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P53675

- CLH2_HUMAN

UniProt

P53675 - CLH2_HUMAN

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Protein
Clathrin heavy chain 2
Gene
CLTCL1, CLH22, CLTCL, CLTD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. signal transducer activity Source: ProtInc
  3. structural molecule activity Source: InterPro

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. intracellular protein transport Source: InterPro
  3. mitotic nuclear division Source: UniProtKB
  4. positive regulation of glucose import Source: UniProtKB
  5. receptor-mediated endocytosis Source: UniProtKB
  6. signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11035. Gap junction degradation.
REACT_11049. Formation of annular gap junctions.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin heavy chain 2
Alternative name(s):
Clathrin heavy chain on chromosome 22
Short name:
CLH-22
Gene namesi
Name:CLTCL1
Synonyms:CLH22, CLTCL, CLTD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:2093. CLTCL1.

Subcellular locationi

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Membranecoated pit; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Cytoplasmic face of coated pits and vesicles By similarity.

GO - Cellular componenti

  1. clathrin coat of coated pit Source: InterPro
  2. clathrin coat of trans-Golgi network vesicle Source: InterPro
  3. clathrin-coated vesicle Source: UniProtKB
  4. coated pit Source: UniProtKB
  5. coated vesicle Source: UniProtKB
  6. spindle Source: UniProtKB
  7. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16401640Clathrin heavy chain 2
PRO_0000205786Add
BLAST

Proteomic databases

MaxQBiP53675.
PaxDbiP53675.
PRIDEiP53675.

PTM databases

PhosphoSiteiP53675.

Expressioni

Tissue specificityi

Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.

Gene expression databases

ArrayExpressiP53675.
BgeeiP53675.
CleanExiHS_CLTCL1.
GenevestigatoriP53675.

Organism-specific databases

HPAiHPA041110.

Interactioni

Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium By similarity. May interact with OCRL By similarity.

Protein-protein interaction databases

BioGridi113854. 14 interactions.
IntActiP53675. 9 interactions.
MINTiMINT-208273.
STRINGi9606.ENSP00000263200.

Structurei

3D structure databases

ProteinModelPortaliP53675.
SMRiP53675. Positions 1-493, 1077-1628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati537 – 683147CHCR 1
Add
BLAST
Repeati686 – 828143CHCR 2
Add
BLAST
Repeati833 – 972140CHCR 3
Add
BLAST
Repeati979 – 1124146CHCR 4
Add
BLAST
Repeati1128 – 1269142CHCR 5
Add
BLAST
Repeati1274 – 1420147CHCR 6
Add
BLAST
Repeati1423 – 1566144CHCR 7
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 479479Globular terminal domain
Add
BLAST
Regioni24 – 6744WD40-like repeat 1
Add
BLAST
Regioni68 – 10740WD40-like repeat 2
Add
BLAST
Regioni108 – 14942WD40-like repeat 3
Add
BLAST
Regioni150 – 19546WD40-like repeat 4
Add
BLAST
Regioni196 – 25762WD40-like repeat 5
Add
BLAST
Regioni258 – 30144WD40-like repeat 6
Add
BLAST
Regioni302 – 33029WD40-like repeat 7
Add
BLAST
Regioni449 – 46517Binding site for the uncoating ATPase, involved in lattice disassembly Reviewed prediction
Add
BLAST
Regioni480 – 52344Flexible linker
Add
BLAST
Regioni524 – 16401117Heavy chain arm
Add
BLAST
Regioni524 – 634111Distal segment
Add
BLAST
Regioni639 – 16401002Proximal segment
Add
BLAST
Regioni1213 – 1522310Involved in binding clathrin light chain By similarity
Add
BLAST
Regioni1551 – 164090Trimerization By similarity
Add
BLAST

Domaini

The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG314149.
HOGENOMiHOG000188877.
HOVERGENiHBG005344.
InParanoidiP53675.
KOiK04646.
OMAiQRCYEEG.
OrthoDBiEOG7Z0JVM.
PhylomeDBiP53675.
TreeFamiTF300059.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
2.130.10.110. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR016025. Clathrin_H-chain_link/propller.
IPR015348. Clathrin_H-chain_linker_core.
IPR001473. Clathrin_H-chain_propeller_N.
IPR022365. Clathrin_H-chain_propeller_rpt.
IPR016341. Clathrin_heavy_chain.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF00637. Clathrin. 7 hits.
PF09268. Clathrin-link. 1 hit.
PF01394. Clathrin_propel. 2 hits.
[Graphical view]
PIRSFiPIRSF002290. Clathrin_H_chain. 1 hit.
SMARTiSM00299. CLH. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF50989. SSF50989. 1 hit.
PROSITEiPS50236. CHCR. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P53675-1) [UniParc]FASTAAdd to Basket

