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P53728

- CYP8_YEAST

UniProt

P53728 - CYP8_YEAST

Protein

Peptidyl-prolyl cis-trans isomerase CYP8

Gene

CPR8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: SGD

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW
    2. protein peptidyl-prolyl isomerization Source: GOC

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Enzyme and pathway databases

    BioCyciYEAST:YNR028W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase CYP8 (EC:5.2.1.8)
    Short name:
    PPIase CYP8
    Alternative name(s):
    Rotamase CYP8
    Gene namesi
    Name:CPR8
    Ordered Locus Names:YNR028W
    ORF Names:N3255
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNR028w.
    SGDiS000005311. CPR8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Peptidyl-prolyl cis-trans isomerase CYP8PRO_0000064175Add
    BLAST

    Proteomic databases

    MaxQBiP53728.
    PaxDbiP53728.
    PeptideAtlasiP53728.
    PRIDEiP53728.

    Expressioni

    Gene expression databases

    GenevestigatoriP53728.

    Interactioni

    Protein-protein interaction databases

    BioGridi35852. 48 interactions.
    DIPiDIP-4261N.
    IntActiP53728. 4 interactions.
    MINTiMINT-483276.
    STRINGi4932.YNR028W.

    Structurei

    3D structure databases

    ProteinModelPortaliP53728.
    SMRiP53728. Positions 33-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 215160PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0652.
    GeneTreeiENSGT00530000066609.
    KOiK01802.
    OrthoDBiEOG7MPRR0.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53728-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSFFLYLYV AFMFSCITAL PLPVDNKRAS SDSLDLKKKY APDPPITHNV    50
    NIGIVFTDPE SSEEAGRLIT IDLYGTMVPK TVMTFCQYVD SVKDRLASRH 100
    SYSPERDFDK ILPNGAIEGS SVSSSSIEET EMLAPKLPEE NHSLIHDRPG 150
    RVSMIKDDKG LKFIIETSET PLEGESVVFG QVTAGLKDLM DKLANVKTDE 200
    NGKPEQPITI GYISSQEHRI QHAKEAHEKY LQRLQDYQNG DLEKGITLKN 250
    YLYQGSQRKL EDAKYNQLHH PLPKIMLGIS VLLLFYVLAK YRKRIFNRSS 300
    KIVSIRED 308
    Length:308
    Mass (Da):34,946
    Last modified:October 1, 1996 - v1
    Checksum:i4E2E75B66134E6B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81L → P in AAT92973. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71643 Genomic DNA. Translation: CAA96308.1.
    AY692954 Genomic DNA. Translation: AAT92973.1.
    BK006947 Genomic DNA. Translation: DAA10568.1.
    PIRiS63359.
    RefSeqiNP_014425.3. NM_001183205.3.

    Genome annotation databases

    EnsemblFungiiYNR028W; YNR028W; YNR028W.
    GeneIDi855762.
    KEGGisce:YNR028W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71643 Genomic DNA. Translation: CAA96308.1 .
    AY692954 Genomic DNA. Translation: AAT92973.1 .
    BK006947 Genomic DNA. Translation: DAA10568.1 .
    PIRi S63359.
    RefSeqi NP_014425.3. NM_001183205.3.

    3D structure databases

    ProteinModelPortali P53728.
    SMRi P53728. Positions 33-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35852. 48 interactions.
    DIPi DIP-4261N.
    IntActi P53728. 4 interactions.
    MINTi MINT-483276.
    STRINGi 4932.YNR028W.

    Proteomic databases

    MaxQBi P53728.
    PaxDbi P53728.
    PeptideAtlasi P53728.
    PRIDEi P53728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNR028W ; YNR028W ; YNR028W .
    GeneIDi 855762.
    KEGGi sce:YNR028W.

    Organism-specific databases

    CYGDi YNR028w.
    SGDi S000005311. CPR8.

    Phylogenomic databases

    eggNOGi COG0652.
    GeneTreei ENSGT00530000066609.
    KOi K01802.
    OrthoDBi EOG7MPRR0.

    Enzyme and pathway databases

    BioCyci YEAST:YNR028W-MONOMER.

    Miscellaneous databases

    NextBioi 980196.

    Gene expression databases

    Genevestigatori P53728.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiCYP8_YEAST
    AccessioniPrimary (citable) accession number: P53728
    Secondary accession number(s): D6W1K2, E9P900
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3