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Protein

Nucleolar GTP-binding protein 2

Gene

NOG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.1 Publication

Miscellaneous

Present with 67700 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi322 – 329GTPSequence analysis8
Nucleotide bindingi366 – 370GTPSequence analysis5

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • ribosomal large subunit export from nucleus Source: SGD

Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33359-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Gene namesi
Name:NOG2
Ordered Locus Names:YNR053C
ORF Names:N3484
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR053C
SGDiS000005336 NOG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158171 – 486Nucleolar GTP-binding protein 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53742
PaxDbiP53742
PRIDEiP53742

PTM databases

iPTMnetiP53742

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35878, 406 interactors
DIPiDIP-976N
IntActiP53742, 58 interactors
MINTiP53742
STRINGi4932.YNR053C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCTelectron microscopy3.08m1-486[»]
6FT6electron microscopy3.90m1-486[»]
ProteinModelPortaliP53742
SMRiP53742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 373CP-type GPROSITE-ProRule annotationAdd BLAST162

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00810000125524
HOGENOMiHOG000189714
InParanoidiP53742
KOiK14537
OMAiNHSMNPE
OrthoDBiEOG092C2X6U

Family and domain databases

Gene3Di1.10.1580.10, 1 hit
InterProiView protein in InterPro
IPR030378 G_CP_dom
IPR023179 GTP-bd_ortho_bundle_sf
IPR006073 GTP_binding_domain
IPR024929 NOG2
IPR012971 NOG2_N_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11089:SF9 PTHR11089:SF9, 1 hit
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF08153 NGP1NT, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51721 G_CP, 1 hit

Sequencei

Sequence statusi: Complete.

P53742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTGKKEKSR RIREGDTKDG NLRVKGENFY RDSKRVKFLN MYTSGKEIRN
60 70 80 90 100
KKGNLIRAAS FQDSTIPDAR VQPDRRWFGN TRVISQDALQ HFRSALGETQ
110 120 130 140 150
KDTYQVLLRR NKLPMSLLEE KDADESPKAR ILDTESYADA FGPKAQRKRP
160 170 180 190 200
RLAASNLEDL VKATNEDITK YEEKQVLDAT LGLMGNQEDK ENGWTSAAKE
210 220 230 240 250
AIFSKGQSKR IWNELYKVID SSDVVIHVLD ARDPLGTRCK SVEEYMKKET
260 270 280 290 300
PHKHLIYVLN KCDLVPTWVA AAWVKHLSKE RPTLAFHASI TNSFGKGSLI
310 320 330 340 350
QLLRQFSQLH TDRKQISVGF IGYPNTGKSS IINTLRKKKV CQVAPIPGET
360 370 380 390 400
KVWQYITLMK RIFLIDCPGI VPPSSKDSEE DILFRGVVRV EHVTHPEQYI
410 420 430 440 450
PGVLKRCQVK HLERTYEISG WKDATEFIEI LARKQGRLLK GGEPDESGVS
460 470 480
KQILNDFNRG KIPWFVLPPE KEGEEKPKKK EVEKTA
Length:486
Mass (Da):55,489
Last modified:October 1, 1996 - v1
Checksum:iD7F670973B85CCEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71668 Genomic DNA Translation: CAA96334.1
BK006947 Genomic DNA Translation: DAA10594.1
PIRiS63384
RefSeqiNP_014451.1, NM_001183230.1

Genome annotation databases

EnsemblFungiiYNR053C; YNR053C; YNR053C
GeneIDi855789
KEGGisce:YNR053C

Similar proteinsi

Entry informationi

Entry nameiNOG2_YEAST
AccessioniPrimary (citable) accession number: P53742
Secondary accession number(s): D6W1M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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