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P53675

- CLH2_HUMAN

UniProt

P53675 - CLH2_HUMAN

Protein

Clathrin heavy chain 2

Gene

CLTCL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. signal transducer activity Source: ProtInc
    3. structural molecule activity Source: InterPro

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. intracellular protein transport Source: InterPro
    3. mitotic nuclear division Source: UniProtKB
    4. positive regulation of glucose import Source: UniProtKB
    5. receptor-mediated endocytosis Source: UniProtKB
    6. signal transduction Source: GOC

    Enzyme and pathway databases

    ReactomeiREACT_11035. Gap junction degradation.
    REACT_11049. Formation of annular gap junctions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Clathrin heavy chain 2
    Alternative name(s):
    Clathrin heavy chain on chromosome 22
    Short name:
    CLH-22
    Gene namesi
    Name:CLTCL1
    Synonyms:CLH22, CLTCL, CLTD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:2093. CLTCL1.

    Subcellular locationi

    Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Membranecoated pit By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Cytoplasmic face of coated pits and vesicles.By similarity

    GO - Cellular componenti

    1. clathrin-coated vesicle Source: UniProtKB
    2. clathrin coat of coated pit Source: InterPro
    3. clathrin coat of trans-Golgi network vesicle Source: InterPro
    4. coated pit Source: UniProtKB
    5. coated vesicle Source: UniProtKB
    6. membrane Source: UniProtKB
    7. spindle Source: UniProtKB
    8. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Coated pit, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26619.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16401640Clathrin heavy chain 2PRO_0000205786Add
    BLAST

    Proteomic databases

    MaxQBiP53675.
    PaxDbiP53675.
    PRIDEiP53675.

    PTM databases

    PhosphoSiteiP53675.

    Expressioni

    Tissue specificityi

    Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.

    Gene expression databases

    ArrayExpressiP53675.
    BgeeiP53675.
    CleanExiHS_CLTCL1.
    GenevestigatoriP53675.

    Organism-specific databases

    HPAiHPA041110.

    Interactioni

    Subunit structurei

    Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium By similarity. May interact with OCRL By similarity.By similarity

    Protein-protein interaction databases

    BioGridi113854. 14 interactions.
    IntActiP53675. 9 interactions.
    MINTiMINT-208273.
    STRINGi9606.ENSP00000263200.

    Structurei

    3D structure databases

    ProteinModelPortaliP53675.
    SMRiP53675. Positions 1-493, 1077-1628.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati537 – 683147CHCR 1Add
    BLAST
    Repeati686 – 828143CHCR 2Add
    BLAST
    Repeati833 – 972140CHCR 3Add
    BLAST
    Repeati979 – 1124146CHCR 4Add
    BLAST
    Repeati1128 – 1269142CHCR 5Add
    BLAST
    Repeati1274 – 1420147CHCR 6Add
    BLAST
    Repeati1423 – 1566144CHCR 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 479479Globular terminal domainAdd
    BLAST
    Regioni24 – 6744WD40-like repeat 1Add
    BLAST
    Regioni68 – 10740WD40-like repeat 2Add
    BLAST
    Regioni108 – 14942WD40-like repeat 3Add
    BLAST
    Regioni150 – 19546WD40-like repeat 4Add
    BLAST
    Regioni196 – 25762WD40-like repeat 5Add
    BLAST
    Regioni258 – 30144WD40-like repeat 6Add
    BLAST
    Regioni302 – 33029WD40-like repeat 7Add
    BLAST
    Regioni449 – 46517Binding site for the uncoating ATPase, involved in lattice disassemblySequence AnalysisAdd
    BLAST
    Regioni480 – 52344Flexible linkerAdd
    BLAST
    Regioni524 – 16401117Heavy chain armAdd
    BLAST
    Regioni524 – 634111Distal segmentAdd
    BLAST
    Regioni639 – 16401002Proximal segmentAdd
    BLAST
    Regioni1213 – 1522310Involved in binding clathrin light chainBy similarityAdd
    BLAST
    Regioni1551 – 164090TrimerizationBy similarityAdd
    BLAST

    Domaini

    The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
    The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node By similarity.By similarity

    Sequence similaritiesi

    Belongs to the clathrin heavy chain family.Curated
    Contains 7 CHCR (clathrin heavy-chain) repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG314149.
    HOGENOMiHOG000188877.
    HOVERGENiHBG005344.
    InParanoidiP53675.
    KOiK04646.
    OMAiQRCYEEG.
    OrthoDBiEOG7Z0JVM.
    PhylomeDBiP53675.
    TreeFamiTF300059.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    2.130.10.110. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000547. Clathrin_H-chain/VPS_repeat.
    IPR016025. Clathrin_H-chain_link/propller.
    IPR015348. Clathrin_H-chain_linker_core.
    IPR001473. Clathrin_H-chain_propeller_N.
    IPR022365. Clathrin_H-chain_propeller_rpt.
    IPR016341. Clathrin_heavy_chain.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF00637. Clathrin. 7 hits.
    PF09268. Clathrin-link. 1 hit.
    PF01394. Clathrin_propel. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002290. Clathrin_H_chain. 1 hit.
    SMARTiSM00299. CLH. 7 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 6 hits.
    SSF50989. SSF50989. 1 hit.
    PROSITEiPS50236. CHCR. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P53675-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, Brain

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQILPVRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV     50
    TIIDMSDPMA PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK 100
    AHTMAEEVIF WKWVSVNTVA LVTETAVYHW SMEGDSQPMK MFDRHTSLVG 150
    CQVIHYRTDE YQKWLLLVGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAA 200
    FAEFKMEGNA KPATLFCFAV RNPTGGKLHI IEVGQPAAGN QPFVKKAVDV 250
    FFPPEAQNDF PVAMQIGAKH GVIYLITKYG YLHLYDLESG VCICMNRISA 300
    DTIFVTAPHK PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR 350
    LAVRSNLAGA EKLFVRKFNT LFAQGSYAEA AKVAASAPKG ILRTRETVQK 400
    FQSIPAQSGQ ASPLLQYFGI LLDQGQLNKL ESLELCHLVL QQGRKQLLEK 450
    WLKEDKLECS EELGDLVKTT DPMLALSVYL RANVPSKVIQ CFAETGQFQK 500
    IVLYAKKVGY TPDWIFLLRG VMKISPEQGL QFSRMLVQDE EPLANISQIV 550
    DIFMENSLIQ QCTSFLLDAL KNNRPAEGLL QTWLLEMNLV HAPQVADAIL 600
    GNKMFTHYDR AHIAQLCEKA GLLQQALEHY TDLYDIKRAV VHTHLLNPEW 650
    LVNFFGSLSV EDSVECLHAM LSANIRQNLQ LCVQVASKYH EQLGTQALVE 700
    LFESFKSYKG LFYFLGSIVN FSQDPDVHLK YIQAACKTGQ IKEVERICRE 750
    SSCYNPERVK NFLKEAKLTD QLPLIIVCDR FGFVHDLVLY LYRNNLQRYI 800
    EIYVQKVNPS RTPAVIGGLL DVDCSEEVIK HLIMAVRGQF STDELVAEVE 850
    KRNRLKLLLP WLESQIQEGC EEPATHNALA KIYIDSNNSP ECFLRENAYY 900
    DSSVVGRYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVCR 950
    KDPELWAHVL EETNPSRRQL IDQVVQTALS ETRDPEEISV TVKAFMTADL 1000
    PNELIELLEK IVLDNSVFSE HRNLQNLLIL TAIKADRTRV MEYISRLDNY 1050
    DALDIASIAV SSALYEEAFT VFHKFDMNAS AIQVLIEHIG NLDRAYEFAE 1100
    RCNEPAVWSQ LAQAQLQKDL VKEAINSYIR GDDPSSYLEV VQSASRSNNW 1150
    EDLVKFLQMA RKKGRESYIE TELIFALAKT SRVSELEDFI NGPNNAHIQQ 1200
    VGDRCYEEGM YEAAKLLYSN VSNFARLAST LVHLGEYQAA VDNSRKASST 1250
    RTWKEVCFAC MDGQEFRFAQ LCGLHIVIHA DELEELMCYY QDRGYFEELI 1300
    LLLEAALGLE RAHMGMFTEL AILYSKFKPQ KMLEHLELFW SRVNIPKVLR 1350
    AAEQAHLWAE LVFLYDKYEE YDNAVLTMMS HPTEAWKEGQ FKDIITKVAN 1400
    VELCYRALQF YLDYKPLLIN DLLLVLSPRL DHTWTVSFFS KAGQLPLVKP 1450
    YLRSVQSHNN KSVNEALNHL LTEEEDYQGL RASIDAYDNF DNISLAQQLE 1500
    KHQLMEFRCI AAYLYKGNNW WAQSVELCKK DHLYKDAMQH AAESRDAELA 1550
    QKLLQWFLEE GKRECFAACL FTCYDLLRPD MVLELAWRHN LVDLAMPYFI 1600
    QVMREYLSKV DKLDALESLR KQEEHVTEPA PLVFDFDGHE 1640
    Length:1,640
    Mass (Da):187,030
    Last modified:November 1, 1997 - v2
    Checksum:iC661E1AB989D8E7F
    GO
    Isoform 2 (identifier: P53675-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, Muscle

    The sequence of this isoform differs from the canonical sequence as follows:
         1479-1535: Missing.

    Show »
    Length:1,583
    Mass (Da):180,296
    Checksum:i5DB1E3D4A77607D8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti193 – 1931P → H in AAC50494. (PubMed:8733128)Curated
    Sequence conflicti215 – 2151L → H in AAC50494. (PubMed:8733128)Curated
    Sequence conflicti320 – 3201K → T in CAA64752. (PubMed:8733129)Curated
    Sequence conflicti530 – 5301L → Q in AAC50494. (PubMed:8733128)Curated
    Sequence conflicti1474 – 14741E → K in AAB40908. (PubMed:8844170)Curated
    Sequence conflicti1474 – 14741E → K in AAB40909. (PubMed:8844170)Curated
    Sequence conflicti1620 – 164021RKQEE…FDGHE → PPSKRSM in AAB40908. (PubMed:8844170)CuratedAdd
    BLAST
    Sequence conflicti1620 – 164021RKQEE…FDGHE → PPSKRSM in AAB40909. (PubMed:8844170)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611P → L.
    Corresponds to variant rs3747059 [ dbSNP | Ensembl ].
    VAR_055653
    Natural varianti205 – 2051K → R.
    Corresponds to variant rs5746697 [ dbSNP | Ensembl ].
    VAR_055654
    Natural varianti279 – 2791Y → C.
    Corresponds to variant rs807459 [ dbSNP | Ensembl ].
    VAR_055655
    Natural varianti691 – 6911E → K.1 Publication
    Corresponds to variant rs1060374 [ dbSNP | Ensembl ].
    VAR_055656
    Natural varianti941 – 9411K → R.
    Corresponds to variant rs35398725 [ dbSNP | Ensembl ].
    VAR_055657
    Natural varianti945 – 9451R → H.
    Corresponds to variant rs36077768 [ dbSNP | Ensembl ].
    VAR_055658
    Natural varianti1046 – 10461R → C.
    Corresponds to variant rs712952 [ dbSNP | Ensembl ].
    VAR_055659
    Natural varianti1195 – 11951N → S.
    Corresponds to variant rs807547 [ dbSNP | Ensembl ].
    VAR_059214
    Natural varianti1316 – 13161M → V.
    Corresponds to variant rs1061325 [ dbSNP | Ensembl ].
    VAR_059215
    Natural varianti1394 – 13941I → T.
    Corresponds to variant rs1633399 [ dbSNP | Ensembl ].
    VAR_059216
    Natural varianti1592 – 15921V → M.
    Corresponds to variant rs2073738 [ dbSNP | Ensembl ].
    VAR_059217
    Natural varianti1620 – 16201R → H.
    Corresponds to variant rs5748024 [ dbSNP | Ensembl ].
    VAR_059218

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1479 – 153557Missing in isoform 2. 3 PublicationsVSP_001100Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41763 mRNA. Translation: AAC50494.1.
    X95486 mRNA. Translation: CAA64752.1.
    X95487 mRNA. Translation: CAA64753.1.
    U60802 mRNA. Translation: AAB40908.1.
    U60803 mRNA. Translation: AAB40909.1.
    AK302506 mRNA. Translation: BAH13731.1.
    CH471176 Genomic DNA. Translation: EAX03047.1.
    CCDSiCCDS46662.1. [P53675-1]
    CCDS54497.1. [P53675-2]
    PIRiG02757.
    T09522.
    RefSeqiNP_001826.3. NM_001835.3. [P53675-2]
    NP_009029.3. NM_007098.3. [P53675-1]
    UniGeneiHs.368266.

    Genome annotation databases

    EnsembliENST00000427926; ENSP00000441158; ENSG00000070371. [P53675-1]
    GeneIDi8218.
    KEGGihsa:8218.
    UCSCiuc011agw.1. human. [P53675-1]
    uc021wld.1. human. [P53675-2]

    Polymorphism databases

    DMDMi2506298.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41763 mRNA. Translation: AAC50494.1 .
    X95486 mRNA. Translation: CAA64752.1 .
    X95487 mRNA. Translation: CAA64753.1 .
    U60802 mRNA. Translation: AAB40908.1 .
    U60803 mRNA. Translation: AAB40909.1 .
    AK302506 mRNA. Translation: BAH13731.1 .
    CH471176 Genomic DNA. Translation: EAX03047.1 .
    CCDSi CCDS46662.1. [P53675-1 ]
    CCDS54497.1. [P53675-2 ]
    PIRi G02757.
    T09522.
    RefSeqi NP_001826.3. NM_001835.3. [P53675-2 ]
    NP_009029.3. NM_007098.3. [P53675-1 ]
    UniGenei Hs.368266.

    3D structure databases

    ProteinModelPortali P53675.
    SMRi P53675. Positions 1-493, 1077-1628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113854. 14 interactions.
    IntActi P53675. 9 interactions.
    MINTi MINT-208273.
    STRINGi 9606.ENSP00000263200.

    PTM databases

    PhosphoSitei P53675.

    Polymorphism databases

    DMDMi 2506298.

    Proteomic databases

    MaxQBi P53675.
    PaxDbi P53675.
    PRIDEi P53675.

    Protocols and materials databases

    DNASUi 8218.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427926 ; ENSP00000441158 ; ENSG00000070371 . [P53675-1 ]
    GeneIDi 8218.
    KEGGi hsa:8218.
    UCSCi uc011agw.1. human. [P53675-1 ]
    uc021wld.1. human. [P53675-2 ]

    Organism-specific databases

    CTDi 8218.
    GeneCardsi GC22M019171.
    H-InvDB HIX0016234.
    HGNCi HGNC:2093. CLTCL1.
    HPAi HPA041110.
    MIMi 601273. gene.
    neXtProti NX_P53675.
    PharmGKBi PA26619.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314149.
    HOGENOMi HOG000188877.
    HOVERGENi HBG005344.
    InParanoidi P53675.
    KOi K04646.
    OMAi QRCYEEG.
    OrthoDBi EOG7Z0JVM.
    PhylomeDBi P53675.
    TreeFami TF300059.

    Enzyme and pathway databases

    Reactomei REACT_11035. Gap junction degradation.
    REACT_11049. Formation of annular gap junctions.

    Miscellaneous databases

    ChiTaRSi CLTCL1. human.
    GenomeRNAii 8218.
    NextBioi 30943.
    PROi P53675.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P53675.
    Bgeei P53675.
    CleanExi HS_CLTCL1.
    Genevestigatori P53675.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    2.130.10.110. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000547. Clathrin_H-chain/VPS_repeat.
    IPR016025. Clathrin_H-chain_link/propller.
    IPR015348. Clathrin_H-chain_linker_core.
    IPR001473. Clathrin_H-chain_propeller_N.
    IPR022365. Clathrin_H-chain_propeller_rpt.
    IPR016341. Clathrin_heavy_chain.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF00637. Clathrin. 7 hits.
    PF09268. Clathrin-link. 1 hit.
    PF01394. Clathrin_propel. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002290. Clathrin_H_chain. 1 hit.
    SMARTi SM00299. CLH. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 6 hits.
    SSF50989. SSF50989. 1 hit.
    PROSITEi PS50236. CHCR. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a new clathrin heavy chain gene with muscle-specific expression from the region commonly deleted in velo-cardio-facial syndrome."
      Sirotkin H., Morrow B., Dasgupta R., Goldberg R., Patangali S.R., Shi G., Cannizzaro L., Shprintzen R., Weissman S., Kucherlapati R.
      Hum. Mol. Genet. 5:617-624(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11."
      Kedra D., Peyrard M., Fransson I., Collins J.E., Dunham I., Roe B.A., Dumanski J.P.
      Hum. Mol. Genet. 5:625-631(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 1451-1640 (ISOFORM 2).
      Tissue: Fetal brain and Skeletal muscle.
    3. "Cloning and characterization of a novel human clathrin heavy chain gene (CLTCL)."
      Long K.R., Trofatter J.A., Ramesh V., McCormick M.K., Buckler A.J.
      Genomics 35:466-472(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-691.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiCLH2_HUMAN
    AccessioniPrimary (citable) accession number: P53675
    Secondary accession number(s): B7Z7U5
    , Q14017, Q15808, Q15809
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3