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P53702

- CCHL_MOUSE

UniProt

P53702 - CCHL_MOUSE

Protein

Cytochrome c-type heme lyase

Gene

Hccs

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Links covalently the heme group to the apoprotein of cytochrome c.By similarity

    Catalytic activityi

    Holocytochrome c = apocytochrome c + heme.

    GO - Molecular functioni

    1. holocytochrome-c synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BRENDAi4.4.1.17. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c-type heme lyase (EC:4.4.1.17)
    Short name:
    CCHL
    Alternative name(s):
    Holocytochrome c-type synthase
    Gene namesi
    Name:Hccs
    Synonyms:Cchl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:106911. Hccs.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Cytochrome c-type heme lyasePRO_0000121713Add
    BLAST

    Proteomic databases

    PaxDbiP53702.
    PRIDEiP53702.

    PTM databases

    PhosphoSiteiP53702.

    Expressioni

    Gene expression databases

    ArrayExpressiP53702.
    CleanExiMM_HCCS.
    GenevestigatoriP53702.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Slc1a1P519065EBI-8579982,EBI-8580001
    XiapQ609895EBI-8579982,EBI-517478

    Protein-protein interaction databases

    IntActiP53702. 4 interactions.
    MINTiMINT-2839666.
    STRINGi10090.ENSMUSP00000107743.

    Structurei

    3D structure databases

    ProteinModelPortaliP53702.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 336HRM 1
    Repeati38 – 436HRM 2

    Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG236101.
    GeneTreeiENSGT00390000004175.
    HOGENOMiHOG000170352.
    HOVERGENiHBG001566.
    InParanoidiP53702.
    KOiK01764.
    OMAiQDAVESM.
    TreeFamiTF105185.

    Family and domain databases

    InterProiIPR000511. Cyt_C/C1_haem_lyase.
    [Graphical view]
    PANTHERiPTHR12743. PTHR12743. 1 hit.
    PfamiPF01265. Cyto_heme_lyase. 1 hit.
    [Graphical view]
    PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
    PS00822. CYTO_HEME_LYASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P53702-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGASASSPAT AVNASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS    50
    ESKAHTVPAH QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ 100
    PFTLSTSREE SSIPRADSEK KWVYPSEQMF WNAMLRKGWK WKDDDISQKD 150
    MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC PCGPSLVRFG GKAREYSPRA 200
    RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK EYQFTILDVR 250
    PAFDSFSAVW DRMKVAWWRW TS 272
    Length:272
    Mass (Da):30,978
    Last modified:October 3, 2012 - v2
    Checksum:iAAAD63DBB3F81E47
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121V → E in AAB19008. (PubMed:8661044)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36788 mRNA. Translation: AAB19008.1.
    AL805974 Genomic DNA. No translation available.
    AL831750 Genomic DNA. Translation: CAM22605.1.
    BC061466 mRNA. Translation: AAH61466.1.
    BC062905 mRNA. Translation: AAH62905.1.
    CCDSiCCDS30535.1.
    RefSeqiNP_032248.3. NM_008222.4.
    XP_006528766.1. XM_006528703.1.
    XP_006528767.1. XM_006528704.1.
    XP_006528768.1. XM_006528705.1.
    UniGeneiMm.284033.

    Genome annotation databases

    EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
    ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
    GeneIDi15159.
    KEGGimmu:15159.
    UCSCiuc009uxx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36788 mRNA. Translation: AAB19008.1 .
    AL805974 Genomic DNA. No translation available.
    AL831750 Genomic DNA. Translation: CAM22605.1 .
    BC061466 mRNA. Translation: AAH61466.1 .
    BC062905 mRNA. Translation: AAH62905.1 .
    CCDSi CCDS30535.1.
    RefSeqi NP_032248.3. NM_008222.4.
    XP_006528766.1. XM_006528703.1.
    XP_006528767.1. XM_006528704.1.
    XP_006528768.1. XM_006528705.1.
    UniGenei Mm.284033.

    3D structure databases

    ProteinModelPortali P53702.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P53702. 4 interactions.
    MINTi MINT-2839666.
    STRINGi 10090.ENSMUSP00000107743.

    PTM databases

    PhosphoSitei P53702.

    Proteomic databases

    PaxDbi P53702.
    PRIDEi P53702.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033717 ; ENSMUSP00000033717 ; ENSMUSG00000031352 .
    ENSMUST00000112115 ; ENSMUSP00000107743 ; ENSMUSG00000031352 .
    GeneIDi 15159.
    KEGGi mmu:15159.
    UCSCi uc009uxx.2. mouse.

    Organism-specific databases

    CTDi 3052.
    MGIi MGI:106911. Hccs.

    Phylogenomic databases

    eggNOGi NOG236101.
    GeneTreei ENSGT00390000004175.
    HOGENOMi HOG000170352.
    HOVERGENi HBG001566.
    InParanoidi P53702.
    KOi K01764.
    OMAi QDAVESM.
    TreeFami TF105185.

    Enzyme and pathway databases

    BRENDAi 4.4.1.17. 3474.

    Miscellaneous databases

    NextBioi 287644.
    PROi P53702.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53702.
    CleanExi MM_HCCS.
    Genevestigatori P53702.

    Family and domain databases

    InterProi IPR000511. Cyt_C/C1_haem_lyase.
    [Graphical view ]
    PANTHERi PTHR12743. PTHR12743. 1 hit.
    Pfami PF01265. Cyto_heme_lyase. 1 hit.
    [Graphical view ]
    PROSITEi PS00821. CYTO_HEME_LYASE_1. 1 hit.
    PS00822. CYTO_HEME_LYASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)."
      Schaefer L., Ballabio A., Zoghbi H.Y.
      Genomics 34:166-172(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCCHL_MOUSE
    AccessioniPrimary (citable) accession number: P53702
    Secondary accession number(s): Q6P5G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3