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Protein

Cytochrome c

Gene

CYC1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211Heme (covalent)PROSITE-ProRule annotation
Binding sitei24 – 241Heme (covalent)PROSITE-ProRule annotation
Metal bindingi25 – 251Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi87 – 871Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  • electron carrier activity Source: CGD
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c
Gene namesi
Name:CYC1
ORF Names:CaO19.1770, CaO19.9339
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000927. CYC1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: GO_Central
  • mitochondrion Source: CGD
  • respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 110109Cytochrome cPRO_0000108318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791N6,N6,N6-trimethyllysineBy similarity

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP53698.

Structurei

3D structure databases

ProteinModelPortaliP53698.
SMRiP53698. Positions 3-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
InParanoidiP53698.
KOiK08738.
OrthoDBiEOG71RXXT.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P53698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPFEKGSE KKGATLFKTR CLQCHTVEKG GPHKVGPNLH GVFGRKSGLA
60 70 80 90 100
EGYSYTDANK KKGVEWTEQT MSDYLENPKK YIPGTKMAFG GLKKPKDRND
110
LVTYLKKATS
Length:110
Mass (Da):12,180
Last modified:January 23, 2007 - v3
Checksum:iA2B251C564DA559B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57896 Genomic DNA. Translation: AAB68996.1.
AACQ01000105 Genomic DNA. Translation: EAK95307.1.
AACQ01000104 Genomic DNA. Translation: EAK95348.1.
RefSeqiXP_714375.1. XM_709282.1.
XP_714415.1. XM_709322.1.

Genome annotation databases

GeneIDi3643937.
3644007.
KEGGical:CaO19.1770.
cal:CaO19.9339.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57896 Genomic DNA. Translation: AAB68996.1.
AACQ01000105 Genomic DNA. Translation: EAK95307.1.
AACQ01000104 Genomic DNA. Translation: EAK95348.1.
RefSeqiXP_714375.1. XM_709282.1.
XP_714415.1. XM_709322.1.

3D structure databases

ProteinModelPortaliP53698.
SMRiP53698. Positions 3-109.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP53698.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3643937.
3644007.
KEGGical:CaO19.1770.
cal:CaO19.9339.

Organism-specific databases

CGDiCAL0000927. CYC1.

Phylogenomic databases

eggNOGiCOG3474.
InParanoidiP53698.
KOiK08738.
OrthoDBiEOG71RXXT.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetic relationships of fungal cytochromes c."
    Janbon G., Rustchenko E., Klug S., Scherer S., Sherman F.
    Yeast 13:985-990(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SOR17.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCYC_CANAL
AccessioniPrimary (citable) accession number: P53698
Secondary accession number(s): Q59XT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.