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Protein

Protein ZRG17

Gene

ZRG17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • zinc II ion transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33349-MONOMER.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZRG17
Alternative name(s):
Zinc-regulated gene 17 protein
Gene namesi
Name:ZRG17
Ordered Locus Names:YNR039C
ORF Names:N3403
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR039C.
SGDiS000005322. ZRG17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 225CytoplasmicSequence analysisAdd BLAST225
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 254LumenalSequence analysis8
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 287CytoplasmicSequence analysisAdd BLAST12
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Topological domaini309LumenalSequence analysis1
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 363CytoplasmicSequence analysisAdd BLAST33
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Topological domaini385 – 399LumenalSequence analysisAdd BLAST15
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 422CytoplasmicSequence analysis2
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 545LumenalSequence analysisAdd BLAST102
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 605CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002034771 – 605Protein ZRG17Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53735.
PRIDEiP53735.

PTM databases

iPTMnetiP53735.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MSC2Q034553EBI-28507,EBI-34990

Protein-protein interaction databases

BioGridi35865. 27 interactors.
DIPiDIP-5210N.
IntActiP53735. 5 interactors.
MINTiMINT-493060.

Structurei

3D structure databases

ProteinModelPortaliP53735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000057080.
InParanoidiP53735.
OMAiHRKGHKY.
OrthoDBiEOG092C3NL1.

Family and domain databases

InterProiIPR002524. Cation_efflux.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.

Sequencei

Sequence statusi: Complete.

P53735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS
60 70 80 90 100
QNRTFFASPR PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA
110 120 130 140 150
LMKGKGNEGR RQSLKYIPAP KLVPPPPRTR SPVRGISPDA GSSKRSSMTL
160 170 180 190 200
DSPFNFTTST LQPHQQTPPS SAASRTSFRK GHRYKHSSVS MNFFQEPEVK
210 220 230 240 250
IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC LITFQVGHLY
260 270 280 290 300
SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV
310 320 330 340 350
LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP
360 370 380 390 400
HSHIANANDS QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP
410 420 430 440 450
IITITYTAYL FIYPLLLDLL SSISDYLATL VISSLILWHG LTIARWTSTV
460 470 480 490 500
LLMGFSTTSL SNSALFNNND STDTTAHTQQ VESKAAKEKP SVRPRSMSSL
510 520 530 540 550
PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE FKSRYILNYD
560 570 580 590 600
DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI

DIDRI
Length:605
Mass (Da):67,461
Last modified:October 1, 1996 - v1
Checksum:i299A89B0E4FCDBC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239A → V in AAT93124 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71654 Genomic DNA. Translation: CAA96319.1.
AY693105 Genomic DNA. Translation: AAT93124.1.
BK006947 Genomic DNA. Translation: DAA10581.1.
PIRiS63370.
RefSeqiNP_014437.1. NM_001183216.1.

Genome annotation databases

EnsemblFungiiYNR039C; YNR039C; YNR039C.
GeneIDi855775.
KEGGisce:YNR039C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71654 Genomic DNA. Translation: CAA96319.1.
AY693105 Genomic DNA. Translation: AAT93124.1.
BK006947 Genomic DNA. Translation: DAA10581.1.
PIRiS63370.
RefSeqiNP_014437.1. NM_001183216.1.

3D structure databases

ProteinModelPortaliP53735.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35865. 27 interactors.
DIPiDIP-5210N.
IntActiP53735. 5 interactors.
MINTiMINT-493060.

Protein family/group databases

TCDBi2.A.4.4.1. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiP53735.

Proteomic databases

MaxQBiP53735.
PRIDEiP53735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNR039C; YNR039C; YNR039C.
GeneIDi855775.
KEGGisce:YNR039C.

Organism-specific databases

EuPathDBiFungiDB:YNR039C.
SGDiS000005322. ZRG17.

Phylogenomic databases

HOGENOMiHOG000057080.
InParanoidiP53735.
OMAiHRKGHKY.
OrthoDBiEOG092C3NL1.

Enzyme and pathway databases

BioCyciYEAST:G3O-33349-MONOMER.

Miscellaneous databases

PROiP53735.

Family and domain databases

InterProiIPR002524. Cation_efflux.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZRG17_YEAST
AccessioniPrimary (citable) accession number: P53735
Secondary accession number(s): D6W1L5, E9P919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.