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Protein

Peptidyl-prolyl cis-trans isomerase CYP8

Gene

CPR8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YNR028W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP8 (EC:5.2.1.8)
Short name:
PPIase CYP8
Alternative name(s):
Rotamase CYP8
Gene namesi
Name:CPR8
Ordered Locus Names:YNR028W
ORF Names:N3255
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR028W.
SGDiS000005311. CPR8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641751 – 308Peptidyl-prolyl cis-trans isomerase CYP8Add BLAST308

Proteomic databases

MaxQBiP53728.
PRIDEiP53728.

Interactioni

Protein-protein interaction databases

BioGridi35852. 105 interactors.
DIPiDIP-4261N.
IntActiP53728. 11 interactors.
MINTiMINT-483276.
STRINGi4932.YNR028W.

Structurei

3D structure databases

ProteinModelPortaliP53728.
SMRiP53728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 215PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST160

Phylogenomic databases

GeneTreeiENSGT00530000066609.
KOiK01802.
OrthoDBiEOG092C3HBF.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P53728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFFLYLYV AFMFSCITAL PLPVDNKRAS SDSLDLKKKY APDPPITHNV
60 70 80 90 100
NIGIVFTDPE SSEEAGRLIT IDLYGTMVPK TVMTFCQYVD SVKDRLASRH
110 120 130 140 150
SYSPERDFDK ILPNGAIEGS SVSSSSIEET EMLAPKLPEE NHSLIHDRPG
160 170 180 190 200
RVSMIKDDKG LKFIIETSET PLEGESVVFG QVTAGLKDLM DKLANVKTDE
210 220 230 240 250
NGKPEQPITI GYISSQEHRI QHAKEAHEKY LQRLQDYQNG DLEKGITLKN
260 270 280 290 300
YLYQGSQRKL EDAKYNQLHH PLPKIMLGIS VLLLFYVLAK YRKRIFNRSS

KIVSIRED
Length:308
Mass (Da):34,946
Last modified:October 1, 1996 - v1
Checksum:i4E2E75B66134E6B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → P in AAT92973 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71643 Genomic DNA. Translation: CAA96308.1.
AY692954 Genomic DNA. Translation: AAT92973.1.
BK006947 Genomic DNA. Translation: DAA10568.1.
PIRiS63359.
RefSeqiNP_014425.3. NM_001183205.3.

Genome annotation databases

EnsemblFungiiYNR028W; YNR028W; YNR028W.
GeneIDi855762.
KEGGisce:YNR028W.

Similar proteinsi

Entry informationi

Entry nameiCYP8_YEAST
AccessioniPrimary (citable) accession number: P53728
Secondary accession number(s): D6W1K2, E9P900
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names