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Protein

54S ribosomal protein L50, mitochondrial

Gene

MRPL50

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33336-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L50, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL9m1 Publication
Gene namesi
Name:MRPL50
Ordered Locus Names:YNR022C
ORF Names:N3220
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNR022C.
SGDiS000005305. MRPL50.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000305841 – 13954S ribosomal protein L50, mitochondrialAdd BLAST139

Proteomic databases

MaxQBiP53724.
PRIDEiP53724.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSC82P151083EBI-28472,EBI-8666

Protein-protein interaction databases

BioGridi35847. 90 interactors.
DIPiDIP-1265N.
IntActiP53724. 12 interactors.
MINTiMINT-402743.
STRINGi4932.YNR022C.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20G1-139[»]
5MRCelectron microscopy3.25G10-83[»]
5MREelectron microscopy3.75G10-83[»]
5MRFelectron microscopy4.97G10-83[»]
ProteinModelPortaliP53724.
SMRiP53724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000057082.
InParanoidiP53724.
OMAiNYNGARY.
OrthoDBiEOG092C5E3D.

Family and domain databases

Gene3Di3.40.5.10. 1 hit.
InterProiView protein in InterPro
IPR020070. Ribosomal_L9_N.

Sequencei

Sequence statusi: Complete.

P53724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHCTQVCLS ALTKRTHRVK VQVLKDFPRF QLYKGQVANV KPSLMRNYLH
60 70 80 90 100
NFNGAKYILS EEHDINTELL KQYQTLEAKL EEDHQQLSKR HETEVQKNME
110 120 130
LRKESVFGHK KEEKPKEEKK GLLDSGITIE EVKIPGLDI
Length:139
Mass (Da):16,283
Last modified:October 1, 1996 - v1
Checksum:i9B03AA8C283063E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71637 Genomic DNA. Translation: CAA96301.1.
BK006947 Genomic DNA. Translation: DAA10563.1.
PIRiS63353.
RefSeqiNP_014419.1. NM_001183199.1.

Genome annotation databases

EnsemblFungiiYNR022C; YNR022C; YNR022C.
GeneIDi855756.
KEGGisce:YNR022C.

Similar proteinsi

Entry informationi

Entry nameiRM50_YEAST
AccessioniPrimary (citable) accession number: P53724
Secondary accession number(s): D6W1J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names