Also known as: Long, Brain

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV     50
TIIDMSDPMA PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK 100
AHTMAEEVIF WKWVSVNTVA LVTETAVYHW SMEGDSQPMK MFDRHTSLVG 150
CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAA 200
FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN QPFVKKAVDV 250
FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA 300
DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR 350
LAVRSNLAGA EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK 400
FQSIPAQSGQ ASPLLQYFGI LLDQGQLNKL ESLELCHLVL QQGRKQLLEK 450
WLKEDKLECS EELGDLVKTT DPMLALSVYL RANVPSKVIQ CFAETGQFQK 500
IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE EPLANISQIV 550
DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL 600
GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW 650
LVNFFGSLSV EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE 700
LFESFKSYKG LFYFLGSIVN FSQDPDVHLK YIQAACKTGQ IKEVERICRE 750
SSCYNPERVK NFLKEAKLTD QLPLIIVCDR FGFVHDLVLY LYRNNLQRYI 800
EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF STDELVAEVE 850
KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY 900
DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR 950
KDPELWAHVL EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL 1000
PNELIELLEK IVLDNSVFSE HRNLQNLLIL TAIKADRTRV MEYISRLDNY 1050
DALDIASIAV SSALYEEAFT VFHKFDMNAS AIQVLIEHIG NLDRAYEFAE 1100
RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV VQSASRSNNW 1150
EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ 1200
VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST 1250
RTWKEVCFAC MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI 1300
LLLEAALGLE RAHMGMFTEL AILYSKFKPQ KMLEHLELFW SRVNIPKVLR 1350
AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS HPTEAWKEGQ FKDIITKVAN 1400
VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS KAGQLPLVKP 1450
YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNISLAQQLE 1500
KHQLMEFRCI AAYLYKGNNW WAQSVELCKK DHLYKDAMQH AAESRDAELA 1550
QKLLQWFLEE GKRECFAACL FTCYDLLRPD MVLELAWRHN LVDLAMPYFI 1600
QVMREYLSKV DKLDALESLR KQEEHVTEPA PLVFDFDGHE 1640
Length:1,640
Mass (Da):187,030
Last modified:November 1, 1997 - v2
Checksum:iC661E1AB989D8E7F
GO
Isoform 2 (identifier: P53675-2) [UniParc]FASTAAdd to Basket

Also known as: Short, Muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1479-1535: Missing.

Show »
Length:1,583
Mass (Da):180,296
Checksum:i5DB1E3D4A77607D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611P → L.
Corresponds to variant rs3747059 [ dbSNP | Ensembl ].
VAR_055653
Natural varianti205 – 2051K → R.
Corresponds to variant rs5746697 [ dbSNP | Ensembl ].
VAR_055654
Natural varianti279 – 2791Y → C.
Corresponds to variant rs807459 [ dbSNP | Ensembl ].
VAR_055655
Natural varianti691 – 6911E → K.1 Publication
Corresponds to variant rs1060374 [ dbSNP | Ensembl ].
VAR_055656
Natural varianti941 – 9411K → R.
Corresponds to variant rs35398725 [ dbSNP | Ensembl ].
VAR_055657
Natural varianti945 – 9451R → H.
Corresponds to variant rs36077768 [ dbSNP | Ensembl ].
VAR_055658
Natural varianti1046 – 10461R → C.
Corresponds to variant rs712952 [ dbSNP | Ensembl ].
VAR_055659
Natural varianti1195 – 11951N → S.
Corresponds to variant rs807547 [ dbSNP | Ensembl ].
VAR_059214
Natural varianti1316 – 13161M → V.
Corresponds to variant rs1061325 [ dbSNP | Ensembl ].
VAR_059215
Natural varianti1394 – 13941I → T.
Corresponds to variant rs1633399 [ dbSNP | Ensembl ].
VAR_059216
Natural varianti1592 – 15921V → M.
Corresponds to variant rs2073738 [ dbSNP | Ensembl ].
VAR_059217
Natural varianti1620 – 16201R → H.
Corresponds to variant rs5748024 [ dbSNP | Ensembl ].
VAR_059218

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1479 – 153557Missing in isoform 2.
VSP_001100Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931P → H in AAC50494. 1 Publication
Sequence conflicti215 – 2151L → H in AAC50494. 1 Publication
Sequence conflicti320 – 3201K → T in CAA64752. 1 Publication
Sequence conflicti530 – 5301L → Q in AAC50494. 1 Publication
Sequence conflicti1474 – 14741E → K in AAB40908. 1 Publication
Sequence conflicti1474 – 14741E → K in AAB40909. 1 Publication
Sequence conflicti1620 – 164021RKQEE…FDGHE → PPSKRSM in AAB40908. 1 Publication
Add
BLAST
Sequence conflicti1620 – 164021RKQEE…FDGHE → PPSKRSM in AAB40909. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41763 mRNA. Translation: AAC50494.1.
X95486 mRNA. Translation: CAA64752.1.
X95487 mRNA. Translation: CAA64753.1.
U60802 mRNA. Translation: AAB40908.1.
U60803 mRNA. Translation: AAB40909.1.
AK302506 mRNA. Translation: BAH13731.1.
CH471176 Genomic DNA. Translation: EAX03047.1.
CCDSiCCDS46662.1. [P53675-1]
CCDS54497.1. [P53675-2]
PIRiG02757.
T09522.
RefSeqiNP_001826.3. NM_001835.3. [P53675-2]
NP_009029.3. NM_007098.3. [P53675-1]
UniGeneiHs.368266.

