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Protein

ABC transporter ATP-binding protein/permease PDR18

Gene

PDR18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi765 – 772ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • xenobiotic-transporting ATPase activity Source: SGD

GO - Biological processi

  • cellular response to drug Source: GO_Central
  • drug transport Source: SGD
  • response to drug Source: SGD
  • sterol homeostasis Source: SGD
  • sterol import Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33374-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding protein/permease PDR18
Alternative name(s):
Pleiotropic drug resistance protein 18
Gene namesi
Name:PDR18
Ordered Locus Names:YNR070W
ORF Names:N3568
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR070W.
SGDiS000005353. PDR18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Transmembranei642 – 662HelicalSequence analysisAdd BLAST21
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Transmembranei1092 – 1112HelicalSequence analysisAdd BLAST21
Transmembranei1150 – 1170HelicalSequence analysisAdd BLAST21
Transmembranei1178 – 1198HelicalSequence analysisAdd BLAST21
Transmembranei1210 – 1230HelicalSequence analysisAdd BLAST21
Transmembranei1235 – 1255HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934661 – 1333ABC transporter ATP-binding protein/permease PDR18Add BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi697N-linked (GlcNAc...)Sequence analysis1
Glycosylationi733N-linked (GlcNAc...)Sequence analysis1
Glycosylationi958N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1320N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP53756.
PRIDEiP53756.

Interactioni

Protein-protein interaction databases

BioGridi35896. 16 interactors.
DIPiDIP-7300N.
IntActiP53756. 2 interactors.
MINTiMINT-1360213.

Structurei

3D structure databases

ProteinModelPortaliP53756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 281ABC transporter 1PROSITE-ProRule annotationAdd BLAST252
Domaini729 – 971ABC transporter 2PROSITE-ProRule annotationAdd BLAST243

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
InParanoidiP53756.
OMAiATADCAY.
OrthoDBiEOG092C1HKF.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECVSVEGLD SSFLEGQTFG DILCLPWTII KGIRERKNRN KMKIILKNVS
60 70 80 90 100
LLAKSGEMVL VLGRPGAGCT SFLKSAAGET SQFAGGVTTG HISYDGIPQK
110 120 130 140 150
EMMQHYKPDV IYNGEQDVHF PHLTVKQTLD FAISCKMPAK RVNNVTKEEY
160 170 180 190 200
ITANREFYAK IFGLTHTFDT KVGNDFISGV SGGERKRVSI AEALAAKGSI
210 220 230 240 250
YCWDNATRGL DSSTALEFAR AIRTMTNLLG TTALVTVYQA SENIYETFDK
260 270 280 290 300
VTVLYAGRQI FCGKTTEAKD YFENMGYLCP PRQSTAEYLT AITDPNGLHE
310 320 330 340 350
IKPGFEYQVP HTADEFEKYW LDSPEYARLK GEIQKYKHEV NTEWTKKTYN
360 370 380 390 400
ESMAQEKSKG TRKKSYYTVS YWEQIRLCTI RGFLRIYGDK SYTVINTCAA
410 420 430 440 450
IAQAFITGSL FYQAPSSTLG AFSRSGVLFF SLLYYSLMGL ANISFEHRPI
460 470 480 490 500
LQKHKVYSLY HPSAEALAST ISSFPFRMIG LTFFIIILYF LAGLHRSAGA
510 520 530 540 550
FFTMYLLLTM CSEAITSLFQ MVSSLCDTLS QANSIAGVVM LSIAMYSTYM
560 570 580 590 600
IQLPSMHPWF KWISYILPIR YAFESMLNAE FHGRHMDCGG TLVPSGPGFE
610 620 630 640 650
NILPENQVCA FVGSRPGQSW VLGDDYLRAQ YQYEYKNTWR NFGIMWCFLI
660 670 680 690 700
GYIVLRAVFT EYKSPVKSGG DALVVKKGTK NAIQRSWSSK NDEENLNASI
710 720 730 740 750
ATQDMKEIAS SNDDSTSADF EGLESTGVFI WKNVSFTIPH SSGQRKLLDS
760 770 780 790 800
VSGYCVPGTL TALIGESGAG KTTLLNTLAQ RNVGTITGDM LVDGLPMDAS
810 820 830 840 850
FKRRTGYVQQ QDLHVAELTV KESLQFSARM RRPQSIPDAE KMEYVEKIIS
860 870 880 890 900
ILEMQEFSEA LVGEIGYGLN VEQRKKLSIG VELVGKPDLL LFLDEPTSGL
910 920 930 940 950
DSQSAWAVVK MLKRLALAGQ SILCTIHQPS ATLFEQFDRL LLLGKGGQTI
960 970 980 990 1000
YFGEIGKNSS SVIKYFEKNG ARKCQQNENP AEYILEAIGA GATASVQQNW
1010 1020 1030 1040 1050
PDIWQKSHEY ANINEKINDM IKDLSSTTLH KTATRASKYA TSYSYQFHHV
1060 1070 1080 1090 1100
LKRSSLTFWR NLNYIMAKMM LLMISGLFIG FTFFHVGVNA IGLQNSLFAC
1110 1120 1130 1140 1150
FMAIVISAPA TNQIQERATV AKELYEVRES KSNMFHWSLL LITHYLNELP
1160 1170 1180 1190 1200
YHLLFSTIFF VSSYFPLGVF TEASRSSVFY LNYAILFQLY YIGLALMILY
1210 1220 1230 1240 1250
MSPNLQSANV IVGFILSFLL SFCGAVQPAS LMPGFWTFMW KLSPYTYFLQ
1260 1270 1280 1290 1300
NLVGLLMHDK PVRCSKKELS LFNPPVGQTC GEFTKPFFEF GTGYIANPDA
1310 1320 1330
TADCAYCQYK VGDEYLARIN ASFSYLWRNF GFI
Length:1,333
Mass (Da):149,750
Last modified:October 1, 1996 - v1
Checksum:i61B4758E0245CB70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71685 Genomic DNA. Translation: CAA96352.1.
Z71686 Genomic DNA. Translation: CAA96354.1.
BK006947 Genomic DNA. Translation: DAA10611.1.
PIRiS63403.
RefSeqiNP_014468.3. NM_001183247.4.

Genome annotation databases

EnsemblFungiiYNR070W; YNR070W; YNR070W.
GeneIDi855807.
KEGGisce:YNR070W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71685 Genomic DNA. Translation: CAA96352.1.
Z71686 Genomic DNA. Translation: CAA96354.1.
BK006947 Genomic DNA. Translation: DAA10611.1.
PIRiS63403.
RefSeqiNP_014468.3. NM_001183247.4.

3D structure databases

ProteinModelPortaliP53756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35896. 16 interactors.
DIPiDIP-7300N.
IntActiP53756. 2 interactors.
MINTiMINT-1360213.

Proteomic databases

MaxQBiP53756.
PRIDEiP53756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR070W; YNR070W; YNR070W.
GeneIDi855807.
KEGGisce:YNR070W.

Organism-specific databases

EuPathDBiFungiDB:YNR070W.
SGDiS000005353. PDR18.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
InParanoidiP53756.
OMAiATADCAY.
OrthoDBiEOG092C1HKF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33374-MONOMER.

Miscellaneous databases

PROiP53756.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDR18_YEAST
AccessioniPrimary (citable) accession number: P53756
Secondary accession number(s): D6W1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.