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P53756 (PDR18_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter ATP-binding protein/permease PDR18
Alternative name(s):
Pleiotropic drug resistance protein 18
Gene names
Name:PDR18
Ordered Locus Names:YNR070W
ORF Names:N3568
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13331333ABC transporter ATP-binding protein/permease PDR18
PRO_0000093466

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane392 – 41221Helical; Potential
Transmembrane425 – 44521Helical; Potential
Transmembrane474 – 49421Helical; Potential
Transmembrane499 – 51921Helical; Potential
Transmembrane534 – 55421Helical; Potential
Transmembrane642 – 66221Helical; Potential
Transmembrane1071 – 109121Helical; Potential
Transmembrane1092 – 111221Helical; Potential
Transmembrane1150 – 117021Helical; Potential
Transmembrane1178 – 119821Helical; Potential
Transmembrane1210 – 123021Helical; Potential
Transmembrane1235 – 125521Helical; Potential
Domain30 – 281252ABC transporter 1
Domain729 – 971243ABC transporter 2
Nucleotide binding765 – 7728ATP Potential

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation3501N-linked (GlcNAc...) Potential
Glycosylation6971N-linked (GlcNAc...) Potential
Glycosylation7331N-linked (GlcNAc...) Potential
Glycosylation9581N-linked (GlcNAc...) Potential
Glycosylation13201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P53756 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 61B4758E0245CB70

FASTA1,333149,750
        10         20         30         40         50         60 
MECVSVEGLD SSFLEGQTFG DILCLPWTII KGIRERKNRN KMKIILKNVS LLAKSGEMVL 

        70         80         90        100        110        120 
VLGRPGAGCT SFLKSAAGET SQFAGGVTTG HISYDGIPQK EMMQHYKPDV IYNGEQDVHF 

       130        140        150        160        170        180 
PHLTVKQTLD FAISCKMPAK RVNNVTKEEY ITANREFYAK IFGLTHTFDT KVGNDFISGV 

       190        200        210        220        230        240 
SGGERKRVSI AEALAAKGSI YCWDNATRGL DSSTALEFAR AIRTMTNLLG TTALVTVYQA 

       250        260        270        280        290        300 
SENIYETFDK VTVLYAGRQI FCGKTTEAKD YFENMGYLCP PRQSTAEYLT AITDPNGLHE 

       310        320        330        340        350        360 
IKPGFEYQVP HTADEFEKYW LDSPEYARLK GEIQKYKHEV NTEWTKKTYN ESMAQEKSKG 

       370        380        390        400        410        420 
TRKKSYYTVS YWEQIRLCTI RGFLRIYGDK SYTVINTCAA IAQAFITGSL FYQAPSSTLG 

       430        440        450        460        470        480 
AFSRSGVLFF SLLYYSLMGL ANISFEHRPI LQKHKVYSLY HPSAEALAST ISSFPFRMIG 

       490        500        510        520        530        540 
LTFFIIILYF LAGLHRSAGA FFTMYLLLTM CSEAITSLFQ MVSSLCDTLS QANSIAGVVM 

       550        560        570        580        590        600 
LSIAMYSTYM IQLPSMHPWF KWISYILPIR YAFESMLNAE FHGRHMDCGG TLVPSGPGFE 

       610        620        630        640        650        660 
NILPENQVCA FVGSRPGQSW VLGDDYLRAQ YQYEYKNTWR NFGIMWCFLI GYIVLRAVFT 

       670        680        690        700        710        720 
EYKSPVKSGG DALVVKKGTK NAIQRSWSSK NDEENLNASI ATQDMKEIAS SNDDSTSADF 

       730        740        750        760        770        780 
EGLESTGVFI WKNVSFTIPH SSGQRKLLDS VSGYCVPGTL TALIGESGAG KTTLLNTLAQ 

       790        800        810        820        830        840 
RNVGTITGDM LVDGLPMDAS FKRRTGYVQQ QDLHVAELTV KESLQFSARM RRPQSIPDAE 

       850        860        870        880        890        900 
KMEYVEKIIS ILEMQEFSEA LVGEIGYGLN VEQRKKLSIG VELVGKPDLL LFLDEPTSGL 

       910        920        930        940        950        960 
DSQSAWAVVK MLKRLALAGQ SILCTIHQPS ATLFEQFDRL LLLGKGGQTI YFGEIGKNSS 

       970        980        990       1000       1010       1020 
SVIKYFEKNG ARKCQQNENP AEYILEAIGA GATASVQQNW PDIWQKSHEY ANINEKINDM 

      1030       1040       1050       1060       1070       1080 
IKDLSSTTLH KTATRASKYA TSYSYQFHHV LKRSSLTFWR NLNYIMAKMM LLMISGLFIG 

      1090       1100       1110       1120       1130       1140 
FTFFHVGVNA IGLQNSLFAC FMAIVISAPA TNQIQERATV AKELYEVRES KSNMFHWSLL 

      1150       1160       1170       1180       1190       1200 
LITHYLNELP YHLLFSTIFF VSSYFPLGVF TEASRSSVFY LNYAILFQLY YIGLALMILY 

      1210       1220       1230       1240       1250       1260 
MSPNLQSANV IVGFILSFLL SFCGAVQPAS LMPGFWTFMW KLSPYTYFLQ NLVGLLMHDK 

      1270       1280       1290       1300       1310       1320 
PVRCSKKELS LFNPPVGQTC GEFTKPFFEF GTGYIANPDA TADCAYCQYK VGDEYLARIN 

      1330 
ASFSYLWRNF GFI 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71685 Genomic DNA. Translation: CAA96352.1.
Z71686 Genomic DNA. Translation: CAA96354.1.
BK006947 Genomic DNA. Translation: DAA10611.1.
PIRS63403.
RefSeqNP_014468.3. NM_001183247.4.

3D structure databases

ProteinModelPortalP53756.
SMRP53756. Positions 43-292, 683-946.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35896. 17 interactions.
DIPDIP-7300N.
IntActP53756. 2 interactions.
MINTMINT-1360213.
STRING4932.YNR070W.

Proteomic databases

PaxDbP53756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNR070W; YNR070W; YNR070W.
GeneID855807.
KEGGsce:YNR070W.

Organism-specific databases

CYGDYNR070w.
SGDS000005353. PDR18.

Phylogenomic databases

eggNOGCOG1131.
GeneTreeENSGT00550000075308.
OMAHLTVKQT.
OrthoDBEOG7N903S.

Enzyme and pathway databases

BioCycYEAST:G3O-33374-MONOMER.

Gene expression databases

GenevestigatorP53756.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio980327.

Entry information

Entry namePDR18_YEAST
AccessionPrimary (citable) accession number: P53756
Secondary accession number(s): D6W1P5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families