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Protein

Nucleolar GTP-binding protein 2

Gene

NOG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi322 – 329GTPSequence analysis8
Nucleotide bindingi366 – 370GTPSequence analysis5

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • ribosomal large subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Gene namesi
Name:NOG2
Ordered Locus Names:YNR053C
ORF Names:N3484
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR053C.
SGDiS000005336. NOG2.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • nucleoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158171 – 486Nucleolar GTP-binding protein 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53742.
PRIDEiP53742.

PTM databases

iPTMnetiP53742.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAK21Q121763EBI-28532,EBI-10944
TIF6Q125224EBI-28532,EBI-9046

Protein-protein interaction databases

BioGridi35878. 83 interactors.
DIPiDIP-976N.
IntActiP53742. 57 interactors.
MINTiMINT-8285431.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCTelectron microscopy3.08m1-486[»]
ProteinModelPortaliP53742.
SMRiP53742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 373CP-type GPROSITE-ProRule annotationAdd BLAST162

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00810000125524.
HOGENOMiHOG000189714.
InParanoidiP53742.
KOiK14537.
OMAiPPNQNDT.
OrthoDBiEOG092C2X6U.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTGKKEKSR RIREGDTKDG NLRVKGENFY RDSKRVKFLN MYTSGKEIRN
60 70 80 90 100
KKGNLIRAAS FQDSTIPDAR VQPDRRWFGN TRVISQDALQ HFRSALGETQ
110 120 130 140 150
KDTYQVLLRR NKLPMSLLEE KDADESPKAR ILDTESYADA FGPKAQRKRP
160 170 180 190 200
RLAASNLEDL VKATNEDITK YEEKQVLDAT LGLMGNQEDK ENGWTSAAKE
210 220 230 240 250
AIFSKGQSKR IWNELYKVID SSDVVIHVLD ARDPLGTRCK SVEEYMKKET
260 270 280 290 300
PHKHLIYVLN KCDLVPTWVA AAWVKHLSKE RPTLAFHASI TNSFGKGSLI
310 320 330 340 350
QLLRQFSQLH TDRKQISVGF IGYPNTGKSS IINTLRKKKV CQVAPIPGET
360 370 380 390 400
KVWQYITLMK RIFLIDCPGI VPPSSKDSEE DILFRGVVRV EHVTHPEQYI
410 420 430 440 450
PGVLKRCQVK HLERTYEISG WKDATEFIEI LARKQGRLLK GGEPDESGVS
460 470 480
KQILNDFNRG KIPWFVLPPE KEGEEKPKKK EVEKTA
Length:486
Mass (Da):55,489
Last modified:October 1, 1996 - v1
Checksum:iD7F670973B85CCEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71668 Genomic DNA. Translation: CAA96334.1.
BK006947 Genomic DNA. Translation: DAA10594.1.
PIRiS63384.
RefSeqiNP_014451.1. NM_001183230.1.

Genome annotation databases

EnsemblFungiiYNR053C; YNR053C; YNR053C.
GeneIDi855789.
KEGGisce:YNR053C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71668 Genomic DNA. Translation: CAA96334.1.
BK006947 Genomic DNA. Translation: DAA10594.1.
PIRiS63384.
RefSeqiNP_014451.1. NM_001183230.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCTelectron microscopy3.08m1-486[»]
ProteinModelPortaliP53742.
SMRiP53742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35878. 83 interactors.
DIPiDIP-976N.
IntActiP53742. 57 interactors.
MINTiMINT-8285431.

PTM databases

iPTMnetiP53742.

Proteomic databases

MaxQBiP53742.
PRIDEiP53742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR053C; YNR053C; YNR053C.
GeneIDi855789.
KEGGisce:YNR053C.

Organism-specific databases

EuPathDBiFungiDB:YNR053C.
SGDiS000005336. NOG2.

Phylogenomic databases

GeneTreeiENSGT00810000125524.
HOGENOMiHOG000189714.
InParanoidiP53742.
KOiK14537.
OMAiPPNQNDT.
OrthoDBiEOG092C2X6U.

Enzyme and pathway databases

BioCyciYEAST:G3O-33359-MONOMER.

Miscellaneous databases

PROiP53742.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOG2_YEAST
AccessioniPrimary (citable) accession number: P53742
Secondary accession number(s): D6W1M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 67700 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.