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P53735 (ZRG17_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ZRG17
Alternative name(s):
Zinc-regulated gene 17 protein
Gene names
Name:ZRG17
Ordered Locus Names:YNR039C
ORF Names:N3403
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.4.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 605605Protein ZRG17
PRO_0000203477

Regions

Topological domain1 – 225225Cytoplasmic Potential
Transmembrane226 – 24621Helical; Potential
Topological domain247 – 2548Lumenal Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 28712Cytoplasmic Potential
Transmembrane288 – 30821Helical; Potential
Topological domain3091Lumenal Potential
Transmembrane310 – 33021Helical; Potential
Topological domain331 – 36333Cytoplasmic Potential
Transmembrane364 – 38421Helical; Potential
Topological domain385 – 39915Lumenal Potential
Transmembrane400 – 42021Helical; Potential
Topological domain421 – 4222Cytoplasmic Potential
Transmembrane423 – 44321Helical; Potential
Topological domain444 – 545102Lumenal Potential
Transmembrane546 – 56621Helical; Potential
Topological domain567 – 60539Cytoplasmic Potential

Amino acid modifications

Modified residue161Phosphoserine Ref.8
Modified residue581Phosphoserine Ref.8
Modified residue1311Phosphoserine Ref.7
Modified residue1371Phosphoserine Ref.8
Modified residue4961Phosphoserine Ref.8
Modified residue4981Phosphoserine Ref.6 Ref.8

Experimental info

Sequence conflict2391A → V in AAT93124. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P53735 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 299A89B0E4FCDBC8

FASTA60567,461
        10         20         30         40         50         60 
METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS QNRTFFASPR 

        70         80         90        100        110        120 
PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA LMKGKGNEGR RQSLKYIPAP 

       130        140        150        160        170        180 
KLVPPPPRTR SPVRGISPDA GSSKRSSMTL DSPFNFTTST LQPHQQTPPS SAASRTSFRK 

       190        200        210        220        230        240 
GHRYKHSSVS MNFFQEPEVK IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC 

       250        260        270        280        290        300 
LITFQVGHLY SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV 

       310        320        330        340        350        360 
LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP HSHIANANDS 

       370        380        390        400        410        420 
QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP IITITYTAYL FIYPLLLDLL 

       430        440        450        460        470        480 
SSISDYLATL VISSLILWHG LTIARWTSTV LLMGFSTTSL SNSALFNNND STDTTAHTQQ 

       490        500        510        520        530        540 
VESKAAKEKP SVRPRSMSSL PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE 

       550        560        570        580        590        600 
FKSRYILNYD DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI 


DIDRI

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498, MASS SPECTROMETRY.
Strain: ADR376.
[7]"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, MASS SPECTROMETRY.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-58; SER-137; SER-496 AND SER-498, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z71654 Genomic DNA. Translation: CAA96319.1.
AY693105 Genomic DNA. Translation: AAT93124.1.
BK006947 Genomic DNA. Translation: DAA10581.1.
PIRS63370.
RefSeqNP_014437.1. NM_001183216.1.

3D structure databases

ProteinModelPortalP53735.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-5210N.
IntActP53735. 6 interactions.
MINTMINT-493060.
STRING4932.YNR039C.

Protein family/group databases

TCDB2.A.4.4.1. cation diffusion facilitator (CDF) family.

Proteomic databases

PaxDbP53735.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNR039C; YNR039C; YNR039C.
GeneID855775.
KEGGsce:YNR039C.

Organism-specific databases

CYGDYNR039c.
SGDS000005322. ZRG17.

Phylogenomic databases

eggNOGNOG80215.
HOGENOMHOG000057080.
OMAQVKPAHR.
OrthoDBEOG4MSH81.

Gene expression databases

GenevestigatorP53735.
GermOnlineYNR039C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002524. Cation_efflux.
[Graphical view]
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980235.

Entry information

Entry nameZRG17_YEAST
AccessionPrimary (citable) accession number: P53735
Secondary accession number(s): D6W1L5, E9P919
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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