Genome annotation databases

EnsembliENST00000263200; ENSP00000445677; ENSG00000070371. [P53675-1]
ENST00000353891; ENSP00000439662; ENSG00000070371. [P53675-2]
ENST00000427926; ENSP00000441158; ENSG00000070371. [P53675-1]
GeneIDi8218.
KEGGihsa:8218.
UCSCiuc011agw.1. human. [P53675-1]
uc021wld.1. human. [P53675-2]

Polymorphism databases

DMDMi2506298.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41763 mRNA. Translation: AAC50494.1 .
X95486 mRNA. Translation: CAA64752.1 .
X95487 mRNA. Translation: CAA64753.1 .
U60802 mRNA. Translation: AAB40908.1 .
U60803 mRNA. Translation: AAB40909.1 .
AK302506 mRNA. Translation: BAH13731.1 .
CH471176 Genomic DNA. Translation: EAX03047.1 .
CCDSi CCDS46662.1. [P53675-1 ]
CCDS54497.1. [P53675-2 ]
PIRi G02757.
T09522.
RefSeqi NP_001826.3. NM_001835.3. [P53675-2 ]
NP_009029.3. NM_007098.3. [P53675-1 ]
UniGenei Hs.368266.

3D structure databases

ProteinModelPortali P53675.
SMRi P53675. Positions 1-493, 1077-1628.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113854. 14 interactions.
IntActi P53675. 9 interactions.
MINTi MINT-208273.
STRINGi 9606.ENSP00000263200.

PTM databases

PhosphoSitei P53675.

Polymorphism databases

DMDMi 2506298.

Proteomic databases

MaxQBi P53675.
PaxDbi P53675.
PRIDEi P53675.

Protocols and materials databases

DNASUi 8218.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263200 ; ENSP00000445677 ; ENSG00000070371 . [P53675-1 ]
ENST00000353891 ; ENSP00000439662 ; ENSG00000070371 . [P53675-2 ]
ENST00000427926 ; ENSP00000441158 ; ENSG00000070371 . [P53675-1 ]
GeneIDi 8218.
KEGGi hsa:8218.
UCSCi uc011agw.1. human. [P53675-1 ]
uc021wld.1. human. [P53675-2 ]

Organism-specific databases

CTDi 8218.
GeneCardsi GC22M019171.
H-InvDB HIX0016234.
HGNCi HGNC:2093. CLTCL1.
HPAi HPA041110.
MIMi 601273. gene.
neXtProti NX_P53675.
PharmGKBi PA26619.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG314149.
HOGENOMi HOG000188877.
HOVERGENi HBG005344.
InParanoidi P53675.
KOi K04646.
OMAi QRCYEEG.
OrthoDBi EOG7Z0JVM.
PhylomeDBi P53675.
TreeFami TF300059.

Enzyme and pathway databases

Reactomei REACT_11035. Gap junction degradation.
REACT_11049. Formation of annular gap junctions.

Miscellaneous databases

ChiTaRSi CLTCL1. human.
GenomeRNAii 8218.
NextBioi 30943.
PROi P53675.
SOURCEi Search...

Gene expression databases

ArrayExpressi P53675.
Bgeei P53675.
CleanExi HS_CLTCL1.
Genevestigatori P53675.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
2.130.10.110. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR016025. Clathrin_H-chain_link/propller.
IPR015348. Clathrin_H-chain_linker_core.
IPR001473. Clathrin_H-chain_propeller_N.
IPR022365. Clathrin_H-chain_propeller_rpt.
IPR016341. Clathrin_heavy_chain.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF00637. Clathrin. 7 hits.
PF09268. Clathrin-link. 1 hit.
PF01394. Clathrin_propel. 2 hits.
[Graphical view ]
PIRSFi PIRSF002290. Clathrin_H_chain. 1 hit.
SMARTi SM00299. CLH. 7 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 6 hits.
SSF50989. SSF50989. 1 hit.
PROSITEi PS50236. CHCR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome."
    Sirotkin H., Morrow B., Dasgupta R., Goldberg R., Patangali S.R., Shi G., Cannizzaro L., Shprintzen R., Weissman S., Kucherlapati R.
    Hum. Mol. Genet. 5:617-624(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11."
    Kedra D., Peyrard M., Fransson I., Collins J.E., Dunham I., Roe B.A., Dumanski J.P.
    Hum. Mol. Genet. 5:625-631(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1451-1640 (ISOFORM 2).
    Tissue: Fetal brain and Skeletal muscle.
  3. "Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL)."
    Long K.R., Trofatter J.A., Ramesh V., McCormick M.K., Buckler A.J.
    Genomics 35:466-472(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-691.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCLH2_HUMAN
AccessioniPrimary (citable) accession number: P53675
Secondary accession number(s): B7Z7U5
, Q14017, Q15808, Q15809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi