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Protein

Mannan polymerase complex subunit MNN9

Gene

MNN9

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.

Pathway:iprotein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • mannosyltransferase activity Source: CGD

GO - Biological processi

  • cellular response to drug Source: CGD
  • cellular response to heat Source: CGD
  • cell wall mannoprotein biosynthetic process Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to heat Source: CGD
  • fungal-type cell wall organization Source: CGD
  • mannosylation Source: GOC
  • protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT62. Glycosyltransferase Family 62.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannan polymerase complex subunit MNN9
Gene namesi
Name:MNN9
ORF Names:CaO19.7383
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0004800. MNN9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei16 – 3318Helical; Signal-anchor for type II membrane proteinAdd
BLAST
Topological domaini34 – 368335LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Mannan polymerase complex subunit MNN9PRO_0000193669Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi1224829. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Belongs to the ANP1/MMN9/VAN1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG73762.
InParanoidiP53697.
KOiK05529.
OrthoDBiEOG73V6VP.

Family and domain databases

InterProiIPR005109. Anp1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF03452. Anp1. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

P53697-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYRNRYLN YIRRKPLALL APITLLVVIY FYFFSAHGFS SNKQKYNYNK
60 70 80 90 100
KSRGWFYKNR DTVILKDLPK NHISHYDLNK LTASKDALNK REEVLILTPM
110 120 130 140 150
SKFLPEYWEN INKLTYDHSL ISLGFIFPRT TQGDDALKEL ENALKKTKRE
160 170 180 190 200
KRLNFKKITI LRQDSNSLQS QLEKDRHAFK VQKERRSMMA LARNSLVFST
210 220 230 240 250
ILPSTSWVLW LDADIVETPV TLIQDLTGHN KPVVSANVHQ RFINQDTKQP
260 270 280 290 300
DIRPYDFNNW VESEEGLKLA ASLPDDEIIV EGYSEMVTHR ALMAHFYDPK
310 320 330 340 350
GDPSTEMTLD GVGGGAVMVK ADVHRDGAMF PSFPFYHLIE TEGFAKMAKR
360
LGYEVYGLPN YLVFHYNE
Length:368
Mass (Da):42,782
Last modified:October 1, 1996 - v1
Checksum:i930DCC64EE8F5EF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63642 Genomic DNA. Translation: AAB05924.1.
AACQ01000066 Genomic DNA. Translation: EAK97629.1.
RefSeqiXP_716624.1. XM_711531.1.

Genome annotation databases

GeneIDi3641735.
KEGGical:CaO19.7383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63642 Genomic DNA. Translation: AAB05924.1.
AACQ01000066 Genomic DNA. Translation: EAK97629.1.
RefSeqiXP_716624.1. XM_711531.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1224829. 1 interaction.

Protein family/group databases

CAZyiGT62. Glycosyltransferase Family 62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3641735.
KEGGical:CaO19.7383.

Organism-specific databases

CGDiCAL0004800. MNN9.

Phylogenomic databases

eggNOGiNOG73762.
InParanoidiP53697.
KOiK05529.
OrthoDBiEOG73V6VP.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR005109. Anp1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF03452. Anp1. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the Candida albicans homolog of Saccharomyces cerevisiae MNN9, required for glycosylation of cell wall mannoproteins."
    Southard S.B., Specht C.A., Mishra C., Chen-Weiner J., Robbins P.W.
    J. Bacteriol. 181:7439-7448(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10261 / CBS 2718 / NBRC 1061.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMNN9_CANAL
AccessioniPrimary (citable) accession number: P53697
Secondary accession number(s): Q5A4F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.