P53702 (CCHL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c-type heme lyase
Short name=CCHL
EC=4.4.1.17

Alternative name(s):
Holocytochrome c-type synthase

Gene names

Name:	Hccs
Synonyms:	Cchl

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Links covalently the heme group to the apoprotein of cytochrome c By similarity.
Catalytic activity	Holocytochrome c = apocytochrome c + heme.
Subcellular location	Mitochondrion inner membrane Potential.
Sequence similarities	Belongs to the cytochrome c-type heme lyase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holocytochrome-c synthase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Cytochrome c-type heme lyase		PRO_0000121713
Regions
	Repeat	28 – 33	6	HRM 1
	Repeat	38 – 43	6	HRM 2

Sequences

	Sequence		Length	Mass (Da)
	P53702 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: A2E8F3DBB5F28E47	FASTA	272	31,008
	10 20 30 40 50 60 MGASASSPAT AENASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS ESKAHTVPAH 70 80 90 100 110 120 QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ PFTLSTSREE SSIPRADSEK 130 140 150 160 170 180 KWVYPSEQMF WNAMLRKGWK WKDDDISQKD MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC 190 200 210 220 230 240 PCGPSLVRFG GKAREYSPRA RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK 250 260 270 EYQFTILDVR PAFDSFSAVW DRMKVAWWRW TS

References

[1]	"Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)." Schaefer L., Ballabio A., Zoghbi H.Y. Genomics 34:166-172(1996) [PubMed: 8661044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36788 mRNA. Translation: AAB19008.1.
IPI	IPI00134572.
UniGene	Mm.284033.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2839666.
STRING	P53702.
Proteomic databases
PRIDE	P53702.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:106911. Hccs.
Phylogenomic databases
eggNOG	roNOG12783.
HOGENOM	HBG627179.
HOVERGEN	HBG001566.
InParanoid	P53702.
OrthoDB	EOG4RJG2H.
PhylomeDB	P53702.
Enzyme and pathway databases
BRENDA	4.4.1.17. 3474.
Gene expression databases
ArrayExpress	P53702.
Bgee	P53702.
CleanEx	MM_HCCS.
Genevestigator	P53702.
GermOnline	ENSMUSG00000031352. Mus musculus.
Family and domain databases
InterPro	IPR000511. Cyt_C/C1_haem_lyase. [Graphical view]
PANTHER	PTHR12743. Cyto_heme_lyase. 1 hit.
Pfam	PF01265. Cyto_heme_lyase. 1 hit. [Graphical view]
PROSITE	PS00821. CYTO_HEME_LYASE_1. 1 hit. PS00822. CYTO_HEME_LYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CCHL_MOUSE

Accession

Primary (citable) accession number: P53702

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	September 21, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program