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Protein

Cytochrome c-type heme lyase

Gene

Hccs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.By similarity

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

  1. holocytochrome-c synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi4.4.1.17. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome c-type synthase
Gene namesi
Name:Hccs
Synonyms:Cchl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:106911. Hccs.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Cytochrome c-type heme lyasePRO_0000121713Add
BLAST

Proteomic databases

PaxDbiP53702.
PRIDEiP53702.

PTM databases

PhosphoSiteiP53702.

Expressioni

Gene expression databases

CleanExiMM_HCCS.
ExpressionAtlasiP53702. baseline and differential.
GenevestigatoriP53702.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc1a1P519065EBI-8579982,EBI-8580001
XiapQ609895EBI-8579982,EBI-517478

Protein-protein interaction databases

IntActiP53702. 4 interactions.
MINTiMINT-2839666.
STRINGi10090.ENSMUSP00000107743.

Structurei

3D structure databases

ProteinModelPortaliP53702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 336HRM 1
Repeati38 – 436HRM 2

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG236101.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiP53702.
KOiK01764.
OMAiRPAFDSF.
TreeFamiTF105185.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53702-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGASASSPAT AVNASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS
60 70 80 90 100
ESKAHTVPAH QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ
110 120 130 140 150
PFTLSTSREE SSIPRADSEK KWVYPSEQMF WNAMLRKGWK WKDDDISQKD
160 170 180 190 200
MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC PCGPSLVRFG GKAREYSPRA
210 220 230 240 250
RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK EYQFTILDVR
260 270
PAFDSFSAVW DRMKVAWWRW TS
Length:272
Mass (Da):30,978
Last modified:October 3, 2012 - v2
Checksum:iAAAD63DBB3F81E47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121V → E in AAB19008. (PubMed:8661044)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36788 mRNA. Translation: AAB19008.1.
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1.
BC061466 mRNA. Translation: AAH61466.1.
BC062905 mRNA. Translation: AAH62905.1.
CCDSiCCDS30535.1.
RefSeqiNP_032248.3. NM_008222.4.
XP_006528766.1. XM_006528703.1.
XP_006528767.1. XM_006528704.1.
XP_006528768.1. XM_006528705.1.
UniGeneiMm.284033.

Genome annotation databases

EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
GeneIDi15159.
KEGGimmu:15159.
UCSCiuc009uxx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36788 mRNA. Translation: AAB19008.1.
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1.
BC061466 mRNA. Translation: AAH61466.1.
BC062905 mRNA. Translation: AAH62905.1.
CCDSiCCDS30535.1.
RefSeqiNP_032248.3. NM_008222.4.
XP_006528766.1. XM_006528703.1.
XP_006528767.1. XM_006528704.1.
XP_006528768.1. XM_006528705.1.
UniGeneiMm.284033.

3D structure databases

ProteinModelPortaliP53702.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP53702. 4 interactions.
MINTiMINT-2839666.
STRINGi10090.ENSMUSP00000107743.

PTM databases

PhosphoSiteiP53702.

Proteomic databases

PaxDbiP53702.
PRIDEiP53702.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
GeneIDi15159.
KEGGimmu:15159.
UCSCiuc009uxx.2. mouse.

Organism-specific databases

CTDi3052.
MGIiMGI:106911. Hccs.

Phylogenomic databases

eggNOGiNOG236101.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiP53702.
KOiK01764.
OMAiRPAFDSF.
TreeFamiTF105185.

Enzyme and pathway databases

BRENDAi4.4.1.17. 3474.

Miscellaneous databases

NextBioi287644.
PROiP53702.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HCCS.
ExpressionAtlasiP53702. baseline and differential.
GenevestigatoriP53702.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)."
    Schaefer L., Ballabio A., Zoghbi H.Y.
    Genomics 34:166-172(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCCHL_MOUSE
AccessioniPrimary (citable) accession number: P53702
Secondary accession number(s): Q6P5G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: January 7, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.