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Protein

Actin-related protein 2/3 complex subunit 2

Gene

ARC35

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

Miscellaneous

Present with 13400 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • structural constituent of cytoskeleton Source: GO_Central
  • structural molecule activity Source: SGD

GO - Biological processi

  • actin cytoskeleton organization Source: SGD
  • actin filament polymerization Source: InterPro
  • Arp2/3 complex-mediated actin nucleation Source: GO_Central
  • microtubule cytoskeleton organization Source: SGD
  • mitochondrion inheritance Source: SGD
  • receptor-mediated endocytosis Source: SGD

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33345-MONOMER
ReactomeiR-SCE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-SCE-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2
Alternative name(s):
Arp2/3 complex 34 kDa subunit
Short name:
p34-ARC
Gene namesi
Name:ARC35
Ordered Locus Names:YNR035C
ORF Names:N3296
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR035C
SGDiS000005318 ARC35

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240411 – 342Actin-related protein 2/3 complex subunit 2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphothreonineCombined sources1
Modified residuei324PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53731
PaxDbiP53731
PRIDEiP53731

PTM databases

iPTMnetiP53731

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35861, 453 interactors
DIPiDIP-2304N
IntActiP53731, 18 interactors
MINTiP53731
STRINGi4932.YNR035C

Structurei

3D structure databases

ProteinModelPortaliP53731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000016794
HOGENOMiHOG000212535
InParanoidiP53731
KOiK05758
OMAiFPRHVES
OrthoDBiEOG092C3H5S

Family and domain databases

Gene3Di3.30.1460.20, 2 hits
InterProiView protein in InterPro
IPR007188 ARPC2
IPR034666 ARPC2/4
PANTHERiPTHR12058 PTHR12058, 1 hit
PfamiView protein in Pfam
PF04045 P34-Arc, 1 hit
SUPFAMiSSF69645 SSF69645, 2 hits

Sequencei

Sequence statusi: Complete.

P53731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLQPQNLL IQKTLNEAIE ALRKGSPLTM DRIVSDFDYT TYHISNTAED
60 70 80 90 100
KSILLLSVKT KAWVSVSECQ LDGSLTLLKF LADHYSSLGG VTIPSEVEPG
110 120 130 140 150
YDYTLQITLA ELVQESILQL SVLKTIILSF PFELAISKFI ELSQQQPAPV
160 170 180 190 200
EAEITGGEVA ANGDNTLFTI KYRDEENIFI KPSNDRVTII FETIFQDETD
210 220 230 240 250
KIFGKVFLQE FVDARKRNRQ IQSAPQVLYS HEPPLELKRL YQPPKVAEQS
260 270 280 290 300
RRFITFVLFP RHFQTKELQF HSICQLTLFR NYFHYHIKCS KAYMHSRMRF
310 320 330 340
RVDSFIKVLN RAKVDEDDEN DELSAEGRQQ ARRTFTGRKI VY
Length:342
Mass (Da):39,566
Last modified:October 1, 1996 - v1
Checksum:i9AF71A93688729F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71650 Genomic DNA Translation: CAA96315.1
BK006947 Genomic DNA Translation: DAA10577.1
PIRiS63366
RefSeqiNP_014433.1, NM_001183212.1

Genome annotation databases

EnsemblFungiiYNR035C; YNR035C; YNR035C
GeneIDi855771
KEGGisce:YNR035C

Similar proteinsi

Entry informationi

Entry nameiARPC2_YEAST
AccessioniPrimary (citable) accession number: P53731
Secondary accession number(s): D6W1L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health