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Protein

Lipocalin-1

Gene

LCN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Taste, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lipocalin-1
Alternative name(s):
Tear lipocalin
Short name:
Tlc
Tear prealbumin
Short name:
TP
Von Ebner gland protein
Short name:
VEG protein
Gene namesi
Name:LCN1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 176157Lipocalin-1PRO_0000017975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 171By similarity

Keywords - PTMi

Disulfide bond

PTM databases

iPTMnetiP53715.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP53715.
SMRiP53715. Positions 31-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG101411.
InParanoidiP53715.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRALLLAIG LGLVAALQAQ EFPAVGQPLQ DLLGRWYLKA MTSDPEIPGK
60 70 80 90 100
KPESVTPLIL KALEGGDLEA QITFLIDGQC QDVTLVLKKT NQPFTFTAYD
110 120 130 140 150
GKRVVYILPS KVKDHYILYC EGELDGQEVR MAKLVGRDPE NNPEALEEFK
160 170
EVARAKGLNP DIVRPQQSET CSPGGN
Length:176
Mass (Da):19,352
Last modified:October 1, 1996 - v1
Checksum:iBB7D6D750D4AC4AB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361G → A in AAC39166 (PubMed:9427546).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77587 mRNA. Translation: AAB34720.1.
U96150 Genomic DNA. Translation: AAC39166.1.
PIRiJC6503.
RefSeqiNP_999021.2. NM_213856.2.
UniGeneiSsc.15787.

Genome annotation databases

GeneIDi396861.
KEGGissc:396861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77587 mRNA. Translation: AAB34720.1.
U96150 Genomic DNA. Translation: AAC39166.1.
PIRiJC6503.
RefSeqiNP_999021.2. NM_213856.2.
UniGeneiSsc.15787.

3D structure databases

ProteinModelPortaliP53715.
SMRiP53715. Positions 31-168.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP53715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396861.
KEGGissc:396861.

Organism-specific databases

CTDi3933.

Phylogenomic databases

HOVERGENiHBG101411.
InParanoidiP53715.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002450. von_Ebner_gland.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01175. VNEBNERGLAND.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Structure and organization of the porcine LCN1 gene encoding tear lipocalin/von Ebner's gland protein."
    Holzfeind P., Merschak P., Wojnar P., Redl B.
    Gene 202:61-67(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiLCN1_PIG
AccessioniPrimary (citable) accession number: P53715
Secondary accession number(s): O19136
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.