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Protein

7-keto 8-aminopelargonic acid transporter

Gene

BIO5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transport into the cell of 7-keto 8-aminopelargonic acid.1 Publication

GO - Molecular functioni

GO - Biological processi

  • biotin biosynthetic process Source: SGD
  • vitamin transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33362-MONOMER.

Protein family/group databases

TCDBi2.A.3.4.4. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
7-keto 8-aminopelargonic acid transporter
Short name:
KAPA transporter
Gene namesi
Name:BIO5
Ordered Locus Names:YNR056C
ORF Names:N3502
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR056C.
SGDiS000005339. BIO5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 77ExtracellularSequence analysis7
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 160CytoplasmicSequence analysisAdd BLAST62
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 204ExtracellularSequence analysisAdd BLAST23
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 230CytoplasmicSequence analysis5
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 281ExtracellularSequence analysisAdd BLAST30
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 321CytoplasmicSequence analysisAdd BLAST19
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 369ExtracellularSequence analysisAdd BLAST27
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 439CytoplasmicSequence analysisAdd BLAST49
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Topological domaini461ExtracellularSequence analysis1
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 507CytoplasmicSequence analysisAdd BLAST25
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Topological domaini529 – 540ExtracellularSequence analysisAdd BLAST12
Transmembranei541 – 560HelicalSequence analysisAdd BLAST20
Topological domaini561CytoplasmicSequence analysis1

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542821 – 5617-keto 8-aminopelargonic acid transporterAdd BLAST561

Proteomic databases

PRIDEiP53744.
TopDownProteomicsiP53744.

Interactioni

Protein-protein interaction databases

BioGridi35882. 5 interactors.
DIPiDIP-7726N.
IntActiP53744. 2 interactors.
MINTiMINT-1358543.

Structurei

3D structure databases

ProteinModelPortaliP53744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP53744.
KOiK19565.
OMAiIDSATHM.
OrthoDBiEOG092C1NT7.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P53744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRVGAVFLF VYERNFFLSI VPDRHRTEIR MSSSERSEVK FDKHFNWWSL
60 70 80 90 100
LGIAFSLSCS WVGISASMAV GIASGGPLLI IYGLIIAAFF SLMCGISLGD
110 120 130 140 150
FAAILPNSSG GSFWVLKMLE QESVTLKTPE YEDPSDDDEE VFLENYCQTF
160 170 180 190 200
NVEVSSKFQK VSSMVVGLLN YFGAIFTTAS ICSSLSMSCI GIHKLLHPDY
210 220 230 240 250
ELKHWHVFVG YECINAVLTL FNIYSTPLPY ISQFGLYTSL LSFAMTFIIC
260 270 280 290 300
IVSRSDNTVD PWPKASNIFG SFDNQTGWNS SGMAFVVGLV NPIWAFVGID
310 320 330 340 350
SATHMIDEVG YSKSRFLVPK VIITTIIVGF VTSFIYCVGL FFCITDQTAV
360 370 380 390 400
VESILPIVEI FYQATGNRNL SVFLQCMCIT TGFVSGIASG TWQSRILQSF
410 420 430 440 450
GKSYAPFYKE GSLGNKSLKK LAVLTPGFKS PLYAHFLSQI CVTIIGCIFM
460 470 480 490 500
GSSTAFNAII TACITLLLMS YAVPSFIFLF VIKKEKFIHR IESDVNCVSR
510 520 530 540 550
PNRRRMSMIP HIICILWTLF CLVFLSFPYT LPVTAGNMNY TSVVYAVVFC
560
IISIVVFPTC I
Length:561
Mass (Da):62,428
Last modified:October 1, 1996 - v1
Checksum:i7FA5A64FA0D4250F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90440 Genomic DNA. Translation: AAB50012.1.
Z71671 Genomic DNA. Translation: CAA96337.1.
BK006947 Genomic DNA. Translation: DAA10597.1.
PIRiS63388.
RefSeqiNP_014454.3. NM_001183233.3.

Genome annotation databases

EnsemblFungiiYNR056C; YNR056C; YNR056C.
GeneIDi855793.
KEGGisce:YNR056C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90440 Genomic DNA. Translation: AAB50012.1.
Z71671 Genomic DNA. Translation: CAA96337.1.
BK006947 Genomic DNA. Translation: DAA10597.1.
PIRiS63388.
RefSeqiNP_014454.3. NM_001183233.3.

3D structure databases

ProteinModelPortaliP53744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35882. 5 interactors.
DIPiDIP-7726N.
IntActiP53744. 2 interactors.
MINTiMINT-1358543.

Protein family/group databases

TCDBi2.A.3.4.4. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PRIDEiP53744.
TopDownProteomicsiP53744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR056C; YNR056C; YNR056C.
GeneIDi855793.
KEGGisce:YNR056C.

Organism-specific databases

EuPathDBiFungiDB:YNR056C.
SGDiS000005339. BIO5.

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP53744.
KOiK19565.
OMAiIDSATHM.
OrthoDBiEOG092C1NT7.

Enzyme and pathway databases

BioCyciYEAST:G3O-33362-MONOMER.

Miscellaneous databases

PROiP53744.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 2 hits.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBIO5_YEAST
AccessioniPrimary (citable) accession number: P53744
Secondary accession number(s): D6W1N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.