SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53735

- ZRG17_YEAST

UniProt

P53735 - ZRG17_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein ZRG17
Gene
ZRG17, YNR039C, N3403
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: SGD
  2. protein binding Source: IntAct
  3. zinc ion transmembrane transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. zinc ion transmembrane transport Source: GOC
  2. zinc ion transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33349-MONOMER.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZRG17
Alternative name(s):
Zinc-regulated gene 17 protein
Gene namesi
Name:ZRG17
Ordered Locus Names:YNR039C
ORF Names:N3403
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNR039c.
SGDiS000005322. ZRG17.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 225225Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei226 – 24621Helical; Reviewed prediction
Add
BLAST
Topological domaini247 – 2548Lumenal Reviewed prediction
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST
Topological domaini276 – 28712Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Topological domaini309 – 3091Lumenal Reviewed prediction
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Topological domaini331 – 36333Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei364 – 38421Helical; Reviewed prediction
Add
BLAST
Topological domaini385 – 39915Lumenal Reviewed prediction
Add
BLAST
Transmembranei400 – 42021Helical; Reviewed prediction
Add
BLAST
Topological domaini421 – 4222Cytoplasmic Reviewed prediction
Transmembranei423 – 44321Helical; Reviewed prediction
Add
BLAST
Topological domaini444 – 545102Lumenal Reviewed prediction
Add
BLAST
Transmembranei546 – 56621Helical; Reviewed prediction
Add
BLAST
Topological domaini567 – 60539Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Protein ZRG17
PRO_0000203477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine1 Publication
Modified residuei131 – 1311Phosphoserine1 Publication
Modified residuei498 – 4981Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53735.
PaxDbiP53735.

Expressioni

Gene expression databases

GenevestigatoriP53735.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MSC2Q034553EBI-28507,EBI-34990

Protein-protein interaction databases

BioGridi35865. 28 interactions.
DIPiDIP-5210N.
IntActiP53735. 5 interactions.
MINTiMINT-493060.
STRINGi4932.YNR039C.

Structurei

3D structure databases

ProteinModelPortaliP53735.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80215.
HOGENOMiHOG000057080.
OMAiAHRKGHK.
OrthoDBiEOG7V1G0C.

Family and domain databases

InterProiIPR002524. Cation_efflux.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53735-1 [UniParc]FASTAAdd to Basket

« Hide

METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS    50
QNRTFFASPR PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA 100
LMKGKGNEGR RQSLKYIPAP KLVPPPPRTR SPVRGISPDA GSSKRSSMTL 150
DSPFNFTTST LQPHQQTPPS SAASRTSFRK GHRYKHSSVS MNFFQEPEVK 200
IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC LITFQVGHLY 250
SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV 300
LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP 350
HSHIANANDS QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP 400
IITITYTAYL FIYPLLLDLL SSISDYLATL VISSLILWHG LTIARWTSTV 450
LLMGFSTTSL SNSALFNNND STDTTAHTQQ VESKAAKEKP SVRPRSMSSL 500
PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE FKSRYILNYD 550
DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI 600
DIDRI 605
Length:605
Mass (Da):67,461
Last modified:October 1, 1996 - v1
Checksum:i299A89B0E4FCDBC8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391A → V in AAT93124. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71654 Genomic DNA. Translation: CAA96319.1.
AY693105 Genomic DNA. Translation: AAT93124.1.
BK006947 Genomic DNA. Translation: DAA10581.1.
PIRiS63370.
RefSeqiNP_014437.1. NM_001183216.1.

Genome annotation databases

EnsemblFungiiYNR039C; YNR039C; YNR039C.
GeneIDi855775.
KEGGisce:YNR039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71654 Genomic DNA. Translation: CAA96319.1 .
AY693105 Genomic DNA. Translation: AAT93124.1 .
BK006947 Genomic DNA. Translation: DAA10581.1 .
PIRi S63370.
RefSeqi NP_014437.1. NM_001183216.1.

3D structure databases

ProteinModelPortali P53735.
ModBasei Search...

Protein-protein interaction databases

BioGridi 35865. 28 interactions.
DIPi DIP-5210N.
IntActi P53735. 5 interactions.
MINTi MINT-493060.
STRINGi 4932.YNR039C.

Protein family/group databases

TCDBi 2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Proteomic databases

MaxQBi P53735.
PaxDbi P53735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNR039C ; YNR039C ; YNR039C .
GeneIDi 855775.
KEGGi sce:YNR039C.

Organism-specific databases

CYGDi YNR039c.
SGDi S000005322. ZRG17.

Phylogenomic databases

eggNOGi NOG80215.
HOGENOMi HOG000057080.
OMAi AHRKGHK.
OrthoDBi EOG7V1G0C.

Enzyme and pathway databases

BioCyci YEAST:G3O-33349-MONOMER.

Miscellaneous databases

NextBioi 980235.

Gene expression databases

Genevestigatori P53735.

Family and domain databases

InterProi IPR002524. Cation_efflux.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZRG17_YEAST
AccessioniPrimary (citable) accession number: P53735
Secondary accession number(s): D6W1L5, E9P919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

Similar proteinsi