Reviewed, UniProtKB/Swiss-Prot P53703 (CCHL_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable cytochrome c-type heme lyase
      Short name=CCHL
    EC=4.4.1.17
Alternative name(s):
    Holocytochrome-c-type synthase

Gene names

Name:	cchl-1
ORF Names:	T06D8.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Links covalently the heme group to the apoprotein of cytochrome c By similarity.
Catalytic activity	Holocytochrome c = apocytochrome c + heme.
Subcellular location	Mitochondrion inner membrane Potential.
Sequence similarities	Belongs to the cytochrome c-type heme lyase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype. Source: WormBase embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase molting cycle, collagen and cuticulin-based cuticle Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holocytochrome-c synthase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Probable cytochrome c-type heme lyase		PRO_0000121714
Regions
	Repeat	35 – 40	6	HRM 1
	Repeat	56 – 61	6	HRM 2

Sequences

	Sequence		Length	Mass (Da)
	P53703-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8916E0315AA46724	FASTA	280	31,263
	10 20 30 40 50 60 MGSSQSTPKV QDANADAERI RKAQHSMAAA GGGSQCPLTP EQRAAASGEN CGAGGACPVG 70 80 90 100 110 120 ADKASINPLN NELEHPNQKP APDQPFALPT KREKSTIPKA GTETETWTYP SPQMFWNAML 130 140 150 160 170 180 KKGWRWQDDS LSKSDMENII SIHNANNEEA WREVLKWENL LHPECAEPKL KSFKGDAKNL 190 200 210 220 230 240 SPRARFRNLF LGYDLPFDRH DWIVDRCGTK QVQYVIDYYD GGAVDPSSKL FTILDVRPAV 250 260 270 280 NDIGNIWDRM VVAYWRFKFE TLGFTPSLPI PPTEGHNVNH

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z49130 Genomic DNA. Translation: CAA88969.1.
PIR	T24579.
RefSeq	NP_496403.1.
UniGene	Cel.6562
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P53703.
Genome annotation databases
Ensembl	T06D8.6.1; T06D8.6.1; T06D8.6; Caenorhabditis elegans. [Genome view] T06D8.6.2; T06D8.6.2; T06D8.6; Caenorhabditis elegans. [Genome view]
GeneID	174713.
KEGG	cel:T06D8.6.
UCSC	T06D8.6.1. c. elegans.
Organism-specific databases
CTD	174713.
WormBase	WBGene00011527. cchl-1.
WormPep	T06D8.6. CE02327. [WorfDB]
Phylogenomic databases
eggNOG	meNOG06955.
HOGENOM	HBG627179.
InParanoid	P53703.
OMA	ALHAKEC.
PhylomeDB	P53703.
Enzyme and pathway databases
BRENDA	4.4.1.17. 672.
Gene expression databases
ArrayExpress	P53703.
Family and domain databases
InterPro	IPR000511. Cyt_C/C1_haem_lyase. [Graphical view]
PANTHER	PTHR12743. Cyto_heme_lyase. 1 hit.
Pfam	PF01265. Cyto_heme_lyase. 1 hit. [Graphical view]
PROSITE	PS00821. CYTO_HEME_LYASE_1. 1 hit. PS00822. CYTO_HEME_LYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	885180.

Entry information

Entry name

CCHL_CAEEL

Accession

Primary (citable) accession number: P53703

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project