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Protein

NAD-dependent histone deacetylase HST4

Gene

HST4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.4 Publications

Miscellaneous

Present with 377 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.PROSITE-ProRule annotation

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei213Proton acceptorPROSITE-ProRule annotation1
Metal bindingi221ZincPROSITE-ProRule annotation1
Metal bindingi224ZincPROSITE-ProRule annotation1
Metal bindingi251ZincPROSITE-ProRule annotation1
Metal bindingi254ZincPROSITE-ProRule annotation1
Binding sitei363NAD; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 119NADBy similarityAdd BLAST20
Nucleotide bindingi184 – 187NADBy similarity4
Nucleotide bindingi310 – 312NADBy similarity3
Nucleotide bindingi340 – 342NADBy similarity3

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • NAD+ binding Source: InterPro
  • NAD-dependent histone deacetylase activity Source: SGD

GO - Biological processi

  • cellular response to biotin starvation Source: SGD
  • chromatin silencing at telomere Source: SGD
  • histone deacetylation Source: SGD
  • replication-born double-strand break repair via sister chromatid exchange Source: SGD
  • short-chain fatty acid metabolic process Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29779-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent histone deacetylase HST4 (EC:3.5.1.-)
Alternative name(s):
Homologous to SIR2 protein 4
Regulatory protein SIR2 homolog 4
Gene namesi
Name:HST4
Ordered Locus Names:YDR191W
ORF Names:YD9346.03
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR191W
SGDiS000002599 HST4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001102841 – 370NAD-dependent histone deacetylase HST4Add BLAST370

Proteomic databases

PaxDbiP53688
PRIDEiP53688

Interactioni

Protein-protein interaction databases

BioGridi32244, 90 interactors
IntActiP53688, 4 interactors
STRINGi4932.YDR191W

Structurei

3D structure databases

ProteinModelPortaliP53688
SMRiP53688
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 370Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST288

Sequence similaritiesi

Belongs to the sirtuin family. Class I subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075988
HOGENOMiHOG000111204
InParanoidiP53688
KOiK11121
OMAiAKHHELI
OrthoDBiEOG092C4DBJ

Family and domain databases

Gene3Di3.30.1600.10, 2 hits
InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR003000 Sirtuin
IPR026591 Sirtuin_cat_small_dom_sf
IPR026590 Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146 SIR2, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305 SIRTUIN, 1 hit

Sequencei

Sequence statusi: Complete.

P53688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQKFVLPIT PPSTAEKKPQ TENRCNENLK PRRLLPQLKK SVRNRKPRLS
60 70 80 90 100
YRPELNSVFD LDAYVDSTHL SKSQRHHMDR DAGFISYALN YSKRMVVVSG
110 120 130 140 150
AGISVAAGIP DFRSSEGIFS TVNGGSGKDL FDYNRVYGDE SMSLKFNQLM
160 170 180 190 200
VSLFRLSKNC QPTKFHEMLN EFARDGRLLR LYTQNIDGLD TQLPHLSTNV
210 220 230 240 250
PLAKPIPSTV QLHGSIKHME CNKCLNIKPF DPELFKCDDK FDSRTEIIPS
260 270 280 290 300
CPQCEEYETV RKMAGLRSTG VGKLRPRVIL YNEVHPEGDF IGEIANNDLK
310 320 330 340 350
KRIDCLIIVG TSLKIPGVKN ICRQFAAKVH ANRGIVLYLN TSMPPKNVLD
360 370
SLKFVDLVVL GDCQHVTSLL
Length:370
Mass (Da):41,765
Last modified:October 1, 1996 - v1
Checksum:i86BB0238BFA914F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48784 Genomic DNA Translation: CAA88705.1
AY557699 Genomic DNA Translation: AAS56025.1
BK006938 Genomic DNA Translation: DAA12034.1
PIRiS52699
RefSeqiNP_010477.3, NM_001180499.3

Genome annotation databases

EnsemblFungiiYDR191W; YDR191W; YDR191W
GeneIDi851772
KEGGisce:YDR191W

Similar proteinsi

Entry informationi

Entry nameiHST4_YEAST
AccessioniPrimary (citable) accession number: P53688
Secondary accession number(s): D6VSH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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