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P53708

- ITA8_HUMAN

UniProt

P53708 - ITA8_HUMAN

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Protein

Integrin alpha-8

Gene

ITGA8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi329 – 3379Sequence Analysis
Calcium bindingi395 – 4039Sequence Analysis
Calcium bindingi459 – 4679Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell-matrix adhesion Source: UniProtKB
  3. cell projection organization Source: Ensembl
  4. establishment of protein localization Source: Ensembl
  5. extracellular matrix organization Source: Reactome
  6. inner ear morphogenesis Source: Ensembl
  7. integrin-mediated signaling pathway Source: UniProtKB-KW
  8. kidney development Source: UniProtKB
  9. memory Source: Ensembl
  10. mesodermal cell differentiation Source: UniProtKB
  11. metanephros development Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
  13. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  14. single organismal cell-cell adhesion Source: UniProtKB
  15. smooth muscle tissue development Source: Ensembl
  16. substrate adhesion-dependent cell spreading Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Integrin, Receptor

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_163906. ECM proteoglycans.
SignaLinkiP53708.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-8
Cleaved into the following 2 chains:
Gene namesi
Name:ITGA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:6144. ITGA8.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell membrane 1 Publication

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cell surface Source: UniProtKB
  3. dendritic spine membrane Source: Ensembl
  4. endoplasmic reticulum Source: UniProtKB
  5. focal adhesion Source: UniProtKB
  6. integrin alpha8-beta1 complex Source: BHF-UCL
  7. integrin complex Source: UniProtKB
  8. perikaryon Source: Ensembl
  9. plasma membrane Source: Reactome
  10. postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Renal hypodysplasia/aplasia 1 (RHDA1) [MIM:191830]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551T → M in RHDA1; unknown pathological significance. 1 Publication
VAR_071106
Natural varianti407 – 4071G → R in RHDA1; the mutant does not localize at the cell membrane. 1 Publication
VAR_071107

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi191830. phenotype.
Orphaneti1848. Bilateral renal agenesis.
PharmGKBiPA29944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence AnalysisAdd
BLAST
Chaini39 – 10631025Integrin alpha-8PRO_0000016310Add
BLAST
Chaini39 – 906868Integrin alpha-8 heavy chainSequence AnalysisPRO_0000016311Add
BLAST
Chaini907 – 1063157Integrin alpha-8 light chainSequence AnalysisPRO_0000016312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 106By similarity
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi150 ↔ 171By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi187 ↔ 200By similarity
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi507 ↔ 518By similarity
Disulfide bondi524 ↔ 580By similarity
Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi641 ↔ 647By similarity
Disulfide bondi713 ↔ 726By similarity
Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi753 – 7531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi780 – 7801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi867 ↔ 924Interchain (between heavy and light chains)By similarity
Glycosylationi896 – 8961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi929 ↔ 934By similarity
Glycosylationi1005 – 10051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP53708.
PRIDEiP53708.

PTM databases

PhosphoSiteiP53708.

Expressioni

Tissue specificityi

Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).2 Publications

Gene expression databases

BgeeiP53708.
CleanExiHS_ITGA8.
GenevestigatoriP53708.

Organism-specific databases

HPAiHPA003432.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.

Protein-protein interaction databases

BioGridi114088. 11 interactions.
STRINGi9606.ENSP00000367316.

