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P53702

- CCHL_MOUSE

UniProt

P53702 - CCHL_MOUSE

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Protein

Cytochrome c-type heme lyase

Gene
Hccs, Cchl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c By similarity.

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

  1. holocytochrome-c synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi4.4.1.17. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome c-type synthase
Gene namesi
Name:Hccs
Synonyms:Cchl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:106911. Hccs.

Subcellular locationi

Mitochondrion inner membrane Reviewed prediction

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Cytochrome c-type heme lyasePRO_0000121713Add
BLAST

Proteomic databases

PaxDbiP53702.
PRIDEiP53702.

PTM databases

PhosphoSiteiP53702.

Expressioni

Gene expression databases

ArrayExpressiP53702.
CleanExiMM_HCCS.
GenevestigatoriP53702.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Slc1a1P519065EBI-8579982,EBI-8580001
XiapQ609895EBI-8579982,EBI-517478

Protein-protein interaction databases

IntActiP53702. 4 interactions.
MINTiMINT-2839666.
STRINGi10090.ENSMUSP00000107743.

Structurei

3D structure databases

ProteinModelPortaliP53702.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 336HRM 1
Repeati38 – 436HRM 2

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG236101.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiP53702.
KOiK01764.
OMAiQDAVESM.
TreeFamiTF105185.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P53702-1 [UniParc]FASTAAdd to Basket

« Hide

MGASASSPAT AVNASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS    50
ESKAHTVPAH QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ 100
PFTLSTSREE SSIPRADSEK KWVYPSEQMF WNAMLRKGWK WKDDDISQKD 150
MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC PCGPSLVRFG GKAREYSPRA 200
RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK EYQFTILDVR 250
PAFDSFSAVW DRMKVAWWRW TS 272
Length:272
Mass (Da):30,978
Last modified:October 3, 2012 - v2
Checksum:iAAAD63DBB3F81E47
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121V → E in AAB19008. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36788 mRNA. Translation: AAB19008.1.
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1.
BC061466 mRNA. Translation: AAH61466.1.
BC062905 mRNA. Translation: AAH62905.1.
CCDSiCCDS30535.1.
RefSeqiNP_032248.3. NM_008222.4.
XP_006528766.1. XM_006528703.1.
XP_006528767.1. XM_006528704.1.
XP_006528768.1. XM_006528705.1.
UniGeneiMm.284033.

Genome annotation databases

EnsembliENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
GeneIDi15159.
KEGGimmu:15159.
UCSCiuc009uxx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36788 mRNA. Translation: AAB19008.1 .
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1 .
BC061466 mRNA. Translation: AAH61466.1 .
BC062905 mRNA. Translation: AAH62905.1 .
CCDSi CCDS30535.1.
RefSeqi NP_032248.3. NM_008222.4.
XP_006528766.1. XM_006528703.1.
XP_006528767.1. XM_006528704.1.
XP_006528768.1. XM_006528705.1.
UniGenei Mm.284033.

3D structure databases

ProteinModelPortali P53702.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P53702. 4 interactions.
MINTi MINT-2839666.
STRINGi 10090.ENSMUSP00000107743.

PTM databases

PhosphoSitei P53702.

Proteomic databases

PaxDbi P53702.
PRIDEi P53702.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033717 ; ENSMUSP00000033717 ; ENSMUSG00000031352 .
ENSMUST00000112115 ; ENSMUSP00000107743 ; ENSMUSG00000031352 .
GeneIDi 15159.
KEGGi mmu:15159.
UCSCi uc009uxx.2. mouse.

Organism-specific databases

CTDi 3052.
MGIi MGI:106911. Hccs.

Phylogenomic databases

eggNOGi NOG236101.
GeneTreei ENSGT00390000004175.
HOGENOMi HOG000170352.
HOVERGENi HBG001566.
InParanoidi P53702.
KOi K01764.
OMAi QDAVESM.
TreeFami TF105185.

Enzyme and pathway databases

BRENDAi 4.4.1.17. 3474.

Miscellaneous databases

NextBioi 287644.
PROi P53702.
SOURCEi Search...

Gene expression databases

ArrayExpressi P53702.
CleanExi MM_HCCS.
Genevestigatori P53702.

Family and domain databases

InterProi IPR000511. Cyt_C/C1_haem_lyase.
[Graphical view ]
PANTHERi PTHR12743. PTHR12743. 1 hit.
Pfami PF01265. Cyto_heme_lyase. 1 hit.
[Graphical view ]
PROSITEi PS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)."
    Schaefer L., Ballabio A., Zoghbi H.Y.
    Genomics 34:166-172(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCCHL_MOUSE
AccessioniPrimary (citable) accession number: P53702
Secondary accession number(s): Q6P5G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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