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Protein

Cytochrome c-type heme lyase

Gene

Hccs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.By similarity

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi4.4.1.17 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome c-type synthase
Gene namesi
Name:Hccs
Synonyms:Cchl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:106911 Hccs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001217132 – 272Cytochrome c-type heme lyaseAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP53702
PaxDbiP53702
PeptideAtlasiP53702
PRIDEiP53702

PTM databases

iPTMnetiP53702
PhosphoSitePlusiP53702
SwissPalmiP53702

Expressioni

Gene expression databases

BgeeiENSMUSG00000031352
CleanExiMM_HCCS
ExpressionAtlasiP53702 baseline and differential
GenevisibleiP53702 MM

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP53702, 4 interactors
MINTiP53702
STRINGi10090.ENSMUSP00000033717

Structurei

3D structure databases

ProteinModelPortaliP53702
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 33HRM 16
Repeati38 – 43HRM 26

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3996 Eukaryota
ENOG410YAUW LUCA
GeneTreeiENSGT00390000004175
HOGENOMiHOG000170352
HOVERGENiHBG001566
InParanoidiP53702
KOiK01764
OMAiIDYYSAP
OrthoDBiEOG091G0JYQ
TreeFamiTF105185

Family and domain databases

InterProiView protein in InterPro
IPR000511 Cyt_C/C1_haem_lyase
PANTHERiPTHR12743 PTHR12743, 1 hit
PfamiView protein in Pfam
PF01265 Cyto_heme_lyase, 1 hit
PROSITEiView protein in PROSITE
PS00821 CYTO_HEME_LYASE_1, 1 hit
PS00822 CYTO_HEME_LYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASASSPAT AVNASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS
60 70 80 90 100
ESKAHTVPAH QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ
110 120 130 140 150
PFTLSTSREE SSIPRADSEK KWVYPSEQMF WNAMLRKGWK WKDDDISQKD
160 170 180 190 200
MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC PCGPSLVRFG GKAREYSPRA
210 220 230 240 250
RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK EYQFTILDVR
260 270
PAFDSFSAVW DRMKVAWWRW TS
Length:272
Mass (Da):30,978
Last modified:October 3, 2012 - v2
Checksum:iAAAD63DBB3F81E47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12V → E in AAB19008 (PubMed:8661044).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36788 mRNA Translation: AAB19008.1
AL805974 Genomic DNA No translation available.
AL831750 Genomic DNA Translation: CAM22605.1
BC061466 mRNA Translation: AAH61466.1
BC062905 mRNA Translation: AAH62905.1
CCDSiCCDS30535.1
RefSeqiNP_001317978.1, NM_001331049.1
NP_001317979.1, NM_001331050.1
NP_032248.3, NM_008222.5
XP_006528768.1, XM_006528705.1
UniGeneiMm.284033

Genome annotation databases

EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352
GeneIDi15159
KEGGimmu:15159
UCSCiuc009uxx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCCHL_MOUSE
AccessioniPrimary (citable) accession number: P53702
Secondary accession number(s): Q6P5G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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