Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P53728

- CYP8_YEAST

UniProt

P53728 - CYP8_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Peptidyl-prolyl cis-trans isomerase CYP8

Gene

CPR8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YNR028W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP8 (EC:5.2.1.8)
Short name:
PPIase CYP8
Alternative name(s):
Rotamase CYP8
Gene namesi
Name:CPR8
Ordered Locus Names:YNR028W
ORF Names:N3255
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNR028w.
SGDiS000005311. CPR8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Peptidyl-prolyl cis-trans isomerase CYP8PRO_0000064175Add
BLAST

Proteomic databases

MaxQBiP53728.
PaxDbiP53728.
PeptideAtlasiP53728.
PRIDEiP53728.

Expressioni

Gene expression databases

GenevestigatoriP53728.

Interactioni

Protein-protein interaction databases

BioGridi35852. 48 interactions.
DIPiDIP-4261N.
IntActiP53728. 4 interactions.
MINTiMINT-483276.
STRINGi4932.YNR028W.

Structurei

3D structure databases

ProteinModelPortaliP53728.
SMRiP53728. Positions 33-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 215160PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0652.
GeneTreeiENSGT00530000066609.
KOiK01802.
OrthoDBiEOG7MPRR0.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53728-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSFFLYLYV AFMFSCITAL PLPVDNKRAS SDSLDLKKKY APDPPITHNV
60 70 80 90 100
NIGIVFTDPE SSEEAGRLIT IDLYGTMVPK TVMTFCQYVD SVKDRLASRH
110 120 130 140 150
SYSPERDFDK ILPNGAIEGS SVSSSSIEET EMLAPKLPEE NHSLIHDRPG
160 170 180 190 200
RVSMIKDDKG LKFIIETSET PLEGESVVFG QVTAGLKDLM DKLANVKTDE
210 220 230 240 250
NGKPEQPITI GYISSQEHRI QHAKEAHEKY LQRLQDYQNG DLEKGITLKN
260 270 280 290 300
YLYQGSQRKL EDAKYNQLHH PLPKIMLGIS VLLLFYVLAK YRKRIFNRSS

KIVSIRED
Length:308
Mass (Da):34,946
Last modified:October 1, 1996 - v1
Checksum:i4E2E75B66134E6B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81L → P in AAT92973. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71643 Genomic DNA. Translation: CAA96308.1.
AY692954 Genomic DNA. Translation: AAT92973.1.
BK006947 Genomic DNA. Translation: DAA10568.1.
PIRiS63359.
RefSeqiNP_014425.3. NM_001183205.3.

Genome annotation databases

EnsemblFungiiYNR028W; YNR028W; YNR028W.
GeneIDi855762.
KEGGisce:YNR028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71643 Genomic DNA. Translation: CAA96308.1 .
AY692954 Genomic DNA. Translation: AAT92973.1 .
BK006947 Genomic DNA. Translation: DAA10568.1 .
PIRi S63359.
RefSeqi NP_014425.3. NM_001183205.3.

3D structure databases

ProteinModelPortali P53728.
SMRi P53728. Positions 33-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35852. 48 interactions.
DIPi DIP-4261N.
IntActi P53728. 4 interactions.
MINTi MINT-483276.
STRINGi 4932.YNR028W.

Proteomic databases

MaxQBi P53728.
PaxDbi P53728.
PeptideAtlasi P53728.
PRIDEi P53728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNR028W ; YNR028W ; YNR028W .
GeneIDi 855762.
KEGGi sce:YNR028W.

Organism-specific databases

CYGDi YNR028w.
SGDi S000005311. CPR8.

Phylogenomic databases

eggNOGi COG0652.
GeneTreei ENSGT00530000066609.
KOi K01802.
OrthoDBi EOG7MPRR0.

Enzyme and pathway databases

BioCyci YEAST:YNR028W-MONOMER.

Miscellaneous databases

NextBioi 980196.

Gene expression databases

Genevestigatori P53728.

Family and domain databases

Gene3Di 2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
[Graphical view ]
PRINTSi PR00153. CSAPPISMRASE.
SUPFAMi SSF50891. SSF50891. 1 hit.
PROSITEi PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCYP8_YEAST
AccessioniPrimary (citable) accession number: P53728
Secondary accession number(s): D6W1K2, E9P900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3