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P53728 (CYP8_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase CYP8

Short name=PPIase CYP8
EC=5.2.1.8
Alternative name(s):
Rotamase CYP8
Gene names
Name:CPR8
Ordered Locus Names:YNR028W
ORF Names:N3255
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Sequence similarities

Contains 1 PPIase cyclophilin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Peptidyl-prolyl cis-trans isomerase CYP8
PRO_0000064175

Regions

Domain56 – 215160PPIase cyclophilin-type

Experimental info

Sequence conflict81L → P in AAT92973. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P53728 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4E2E75B66134E6B0

FASTA30834,946
        10         20         30         40         50         60 
MKSFFLYLYV AFMFSCITAL PLPVDNKRAS SDSLDLKKKY APDPPITHNV NIGIVFTDPE 

        70         80         90        100        110        120 
SSEEAGRLIT IDLYGTMVPK TVMTFCQYVD SVKDRLASRH SYSPERDFDK ILPNGAIEGS 

       130        140        150        160        170        180 
SVSSSSIEET EMLAPKLPEE NHSLIHDRPG RVSMIKDDKG LKFIIETSET PLEGESVVFG 

       190        200        210        220        230        240 
QVTAGLKDLM DKLANVKTDE NGKPEQPITI GYISSQEHRI QHAKEAHEKY LQRLQDYQNG 

       250        260        270        280        290        300 
DLEKGITLKN YLYQGSQRKL EDAKYNQLHH PLPKIMLGIS VLLLFYVLAK YRKRIFNRSS 


KIVSIRED 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71643 Genomic DNA. Translation: CAA96308.1.
AY692954 Genomic DNA. Translation: AAT92973.1.
BK006947 Genomic DNA. Translation: DAA10568.1.
PIRS63359.
RefSeqNP_014425.3. NM_001183205.3.

3D structure databases

ProteinModelPortalP53728.
SMRP53728. Positions 33-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35852. 48 interactions.
DIPDIP-4261N.
IntActP53728. 4 interactions.
MINTMINT-483276.
STRING4932.YNR028W.

Proteomic databases

MaxQBP53728.
PaxDbP53728.
PeptideAtlasP53728.
PRIDEP53728.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNR028W; YNR028W; YNR028W.
GeneID855762.
KEGGsce:YNR028W.

Organism-specific databases

CYGDYNR028w.
SGDS000005311. CPR8.

Phylogenomic databases

eggNOGCOG0652.
GeneTreeENSGT00530000066609.
KOK01802.
OrthoDBEOG7MPRR0.

Enzyme and pathway databases

BioCycYEAST:YNR028W-MONOMER.

Gene expression databases

GenevestigatorP53728.

Family and domain databases

Gene3D2.40.100.10. 1 hit.
InterProIPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSPR00153. CSAPPISMRASE.
SUPFAMSSF50891. SSF50891. 1 hit.
PROSITEPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980196.

Entry information

Entry nameCYP8_YEAST
AccessionPrimary (citable) accession number: P53728
Secondary accession number(s): D6W1K2, E9P900
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families