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P53680

- AP2S1_HUMAN

UniProt

P53680 - AP2S1_HUMAN

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Protein

AP-2 complex subunit sigma

Gene

AP2S1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis.By similarity4 Publications

GO - Molecular functioni

  1. protein transporter activity Source: UniProtKB
  2. transporter activity Source: ProtInc

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. axon guidance Source: Reactome
  3. clathrin coat assembly Source: UniProtKB
  4. endocytosis Source: UniProtKB-KW
  5. epidermal growth factor receptor signaling pathway Source: Reactome
  6. intracellular protein transport Source: InterPro
  7. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  8. neurotrophin TRK receptor signaling pathway Source: Reactome
  9. regulation of defense response to virus by virus Source: Reactome
  10. regulation of endocytosis Source: UniProtKB
  11. synaptic transmission Source: Reactome
  12. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11166. Nef Mediated CD4 Down-regulation.
REACT_11200. Nef Mediated CD8 Down-regulation.
REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_18422. Trafficking of GluR2-containing AMPA receptors.
REACT_22365. Recycling pathway of L1.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit sigma
Alternative name(s):
Adaptor protein complex AP-2 subunit sigma
Adaptor-related protein complex 2 subunit sigma
Clathrin assembly protein 2 sigma small chain
Clathrin coat assembly protein AP17
Clathrin coat-associated protein AP17
HA2 17 kDa subunit
Plasma membrane adaptor AP-2 17 kDa protein
Sigma2-adaptin
Gene namesi
Name:AP2S1
Synonyms:AP17, CLAPS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:565. AP2S1.

Subcellular locationi

Cell membrane. Membranecoated pit; Peripheral membrane protein; Cytoplasmic side
Note: AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.By similarity

GO - Cellular componenti

  1. AP-2 adaptor complex Source: UniProtKB
  2. clathrin-coated endocytic vesicle membrane Source: Reactome
  3. cytosol Source: Reactome
  4. endocytic vesicle membrane Source: Reactome
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypocalciuric hypercalcemia, familial 3 (HHC3) [MIM:600740]: A form of hypocalciuric hypercalcemia, a disorder of mineral homeostasis that is transmitted as an autosomal dominant trait with a high degree of penetrance. It is characterized biochemically by lifelong elevation of serum calcium concentrations and is associated with inappropriately low urinary calcium excretion and a normal or mildly elevated circulating parathyroid hormone level. Hypermagnesemia is typically present. Affected individuals are usually asymptomatic and the disorder is considered benign. However, chondrocalcinosis and pancreatitis occur in some adults.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151R → C in HHC3; there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type, indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. 2 Publications
VAR_069570
Natural varianti15 – 151R → H in HHC3; there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type, indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. 1 Publication
VAR_069571
Natural varianti15 – 151R → L in HHC3; there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type, indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. 1 Publication
VAR_069572

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi600740. phenotype.
Orphaneti101050. Familial hypocalciuric hypercalcemia type 3.
PharmGKBiPA24856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142AP-2 complex subunit sigmaPRO_0000193804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei140 – 1401Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP53680.
PaxDbiP53680.
PRIDEiP53680.

PTM databases

PhosphoSiteiP53680.

Expressioni

Gene expression databases

BgeeiP53680.
CleanExiHS_AP2S1.
ExpressionAtlasiP53680. baseline and differential.
GenevestigatoriP53680.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).

Protein-protein interaction databases

BioGridi107589. 17 interactions.
IntActiP53680. 8 interactions.
MINTiMINT-256650.
STRINGi9606.ENSP00000263270.

Structurei

3D structure databases

ProteinModelPortaliP53680.
SMRiP53680. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5030.
GeneTreeiENSGT00530000062839.
HOGENOMiHOG000185227.
HOVERGENiHBG050517.
InParanoidiP53680.
KOiK11827.
OrthoDBiEOG7S7SGC.
PhylomeDBiP53680.
TreeFamiTF300139.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR027156. APS2.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PTHR11753:SF6. PTHR11753:SF6. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53680-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV
60 70 80 90 100
EFRNFKIIYR RYAGLYFCIC VDVNDNNLAY LEAIHNFVEV LNEYFHNVCE
110 120 130 140
LDLVFNFYKV YTVVDEMFLA GEIRETSQTK VLKQLLMLQS LE
Length:142
Mass (Da):17,018
Last modified:August 16, 2004 - v2
Checksum:iCA3FD868C65AEDF6
GO
Isoform 2 (identifier: P53680-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-89: Missing.

Show »
Length:104
Mass (Da):12,417
Checksum:i0240F8D55B64095C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771N → K in CAA65782. (PubMed:9040778)Curated
Sequence conflicti77 – 771N → K in CAA09018. (PubMed:9767099)Curated
Sequence conflicti83 – 831A → G in CAA65782. (PubMed:9040778)Curated
Sequence conflicti83 – 831A → G in CAA09018. (PubMed:9767099)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151R → C in HHC3; there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type, indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. 2 Publications
VAR_069570
Natural varianti15 – 151R → H in HHC3; there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type, indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. 1 Publication
VAR_069571
Natural varianti15 – 151R → L in HHC3; there is a rightward shift in Ca(2+)concentration-response curves with the mutant compared to wild-type, indicating a decrease in the sensitivity of cells expressing CASR to extracellular calcium. 1 Publication
VAR_069572

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 8938Missing in isoform 2. 1 PublicationVSP_017352Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97074 mRNA. Translation: CAA65782.1.
AJ010148 mRNA. Translation: CAA09018.1.
AJ010149 mRNA. Translation: CAA09019.1.
AK312003 mRNA. Translation: BAG34941.1.
CH471126 Genomic DNA. Translation: EAW57448.1.
BC006337 mRNA. Translation: AAH06337.1.
CCDSiCCDS12693.1. [P53680-2]
CCDS33062.1. [P53680-1]
RefSeqiNP_004060.2. NM_004069.4. [P53680-1]
NP_067586.1. NM_021575.3. [P53680-2]
UniGeneiHs.119591.

Genome annotation databases

EnsembliENST00000263270; ENSP00000263270; ENSG00000042753. [P53680-1]
ENST00000601649; ENSP00000470898; ENSG00000042753. [P53680-2]
GeneIDi1175.
KEGGihsa:1175.
UCSCiuc002pft.1. human. [P53680-1]
uc002pfu.1. human. [P53680-2]

Polymorphism databases

DMDMi51338780.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97074 mRNA. Translation: CAA65782.1 .
AJ010148 mRNA. Translation: CAA09018.1 .
AJ010149 mRNA. Translation: CAA09019.1 .
AK312003 mRNA. Translation: BAG34941.1 .
CH471126 Genomic DNA. Translation: EAW57448.1 .
BC006337 mRNA. Translation: AAH06337.1 .
CCDSi CCDS12693.1. [P53680-2 ]
CCDS33062.1. [P53680-1 ]
RefSeqi NP_004060.2. NM_004069.4. [P53680-1 ]
NP_067586.1. NM_021575.3. [P53680-2 ]
UniGenei Hs.119591.

3D structure databases

ProteinModelPortali P53680.
SMRi P53680. Positions 1-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107589. 17 interactions.
IntActi P53680. 8 interactions.
MINTi MINT-256650.
STRINGi 9606.ENSP00000263270.

Chemistry

BindingDBi P53680.

PTM databases

PhosphoSitei P53680.

Polymorphism databases

DMDMi 51338780.

Proteomic databases

MaxQBi P53680.
PaxDbi P53680.
PRIDEi P53680.

Protocols and materials databases

DNASUi 1175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263270 ; ENSP00000263270 ; ENSG00000042753 . [P53680-1 ]
ENST00000601649 ; ENSP00000470898 ; ENSG00000042753 . [P53680-2 ]
GeneIDi 1175.
KEGGi hsa:1175.
UCSCi uc002pft.1. human. [P53680-1 ]
uc002pfu.1. human. [P53680-2 ]

Organism-specific databases

CTDi 1175.
GeneCardsi GC19M047341.
HGNCi HGNC:565. AP2S1.
MIMi 600740. phenotype.
602242. gene.
neXtProti NX_P53680.
Orphaneti 101050. Familial hypocalciuric hypercalcemia type 3.
PharmGKBi PA24856.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5030.
GeneTreei ENSGT00530000062839.
HOGENOMi HOG000185227.
HOVERGENi HBG050517.
InParanoidi P53680.
KOi K11827.
OrthoDBi EOG7S7SGC.
PhylomeDBi P53680.
TreeFami TF300139.

Enzyme and pathway databases

Reactomei REACT_11166. Nef Mediated CD4 Down-regulation.
REACT_11200. Nef Mediated CD8 Down-regulation.
REACT_121399. MHC class II antigen presentation.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12484. EGFR downregulation.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_18422. Trafficking of GluR2-containing AMPA receptors.
REACT_22365. Recycling pathway of L1.

Miscellaneous databases

ChiTaRSi AP2S1. human.
GeneWikii AP2S1.
GenomeRNAii 1175.
NextBioi 4856.
PROi P53680.
SOURCEi Search...

Gene expression databases

Bgeei P53680.
CleanExi HS_AP2S1.
ExpressionAtlasi P53680. baseline and differential.
Genevestigatori P53680.

Family and domain databases

InterProi IPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR027156. APS2.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view ]
PANTHERi PTHR11753. PTHR11753. 1 hit.
PTHR11753:SF6. PTHR11753:SF6. 1 hit.
Pfami PF01217. Clat_adaptor_s. 1 hit.
[Graphical view ]
PIRSFi PIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMi SSF64356. SSF64356. 1 hit.
PROSITEi PS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3."
    Winterpacht A., Endele S., Enklaar T., Fuhry M., Zabel B.
    Cytogenet. Cell Genet. 75:132-135(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17."
    Holzmann K., Poeltl A., Sauermann G.
    Gene 220:39-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."
    Nakatsu F., Ohno H.
    Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  7. "Adaptors for clathrin coats: structure and function."
    Owen D.J., Collins B.M., Evans P.R.
    Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS.
  8. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."
    Lau A.W., Chou M.M.
    J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE AP-2 COMPLEX IN NON-CLATHRIN-DEPENDENT ENDOCYTOSIS.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: FUNCTION, INVOLVEMENT IN HHC3, VARIANTS HHC3 CYS-15; HIS-15 AND LEU-15, CHARACTERIZATION OF VARIANTS HHC3 CYS-15; HIS-15 AND LEU-15.
  12. "Identification of AP2S1 mutation and effects of low calcium formula in an infant with hypercalcemia and hypercalciuria."
    Fujisawa Y., Yamaguchi R., Satake E., Ohtaka K., Nakanishi T., Ozono K., Ogata T.
    J. Clin. Endocrinol. Metab. 98:E2022-E2027(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HHC3 LEU-15.

Entry informationi

Entry nameiAP2S1_HUMAN
AccessioniPrimary (citable) accession number: P53680
Secondary accession number(s): B2R4Z4, O75977, Q6PK67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3