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P53708

- ITA8_HUMAN

UniProt

P53708 - ITA8_HUMAN

Protein

Integrin alpha-8

Gene

ITGA8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi329 – 3379Sequence Analysis
    Calcium bindingi395 – 4039Sequence Analysis
    Calcium bindingi459 – 4679Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell-matrix adhesion Source: UniProtKB
    3. cell projection organization Source: Ensembl
    4. establishment of protein localization Source: Ensembl
    5. extracellular matrix organization Source: Reactome
    6. inner ear morphogenesis Source: Ensembl
    7. integrin-mediated signaling pathway Source: UniProtKB-KW
    8. memory Source: Ensembl
    9. metanephros development Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
    11. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    12. single organismal cell-cell adhesion Source: UniProtKB
    13. smooth muscle tissue development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion, Differentiation, Neurogenesis

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13552. Integrin cell surface interactions.
    REACT_150331. Molecules associated with elastic fibres.
    REACT_163906. ECM proteoglycans.
    SignaLinkiP53708.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-8
    Cleaved into the following 2 chains:
    Gene namesi
    Name:ITGA8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:6144. ITGA8.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell membrane 1 Publication

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. dendritic spine membrane Source: Ensembl
    3. integrin alpha8-beta1 complex Source: BHF-UCL
    4. integrin complex Source: UniProtKB
    5. perikaryon Source: Ensembl
    6. plasma membrane Source: Reactome
    7. postsynaptic density Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Renal hypodysplasia/aplasia 1 (RHDA1) [MIM:191830]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti255 – 2551T → M in RHDA1; unknown pathological significance. 1 Publication
    VAR_071106
    Natural varianti407 – 4071G → R in RHDA1; the mutant does not localize at the cell membrane. 1 Publication
    VAR_071107

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi191830. phenotype.
    Orphaneti1848. Bilateral renal agenesis.
    PharmGKBiPA29944.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 10631025Integrin alpha-8PRO_0000016310Add
    BLAST
    Chaini39 – 906868Integrin alpha-8 heavy chainSequence AnalysisPRO_0000016311Add
    BLAST
    Chaini907 – 1063157Integrin alpha-8 light chainSequence AnalysisPRO_0000016312Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 106By similarity
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 171By similarity
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi187 ↔ 200By similarity
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi507 ↔ 518By similarity
    Disulfide bondi524 ↔ 580By similarity
    Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi641 ↔ 647By similarity
    Disulfide bondi713 ↔ 726By similarity
    Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi753 – 7531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi780 – 7801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi867 ↔ 924Interchain (between heavy and light chains)By similarity
    Glycosylationi896 – 8961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi923 – 9231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi929 ↔ 934By similarity
    Glycosylationi1005 – 10051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP53708.
    PRIDEiP53708.

    PTM databases

    PhosphoSiteiP53708.

    Expressioni

    Tissue specificityi

    Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).2 Publications

    Gene expression databases

    BgeeiP53708.
    CleanExiHS_ITGA8.
    GenevestigatoriP53708.

    Organism-specific databases

    HPAiHPA003432.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1.

    Protein-protein interaction databases

    BioGridi114088. 3 interactions.
    STRINGi9606.ENSP00000367316.

    Structurei

    3D structure databases

    ProteinModelPortaliP53708.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 1012974ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1034 – 106330CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1013 – 103321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati44 – 10562FG-GAP 1Add
    BLAST
    Repeati122 – 18362FG-GAP 2Add
    BLAST
    Repeati188 – 24053FG-GAP 3Add
    BLAST
    Repeati253 – 31058FG-GAP 4Add
    BLAST
    Repeati311 – 37262FG-GAP 5Add
    BLAST
    Repeati373 – 43159FG-GAP 6Add
    BLAST
    Repeati435 – 49864FG-GAP 7Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi455 – 4573Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26407.
    HOGENOMiHOG000231603.
    HOVERGENiHBG006186.
    InParanoidiP53708.
    KOiK06584.
    OMAiCRQIPFD.
    OrthoDBiEOG7HQN77.
    PhylomeDBiP53708.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 6 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P53708-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPGASRGPR GSQAPLIAPL CCAAAALGML LWSPACQAFN LDVEKLTVYS     50
    GPKGSYFGYA VDFHIPDART ASVLVGAPKA NTSQPDIVEG GAVYYCPWPA 100
    EGSAQCRQIP FDTTNNRKIR VNGTKEPIEF KSNQWFGATV KAHKGKVVAC 150
    APLYHWRTLK PTPEKDPVGT CYVAIQNFSA YAEFSPCRNS NADPEGQGYC 200
    QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ASVADIIANY SFKDILRKLA 250
    GEKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQELVAGIPR GAQNFGYVSI 300
    INSTDMTFIQ NFTGEQMASY FGYTVVVSDV NSDGLDDVLV GAPLFMEREF 350
    ESNPREVGQI YLYLQVSSLL FRDPQILTGT ETFGRFGSAM AHLGDLNQDG 400
    YNDIAIGVPF AGKDQRGKVL IYNGNKDGLN TKPSQVLQGV WASHAVPSGF 450
    GFTLRGDSDI DKNDYPDLIV GAFGTGKVAV YRARPVVTVD AQLLLHPMII 500
    NLENKTCQVP DSMTSAACFS LRVCASVTGQ SIANTIVLMA EVQLDSLKQK 550
    GAIKRTLFLD NHQAHRVFPL VIKRQKSHQC QDFIVYLRDE TEFRDKLSPI 600
    NISLNYSLDE STFKEGLEVK PILNYYRENI VSEQAHILVD CGEDNLCVPD 650
    LKLSARPDKH QVIIGDENHL MLIINARNEG EGAYEAELFV MIPEEADYVG 700
    IERNNKGFRP LSCEYKMENV TRMVVCDLGN PMVSGTNYSL GLRFAVPRLE 750
    KTNMSINFDL QIRSSNKDNP DSNFVSLQIN ITAVAQVEIR GVSHPPQIVL 800
    PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISDTIL EVGWPFSARD 850
    EFLLYIFHIQ TLGPLQCQPN PNINPQDIKP AASPEDTPEL SAFLRNSTIP 900
    HLVRKRDVHV VEFHRQSPAK ILNCTNIECL QISCAVGRLE GGESAVLKVR 950
    SRLWAHTFLQ RKNDPYALAS LVSFEVKKMP YTDQPAKLPE GSIVIKTSVI 1000
    WATPNVSFSI PLWVIILAIL LGLLVLAILT LALWKCGFFD RARPPQEDMT 1050
    DREQLTNDKT PEA 1063
    Length:1,063
    Mass (Da):117,474
    Last modified:November 2, 2010 - v3
    Checksum:i8F9614BDBB897D77
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471T → A in AAA93514. (PubMed:7768999)Curated
    Sequence conflicti166 – 1661D → G in AAA93514. (PubMed:7768999)Curated
    Sequence conflicti188 – 1881R → G in AAA93514. (PubMed:7768999)Curated
    Sequence conflicti304 – 3041T → Y in AAA93514. (PubMed:7768999)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti216 – 2161V → L.1 Publication
    Corresponds to variant rs7895372 [ dbSNP | Ensembl ].
    VAR_018673
    Natural varianti255 – 2551T → M in RHDA1; unknown pathological significance. 1 Publication
    VAR_071106
    Natural varianti407 – 4071G → R in RHDA1; the mutant does not localize at the cell membrane. 1 Publication
    VAR_071107
    Natural varianti567 – 5671V → L.1 Publication
    VAR_034682
    Natural varianti577 – 5771S → F.2 Publications
    Corresponds to variant rs2298033 [ dbSNP | Ensembl ].
    VAR_018674
    Natural varianti581 – 5811Q → P.2 Publications
    Corresponds to variant rs9333269 [ dbSNP | Ensembl ].
    VAR_018675
    Natural varianti748 – 7481R → H.2 Publications
    Corresponds to variant rs9333174 [ dbSNP | Ensembl ].
    VAR_018676
    Natural varianti993 – 9931I → V.2 Publications
    Corresponds to variant rs9333241 [ dbSNP | Ensembl ].
    VAR_018677
    Natural varianti994 – 9941V → A.3 Publications
    Corresponds to variant rs1041135 [ dbSNP | Ensembl ].
    VAR_018678

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY371697 Genomic DNA. Translation: AAQ56848.2.
    EF444991 Genomic DNA. Translation: ACA06009.1.
    AL359645, AL590636 Genomic DNA. Translation: CAH73424.1.
    AL590636, AL359645 Genomic DNA. Translation: CAI14955.1.
    CH471072 Genomic DNA. Translation: EAW86235.1.
    L36531 mRNA. Translation: AAA93514.1.
    CCDSiCCDS31155.1.
    RefSeqiNP_003629.2. NM_003638.2.
    UniGeneiHs.171311.
    Hs.592472.

