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Protein

Structural maintenance of chromosomes protein 6

Gene

smc6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 131ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • double-stranded DNA-dependent ATPase activity Source: PomBase

GO - Biological processi

  • double-strand break repair via homologous recombination Source: PomBase
  • meiotic cell cycle Source: UniProtKB-KW

Keywordsi

Biological processDNA damage, DNA recombination, DNA repair, Meiosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 6
Alternative name(s):
DNA repair protein rad18
Gene namesi
Name:smc6
Synonyms:rad18
ORF Names:SPCC5E4.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC5E4.06.
PomBaseiSPCC5E4.06. smc6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
  • Smc5-Smc6 complex Source: PomBase

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi151A → T in NA74; induces defects in DNA repair. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190211 – 1140Structural maintenance of chromosomes protein 6Add BLAST1140

Post-translational modificationi

Sumoylated by nse2.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP53692.
PRIDEiP53692.

Interactioni

Subunit structurei

Two subcomplexes smc5-smc6-nse2 and nse1-nse3-nse4 exist. These subcomplexes are then brought together via a number of interactions, forming the Smc5-Smc6 complex.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi275593. 26 interactors.
IntActiP53692. 8 interactors.
MINTiMINT-4690882.
STRINGi4896.SPCC5E4.06.1.

Structurei

Secondary structure

11140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi450 – 491Combined sources42
Turni492 – 498Combined sources7
Helixi502 – 511Combined sources10
Helixi512 – 514Combined sources3
Turni515 – 522Combined sources8
Helixi524 – 528Combined sources5
Helixi532 – 539Combined sources8
Helixi553 – 556Combined sources4
Beta strandi557 – 560Combined sources4
Helixi562 – 564Combined sources3
Helixi565 – 571Combined sources7
Helixi575 – 577Combined sources3
Beta strandi578 – 583Combined sources6
Helixi584 – 597Combined sources14
Beta strandi603 – 605Combined sources3
Helixi614 – 616Combined sources3
Helixi626 – 628Combined sources3
Beta strandi629 – 632Combined sources4
Helixi634 – 644Combined sources11
Helixi646 – 648Combined sources3
Beta strandi649 – 651Combined sources3
Helixi655 – 663Combined sources9
Beta strandi671 – 675Combined sources5
Beta strandi677 – 679Combined sources3
Beta strandi683 – 686Combined sources4
Beta strandi693 – 698Combined sources6
Beta strandi707 – 709Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MG8X-ray2.75B/D448-720[»]
ProteinModelPortaliP53692.
SMRiP53692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni494 – 710Flexible hingeAdd BLAST217

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili262 – 290Sequence analysisAdd BLAST29
Coiled coili329 – 369Sequence analysisAdd BLAST41
Coiled coili448 – 493Sequence analysisAdd BLAST46
Coiled coili711 – 978Sequence analysisAdd BLAST268
Coiled coili1113 – 1140Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 25Nuclear localization signalSequence analysis4
Motifi41 – 44Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1044 – 1079Ala/Asp-rich (DA-box)Add BLAST36

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of smc5, forming a V-shaped heterodimer.By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC6 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP53692.
OMAiCQLHYKE.
OrthoDBiEOG092C08UT.
PhylomeDBiP53692.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR027132. SMC6.
PANTHERiPTHR19306:SF10. PTHR19306:SF10. 1 hit.
PfamiView protein in Pfam
PF02463. SMC_N. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

P53692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTELTNVSL EEAITEKTSE NRRKRDSDVL QTEEVDLSNV KRIRASRNQD
60 70 80 90 100
NRPERQSRLQ RSSSLIEQVR GNEDGENDVL NQTRETNSNF DNRVGVIECI
110 120 130 140 150
HLVNFMCHDS LKINFGPRIN FVIGHNGSGK SAILTGLTIC LGAKASNTNR
160 170 180 190 200
APNMKSLVKQ GKNYARISVT ISNRGFEAYQ PEIYGKSITI ERTIRREGSS
210 220 230 240 250
EYRLRSFNGT VISTKRDELD NICDHMGLQI DNPMNILTQD TARQFLGNSS
260 270 280 290 300
PKEKYQLFMK GIQLKQLEEN YSLIEQSLIN TKNVLGNKKT GVSYLAKKEE
310 320 330 340 350
EYKLLWEQSR ETENLHNLLE QKKGEMVWAQ VVEVEKELLL AEKEFQHAEV
360 370 380 390 400
KLSEAKENLE SIVTNQSDID GKISSKEEVI GRAKGETDTT KSKFEDIVKT
410 420 430 440 450
FDGYRSEMND VDIQKRDIQN SINAAKSCLD VYREQLNTER ARENNLGGSQ
460 470 480 490 500
IEKRANESNN LQREIADLSE QIVELESKRN DLHSALLEMG GNLTSLLTKK
510 520 530 540 550
DSIANKISDQ SEHLKVLEDV QRDKVSAFGK NMPQLLKLIT RETRFQHPPK
560 570 580 590 600
GPMGKYMTVK EQKWHLIIER ILGNVINGFI VRSHHDQLIL KELMRQSNCH
610 620 630 640 650
ATVVVGKYDP FDYSSGEPDS QYPTVLKIIK FDDDEVLHTL INHLGIEKML
660 670 680 690 700
LIEDRREAEA YMKRGIANVT QCYALDPRNR GYGFRIVSTQ RSSGISKVTP
710 720 730 740 750
WNRPPRIGFS SSTSIEAEKK ILDDLKKQYN FASNQLNEAK IEQAKFKRDE
760 770 780 790 800
QLLVEKIEGI KKRILLKRRE VNSLESQELS VLDTEKIQTL ERRISETEKE
810 820 830 840 850
LESYAGQLQD AKNEEHRIRD NQRPVIEEIR IYREKIQTET QRLSSLQTEL
860 870 880 890 900
SRLRDEKRNS EVDIERHRQT VESCTNILRE KEAKKVQCAQ VVADYTAKAN
910 920 930 940 950
TRCERVPVQL SPAELDNEIE RLQMQIAEWR NRTGVSVEQA AEDYLNAKEK
960 970 980 990 1000
HDQAKVLVAR LTQLLQALEE TLRRRNEMWT KFRKLITLRT KELFELYLSQ
1010 1020 1030 1040 1050
RNFTGKLVIK HQEEFLEPRV YPANRNLATA HNRHEKSKVS VQGLSGGEKS
1060 1070 1080 1090 1100
FATICMLLSI WEAMSCPLRC LDEFDVFMDA VNRLVSIKMM VDSAKDSSDK
1110 1120 1130 1140
QFIFITPQDM GQIGLDKDVV VFRLSDPVVS SSALPPSTAP
Length:1,140
Mass (Da):130,929
Last modified:October 1, 1996 - v1
Checksum:i2D9680F4771016ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80929 Genomic DNA. Translation: CAA56900.1.
CU329672 Genomic DNA. Translation: CAA21961.1.
PIRiT41457.
RefSeqiNP_587906.1. NM_001022898.2.

Genome annotation databases

EnsemblFungiiSPCC5E4.06.1; SPCC5E4.06.1:pep; SPCC5E4.06.
GeneIDi2539020.
KEGGispo:SPCC5E4.06.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSMC6_SCHPO
AccessioniPrimary (citable) accession number: P53692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families