ID CYC_CANAL Reviewed; 110 AA. AC P53698; A0A1D8PIM8; Q59XT5; DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 27-MAR-2024, entry version 151. DE RecName: Full=Cytochrome c; GN Name=CYC1; OrderedLocusNames=CAALFM_C210110WA; GN ORFNames=CaO19.1770, CaO19.9339; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=SOR17; RX PubMed=9271112; RX DOI=10.1002/(sici)1097-0061(199708)13:10<985::aid-yea153>3.0.co;2-t; RA Janbon G., Rustchenko E., Klug S., Scherer S., Sherman F.; RT "Phylogenetic relationships of fungal cytochromes c."; RL Yeast 13:985-990(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [3] RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). CC -!- FUNCTION: Electron carrier protein. The oxidized form of the cytochrome CC c heme group can accept an electron from the heme group of the CC cytochrome c1 subunit of cytochrome reductase. Cytochrome c then CC transfers this electron to the cytochrome oxidase complex, the final CC protein carrier in the mitochondrial electron-transport chain. CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Note=Loosely CC associated with the inner membrane. CC -!- PTM: Binds 1 heme c group covalently per subunit. CC -!- SIMILARITY: Belongs to the cytochrome c family. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Life shuttle - Issue 76 of CC November 2006; CC URL="https://web.expasy.org/spotlight/back_issues/076"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U57896; AAB68996.1; -; Genomic_DNA. DR EMBL; CP017624; AOW27988.1; -; Genomic_DNA. DR RefSeq; XP_714415.1; XM_709322.1. DR AlphaFoldDB; P53698; -. DR SMR; P53698; -. DR STRING; 237561.P53698; -. DR EnsemblFungi; C2_10110W_A-T; C2_10110W_A-T-p1; C2_10110W_A. DR GeneID; 3643937; -. DR KEGG; cal:CAALFM_C210110WA; -. DR CGD; CAL0000196284; CYC1. DR VEuPathDB; FungiDB:C2_10110W_A; -. DR eggNOG; KOG3453; Eukaryota. DR HOGENOM; CLU_060944_3_0_1; -. DR InParanoid; P53698; -. DR OMA; WGCPASE; -. DR OrthoDB; 4150at2759; -. DR PRO; PR:P53698; -. DR Proteomes; UP000000559; Chromosome 2. DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IDA:CGD. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0009055; F:electron transfer activity; IGI:CGD. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central. DR GO; GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IGI:CGD. DR Gene3D; 1.10.760.10; Cytochrome c-like domain; 1. DR InterPro; IPR009056; Cyt_c-like_dom. DR InterPro; IPR036909; Cyt_c-like_dom_sf. DR InterPro; IPR002327; Cyt_c_1A/1B. DR PANTHER; PTHR11961; CYTOCHROME C; 1. DR PANTHER; PTHR11961:SF12; CYTOCHROME C; 1. DR Pfam; PF00034; Cytochrom_C; 1. DR PRINTS; PR00604; CYTCHRMECIAB. DR SUPFAM; SSF46626; Cytochrome c; 1. DR PROSITE; PS51007; CYTC; 1. PE 3: Inferred from homology; KW Electron transport; Heme; Iron; Metal-binding; Methylation; Mitochondrion; KW Reference proteome; Respiratory chain; Transport. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000250" FT CHAIN 2..110 FT /note="Cytochrome c" FT /id="PRO_0000108318" FT BINDING 21 FT /ligand="heme c" FT /ligand_id="ChEBI:CHEBI:61717" FT /note="covalent" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433" FT BINDING 24 FT /ligand="heme c" FT /ligand_id="ChEBI:CHEBI:61717" FT /note="covalent" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433" FT BINDING 25 FT /ligand="heme c" FT /ligand_id="ChEBI:CHEBI:61717" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433" FT BINDING 87 FT /ligand="heme c" FT /ligand_id="ChEBI:CHEBI:61717" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00433" FT MOD_RES 79 FT /note="N6,N6,N6-trimethyllysine" FT /evidence="ECO:0000250" SQ SEQUENCE 110 AA; 12180 MW; A2B251C564DA559B CRC64; MPAPFEKGSE KKGATLFKTR CLQCHTVEKG GPHKVGPNLH GVFGRKSGLA EGYSYTDANK KKGVEWTEQT MSDYLENPKK YIPGTKMAFG GLKKPKDRND LVTYLKKATS //