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P53756

- PDR18_YEAST

UniProt

P53756 - PDR18_YEAST

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Protein

ABC transporter ATP-binding protein/permease PDR18

Gene

PDR18

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi765 – 7728ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xenobiotic-transporting ATPase activity Source: SGD

GO - Biological processi

  1. drug transmembrane transport Source: GOC
  2. drug transport Source: SGD
  3. response to drug Source: SGD
  4. sterol homeostasis Source: SGD
  5. xenobiotic transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33374-MONOMER.
ReactomeiREACT_189334. ABCA transporters in lipid homeostasis.
REACT_269941. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding protein/permease PDR18
Alternative name(s):
Pleiotropic drug resistance protein 18
Gene namesi
Name:PDR18
Ordered Locus Names:YNR070W
ORF Names:N3568
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNR070w.
SGDiS000005353. PDR18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST
Transmembranei474 – 49421HelicalSequence AnalysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence AnalysisAdd
BLAST
Transmembranei534 – 55421HelicalSequence AnalysisAdd
BLAST
Transmembranei642 – 66221HelicalSequence AnalysisAdd
BLAST
Transmembranei1071 – 109121HelicalSequence AnalysisAdd
BLAST
Transmembranei1092 – 111221HelicalSequence AnalysisAdd
BLAST
Transmembranei1150 – 117021HelicalSequence AnalysisAdd
BLAST
Transmembranei1178 – 119821HelicalSequence AnalysisAdd
BLAST
Transmembranei1210 – 123021HelicalSequence AnalysisAdd
BLAST
Transmembranei1235 – 125521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333ABC transporter ATP-binding protein/permease PDR18PRO_0000093466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi697 – 6971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi958 – 9581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1320 – 13201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP53756.

Expressioni

Gene expression databases

GenevestigatoriP53756.

Interactioni

Protein-protein interaction databases

BioGridi35896. 17 interactions.
DIPiDIP-7300N.
IntActiP53756. 2 interactions.
MINTiMINT-1360213.
STRINGi4932.YNR070W.

