Reviewed, UniProtKB/Swiss-Prot P53700 (CCHL_CANAL)

Names and origin

Protein names

Recommended name:
    Cytochrome c heme lyase
      Short name=CCHL
    EC=4.4.1.17
Alternative name(s):
    Holocytochrome-c synthase

Gene names

Name:

CYC3

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Links covalently the heme group to the apoprotein of cytochrome c.
Catalytic activity	Holocytochrome c = apocytochrome c + heme.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c-type heme lyase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Lyase
Gene Ontology (GO)
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holocytochrome-c synthase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Cytochrome c heme lyase		PRO_0000121717
Regions
	Repeat	25 – 30	6	HRM 1
	Repeat	39 – 44	6	HRM 2

Sequences

	Sequence		Length	Mass (Da)
	P53700-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C8333BA3EC2B9ADB	FASTA	264	30,182
	10 20 30 40 50 60 MGWFWADKPS QDTVKATSSF TTPSACPIDH SKLASSSPTC PVKLNNDNDE VLNPLNNMPM 70 80 90 100 110 120 AISSERAPGQ RIKLSTERTI STIPRGESED QGLWEYPSPQ QMLNAMLSKG KGDVVPEDAV 130 140 150 160 170 180 ESMVEVHNFL NEGAWQQILT WEDQYTQQTK VEPRLKKFTG RPHDLSPKAR MYLWLGQLFP 190 200 210 220 230 240 ETFNTIPPFD RHDWTVLRSC GRNQGWKEVR YVIDYYGAPD DEEAGMPAFM LDTRPALDNL 250 260 TNARDRFTHW AYPLWKKAMG EVRD

References

[1]

"Molecular cloning and characterization of a Candida albicans gene coding for cytochrome c haem lyase and a cell wall-related protein." Cervera A.M., Gozalbo D., McCreath K.J., Gow N.A., Martinez J.P., Casanova M. Mol. Microbiol. 30:67-81(1998) [PubMed: 9786186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WO-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U62148 Genomic DNA. Translation: AAB04135.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.4.1.17. 1124.
Family and domain databases
InterPro	IPR000511. Cyt_C/C1_haem_lyase. [Graphical view]
PANTHER	PTHR12743. Cyto_heme_lyase. 1 hit.
Pfam	PF01265. Cyto_heme_lyase. 1 hit. [Graphical view]
PROSITE	PS00821. CYTO_HEME_LYASE_1. 1 hit. PS00822. CYTO_HEME_LYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCHL_CANAL

Accession

Primary (citable) accession number: P53700

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)