P53698 (CYC_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c

Gene names

Name:	CYC1
ORF Names:	CaO19.1770, CaO19.9339

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Methylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial electron transport, ubiquinol to cytochrome c Inferred from genetic interaction Ref.1. Source: CGD
Cellular_component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 14693527. Source: CGD respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	electron carrier activity Inferred from genetic interaction Ref.1. Source: CGD heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 110	109	Cytochrome c		PRO_0000108318
Sites
	Metal binding	25	1	Iron (heme axial ligand) Potential
	Metal binding	87	1	Iron (heme axial ligand) Potential
	Binding site	21	1	Heme (covalent) Potential
	Binding site	24	1	Heme (covalent) Potential
Amino acid modifications
	Modified residue	79	1	N6,N6,N6-trimethyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P53698 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A2B251C564DA559B	FASTA	110	12,180
	10 20 30 40 50 60 MPAPFEKGSE KKGATLFKTR CLQCHTVEKG GPHKVGPNLH GVFGRKSGLA EGYSYTDANK 70 80 90 100 110 KKGVEWTEQT MSDYLENPKK YIPGTKMAFG GLKKPKDRND LVTYLKKATS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Phylogenetic relationships of fungal cytochromes c." Janbon G., Rustchenko E., Klug S., Scherer S., Sherman F. Yeast 13:985-990(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SOR17.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57896 Genomic DNA. Translation: AAB68996.1. AACQ01000105 Genomic DNA. Translation: EAK95307.1. AACQ01000104 Genomic DNA. Translation: EAK95348.1.
RefSeq	XP_714375.1. XM_709282.1. XP_714415.1. XM_709322.1.
3D structure databases
ProteinModelPortal	P53698.
SMR	P53698. Positions 3-109.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0000927.
Proteomic databases
PRIDE	P53698.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643937. 3644007.
KEGG	cal:CaO19.1770. cal:CaO19.9339.
Organism-specific databases
CGD	CAL0000927. CYC1.
Phylogenomic databases
eggNOG	COG3474.
KO	K08738.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
PANTHER	PTHR11961. PTHR11961. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC_CANAL

Accession

Primary (citable) accession number: P53698
Secondary accession number(s): Q59XT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program