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Protein

7-keto 8-aminopelargonic acid transporter

Gene

BIO5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transport into the cell of 7-keto 8-aminopelargonic acid.1 Publication

GO - Molecular functioni

GO - Biological processi

  • biotin biosynthetic process Source: SGD
  • vitamin transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33362-MONOMER.

Protein family/group databases

TCDBi2.A.3.4.4. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
7-keto 8-aminopelargonic acid transporter
Short name:
KAPA transporter
Gene namesi
Name:BIO5
Ordered Locus Names:YNR056C
ORF Names:N3502
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR056C.
SGDiS000005339. BIO5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 777ExtracellularSequence analysis
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 16062CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 20423ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence analysisAdd
BLAST
Topological domaini226 – 2305CytoplasmicSequence analysis
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Topological domaini252 – 28130ExtracellularSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Topological domaini303 – 32119CytoplasmicSequence analysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence analysisAdd
BLAST
Topological domaini343 – 36927ExtracellularSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 43949CytoplasmicSequence analysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST
Topological domaini461 – 4611ExtracellularSequence analysis
Transmembranei462 – 48221HelicalSequence analysisAdd
BLAST
Topological domaini483 – 50725CytoplasmicSequence analysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence analysisAdd
BLAST
Topological domaini529 – 54012ExtracellularSequence analysisAdd
BLAST
Transmembranei541 – 56020HelicalSequence analysisAdd
BLAST
Topological domaini561 – 5611CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5615617-keto 8-aminopelargonic acid transporterPRO_0000054282Add
BLAST

Proteomic databases

TopDownProteomicsiP53744.

Interactioni

Protein-protein interaction databases

BioGridi35882. 5 interactions.
DIPiDIP-7726N.
IntActiP53744. 2 interactions.
MINTiMINT-1358543.

Structurei

3D structure databases

ProteinModelPortaliP53744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP53744.
KOiK19565.
OMAiIDSATHM.
OrthoDBiEOG092C1NT7.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P53744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRVGAVFLF VYERNFFLSI VPDRHRTEIR MSSSERSEVK FDKHFNWWSL
60 70 80 90 100
LGIAFSLSCS WVGISASMAV GIASGGPLLI IYGLIIAAFF SLMCGISLGD
110 120 130 140 150
FAAILPNSSG GSFWVLKMLE QESVTLKTPE YEDPSDDDEE VFLENYCQTF
160 170 180 190 200
NVEVSSKFQK VSSMVVGLLN YFGAIFTTAS ICSSLSMSCI GIHKLLHPDY
210 220 230 240 250
ELKHWHVFVG YECINAVLTL FNIYSTPLPY ISQFGLYTSL LSFAMTFIIC
260 270 280 290 300
IVSRSDNTVD PWPKASNIFG SFDNQTGWNS SGMAFVVGLV NPIWAFVGID
310 320 330 340 350
SATHMIDEVG YSKSRFLVPK VIITTIIVGF VTSFIYCVGL FFCITDQTAV
360 370 380 390 400
VESILPIVEI FYQATGNRNL SVFLQCMCIT TGFVSGIASG TWQSRILQSF
410 420 430 440 450
GKSYAPFYKE GSLGNKSLKK LAVLTPGFKS PLYAHFLSQI CVTIIGCIFM
460 470 480 490 500
GSSTAFNAII TACITLLLMS YAVPSFIFLF VIKKEKFIHR IESDVNCVSR
510 520 530 540 550
PNRRRMSMIP HIICILWTLF CLVFLSFPYT LPVTAGNMNY TSVVYAVVFC
560
IISIVVFPTC I
Length:561
Mass (Da):62,428
Last modified:October 1, 1996 - v1
Checksum:i7FA5A64FA0D4250F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90440 Genomic DNA. Translation: AAB50012.1.
Z71671 Genomic DNA. Translation: CAA96337.1.
BK006947 Genomic DNA. Translation: DAA10597.1.
PIRiS63388.
RefSeqiNP_014454.3. NM_001183233.3.

Genome annotation databases

EnsemblFungiiYNR056C; YNR056C; YNR056C.
GeneIDi855793.
KEGGisce:YNR056C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90440 Genomic DNA. Translation: AAB50012.1.
Z71671 Genomic DNA. Translation: CAA96337.1.
BK006947 Genomic DNA. Translation: DAA10597.1.
PIRiS63388.
RefSeqiNP_014454.3. NM_001183233.3.

3D structure databases

ProteinModelPortaliP53744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35882. 5 interactions.
DIPiDIP-7726N.
IntActiP53744. 2 interactions.
MINTiMINT-1358543.

Protein family/group databases

TCDBi2.A.3.4.4. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

TopDownProteomicsiP53744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR056C; YNR056C; YNR056C.
GeneIDi855793.
KEGGisce:YNR056C.

Organism-specific databases

EuPathDBiFungiDB:YNR056C.
SGDiS000005339. BIO5.

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP53744.
KOiK19565.
OMAiIDSATHM.
OrthoDBiEOG092C1NT7.

Enzyme and pathway databases

BioCyciYEAST:G3O-33362-MONOMER.

Miscellaneous databases

PROiP53744.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIO5_YEAST
AccessioniPrimary (citable) accession number: P53744
Secondary accession number(s): D6W1N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.