    Genome annotation databases

    EnsembliENST00000378076; ENSP00000367316; ENSG00000077943.
    GeneIDi8516.
    KEGGihsa:8516.
    UCSCiuc001ioc.1. human.

    Polymorphism databases

    DMDMi311033437.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY371697 Genomic DNA. Translation: AAQ56848.2 .
    EF444991 Genomic DNA. Translation: ACA06009.1 .
    AL359645 , AL590636 Genomic DNA. Translation: CAH73424.1 .
    AL590636 , AL359645 Genomic DNA. Translation: CAI14955.1 .
    CH471072 Genomic DNA. Translation: EAW86235.1 .
    L36531 mRNA. Translation: AAA93514.1 .
    CCDSi CCDS31155.1.
    RefSeqi NP_003629.2. NM_003638.2.
    UniGenei Hs.171311.
    Hs.592472.

    3D structure databases

    ProteinModelPortali P53708.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114088. 3 interactions.
    STRINGi 9606.ENSP00000367316.

    PTM databases

    PhosphoSitei P53708.

    Polymorphism databases

    DMDMi 311033437.

    Proteomic databases

    PaxDbi P53708.
    PRIDEi P53708.

    Protocols and materials databases

    DNASUi 8516.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378076 ; ENSP00000367316 ; ENSG00000077943 .
    GeneIDi 8516.
    KEGGi hsa:8516.
    UCSCi uc001ioc.1. human.

    Organism-specific databases

    CTDi 8516.
    GeneCardsi GC10M015599.
    H-InvDB HIX0035424.
    HGNCi HGNC:6144. ITGA8.
    HPAi HPA003432.
    MIMi 191830. phenotype.
    604063. gene.
    neXtProti NX_P53708.
    Orphaneti 1848. Bilateral renal agenesis.
    PharmGKBi PA29944.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26407.
    HOGENOMi HOG000231603.
    HOVERGENi HBG006186.
    InParanoidi P53708.
    KOi K06584.
    OMAi CRQIPFD.
    OrthoDBi EOG7HQN77.
    PhylomeDBi P53708.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_13552. Integrin cell surface interactions.
    REACT_150331. Molecules associated with elastic fibres.
    REACT_163906. ECM proteoglycans.
    SignaLinki P53708.

    Miscellaneous databases

    GeneWikii ITGA8.
    GenomeRNAii 8516.
    NextBioi 31878.
    PROi P53708.
    SOURCEi Search...

    Gene expression databases

    Bgeei P53708.
    CleanExi HS_ITGA8.
    Genevestigatori P53708.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 1 hit.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 6 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. SeattleSNPs variation discovery resource
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-216; PHE-577; PRO-581; HIS-748; VAL-993 AND ALA-994.
    2. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells."
      Schnapp L.M., Breuss J.M., Ramos D.M., Sheppard D., Pytela R.
      J. Cell Sci. 108:537-544(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-1063, TISSUE SPECIFICITY, VARIANT ALA-994.
    6. "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis."
      Hartner A., Schoecklmann H., Proels F., Mueller U., Sterzel R.B.
      Kidney Int. 56:1468-1480(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1."
      Lu M., Munger J.S., Steadele M., Busald C., Tellier M., Schnapp L.M.
      J. Cell Sci. 115:4641-4648(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway."
      Farias E., Lu M., Li X., Schnapp L.M.
      Biochem. Biophys. Res. Commun. 329:305-311(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: SUBCELLULAR LOCATION, VARIANTS RHDA1 MET-255 AND ARG-407, CHARACTERIZATION OF VARIANT RHDA1 ARG-407.
    10. "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)."
      Ekwa-Ekoka C., Diaz G.A., Carlson C., Hasegawa T., Samudrala R., Lim K.-C., Yabu J.M., Levy B., Schnapp L.M.
      Matrix Biol. 23:487-496(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LEU-567; PHE-577; PRO-581; HIS-748; VAL-993 AND ALA-994.

    Entry informationi

    Entry nameiITA8_HUMAN
    AccessioniPrimary (citable) accession number: P53708
    Secondary accession number(s): B0YJ31, Q5VX94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3