LIM/homeobox protein Lhx4 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot P53776 (LHX4_MOUSE)

Last modified June 16, 2009. Version 68. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
LIM/homeobox protein Lhx4
Short name=LIM homeobox protein 4

Gene names

Name:	Lhx4
Synonyms:	Gsh-4, Gsh4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.
Subcellular location	Nucleus Potential.
Tissue specificity	Transient expression in ventrolateral regions of the developing neural tube and hindbrain.
Sequence similarities	Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox LIM domain Repeat
Ligand	DNA-binding Metal-binding Zinc
Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from mutant phenotype. Source: MGI medial motor column neuron differentiation Inferred from genetic interaction. Source: MGI motor axon guidance Inferred from genetic interaction. Source: MGI organ morphogenesis Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 390

390

LIM/homeobox protein Lhx4

PRO_0000075788

Regions

Domain

28 – 87

LIM zinc-binding 1

Domain

88 – 150

LIM zinc-binding 2

DNA binding

157 – 216

Homeobox

Experimental info

Sequence conflict

377

S → T in AAH49834. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P53776-1 [UniParc].

Last modified October 14, 2008. Version 4.
Checksum: FF70967D30C724C4
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FASTA

390

43,078

        10         20         30         40         50         60 
MMQSAAVPAE GAVKGLPEML GVPMQQIPQC AGCNQHILDK FILKVLDRHW HSSCLKCADC 

        70         80         90        100        110        120 
QMQLADRCFS RAGSVYCKED FFKRFGTKCT ACQQGIPPTQ VVRKAQDFVY HLHCFACIIC 

       130        140        150        160        170        180 
NRQLATGDEF YLMEDGRLVC KEDYETAKQN DDSEAGAKRP RTTITAKQLE TLKNAYKNSP 

       190        200        210        220        230        240 
KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RHRWGQFYKS VKRSRGGSKQ 

       250        260        270        280        290        300 
EKESSAEDCG VSDSELSFRE DQILSELGHT NRIYGNVGDV TGGQLMNGSF SMDGTGQSYQ 

       310        320        330        340        350        360 
DLRDGSPYGI PQSPSSISSL PSHAPLLNGL DYTVDSNLGI IAHAGQGVSQ TLRAMAGGPT 

       370        380        390 
SDLSTGSSVG YPDFPTSPAS WLDEMDHPPF

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[2]	Sakai T., Kawaguchi A., Nagashima M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-390.
[3]	"Lhx4, a LIM homeobox gene." Yamashita T., Moriyama K., Sheng H.Z., Westphal H. Genomics 44:144-146(1997) [PubMed: 9286712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-219. Strain: FVB/N. Tissue: Embryo.
[4]	"Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival." Li H., Witte D.P., Branford W.W., Aronow B.J., Weinstein M., Kaur S., Wert S., Singh G., Schreiner C.M., Whitsett J.A., Scott W.J. Jr., Potter S.S. EMBO J. 13:2876-2885(1994) [PubMed: 7913017] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-390.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	BC049834 mRNA. Translation: AAH49834.1. AF135415 mRNA. Translation: AAD30125.1. Different initiation. U89343 mRNA. Translation: AAC53336.1. S71659 mRNA. Translation: AAB31260.1.
IPI	IPI00134772.
PIR	S46332.
RefSeq	NP_034842.2.
UniGene	Mm.103624
3D structure databases
HSSP	HSSP built from PDB template 1BW5 based on UniProtKB P50480.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000026468. Mus musculus. [Contig view]
GeneID	16872.
KEGG	mmu:16872.
Organism-specific databases
MGI	MGI:101776. Lhx4.
Phylogenomic databases
HOVERGEN	P53776.
OMA	P53776. HDIRAGS.
Gene expression databases
ArrayExpress	P53776.
Bgee	P53776.
CleanEx	MM_LHX4.
GermOnline	ENSMUSG00000026468. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR001781. Znf_LIM. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. G3DSA:2.10.110.10. Znf_LIM. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. PD000094. LIM. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

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Entry information

Entry name

LHX4_MOUSE

Accession

Primary (citable) accession number: P53776
Secondary accession number(s): O08916, Q810K7, Q9R280

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 14, 2008
Last modified:	June 16, 2009
This is version 68 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents