P53675 (CLH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Clathrin heavy chain 2

Alternative name(s):
Clathrin heavy chain on chromosome 22
Short name=CLH-22

Gene names

Name:	CLTCL1
Synonyms:	CLH22, CLTCL, CLTD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1640 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network By similarity.
Subunit structure	Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium By similarity. May interact with OCRL By similarity.
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Membrane › coated pit; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Cytoplasmic face of coated pits and vesicles By similarity.
Tissue specificity	Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.
Domain	The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice. The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node By similarity.
Sequence similarities	Belongs to the clathrin heavy chain family.

Ontologies

Keywords
Cellular component	Coated pit Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.1. Source: ProtInc intracellular protein transport Inferred from electronic annotation. Source: InterPro mitosis Inferred from direct assay PubMed 19509056. Source: UniProtKB positive regulation of glucose import Inferred from mutant phenotype PubMed 19478182. Source: UniProtKB receptor-mediated endocytosis Inferred from direct assay PubMed 19509056. Source: UniProtKB
Cellular_component	clathrin coat of coated pit Inferred from electronic annotation. Source: InterPro clathrin coat of trans-Golgi network vesicle Inferred from electronic annotation. Source: InterPro clathrin-coated vesicle Inferred from direct assay PubMed 19478182. Source: UniProtKB coated pit Inferred from direct assay PubMed 19509056. Source: UniProtKB spindle Inferred from direct assay PubMed 19509056. Source: UniProtKB trans-Golgi network Inferred from direct assay PubMed 19509056. Source: UniProtKB
Molecular_function	signal transducer activity Traceable author statement Ref.3. Source: ProtInc structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P53675-1)

Also known as: Long; Brain;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P53675-2)

Also known as: Short; Muscle;

The sequence of this isoform differs from the canonical sequence as follows:
     1479-1535: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1640	1640	Clathrin heavy chain 2		PRO_0000205786
Regions
	Region	1 – 479	479	Globular terminal domain
	Region	24 – 67	44	WD40-like repeat 1
	Region	68 – 107	40	WD40-like repeat 2
	Region	108 – 149	42	WD40-like repeat 3
	Region	150 – 195	46	WD40-like repeat 4
	Region	196 – 257	62	WD40-like repeat 5
	Region	258 – 301	44	WD40-like repeat 6
	Region	302 – 330	29	WD40-like repeat 7
	Region	449 – 465	17	Binding site for the uncoating ATPase, involved in lattice disassembly Potential
	Region	480 – 523	44	Flexible linker
	Region	524 – 1640	1117	Heavy chain arm
	Region	524 – 634	111	Distal segment
	Region	639 – 1640	1002	Proximal segment
	Region	1213 – 1522	310	Involved in binding clathrin light chain By similarity
	Region	1551 – 1640	90	Trimerization By similarity
Natural variations
	Alternative sequence	1479 – 1535	57	Missing in isoform 2.		VSP_001100
	Natural variant	61	1	P → L. Corresponds to variant rs3747059 [ dbSNP | Ensembl ].		VAR_055653
	Natural variant	205	1	K → R. Corresponds to variant rs5746697 [ dbSNP | Ensembl ].		VAR_055654
	Natural variant	279	1	Y → C. Corresponds to variant rs807459 [ dbSNP | Ensembl ].		VAR_055655
	Natural variant	691	1	E → K. Ref.3 Corresponds to variant rs1060374 [ dbSNP | Ensembl ].		VAR_055656
	Natural variant	941	1	K → R. Corresponds to variant rs35398725 [ dbSNP | Ensembl ].		VAR_055657
	Natural variant	945	1	R → H. Corresponds to variant rs36077768 [ dbSNP | Ensembl ].		VAR_055658
	Natural variant	1046	1	R → C. Corresponds to variant rs712952 [ dbSNP | Ensembl ].		VAR_055659
	Natural variant	1195	1	N → S. Corresponds to variant rs807547 [ dbSNP | Ensembl ].		VAR_059214
	Natural variant	1316	1	M → V. Corresponds to variant rs1061325 [ dbSNP | Ensembl ].		VAR_059215
	Natural variant	1394	1	I → T. Corresponds to variant rs1633399 [ dbSNP | Ensembl ].		VAR_059216
	Natural variant	1592	1	V → M. Corresponds to variant rs2073738 [ dbSNP | Ensembl ].		VAR_059217
	Natural variant	1620	1	R → H. Corresponds to variant rs5748024 [ dbSNP | Ensembl ].		VAR_059218
Experimental info
	Sequence conflict	193	1	P → H in AAC50494. Ref.1
	Sequence conflict	215	1	L → H in AAC50494. Ref.1
	Sequence conflict	320	1	K → T in CAA64752. Ref.2
	Sequence conflict	530	1	L → Q in AAC50494. Ref.1
	Sequence conflict	1474	1	E → K in AAB40908. Ref.3
	Sequence conflict	1474	1	E → K in AAB40909. Ref.3
	Sequence conflict	1620 – 1640	21	RKQEE…FDGHE → PPSKRSM in AAB40908. Ref.3
	Sequence conflict	1620 – 1640	21	RKQEE…FDGHE → PPSKRSM in AAB40909. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) (Brain) [UniParc]. Last modified November 1, 1997. Version 2. Checksum: C661E1AB989D8E7F	FASTA	1,640	187,030
	10 20 30 40 50 60 MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV TIIDMSDPMA 70 80 90 100 110 120 PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMAEEVIF WKWVSVNTVA 130 140 150 160 170 180 LVTETAVYHW SMEGDSQPMK MFDRHTSLVG CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA 190 200 210 220 230 240 MQLYSVDRKV SQPIEGHAAA FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN 250 260 270 280 290 300 QPFVKKAVDV FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA 310 320 330 340 350 360 DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR LAVRSNLAGA 370 380 390 400 410 420 EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK FQSIPAQSGQ ASPLLQYFGI 430 440 450 460 470 480 LLDQGQLNKL ESLELCHLVL QQGRKQLLEK WLKEDKLECS EELGDLVKTT DPMLALSVYL 490 500 510 520 530 540 RANVPSKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE 550 560 570 580 590 600 EPLANISQIV DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL 610 620 630 640 650 660 GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW LVNFFGSLSV 670 680 690 700 710 720 EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE LFESFKSYKG LFYFLGSIVN 730 740 750 760 770 780 FSQDPDVHLK YIQAACKTGQ IKEVERICRE SSCYNPERVK NFLKEAKLTD QLPLIIVCDR 790 800 810 820 830 840 FGFVHDLVLY LYRNNLQRYI EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF 850 860 870 880 890 900 STDELVAEVE KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY 910 920 930 940 950 960 DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR KDPELWAHVL 970 980 990 1000 1010 1020 EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1030 1040 1050 1060 1070 1080 HRNLQNLLIL TAIKADRTRV MEYISRLDNY DALDIASIAV SSALYEEAFT VFHKFDMNAS 1090 1100 1110 1120 1130 1140 AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV 1150 1160 1170 1180 1190 1200 VQSASRSNNW EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ 1210 1220 1230 1240 1250 1260 VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST RTWKEVCFAC 1270 1280 1290 1300 1310 1320 MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI LLLEAALGLE RAHMGMFTEL 1330 1340 1350 1360 1370 1380 AILYSKFKPQ KMLEHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS 1390 1400 1410 1420 1430 1440 HPTEAWKEGQ FKDIITKVAN VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS 1450 1460 1470 1480 1490 1500 KAGQLPLVKP YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNISLAQQLE 1510 1520 1530 1540 1550 1560 KHQLMEFRCI AAYLYKGNNW WAQSVELCKK DHLYKDAMQH AAESRDAELA QKLLQWFLEE 1570 1580 1590 1600 1610 1620 GKRECFAACL FTCYDLLRPD MVLELAWRHN LVDLAMPYFI QVMREYLSKV DKLDALESLR 1630 1640 KQEEHVTEPA PLVFDFDGHE
	Isoform 2 (Short) (Muscle) [UniParc]. Checksum: 5DB1E3D4A77607D8	FASTA	1,583	180,296
	10 20 30 40 50 60 MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV TIIDMSDPMA 70 80 90 100 110 120 PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMAEEVIF WKWVSVNTVA 130 140 150 160 170 180 LVTETAVYHW SMEGDSQPMK MFDRHTSLVG CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA 190 200 210 220 230 240 MQLYSVDRKV SQPIEGHAAA FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN 250 260 270 280 290 300 QPFVKKAVDV FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA 310 320 330 340 350 360 DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR LAVRSNLAGA 370 380 390 400 410 420 EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK FQSIPAQSGQ ASPLLQYFGI 430 440 450 460 470 480 LLDQGQLNKL ESLELCHLVL QQGRKQLLEK WLKEDKLECS EELGDLVKTT DPMLALSVYL 490 500 510 520 530 540 RANVPSKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE 550 560 570 580 590 600 EPLANISQIV DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL 610 620 630 640 650 660 GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW LVNFFGSLSV 670 680 690 700 710 720 EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE LFESFKSYKG LFYFLGSIVN 730 740 750 760 770 780 FSQDPDVHLK YIQAACKTGQ IKEVERICRE SSCYNPERVK NFLKEAKLTD QLPLIIVCDR 790 800 810 820 830 840 FGFVHDLVLY LYRNNLQRYI EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF 850 860 870 880 890 900 STDELVAEVE KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY 910 920 930 940 950 960 DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR KDPELWAHVL 970 980 990 1000 1010 1020 EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1030 1040 1050 1060 1070 1080 HRNLQNLLIL TAIKADRTRV MEYISRLDNY DALDIASIAV SSALYEEAFT VFHKFDMNAS 1090 1100 1110 1120 1130 1140 AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV 1150 1160 1170 1180 1190 1200 VQSASRSNNW EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ 1210 1220 1230 1240 1250 1260 VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST RTWKEVCFAC 1270 1280 1290 1300 1310 1320 MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI LLLEAALGLE RAHMGMFTEL 1330 1340 1350 1360 1370 1380 AILYSKFKPQ KMLEHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS 1390 1400 1410 1420 1430 1440 HPTEAWKEGQ FKDIITKVAN VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS 1450 1460 1470 1480 1490 1500 KAGQLPLVKP YLRSVQSHNN KSVNEALNHL LTEEEDYQDA MQHAAESRDA ELAQKLLQWF 1510 1520 1530 1540 1550 1560 LEEGKRECFA ACLFTCYDLL RPDMVLELAW RHNLVDLAMP YFIQVMREYL SKVDKLDALE 1570 1580 SLRKQEEHVT EPAPLVFDFD GHE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome." Sirotkin H., Morrow B., Dasgupta R., Goldberg R., Patangali S.R., Shi G., Cannizzaro L., Shprintzen R., Weissman S., Kucherlapati R. Hum. Mol. Genet. 5:617-624(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11." Kedra D., Peyrard M., Fransson I., Collins J.E., Dunham I., Roe B.A., Dumanski J.P. Hum. Mol. Genet. 5:625-631(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1451-1640 (ISOFORM 2). Tissue: Fetal brain and Skeletal muscle.
[3]	"Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL)." Long K.R., Trofatter J.A., Ramesh V., McCormick M.K., Buckler A.J. Genomics 35:466-472(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-691.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	U41763 mRNA. Translation: AAC50494.1. X95486 mRNA. Translation: CAA64752.1. X95487 mRNA. Translation: CAA64753.1. U60802 mRNA. Translation: AAB40908.1. U60803 mRNA. Translation: AAB40909.1. AK302506 mRNA. Translation: BAH13731.1. CH471176 Genomic DNA. Translation: EAX03047.1.
IPI	IPI00022881. IPI00300446.
PIR	G02757. T09522.
RefSeq	NP_001826.3. NM_001835.3. NP_009029.3. NM_007098.3.
UniGene	Hs.368266.
3D structure databases
ProteinModelPortal	P53675.
ModBase	Search...
Protein-protein interaction databases
IntAct	P53675. 8 interactions.
MINT	MINT-208273.
STRING	9606.ENSP00000263200.
PTM databases
PhosphoSite	P53675.
Polymorphism databases
DMDM	2506298.
Proteomic databases
PaxDb	P53675.
PRIDE	P53675.
Protocols and materials databases
DNASU	8218.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263200; ENSP00000445677; ENSG00000070371. ENST00000353891; ENSP00000439662; ENSG00000070371. ENST00000427926; ENSP00000441158; ENSG00000070371.
GeneID	8218.
KEGG	hsa:8218.
UCSC	uc011agw.1. human. uc021wld.1. human.
Organism-specific databases
CTD	8218.
GeneCards	GC22M019171.
H-InvDB	HIX0016234.
HGNC	HGNC:2093. CLTCL1.
HPA	HPA041110.
MIM	601273. gene.
neXtProt	NX_P53675.
PharmGKB	PA26619.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG314149.
HOGENOM	HOG000188877.
HOVERGEN	HBG005344.
InParanoid	P53675.
KO	K04646.
OMA	EPQPIVF.
OrthoDB	EOG4TXBR0.
PhylomeDB	P53675.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	P53675.
Bgee	P53675.
CleanEx	HS_CLTCL1.
Genevestigator	P53675.
GermOnline	ENSG00000070371. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 3 hits. 2.130.10.110. 1 hit.
InterPro	IPR016024. ARM-type_fold. IPR000547. Clathrin_H-chain/VPS_repeat. IPR016025. Clathrin_H-chain_link/propller. IPR015348. Clathrin_H-chain_linker_core. IPR001473. Clathrin_H-chain_propeller_N. IPR022365. Clathrin_H-chain_propeller_rpt. IPR016341. Clathrin_heavy_chain. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF00637. Clathrin. 7 hits. PF09268. Clathrin-link. 1 hit. PF01394. Clathrin_propel. 2 hits. [Graphical view]
PIRSF	PIRSF002290. Clathrin_H_chain. 1 hit.
SMART	SM00299. CLH. 7 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 6 hits. SSF50989. Clathrin_H-chain_propeller_N. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	CLTCL1. human.
GenomeRNAi	8218.
NextBio	30943.
SOURCE	Search...

Entry information

Entry name

CLH2_HUMAN

Accession

Primary (citable) accession number: P53675
Secondary accession number(s): B7Z7U5 , Q14017, Q15808, Q15809

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.