P53697 (MNN9_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannan polymerase complex subunit MNN9

Gene names

Name:	MNN9
ORF Names:	CaO19.7383

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the ANP1/MMN9/VAN1 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell wall mannoprotein biosynthetic process Inferred from mutant phenotype Ref.1. Source: CGD cellular response to biotic stimulus Inferred from mutant phenotype Ref.1. Source: CGD cellular response to drug Inferred from mutant phenotype Ref.1. Source: CGD cellular response to heat Inferred from mutant phenotype Ref.1. Source: CGD filamentous growth of a population of unicellular organisms in response to biotic stimulus Inferred from mutant phenotype Ref.1. Source: CGD filamentous growth of a population of unicellular organisms in response to heat Inferred from mutant phenotype Ref.1. Source: CGD fungal-type cell wall organization Inferred from mutant phenotype PubMed 10672182. Source: CGD protein glycosylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from sequence or structural similarity Ref.1. Source: CGD
Molecular_function	mannosyltransferase activity Inferred from mutant phenotype Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Mannan polymerase complex subunit MNN9		PRO_0000193669
Regions
	Topological domain	1 – 15	15	Cytoplasmic Potential
	Transmembrane	16 – 33	18	Helical; Signal-anchor for type II membrane protein
	Topological domain	34 – 368	335	Lumenal Potential

Sequences

	Sequence		Length	Mass (Da)
	P53697 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 930DCC64EE8F5EF5	FASTA	368	42,782
	10 20 30 40 50 60 MVHYRNRYLN YIRRKPLALL APITLLVVIY FYFFSAHGFS SNKQKYNYNK KSRGWFYKNR 70 80 90 100 110 120 DTVILKDLPK NHISHYDLNK LTASKDALNK REEVLILTPM SKFLPEYWEN INKLTYDHSL 130 140 150 160 170 180 ISLGFIFPRT TQGDDALKEL ENALKKTKRE KRLNFKKITI LRQDSNSLQS QLEKDRHAFK 190 200 210 220 230 240 VQKERRSMMA LARNSLVFST ILPSTSWVLW LDADIVETPV TLIQDLTGHN KPVVSANVHQ 250 260 270 280 290 300 RFINQDTKQP DIRPYDFNNW VESEEGLKLA ASLPDDEIIV EGYSEMVTHR ALMAHFYDPK 310 320 330 340 350 360 GDPSTEMTLD GVGGGAVMVK ADVHRDGAMF PSFPFYHLIE TEGFAKMAKR LGYEVYGLPN YLVFHYNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, required for glycosylation of cell wall mannoproteins." Southard S.B., Specht C.A., Mishra C., Chen-Weiner J., Robbins P.W. J. Bacteriol. 181:7439-7448(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10261 / CBS 2718 / NBRC 1061.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U63642 Genomic DNA. Translation: AAB05924.1. AACQ01000066 Genomic DNA. Translation: EAK97629.1.
RefSeq	XP_716624.1. XM_711531.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004800.
Protein family/group databases
CAZy	GT62. Glycosyltransferase Family 62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641735.
KEGG	cal:CaO19.7383.
Organism-specific databases
CGD	CAL0004800. MNN9.
Phylogenomic databases
eggNOG	NOG73762.
KO	K05529.
Enzyme and pathway databases
UniPathway	UPA00378.
Family and domain databases
InterPro	IPR005109. Anp1. [Graphical view]
Pfam	PF03452. Anp1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MNN9_CANAL

Accession

Primary (citable) accession number: P53697
Secondary accession number(s): Q5A4F1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program