P53774 (DLL2_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein DLL-2
Short name=XDLL-2

Gene names

Name:

dll2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have a regulatory function in the initial formation of the epidermis.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in the embryonic ectoderm and is specifically repressed in the CNS. High level of expression in adult skin.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Homeobox protein DLL-2		PRO_0000049037
Regions
	DNA binding	130 – 189	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P53774 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 298F1BD60A53CB5A	FASTA	277	31,656
	10 20 30 40 50 60 MSGPYEKKMA VLTDLSTSSH PVTKDSPTLP ESSATDMGYY NGHLSTGQHD FFQTQAYSPT 70 80 90 100 110 120 ISSYGYPHPP HPQYNFNGLV GNESFLPKDD YQYGYRPFVH YREPPVQETV SVKEEPETEV 130 140 150 160 170 180 RMVNGKPKKI RKPRTIYSSY QLAALQRRFQ KAQYLALPER AELAAQLGLT QTQVKIWFQN 190 200 210 220 230 240 RRSKFKKLYK NGEGPDMEHS PNNSDSMACN SPSSPPIWDN SGSRTPLQQQ QQQQSLPQCS 250 260 270 SPSYLENYHS WYTQQNQSGQ HLQPSEVMHQ PPPDTVY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expression of a Distal-less homeobox gene Xdll-2 in ectodermal cell lineages." Dirksen M.L., Morasso M.I., Sargent T.D., Jamrich M. Mech. Dev. 46:63-70(1994) [PubMed: 7915132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S74210 mRNA. Translation: AAB31740.2. BC123268 mRNA. Translation: AAI23269.1.
RefSeq	NP_001090515.1. NM_001097046.1.
UniGene	Xl.59850.
3D structure databases
ProteinModelPortal	P53774.
SMR	P53774. Positions 131-187.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	779428.
KEGG	xla:779428.
Organism-specific databases
CTD	779428.
Xenbase	XB-GENE-5879348. dlx3.
Phylogenomic databases
HOVERGEN	HBG005493.
Family and domain databases
InterPro	IPR022135. DLL_N. IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR000047. HTH_motif. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09315.
Pfam	PF12413. DLL_N. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLL2_XENLA

Accession

Primary (citable) accession number: P53774
Secondary accession number(s): Q0IH82

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program