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P53702 (CCHL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c-type heme lyase

Short name=CCHL
EC=4.4.1.17
Alternative name(s):
Holocytochrome c-type synthase
Gene names
Name:Hccs
Synonyms:Cchl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Links covalently the heme group to the apoprotein of cytochrome c By similarity.

Catalytic activity

Holocytochrome c = apocytochrome c + heme.

Subcellular location

Mitochondrion inner membrane Potential.

Sequence similarities

Belongs to the cytochrome c-type heme lyase family.

Contains 2 HRM (heme regulatory motif) repeats.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Cytochrome c-type heme lyase
PRO_0000121713

Regions

Repeat28 – 336HRM 1
Repeat38 – 436HRM 2

Experimental info

Sequence conflict121V → E in AAB19008. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P53702 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: AAAD63DBB3F81E47

FASTA27230,978
        10         20         30         40         50         60 
MGASASSPAT AVNASNASDG QPASPPSGCP MHKGQRKGCP VTAATSDLTS ESKAHTVPAH 

        70         80         90        100        110        120 
QDRAYDYVEC PVTGARAKDK ESLDPSNLMP PPNQTPSPDQ PFTLSTSREE SSIPRADSEK 

       130        140        150        160        170        180 
KWVYPSEQMF WNAMLRKGWK WKDDDISQKD MYNIIRIHNQ NNEQAWKEIL KWEALHAHEC 

       190        200        210        220        230        240 
PCGPSLVRFG GKAREYSPRA RIRSWMGYEL PFDRHDWIIN RCGTEVRYVI DYYDGGEVNK 

       250        260        270 
EYQFTILDVR PAFDSFSAVW DRMKVAWWRW TS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)."
Schaefer L., Ballabio A., Zoghbi H.Y.
Genomics 34:166-172(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36788 mRNA. Translation: AAB19008.1.
AL805974 Genomic DNA. No translation available.
AL831750 Genomic DNA. Translation: CAM22605.1.
BC061466 mRNA. Translation: AAH61466.1.
BC062905 mRNA. Translation: AAH62905.1.
CCDSCCDS30535.1.
RefSeqNP_032248.3. NM_008222.4.
XP_006528766.1. XM_006528703.1.
XP_006528767.1. XM_006528704.1.
XP_006528768.1. XM_006528705.1.
UniGeneMm.284033.

3D structure databases

ProteinModelPortalP53702.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP53702. 4 interactions.
MINTMINT-2839666.
STRING10090.ENSMUSP00000107743.

PTM databases

PhosphoSiteP53702.

Proteomic databases

PaxDbP53702.
PRIDEP53702.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033717; ENSMUSP00000033717; ENSMUSG00000031352.
ENSMUST00000112115; ENSMUSP00000107743; ENSMUSG00000031352.
GeneID15159.
KEGGmmu:15159.
UCSCuc009uxx.2. mouse.

Organism-specific databases

CTD3052.
MGIMGI:106911. Hccs.

Phylogenomic databases

eggNOGNOG236101.
GeneTreeENSGT00390000004175.
HOGENOMHOG000170352.
HOVERGENHBG001566.
InParanoidP53702.
KOK01764.
OMAQDAVESM.
TreeFamTF105185.

Enzyme and pathway databases

BRENDA4.4.1.17. 3474.

Gene expression databases

ArrayExpressP53702.
CleanExMM_HCCS.
GenevestigatorP53702.

Family and domain databases

InterProIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERPTHR12743. PTHR12743. 1 hit.
PfamPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287644.
PROP53702.
SOURCESearch...

Entry information

Entry nameCCHL_MOUSE
AccessionPrimary (citable) accession number: P53702
Secondary accession number(s): Q6P5G5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot