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Protein

Cytochrome c-type heme lyase

Gene

Hccs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.By similarity

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi4.4.1.17. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome c-type synthase
Gene namesi
Name:Hccs
Synonyms:Cchl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:106911. Hccs.

Subcellular locationi

  • Mitochondrion inner membrane Curated
  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001217132 – 272Cytochrome c-type heme lyaseAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP53702.
PaxDbiP53702.
PeptideAtlasiP53702.
PRIDEiP53702.

PTM databases

iPTMnetiP53702.
PhosphoSitePlusiP53702.
SwissPalmiP53702.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031352.
CleanExiMM_HCCS.
ExpressionAtlasiP53702. baseline and differential.
GenevisibleiP53702. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc1a1P519065EBI-8579982,EBI-8580001
XiapQ609895EBI-8579982,EBI-517478

Protein-protein interaction databases

IntActiP53702. 4 interactors.
MINTiMINT-2839666.
STRINGi10090.ENSMUSP00000033717.

Structurei

3D structure databases

ProteinModelPortaliP53702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 33HRM 16
Repeati38 – 43HRM 26

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3996. Eukaryota.
ENOG410YAUW. LUCA.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiP53702.
KOiK01764.
OMAiMRWKYEL.
OrthoDBiEOG091G0JYQ.
TreeFamiTF105185.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASASSPAT AVNASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS
60 70 80 90 100
ESKAHTVPAH QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ
110 120 130 140 150
PFTLSTSREE SSIPRADSEK KWVYPSEQMF WNAMLRKGWK WKDDDISQKD
160 170 180 190 200
MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC PCGPSLVRFG GKAREYSPRA
210 220 230 240 250
RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK EYQFTILDVR
260 270
PAFDSFSAVW DRMKVAWWRW TS
Length:272
Mass (Da):30,978
Last modified:October 3, 2012 - v2
Checksum:iAAAD63DBB3F81E47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12V → E in AAB19008 (PubMed:8661044).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36788 mRNA. Translation: AAB19008.1.
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1.
BC061466 mRNA. Translation: AAH61466.1.
BC062905 mRNA. Translation: AAH62905.1.
CCDSiCCDS30535.1.
RefSeqiNP_001317978.1. NM_001331049.1.
NP_001317979.1. NM_001331050.1.
NP_032248.3. NM_008222.5.
XP_006528768.1. XM_006528705.1.
UniGeneiMm.284033.

Genome annotation databases

EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
GeneIDi15159.
KEGGimmu:15159.
UCSCiuc009uxx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36788 mRNA. Translation: AAB19008.1.
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1.
BC061466 mRNA. Translation: AAH61466.1.
BC062905 mRNA. Translation: AAH62905.1.
CCDSiCCDS30535.1.
RefSeqiNP_001317978.1. NM_001331049.1.
NP_001317979.1. NM_001331050.1.
NP_032248.3. NM_008222.5.
XP_006528768.1. XM_006528705.1.
UniGeneiMm.284033.

3D structure databases

ProteinModelPortaliP53702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53702. 4 interactors.
MINTiMINT-2839666.
STRINGi10090.ENSMUSP00000033717.

PTM databases

iPTMnetiP53702.
PhosphoSitePlusiP53702.
SwissPalmiP53702.

Proteomic databases

EPDiP53702.
PaxDbiP53702.
PeptideAtlasiP53702.
PRIDEiP53702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
GeneIDi15159.
KEGGimmu:15159.
UCSCiuc009uxx.2. mouse.

Organism-specific databases

CTDi3052.
MGIiMGI:106911. Hccs.

Phylogenomic databases

eggNOGiKOG3996. Eukaryota.
ENOG410YAUW. LUCA.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiP53702.
KOiK01764.
OMAiMRWKYEL.
OrthoDBiEOG091G0JYQ.
TreeFamiTF105185.

Enzyme and pathway databases

BRENDAi4.4.1.17. 3474.

Miscellaneous databases

PROiP53702.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031352.
CleanExiMM_HCCS.
ExpressionAtlasiP53702. baseline and differential.
GenevisibleiP53702. MM.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCHL_MOUSE
AccessioniPrimary (citable) accession number: P53702
Secondary accession number(s): Q6P5G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.