Structurei

3D structure databases

ProteinModelPortaliP53708.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 1012974ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1034 – 106330CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1013 – 103321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 10562FG-GAP 1Add
BLAST
Repeati122 – 18362FG-GAP 2Add
BLAST
Repeati188 – 24053FG-GAP 3Add
BLAST
Repeati253 – 31058FG-GAP 4Add
BLAST
Repeati311 – 37262FG-GAP 5Add
BLAST
Repeati373 – 43159FG-GAP 6Add
BLAST
Repeati435 – 49864FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi455 – 4573Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26407.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000231603.
HOVERGENiHBG006186.
InParanoidiP53708.
KOiK06584.
OMAiCRQIPFD.
OrthoDBiEOG7HQN77.
PhylomeDBiP53708.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 6 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53708 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPGASRGPR GSQAPLIAPL CCAAAALGML LWSPACQAFN LDVEKLTVYS
60 70 80 90 100
GPKGSYFGYA VDFHIPDART ASVLVGAPKA NTSQPDIVEG GAVYYCPWPA
110 120 130 140 150
EGSAQCRQIP FDTTNNRKIR VNGTKEPIEF KSNQWFGATV KAHKGKVVAC
160 170 180 190 200
APLYHWRTLK PTPEKDPVGT CYVAIQNFSA YAEFSPCRNS NADPEGQGYC
210 220 230 240 250
QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ASVADIIANY SFKDILRKLA
260 270 280 290 300
GEKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQELVAGIPR GAQNFGYVSI
310 320 330 340 350
INSTDMTFIQ NFTGEQMASY FGYTVVVSDV NSDGLDDVLV GAPLFMEREF
360 370 380 390 400
ESNPREVGQI YLYLQVSSLL FRDPQILTGT ETFGRFGSAM AHLGDLNQDG
410 420 430 440 450
YNDIAIGVPF AGKDQRGKVL IYNGNKDGLN TKPSQVLQGV WASHAVPSGF
460 470 480 490 500
GFTLRGDSDI DKNDYPDLIV GAFGTGKVAV YRARPVVTVD AQLLLHPMII
510 520 530 540 550
NLENKTCQVP DSMTSAACFS LRVCASVTGQ SIANTIVLMA EVQLDSLKQK
560 570 580 590 600
GAIKRTLFLD NHQAHRVFPL VIKRQKSHQC QDFIVYLRDE TEFRDKLSPI
610 620 630 640 650
NISLNYSLDE STFKEGLEVK PILNYYRENI VSEQAHILVD CGEDNLCVPD
660 670 680 690 700
LKLSARPDKH QVIIGDENHL MLIINARNEG EGAYEAELFV MIPEEADYVG
710 720 730 740 750
IERNNKGFRP LSCEYKMENV TRMVVCDLGN PMVSGTNYSL GLRFAVPRLE
760 770 780 790 800
KTNMSINFDL QIRSSNKDNP DSNFVSLQIN ITAVAQVEIR GVSHPPQIVL
810 820 830 840 850
PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISDTIL EVGWPFSARD
860 870 880 890 900
EFLLYIFHIQ TLGPLQCQPN PNINPQDIKP AASPEDTPEL SAFLRNSTIP
910 920 930 940 950
HLVRKRDVHV VEFHRQSPAK ILNCTNIECL QISCAVGRLE GGESAVLKVR
960 970 980 990 1000
SRLWAHTFLQ RKNDPYALAS LVSFEVKKMP YTDQPAKLPE GSIVIKTSVI
1010 1020 1030 1040 1050
WATPNVSFSI PLWVIILAIL LGLLVLAILT LALWKCGFFD RARPPQEDMT
1060
DREQLTNDKT PEA
Length:1,063
Mass (Da):117,474
Last modified:November 2, 2010 - v3
Checksum:i8F9614BDBB897D77
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471T → A in AAA93514. (PubMed:7768999)Curated
Sequence conflicti166 – 1661D → G in AAA93514. (PubMed:7768999)Curated
Sequence conflicti188 – 1881R → G in AAA93514. (PubMed:7768999)Curated
Sequence conflicti304 – 3041T → Y in AAA93514. (PubMed:7768999)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161V → L.1 Publication
Corresponds to variant rs7895372 [ dbSNP | Ensembl ].
VAR_018673
Natural varianti255 – 2551T → M in RHDA1; unknown pathological significance. 1 Publication
VAR_071106
Natural varianti407 – 4071G → R in RHDA1; the mutant does not localize at the cell membrane. 1 Publication
VAR_071107
Natural varianti567 – 5671V → L.1 Publication
VAR_034682
Natural varianti577 – 5771S → F.2 Publications
Corresponds to variant rs2298033 [ dbSNP | Ensembl ].
VAR_018674
Natural varianti581 – 5811Q → P.2 Publications
Corresponds to variant rs9333269 [ dbSNP | Ensembl ].
VAR_018675
Natural varianti748 – 7481R → H.2 Publications
Corresponds to variant rs9333174 [ dbSNP | Ensembl ].
VAR_018676
Natural varianti993 – 9931I → V.2 Publications
Corresponds to variant rs9333241 [ dbSNP | Ensembl ].
VAR_018677
Natural varianti994 – 9941V → A.3 Publications
Corresponds to variant rs1041135 [ dbSNP | Ensembl ].
VAR_018678

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY371697 Genomic DNA. Translation: AAQ56848.2.
EF444991 Genomic DNA. Translation: ACA06009.1.
AL359645, AL590636 Genomic DNA. Translation: CAH73424.1.
AL590636, AL359645 Genomic DNA. Translation: CAI14955.1.
CH471072 Genomic DNA. Translation: EAW86235.1.
L36531 mRNA. Translation: AAA93514.1.
CCDSiCCDS31155.1.
RefSeqiNP_003629.2. NM_003638.2.
UniGeneiHs.171311.
Hs.592472.

