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P53756

- PDR18_YEAST

UniProt

P53756 - PDR18_YEAST

Protein

ABC transporter ATP-binding protein/permease PDR18

Gene

PDR18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi765 – 7728ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xenobiotic-transporting ATPase activity Source: SGD

    GO - Biological processi

    1. drug transmembrane transport Source: GOC
    2. drug transport Source: SGD
    3. response to drug Source: SGD
    4. sterol homeostasis Source: SGD
    5. xenobiotic transport Source: GOC

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33374-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ABC transporter ATP-binding protein/permease PDR18
    Alternative name(s):
    Pleiotropic drug resistance protein 18
    Gene namesi
    Name:PDR18
    Ordered Locus Names:YNR070W
    ORF Names:N3568
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNR070w.
    SGDiS000005353. PDR18.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13331333ABC transporter ATP-binding protein/permease PDR18PRO_0000093466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi958 – 9581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1320 – 13201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP53756.

    Expressioni

    Gene expression databases

    GenevestigatoriP53756.

    Interactioni

    Protein-protein interaction databases

    BioGridi35896. 17 interactions.
    DIPiDIP-7300N.
    IntActiP53756. 2 interactions.
    MINTiMINT-1360213.
    STRINGi4932.YNR070W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53756.
    SMRiP53756. Positions 45-292, 683-946.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei474 – 49421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei534 – 55421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei642 – 66221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1071 – 109121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1092 – 111221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1150 – 117021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1178 – 119821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1210 – 123021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1235 – 125521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 281252ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini729 – 971243ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    GeneTreeiENSGT00550000075308.
    OMAiEYANINE.
    OrthoDBiEOG7N903S.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    IPR010929. PDR_CDR_ABC.
    [Graphical view]
    PfamiPF01061. ABC2_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    PF06422. PDR_CDR. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53756-1 [UniParc]FASTAAdd to Basket

    « Hide

    MECVSVEGLD SSFLEGQTFG DILCLPWTII KGIRERKNRN KMKIILKNVS     50
    LLAKSGEMVL VLGRPGAGCT SFLKSAAGET SQFAGGVTTG HISYDGIPQK 100
    EMMQHYKPDV IYNGEQDVHF PHLTVKQTLD FAISCKMPAK RVNNVTKEEY 150
    ITANREFYAK IFGLTHTFDT KVGNDFISGV SGGERKRVSI AEALAAKGSI 200
    YCWDNATRGL DSSTALEFAR AIRTMTNLLG TTALVTVYQA SENIYETFDK 250
    VTVLYAGRQI FCGKTTEAKD YFENMGYLCP PRQSTAEYLT AITDPNGLHE 300
    IKPGFEYQVP HTADEFEKYW LDSPEYARLK GEIQKYKHEV NTEWTKKTYN 350
    ESMAQEKSKG TRKKSYYTVS YWEQIRLCTI RGFLRIYGDK SYTVINTCAA 400
    IAQAFITGSL FYQAPSSTLG AFSRSGVLFF SLLYYSLMGL ANISFEHRPI 450
    LQKHKVYSLY HPSAEALAST ISSFPFRMIG LTFFIIILYF LAGLHRSAGA 500
    FFTMYLLLTM CSEAITSLFQ MVSSLCDTLS QANSIAGVVM LSIAMYSTYM 550
    IQLPSMHPWF KWISYILPIR YAFESMLNAE FHGRHMDCGG TLVPSGPGFE 600
    NILPENQVCA FVGSRPGQSW VLGDDYLRAQ YQYEYKNTWR NFGIMWCFLI 650
    GYIVLRAVFT EYKSPVKSGG DALVVKKGTK NAIQRSWSSK NDEENLNASI 700
    ATQDMKEIAS SNDDSTSADF EGLESTGVFI WKNVSFTIPH SSGQRKLLDS 750
    VSGYCVPGTL TALIGESGAG KTTLLNTLAQ RNVGTITGDM LVDGLPMDAS 800
    FKRRTGYVQQ QDLHVAELTV KESLQFSARM RRPQSIPDAE KMEYVEKIIS 850
    ILEMQEFSEA LVGEIGYGLN VEQRKKLSIG VELVGKPDLL LFLDEPTSGL 900
    DSQSAWAVVK MLKRLALAGQ SILCTIHQPS ATLFEQFDRL LLLGKGGQTI 950
    YFGEIGKNSS SVIKYFEKNG ARKCQQNENP AEYILEAIGA GATASVQQNW 1000
    PDIWQKSHEY ANINEKINDM IKDLSSTTLH KTATRASKYA TSYSYQFHHV 1050
    LKRSSLTFWR NLNYIMAKMM LLMISGLFIG FTFFHVGVNA IGLQNSLFAC 1100
    FMAIVISAPA TNQIQERATV AKELYEVRES KSNMFHWSLL LITHYLNELP 1150
    YHLLFSTIFF VSSYFPLGVF TEASRSSVFY LNYAILFQLY YIGLALMILY 1200
    MSPNLQSANV IVGFILSFLL SFCGAVQPAS LMPGFWTFMW KLSPYTYFLQ 1250
    NLVGLLMHDK PVRCSKKELS LFNPPVGQTC GEFTKPFFEF GTGYIANPDA 1300
    TADCAYCQYK VGDEYLARIN ASFSYLWRNF GFI 1333
    Length:1,333
    Mass (Da):149,750
    Last modified:October 1, 1996 - v1
    Checksum:i61B4758E0245CB70
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71685 Genomic DNA. Translation: CAA96352.1.
    Z71686 Genomic DNA. Translation: CAA96354.1.
    BK006947 Genomic DNA. Translation: DAA10611.1.
    PIRiS63403.
    RefSeqiNP_014468.3. NM_001183247.4.

    Genome annotation databases

    EnsemblFungiiYNR070W; YNR070W; YNR070W.
    GeneIDi855807.
    KEGGisce:YNR070W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71685 Genomic DNA. Translation: CAA96352.1 .
    Z71686 Genomic DNA. Translation: CAA96354.1 .
    BK006947 Genomic DNA. Translation: DAA10611.1 .
    PIRi S63403.
    RefSeqi NP_014468.3. NM_001183247.4.

    3D structure databases

    ProteinModelPortali P53756.
    SMRi P53756. Positions 45-292, 683-946.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35896. 17 interactions.
    DIPi DIP-7300N.
    IntActi P53756. 2 interactions.
    MINTi MINT-1360213.
    STRINGi 4932.YNR070W.

    Proteomic databases

    PaxDbi P53756.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNR070W ; YNR070W ; YNR070W .
    GeneIDi 855807.
    KEGGi sce:YNR070W.

    Organism-specific databases

    CYGDi YNR070w.
    SGDi S000005353. PDR18.

    Phylogenomic databases

    eggNOGi COG1131.
    GeneTreei ENSGT00550000075308.
    OMAi EYANINE.
    OrthoDBi EOG7N903S.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33374-MONOMER.

    Miscellaneous databases

    NextBioi 980327.

    Gene expression databases

    Genevestigatori P53756.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    IPR010929. PDR_CDR_ABC.
    [Graphical view ]
    Pfami PF01061. ABC2_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    PF06422. PDR_CDR. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiPDR18_YEAST
    AccessioniPrimary (citable) accession number: P53756
    Secondary accession number(s): D6W1P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3