary gland development Source: UniProtKB
    8. sensory organ development Source: UniProtKB
    9. Sertoli cell development Source: UniProtKB
    10. sex determination Source: UniProtKB
    11. spermatid differentiation Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-3
    Gene namesi
    Name:Sox3
    Synonyms:Sox-3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:98365. Sox3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Transcription factor SOX-3PRO_0000048721Add
    BLAST

    Proteomic databases

    PaxDbiP53784.
    PRIDEiP53784.

    PTM databases

    PhosphoSiteiP53784.

    Expressioni

    Tissue specificityi

    Mainly in the developing central nervous system. Expressed in developing urogenital ridge.

    Gene expression databases

    BgeeiP53784.
    CleanExiMM_SOX3.
    GenevestigatoriP53784.

    Interactioni

    Subunit structurei

    Interacts with SOX2 and FGFR1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP53784.
    SMRiP53784. Positions 67-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 6310Poly-Gly
    Compositional biasi164 – 17714Poly-AlaAdd
    BLAST
    Compositional biasi219 – 2235Poly-Pro
    Compositional biasi252 – 2598Poly-Ala
    Compositional biasi269 – 2768Poly-Ala
    Compositional biasi282 – 29312Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG321816.
    HOGENOMiHOG000231647.
    HOVERGENiHBG105663.
    InParanoidiQ80XF1.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029550. SOX-3.
    IPR022097. TF_SOX.
    [Graphical view]
    PANTHERiPTHR10270:SF111. PTHR10270:SF111. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53784-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSLLETELK NPVGPPTPAA GTGVPAAPGA AGKSGANPAG GANAGNGGSG    50
    GANGGGGGGG GGGSDQDRVK RPMNAFMVWS RGQRRKMALE NPKMHNSEIS 100
    KRLGADWKLL TDAEKRPFID EAKRLRAVHM KEYPDYKYRP RRKTKTLLKK 150
    DKYSLPGGLL PPGAAAAAAA AAAAAAASSP VGVGQRLDTY THVNGWANGA 200
    YSLVQEQLGY AQPPSMSSPP PPPALPQMHR YDMAGLQYSP MMPPGAQSYM 250
    NAAAAAAAAS GYGGMAPSAA AAAAAAYGQQ PATAAAAAAA AAAMSLGPMG 300
    SVVKSEPSSP PPAIASHSQR ACLGDLRDMI SMYLPPGGDA ADAASPLPGG 350
    RLHGVHQHYQ GAGTAVNGTV PLTHI 375
    Length:375
    Mass (Da):37,789
    Last modified:July 27, 2011 - v2
    Checksum:i3E117E20D40BFE34
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601L → P in CAA63845. (PubMed:8625802)Curated
    Sequence conflicti160 – 1601L → P in AAL40744. (PubMed:12748963)Curated
    Sequence conflicti315 – 3151A → R in CAA63845. (PubMed:8625802)Curated
    Sequence conflicti315 – 3151A → R in AAL40744. (PubMed:12748963)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94125 Genomic DNA. Translation: CAA63845.1.
    AF434675 Genomic DNA. Translation: AAL40744.1.
    AB108674 mRNA. Translation: BAC75669.1.
    PIRiS10948.
    UniGeneiMm.35784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94125 Genomic DNA. Translation: CAA63845.1 .
    AF434675 Genomic DNA. Translation: AAL40744.1 .
    AB108674 mRNA. Translation: BAC75669.1 .
    PIRi S10948.
    UniGenei Mm.35784.

    3D structure databases

    ProteinModelPortali P53784.
    SMRi P53784. Positions 67-145.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P53784.

    Proteomic databases

    PaxDbi P53784.
    PRIDEi P53784.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98365. Sox3.

    Phylogenomic databases

    eggNOGi NOG321816.
    HOGENOMi HOG000231647.
    HOVERGENi HBG105663.
    InParanoidi Q80XF1.

    Miscellaneous databases

    ChiTaRSi SOX3. mouse.
    PROi P53784.
    SOURCEi Search...

    Gene expression databases

    Bgeei P53784.
    CleanExi MM_SOX3.
    Genevestigatori P53784.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029550. SOX-3.
    IPR022097. TF_SOX.
    [Graphical view ]
    PANTHERi PTHR10270:SF111. PTHR10270:SF111. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2."
      Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M., Norris D., Rastan S., Stevanovic M., Goodfellow P.N., Lovell-Badge R.
      Development 122:509-520(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    2. "Expression of Sox3 throughout the developing central nervous system is dependent on the combined action of discrete, evolutionarily conserved regulatory elements."
      Brunelli S., Silva Casey E., Bell D., Harland R., Lovell-Badge R.
      Genesis 36:12-24(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "Interplay of SOX and POU factors in regulation of the nestin gene in neural primordial cells."
      Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H.
      Mol. Cell. Biol. 24:8834-8846(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Ola.
    4. "SOX3 is required during the formation of the hypothalamo-pituitary axis."
      Rizzoti K., Brunelli S., Carmignac D., Thomas P.Q., Robinson I.C., Lovell-Badge R.
      Nat. Genet. 36:247-255(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis."
      Rizzoti K., Lovell-Badge R.
      Development 134:3437-3448(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SOX2 AND FGFR1.
    6. Cited for: FUNCTION.

    Entry informationi

    Entry nameiSOX3_MOUSE
    AccessioniPrimary (citable) accession number: P53784
    Secondary accession number(s): Q80XF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3