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P53735

- ZRG17_YEAST

UniProt

P53735 - ZRG17_YEAST

Protein

Protein ZRG17

Gene

ZRG17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metal ion transmembrane transporter activity Source: SGD
    2. protein binding Source: IntAct
    3. zinc ion transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. zinc ion transmembrane transport Source: GOC
    2. zinc ion transport Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33349-MONOMER.

    Protein family/group databases

    TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ZRG17
    Alternative name(s):
    Zinc-regulated gene 17 protein
    Gene namesi
    Name:ZRG17
    Ordered Locus Names:YNR039C
    ORF Names:N3403
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNR039c.
    SGDiS000005322. ZRG17.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Protein ZRG17PRO_0000203477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine1 Publication
    Modified residuei131 – 1311Phosphoserine1 Publication
    Modified residuei498 – 4981Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP53735.
    PaxDbiP53735.

    Expressioni

    Gene expression databases

    GenevestigatoriP53735.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MSC2Q034553EBI-28507,EBI-34990

    Protein-protein interaction databases

    BioGridi35865. 28 interactions.
    DIPiDIP-5210N.
    IntActiP53735. 5 interactions.
    MINTiMINT-493060.
    STRINGi4932.YNR039C.

    Structurei

    3D structure databases

    ProteinModelPortaliP53735.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 225225CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini247 – 2548LumenalSequence Analysis
    Topological domaini276 – 28712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 3091LumenalSequence Analysis
    Topological domaini331 – 36333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini385 – 39915LumenalSequence AnalysisAdd
    BLAST
    Topological domaini421 – 4222CytoplasmicSequence Analysis
    Topological domaini444 – 545102LumenalSequence AnalysisAdd
    BLAST
    Topological domaini567 – 60539CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei364 – 38421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei400 – 42021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei546 – 56621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80215.
    HOGENOMiHOG000057080.
    OMAiAHRKGHK.
    OrthoDBiEOG7V1G0C.

    Family and domain databases

    InterProiIPR002524. Cation_efflux.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53735-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS    50
    QNRTFFASPR PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA 100
    LMKGKGNEGR RQSLKYIPAP KLVPPPPRTR SPVRGISPDA GSSKRSSMTL 150
    DSPFNFTTST LQPHQQTPPS SAASRTSFRK GHRYKHSSVS MNFFQEPEVK 200
    IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC LITFQVGHLY 250
    SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV 300
    LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP 350
    HSHIANANDS QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP 400
    IITITYTAYL FIYPLLLDLL SSISDYLATL VISSLILWHG LTIARWTSTV 450
    LLMGFSTTSL SNSALFNNND STDTTAHTQQ VESKAAKEKP SVRPRSMSSL 500
    PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE FKSRYILNYD 550
    DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI 600
    DIDRI 605
    Length:605
    Mass (Da):67,461
    Last modified:October 1, 1996 - v1
    Checksum:i299A89B0E4FCDBC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti239 – 2391A → V in AAT93124. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71654 Genomic DNA. Translation: CAA96319.1.
    AY693105 Genomic DNA. Translation: AAT93124.1.
    BK006947 Genomic DNA. Translation: DAA10581.1.
    PIRiS63370.
    RefSeqiNP_014437.1. NM_001183216.1.

    Genome annotation databases

    EnsemblFungiiYNR039C; YNR039C; YNR039C.
    GeneIDi855775.
    KEGGisce:YNR039C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71654 Genomic DNA. Translation: CAA96319.1 .
    AY693105 Genomic DNA. Translation: AAT93124.1 .
    BK006947 Genomic DNA. Translation: DAA10581.1 .
    PIRi S63370.
    RefSeqi NP_014437.1. NM_001183216.1.

    3D structure databases

    ProteinModelPortali P53735.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35865. 28 interactions.
    DIPi DIP-5210N.
    IntActi P53735. 5 interactions.
    MINTi MINT-493060.
    STRINGi 4932.YNR039C.

    Protein family/group databases

    TCDBi 2.A.4.4.1. the cation diffusion facilitator (cdf) family.

    Proteomic databases

    MaxQBi P53735.
    PaxDbi P53735.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNR039C ; YNR039C ; YNR039C .
    GeneIDi 855775.
    KEGGi sce:YNR039C.

    Organism-specific databases

    CYGDi YNR039c.
    SGDi S000005322. ZRG17.

    Phylogenomic databases

    eggNOGi NOG80215.
    HOGENOMi HOG000057080.
    OMAi AHRKGHK.
    OrthoDBi EOG7V1G0C.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33349-MONOMER.

    Miscellaneous databases

    NextBioi 980235.

    Gene expression databases

    Genevestigatori P53735.

    Family and domain databases

    InterProi IPR002524. Cation_efflux.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZRG17_YEAST
    AccessioniPrimary (citable) accession number: P53735
    Secondary accession number(s): D6W1L5, E9P919
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3