Reviewed, UniProtKB/Swiss-Prot P53677 (AP3M2_HUMAN)

Names and origin

Protein names

Recommended name:
    AP-3 complex subunit mu-2
Alternative name(s):
    Adapter-related protein complex 3 mu-2 subunit
    Mu3B-adaptin
    Golgi adaptor AP-1 47 kDa protein homolog 2
    HA1 47 kDa subunit homolog 2
    Clathrin assembly protein assembly protein complex 1 medium chain homolog 2
    Clathrin coat assembly protein AP47 homolog 2
    Clathrin coat-associated protein AP47 homolog 2
    P47B

Gene names

Name:

AP3M2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Subunit structure	Adaptor protein complex 3 (AP-3) is an heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).
Subcellular location	Golgi apparatus.
Sequence similarities	Belongs to the adaptor complexes medium subunit family. Contains 1 MHD (mu homology) domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell clathrin adaptor complex Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	AP-3 complex subunit mu-2		PRO_0000193784
Regions
	Domain	173 – 418	246	MHD

Sequences

	Sequence		Length	Mass (Da)
	P53677-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8FCC8BB10505A7D5	FASTA	418	46,977
	10 20 30 40 50 60 MIHSLFLINS SGDIFLEKHW KSVVSRSVCD YFFEAQERAT EAENVPPVIP TPHHYLLSVY 70 80 90 100 110 120 RHKIFFVAVI QTEVPPLFVI EFLHRVVDTF QDYFGVCSEP VIKDNVVVVY EVLEEMLDNG 130 140 150 160 170 180 FPLATESNIL KELIKPPTIL RTVVNTITGS TNVGDQLPTG QLSVVPWRRT GVKYTNNEAY 190 200 210 220 230 240 FDVIEEIDAI IDKSGSTITA EIQGVIDACV KLTGMPDLTL SFMNPRLLDD VSFHPCVRFK 250 260 270 280 290 300 RWESERILSF IPPDGNFRLL SYHVSAQNLV AIPVYVKHNI SFRDSSSLGR FEITVGPKQT 310 320 330 340 350 360 MGKTIEGVTV TSQMPKGVLN MSLTPSQGTH TFDPVTKMLS WDVGKINPQK LPSLKGTMSL 370 380 390 400 410 QAGASKPDEN PTINLQFKIQ QLAISGLKVN RLDMYGEKYK PFKGIKYMTK AGKFQVRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification." Koyama K., Sudo K., Nakamura Y. Genomics 26:245-253(1995) [PubMed: 7601449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D38293 mRNA. Translation: BAA07415.1. BC056398 mRNA. Translation: AAH56398.1.
IPI	IPI00022883.
PIR	A57170.
RefSeq	NP_001127768.1. NP_006794.1.
UniGene	Hs.654529
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P53677.
2-D gel databases
REPRODUCTION-2DPAGE	P53677.
Proteomic databases
PRIDE	P53677.
Genome annotation databases
Ensembl	ENST00000174653; ENSP00000174653; ENSG00000070718; Homo sapiens. [Genome view] ENST00000396926; ENSP00000380132; ENSG00000070718; Homo sapiens. [Genome view]
GeneID	10947.
KEGG	hsa:10947.
UCSC	uc003xoo.1. human.
Organism-specific databases
CTD	10947.
GeneCards	GC08P042129.
H-InvDB	HIX0025566.
HGNC	HGNC:570. AP3M2.
HPA	CAB014876.
MIM	610469. gene.
PharmGKB	PA24861.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P53677.
HOVERGEN	P53677.
OMA	KLLSWDV
OrthoDB	EOG9Z0DRT
Gene expression databases
ArrayExpress	P53677.
Bgee	P53677.
CleanEx	HS_AP3M2.
Genevestigator	P53677.
GermOnline	ENSG00000070718. Homo sapiens.
Family and domain databases
InterPro	IPR001392. Clathrin_mu. IPR008968. Clathrin_mu_C. IPR018240. Clathrin_mu_CS. IPR000804. Clathrin_sigma/coatomer_zeta. IPR011012. Longin-like. [Graphical view]
Pfam	PF00928. Adap_comp_sub. 1 hit. PF01217. Clat_adaptor_s. 1 hit. [Graphical view]
PIRSF	PIRSF005992. Clathrin_mu. 1 hit.
PRINTS	PR00314. CLATHRINADPT.
PROSITE	PS00990. CLAT_ADAPTOR_M_1. 1 hit. PS00991. CLAT_ADAPTOR_M_2. 1 hit. PS51072. MHD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	41593.
SOURCE	Search...

Entry information

Entry name

AP3M2_HUMAN

Accession

Primary (citable) accession number: P53677

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.