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Protein

M-phase phosphoprotein 6 homolog

Gene

MPP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin. Binds RNA.1 Publication

Miscellaneous

Present with 1350 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • poly(U) RNA binding Source: SGD

GO - Biological processi

  • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • nuclear mRNA surveillance of mRNA 3'-end processing Source: SGD
  • nuclear mRNA surveillance of spliceosomal pre-mRNA splicing Source: SGD
  • nuclear polyadenylation-dependent CUT catabolic process Source: SGD
  • nuclear polyadenylation-dependent rRNA catabolic process Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33338-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase phosphoprotein 6 homolog
Alternative name(s):
Exosome-associated RNA-binding protein MPP6
Gene namesi
Name:MPP6
Ordered Locus Names:YNR024W
ORF Names:N3230
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR024W
SGDiS000005307 MPP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Lethal in combination with the absence of either RRP6 or its cofactor RRP47. Weak but detectable stabilization of unspliced pre-mRNAs, and stronger stabilization is detected for mRNAs with defects in 3' cleavage and polyadenylation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002034742 – 186M-phase phosphoprotein 6 homologAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP53725
PaxDbiP53725
PRIDEiP53725

PTM databases

iPTMnetiP53725

Interactioni

Protein-protein interaction databases

BioGridi35849, 92 interactors
DIPiDIP-4263N
IntActiP53725, 1 interactor
MINTiP53725
STRINGi4932.YNR024W

Structurei

Secondary structure

1186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi103 – 105Combined sources3
Beta strandi111 – 114Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5OKZX-ray3.20J/T/d/n1-186[»]
5VZJX-ray3.30L81-120[»]
6FSZelectron microscopy4.60NN90-118[»]
ProteinModelPortaliP53725
SMRiP53725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP53725
KOiK12594
OMAiGEQNEDE
OrthoDBiEOG092C5EQO

Family and domain databases

InterProiView protein in InterPro
IPR019324 MPP6
PfamiView protein in Pfam
PF10175 MPP6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANNGVTGK LSSRVMNMKF MKFGKTDDEE SSNSNTPSNI NSDVEPIEQK
60 70 80 90 100
GKLFGLDDSA WDLNSYKDDL KKISGKEKKK VKRVVYKKRP NLIISNVGYS
110 120 130 140 150
ELRKPEGVIS GRKTFGDNSD DSGSRKRKFD EGEQNEDEKR DAKDKEFTGS
160 170 180
QDDGEDEYDL DKLFKDSIKK KKTNHNGKNK NRNSKK
Length:186
Mass (Da):21,142
Last modified:October 1, 1996 - v1
Checksum:iB1DEE530E6F9379C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71639 Genomic DNA Translation: CAA96303.1
BK006947 Genomic DNA Translation: DAA10565.1
PIRiS63355
RefSeqiNP_014421.3, NM_001183201.3

Genome annotation databases

EnsemblFungiiYNR024W; YNR024W; YNR024W
GeneIDi855758
KEGGisce:YNR024W

Similar proteinsi

Entry informationi

Entry nameiMPP6_YEAST
AccessioniPrimary (citable) accession number: P53725
Secondary accession number(s): D6W1J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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