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Protein

Peptidyl-prolyl cis-trans isomerase CPR6

Gene

CPR6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Miscellaneous

Present with 18600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD
  • ribosome binding Source: SGD
  • unfolded protein binding Source: SGD

GO - Biological processi

  • protein folding Source: SGD
  • protein refolding Source: SGD

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YLR216C-MONOMER
ReactomeiR-SCE-8939211 ESR-mediated signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CPR6 (EC:5.2.1.8)
Short name:
PPIase CPR6
Alternative name(s):
Rotamase CPR6
Gene namesi
Name:CPR6
Ordered Locus Names:YLR216C
ORF Names:L8167.24
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR216C
SGDiS000004206 CPR6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641731 – 371Peptidyl-prolyl cis-trans isomerase CPR6Add BLAST371

Proteomic databases

MaxQBiP53691
PaxDbiP53691
PRIDEiP53691

Interactioni

Subunit structurei

Interacts with RPD3.

Binary interactionsi

Show more details

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi31484, 154 interactors
DIPiDIP-1274N
IntActiP53691, 32 interactors
MINTiP53691
STRINGi4932.YLR216C

Structurei

3D structure databases

ProteinModelPortaliP53691
SMRiP53691
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 174PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST168
Repeati219 – 252TPR 1Add BLAST34
Repeati270 – 303TPR 2Add BLAST34
Repeati308 – 341TPR 3Add BLAST34

Sequence similaritiesi

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

GeneTreeiENSGT00550000074595
HOGENOMiHOG000065980
InParanoidiP53691
KOiK05864
OMAiAMCAIKL
OrthoDBiEOG092C5DG5

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00028 TPR, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
SSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P53691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRPKTFFDI SIGGKPQGRI VFELYNDIVP KTAENFLKLC EGNAGMAKTK
60 70 80 90 100
PDVPLSYKGS IFHRVIKDFM CQFGDFTNFN GTGGESIYDE KFEDENFTVK
110 120 130 140 150
HDKPFLLSMA NAGPNTNGSQ AFITCVPTPH LDGKHVVFGE VIQGKRIVRL
160 170 180 190 200
IENQQCDQEN NKPLRDVKID DCGVLPDDYQ VPENAEATPT DEYGDNYEDV
210 220 230 240 250
LKQDEKVDLK NFDTVLKAIE TVKNIGTEQF KKQNYSVALE KYVKCDKFLK
260 270 280 290 300
EYFPEDLEKE QIEKINQLKV SIPLNIAICA LKLKDYKQVL VASSEVLYAE
310 320 330 340 350
AADEKAKAKA LYRRGLAYYH VNDTDMALND LEMATTFQPN DAAILKAIHN
360 370
TKLKRKQQNE KAKKSLSKMF S
Length:371
Mass (Da):42,072
Last modified:October 1, 1996 - v1
Checksum:i188666D94866DDDD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12I → V in AAS56285 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48867 mRNA Translation: AAC49414.1
U14913 Genomic DNA Translation: AAB67445.1
AY557959 Genomic DNA Translation: AAS56285.1
BK006945 Genomic DNA Translation: DAA09533.1
PIRiS48567
RefSeqiNP_013317.1, NM_001182103.1

Genome annotation databases

EnsemblFungiiYLR216C; YLR216C; YLR216C
GeneIDi850914
KEGGisce:YLR216C

Similar proteinsi

Entry informationi

Entry nameiPPID_YEAST
AccessioniPrimary (citable) accession number: P53691
Secondary accession number(s): D6VYL7, Q6Q5K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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