Genome annotation databases

EnsembliENST00000378076; ENSP00000367316; ENSG00000077943.
GeneIDi8516.
KEGGihsa:8516.
UCSCiuc001ioc.1. human.

Polymorphism databases

DMDMi311033437.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY371697 Genomic DNA. Translation: AAQ56848.2 .
EF444991 Genomic DNA. Translation: ACA06009.1 .
AL359645 , AL590636 Genomic DNA. Translation: CAH73424.1 .
AL590636 , AL359645 Genomic DNA. Translation: CAI14955.1 .
CH471072 Genomic DNA. Translation: EAW86235.1 .
L36531 mRNA. Translation: AAA93514.1 .
CCDSi CCDS31155.1.
RefSeqi NP_003629.2. NM_003638.2.
UniGenei Hs.171311.
Hs.592472.

3D structure databases

ProteinModelPortali P53708.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114088. 11 interactions.
STRINGi 9606.ENSP00000367316.

PTM databases

PhosphoSitei P53708.

Polymorphism databases

DMDMi 311033437.

Proteomic databases

PaxDbi P53708.
PRIDEi P53708.

Protocols and materials databases

DNASUi 8516.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378076 ; ENSP00000367316 ; ENSG00000077943 .
GeneIDi 8516.
KEGGi hsa:8516.
UCSCi uc001ioc.1. human.

Organism-specific databases

CTDi 8516.
GeneCardsi GC10M015555.
H-InvDB HIX0035424.
HGNCi HGNC:6144. ITGA8.
HPAi HPA003432.
MIMi 191830. phenotype.
604063. gene.
neXtProti NX_P53708.
Orphaneti 1848. Bilateral renal agenesis.
PharmGKBi PA29944.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26407.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000231603.
HOVERGENi HBG006186.
InParanoidi P53708.
KOi K06584.
OMAi CRQIPFD.
OrthoDBi EOG7HQN77.
PhylomeDBi P53708.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_13552. Integrin cell surface interactions.
REACT_150331. Molecules associated with elastic fibres.
REACT_163906. ECM proteoglycans.
SignaLinki P53708.

Miscellaneous databases

GeneWikii ITGA8.
GenomeRNAii 8516.
NextBioi 31878.
PROi P53708.
SOURCEi Search...

Gene expression databases

Bgeei P53708.
CleanExi HS_ITGA8.
Genevestigatori P53708.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view ]
Pfami PF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 6 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. SeattleSNPs variation discovery resource
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-216; PHE-577; PRO-581; HIS-748; VAL-993 AND ALA-994.
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells."
    Schnapp L.M., Breuss J.M., Ramos D.M., Sheppard D., Pytela R.
    J. Cell Sci. 108:537-544(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-1063, TISSUE SPECIFICITY, VARIANT ALA-994.
  6. "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis."
    Hartner A., Schoecklmann H., Proels F., Mueller U., Sterzel R.B.
    Kidney Int. 56:1468-1480(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1."
    Lu M., Munger J.S., Steadele M., Busald C., Tellier M., Schnapp L.M.
    J. Cell Sci. 115:4641-4648(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway."
    Farias E., Lu M., Li X., Schnapp L.M.
    Biochem. Biophys. Res. Commun. 329:305-311(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: SUBCELLULAR LOCATION, VARIANTS RHDA1 MET-255 AND ARG-407, CHARACTERIZATION OF VARIANT RHDA1 ARG-407.
  10. "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)."
    Ekwa-Ekoka C., Diaz G.A., Carlson C., Hasegawa T., Samudrala R., Lim K.-C., Yabu J.M., Levy B., Schnapp L.M.
    Matrix Biol. 23:487-496(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-567; PHE-577; PRO-581; HIS-748; VAL-993 AND ALA-994.

Entry informationi

Entry nameiITA8_HUMAN
AccessioniPrimary (citable) accession number: P53708
Secondary accession number(s): B0YJ31, Q5VX94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3