Structurei

3D structure databases

ProteinModelPortaliP53756.
SMRiP53756. Positions 45-317, 683-946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 281252ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini729 – 971243ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1131.
GeneTreeiENSGT00550000075308.
InParanoidiP53756.
OMAiEYANINE.
OrthoDBiEOG7N903S.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53756-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MECVSVEGLD SSFLEGQTFG DILCLPWTII KGIRERKNRN KMKIILKNVS
60 70 80 90 100
LLAKSGEMVL VLGRPGAGCT SFLKSAAGET SQFAGGVTTG HISYDGIPQK
110 120 130 140 150
EMMQHYKPDV IYNGEQDVHF PHLTVKQTLD FAISCKMPAK RVNNVTKEEY
160 170 180 190 200
ITANREFYAK IFGLTHTFDT KVGNDFISGV SGGERKRVSI AEALAAKGSI
210 220 230 240 250
YCWDNATRGL DSSTALEFAR AIRTMTNLLG TTALVTVYQA SENIYETFDK
260 270 280 290 300
VTVLYAGRQI FCGKTTEAKD YFENMGYLCP PRQSTAEYLT AITDPNGLHE
310 320 330 340 350
IKPGFEYQVP HTADEFEKYW LDSPEYARLK GEIQKYKHEV NTEWTKKTYN
360 370 380 390 400
ESMAQEKSKG TRKKSYYTVS YWEQIRLCTI RGFLRIYGDK SYTVINTCAA
410 420 430 440 450
IAQAFITGSL FYQAPSSTLG AFSRSGVLFF SLLYYSLMGL ANISFEHRPI
460 470 480 490 500
LQKHKVYSLY HPSAEALAST ISSFPFRMIG LTFFIIILYF LAGLHRSAGA
510 520 530 540 550
FFTMYLLLTM CSEAITSLFQ MVSSLCDTLS QANSIAGVVM LSIAMYSTYM
560 570 580 590 600
IQLPSMHPWF KWISYILPIR YAFESMLNAE FHGRHMDCGG TLVPSGPGFE
610 620 630 640 650
NILPENQVCA FVGSRPGQSW VLGDDYLRAQ YQYEYKNTWR NFGIMWCFLI
660 670 680 690 700
GYIVLRAVFT EYKSPVKSGG DALVVKKGTK NAIQRSWSSK NDEENLNASI
710 720 730 740 750
ATQDMKEIAS SNDDSTSADF EGLESTGVFI WKNVSFTIPH SSGQRKLLDS
760 770 780 790 800
VSGYCVPGTL TALIGESGAG KTTLLNTLAQ RNVGTITGDM LVDGLPMDAS
810 820 830 840 850
FKRRTGYVQQ QDLHVAELTV KESLQFSARM RRPQSIPDAE KMEYVEKIIS
860 870 880 890 900
ILEMQEFSEA LVGEIGYGLN VEQRKKLSIG VELVGKPDLL LFLDEPTSGL
910 920 930 940 950
DSQSAWAVVK MLKRLALAGQ SILCTIHQPS ATLFEQFDRL LLLGKGGQTI
960 970 980 990 1000
YFGEIGKNSS SVIKYFEKNG ARKCQQNENP AEYILEAIGA GATASVQQNW
1010 1020 1030 1040 1050
PDIWQKSHEY ANINEKINDM IKDLSSTTLH KTATRASKYA TSYSYQFHHV
1060 1070 1080 1090 1100
LKRSSLTFWR NLNYIMAKMM LLMISGLFIG FTFFHVGVNA IGLQNSLFAC
1110 1120 1130 1140 1150
FMAIVISAPA TNQIQERATV AKELYEVRES KSNMFHWSLL LITHYLNELP
1160 1170 1180 1190 1200
YHLLFSTIFF VSSYFPLGVF TEASRSSVFY LNYAILFQLY YIGLALMILY
1210 1220 1230 1240 1250
MSPNLQSANV IVGFILSFLL SFCGAVQPAS LMPGFWTFMW KLSPYTYFLQ
1260 1270 1280 1290 1300
NLVGLLMHDK PVRCSKKELS LFNPPVGQTC GEFTKPFFEF GTGYIANPDA
1310 1320 1330
TADCAYCQYK VGDEYLARIN ASFSYLWRNF GFI
Length:1,333
Mass (Da):149,750
Last modified:October 1, 1996 - v1
Checksum:i61B4758E0245CB70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71685 Genomic DNA. Translation: CAA96352.1.
Z71686 Genomic DNA. Translation: CAA96354.1.
BK006947 Genomic DNA. Translation: DAA10611.1.
PIRiS63403.
RefSeqiNP_014468.3. NM_001183247.4.

Genome annotation databases

EnsemblFungiiYNR070W; YNR070W; YNR070W.
GeneIDi855807.
KEGGisce:YNR070W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71685 Genomic DNA. Translation: CAA96352.1 .
Z71686 Genomic DNA. Translation: CAA96354.1 .
BK006947 Genomic DNA. Translation: DAA10611.1 .
PIRi S63403.
RefSeqi NP_014468.3. NM_001183247.4.

3D structure databases

ProteinModelPortali P53756.
SMRi P53756. Positions 45-317, 683-946.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35896. 17 interactions.
DIPi DIP-7300N.
IntActi P53756. 2 interactions.
MINTi MINT-1360213.
STRINGi 4932.YNR070W.

Proteomic databases

PaxDbi P53756.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNR070W ; YNR070W ; YNR070W .
GeneIDi 855807.
KEGGi sce:YNR070W.

Organism-specific databases

CYGDi YNR070w.
SGDi S000005353. PDR18.

Phylogenomic databases

eggNOGi COG1131.
GeneTreei ENSGT00550000075308.
InParanoidi P53756.
OMAi EYANINE.
OrthoDBi EOG7N903S.

Enzyme and pathway databases

BioCyci YEAST:G3O-33374-MONOMER.
Reactomei REACT_189334. ABCA transporters in lipid homeostasis.
REACT_269941. HDL-mediated lipid transport.

Miscellaneous databases

NextBioi 980327.

Gene expression databases

Genevestigatori P53756.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view ]
Pfami PF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF06422. PDR_CDR. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiPDR18_YEAST
AccessioniPrimary (citable) accession number: P53756
Secondary accession number(s): D6W1P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3