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Protein

Cytochrome c

Gene

CYC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21Heme (covalent)PROSITE-ProRule annotation1
Binding sitei24Heme (covalent)PROSITE-ProRule annotation1
Metal bindingi25Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi87Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • electron carrier activity Source: CGD
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • mitochondrial electron transport, ubiquinol to cytochrome c Source: CGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYC1
Ordered Locus Names:CAALFM_C210110WA
ORF Names:CaO19.1770, CaO19.9339
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000196284. CYC1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: UniProtKB-SubCell
  • mitochondrion Source: CGD
  • respiratory chain Source: UniProtKB-KW

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001083182 – 110Cytochrome cAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79N6,N6,N6-trimethyllysineBy similarity1

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP53698.

Structurei

3D structure databases

ProteinModelPortaliP53698.
SMRiP53698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

InParanoidiP53698.
KOiK08738.
OrthoDBiEOG092C56RQ.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiView protein in Pfam
PF00034. Cytochrom_C. 1 hit.
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiView protein in PROSITE
PS51007. CYTC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPFEKGSE KKGATLFKTR CLQCHTVEKG GPHKVGPNLH GVFGRKSGLA
60 70 80 90 100
EGYSYTDANK KKGVEWTEQT MSDYLENPKK YIPGTKMAFG GLKKPKDRND
110
LVTYLKKATS
Length:110
Mass (Da):12,180
Last modified:January 23, 2007 - v3
Checksum:iA2B251C564DA559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57896 Genomic DNA. Translation: AAB68996.1.
CP017624 Genomic DNA. Translation: AOW27988.1.
RefSeqiXP_714415.1. XM_709322.1.

Genome annotation databases

GeneIDi3643937.
KEGGical:CAALFM_C210110WA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYC_CANAL
AccessioniPrimary (citable) accession number: P53698
Secondary accession number(s): A0A1D8PIM8, Q59XT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families